Gabor Szabo

Summary

Publications

  1. ncbi request reprint Brain death impairs coronary endothelial function
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neueneheimer Feld 110, 69120 Heidelberg, Germany
    Transplantation 73:1846-8. 2002
  2. ncbi request reprint A new computer model of mitral valve hemodynamics during ventricular filling
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 26:239-47. 2004
  3. ncbi request reprint Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest
    Terézia B Andrási
    Dept of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus Univ Hospital, Fetscherstrasse 74, Haus 59, 01307 Dresden, Germany
    Am J Physiol Heart Circ Physiol 288:H2972-8. 2005
  4. ncbi request reprint Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 27:226-34. 2005
  5. ncbi request reprint Adaptation of the right ventricle to an increased afterload in the chronically volume overloaded heart
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Thorac Surg 82:989-95. 2006
  6. ncbi request reprint Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death
    G Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Ann Thorac Surg 67:18-25; discussion 25-6. 1999
  7. ncbi request reprint Poly(ADP-ribose) polymerase activation in the reperfused myocardium
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Cardiovasc Res 61:471-80. 2004
  8. ncbi request reprint Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Eur J Cardiothorac Surg 25:825-32. 2004
  9. ncbi request reprint INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany, D 69120
    Shock 21:426-32. 2004
  10. ncbi request reprint Physiologic changes after brain death
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Heart Lung Transplant 23:S223-6. 2004

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Brain death impairs coronary endothelial function
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neueneheimer Feld 110, 69120 Heidelberg, Germany
    Transplantation 73:1846-8. 2002
    ..To characterize the impact of brain death (BD) on endothelial dysfunction after cardiac transplantation we investigated coronary circulation and vasomotor function in a canine model...
  2. ncbi request reprint A new computer model of mitral valve hemodynamics during ventricular filling
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 26:239-47. 2004
    ..The purpose of the present study was to develop a lumped parameter model of left ventricular filling and validate it in porcine trials under physiological conditions and after valve replacement...
  3. ncbi request reprint Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest
    Terézia B Andrási
    Dept of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus Univ Hospital, Fetscherstrasse 74, Haus 59, 01307 Dresden, Germany
    Am J Physiol Heart Circ Physiol 288:H2972-8. 2005
    ..135 +/- 9 ng/ml, P < 0.05). Pharmacological PARP inhibition protects against development of post-CPB mesenteric vascular dysfunction by improving hemodynamics, restoring nitric oxide production, and reducing neutrophil adhesion...
  4. ncbi request reprint Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 27:226-34. 2005
    ..Poly (ADP-ribose) polymerase (PARP) activation plays a key role in free radical induced injury in ischemia/reperfusion. We investigated the effects of INO-1001 a novel PARP inhibitor on postischemic myocardial and endothelial function...
  5. ncbi request reprint Adaptation of the right ventricle to an increased afterload in the chronically volume overloaded heart
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Thorac Surg 82:989-95. 2006
    ..We determined the effects of an acute increase of right ventricular afterload in normal and chronically volume overloaded hearts...
  6. ncbi request reprint Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death
    G Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Ann Thorac Surg 67:18-25; discussion 25-6. 1999
    ..The aim of the present study was to investigate coronary perfusion changes during brain death and their role in cardiac dysfunction...
  7. ncbi request reprint Poly(ADP-ribose) polymerase activation in the reperfused myocardium
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Cardiovasc Res 61:471-80. 2004
    ..The objective of the current review is to provide an overview of the experimental evidence implicating PARP as a pathophysiological modulator of myocardial injury in vitro and in vivo...
  8. ncbi request reprint Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Eur J Cardiothorac Surg 25:825-32. 2004
    ..To investigate the effects of PARP inhibition on cardiac and pulmonary function during reperfusion in a clinically relevant experimental model of cardiopulmonary bypass...
  9. ncbi request reprint INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany, D 69120
    Shock 21:426-32. 2004
    ..05). Thus, PARP inhibition improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation...
  10. ncbi request reprint Physiologic changes after brain death
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Heart Lung Transplant 23:S223-6. 2004
    ..On the basis of recent experimental and clinical data, the reduced myocardial contractility after brain death might be seen as a physiologic response to decreased pre- and afterload and coronary perfusion...
  11. doi request reprint Vardenafil protects against myocardial and endothelial injuries after cardiopulmonary bypass
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 36:657-64. 2009
    ..We investigated the effects of vardenafil, a selective phosphodiesterase-5 inhibitor on myocardial and endothelial functions during reperfusion in a canine model of cardioplegic arrest and extracorporal circulation...
  12. ncbi request reprint Effects of inosine on reperfusion injury after heart transplantation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 30:96-102. 2006
    ..Inosine, a break-down product of adenosine, has been recently shown to exert inodilatory and anti-inflammatory properties. We investigated the effects of inosine on ischemia/reperfusion injury in a rat heart transplantation model...
  13. ncbi request reprint Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Curr Vasc Pharmacol 3:215-20. 2005
    ..The present review overviews the pathophysiological role of the peroxynitrite-PARP pathway in cardiac ischemia/reperfusion injury with special reference to the therapeutic potential of PARP inhibitors in the treatment of this disease...
  14. ncbi request reprint Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, In Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Thorac Cardiovasc Surg 126:651-8. 2003
    ..We investigated the effects of poly-ADP-ribose synthetase inhibition on myocardial and endothelial function during reperfusion in an experimental model of cardiopulmonary bypass...
  15. ncbi request reprint Immunomodulatory effects of poly(ADP-ribose) polymerase inhibition contribute to improved cardiac function and survival during acute cardiac rejection
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 25:794-804. 2006
    ..Therefore, we investigated whether PARP inhibition improves transplant outcome and the extent to which immunologic factors contribute to the effects of PARP inhibition...
  16. ncbi request reprint L-arginine improves endothelial and myocardial function after brain death
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Transplantation 82:108-12. 2006
    ..Recently, we showed that brain death (BD) leads to a severe impairment of endothelial function...
  17. ncbi request reprint Downregulation of myocardial contractility via intact ventriculo--arterial coupling in the brain dead organ donor
    G Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, 69120, Germany
    Eur J Cardiothorac Surg 20:170-6. 2001
    ..To test the hypothesis that altered loading conditions play a key role in hemodynamic instability and cardiac dysfunction in the brain dead (BD) organ donor...
  18. ncbi request reprint The role of endothelin-B receptors in myocardial and endothelial reperfusion injury after heart transplantation
    G Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Thorac Cardiovasc Surg 49:167-71. 2001
    ....
  19. ncbi request reprint Myocardial performance after brain death: studies in isolated hearts
    G Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Ann Transplant 5:45-50. 2000
    ..Brain death was induced by inflation of a subdural balloon catheter. Loading conditions and coronary perfusion pressure were kept identical in all cross-circulated hearts throughout the experiment...
  20. ncbi request reprint Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Circ Res 90:100-6. 2002
    ....
  21. ncbi request reprint Contractility-afterload mismatch after the Fontan operation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Cardiol Young 15:35-8. 2005
  22. ncbi request reprint Ventricular energetics after the Fontan operation: contractility-afterload mismatch
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Germany
    J Thorac Cardiovasc Surg 125:1061-9. 2003
    ..The present study investigated cardiac performance after the Fontan operation by using ventricular-vascular coupling framework analysis...
  23. doi request reprint Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta
    Sevil Korkmaz
    Department of Cardiac Surgery, University of Heidelberg, 2 OG INF 326, 69120 Heidelberg, Germany
    Eur J Pharmacol 615:155-62. 2009
    ..This work supports the view that acute PDE5-inhibition might be advantageous in the treatment of endothelial dysfunction induced by disturbed NO-cGMP pathway due to nitro-oxidative stress...
  24. ncbi request reprint Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 32:2392-7. 2004
    ....
  25. doi request reprint Enhancement of myocardial and vascular function after phosphodiesterase-5 inhibition in a rat model
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326, Heidelberg, Germany
    Thorac Cardiovasc Surg 60:247-54. 2012
    ..In the present study, we investigated the effects of vardenafil on myocardial contractility and vascular function in a dose-response study...
  26. doi request reprint Vascular dysfunction induced by hypochlorite is improved by the selective phosphodiesterase-5-inhibitor vardenafil
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, 2 OG INF 326, 69120 Heidelberg, Germany
    Eur J Pharmacol 710:110-9. 2013
    ..PDE-5-inhibition may represent a potential therapy approach for treating vascular dysfunction induced by oxidative stress...
  27. pmc Catalytic peroxynitrite decomposition improves reperfusion injury after heart transplantation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Thorac Cardiovasc Surg 143:1443-9. 2012
    ..The present study investigated the effects of the potent peroxynitrite decomposition catalyst FP15 on myocardial and endothelial function after hypothermic ischemia-reperfusion in a heterotopic rat heart transplantation model...
  28. doi request reprint Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:1414-8. 2008
    ..We could show that up-regulating this pathway has a preconditioning-like effect and can effectively reduce ischemia/reperfusion injury...
  29. pmc Cardioprotective effects of hydrogen sulfide
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheiemer Feld 110, 69120 Heidelberg, Germany
    Nitric Oxide 25:201-10. 2011
    ....
  30. doi request reprint Selective phosphodiesterase-5 inhibition reduces neointimal hyperplasia in rat carotid arteries after surgical endarterectomy
    Kristof Hirschberg
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Thorac Cardiovasc Surg 137:1508-14. 2009
    ..In a rat model of endarterectomy, we investigated the effect of pharmacologic inhibition of cyclic guanosine monophosphate degradation on neointima formation by using the selective phosphodiesterase-5 inhibitor vardenafil...
  31. ncbi request reprint Modulation of catecholamine responsiveness and beta-adrenergic receptor/adenylyl cyclase pathway during cardiac allograft rejection1 2
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Transplantation 73:535-40. 2002
    ..This study investigated the changes of catecholamine responsiveness and beta-adrenergic receptor/adenylyl cyclase pathway during acute cardiac transplant rejection...
  32. doi request reprint Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia-reperfusion injury after cardiopulmonary bypass
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 39:248-55. 2011
    ....
  33. ncbi request reprint L-arginine protects the mesenteric vascular circulation against cardiopulmonary bypass-induced vascular dysfunction
    Terézia Bogdana Andrási
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Surgery 134:72-9. 2003
    ..The aim of our study was to determine whether addition of the nitric oxide donor l-arginine at reperfusion may prevent the cardiopulmonary bypass (CPB)-induced vascular alterations in the intestine...
  34. doi request reprint Effects of novel synthetic serine protease inhibitors on postoperative blood loss, coagulation parameters, and vascular relaxation after cardiac surgery
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Thorac Cardiovasc Surg 139:181-8; discussion 188. 2010
    ..This study investigated effects of the novel synthetic serine protease inhibitors CU-2010 and CU-2020 on blood loss, coagulation parameters, and coronary relaxation in a canine model...
  35. ncbi request reprint Poly(ADP-ribose) polymerase inhibition reverses vascular dysfunction after gamma-irradiation
    Carsten J Beller
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 65:1528-35. 2006
    ..In the present study, we assessed the effect of PARP inhibition on changes in vascular function after acute and short-term irradiation...
  36. doi request reprint Nitric oxide- and heme-independent activation of soluble guanylate cyclase attenuates peroxynitrite-induced endothelial dysfunction in rat aorta
    Sevil Korkmaz
    Department of Cardiac Surgery, Laboratory of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Cardiovasc Pharmacol Ther 18:70-7. 2013
    ....
  37. ncbi request reprint Poly(ADP-ribose) polymerase inhibition combined with irradiation: a dual treatment concept to prevent neointimal hyperplasia after endarterectomy
    Carsten J Beller
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 66:867-75. 2006
    ....
  38. pmc Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, INF 326 OG 2, Heidelberg, Germany
    Exp Gerontol 42:676-85. 2007
    ..Pharmacological inhibition of PARP may represent a novel therapeutic utility to improve aging-associated cardiovascular dysfunction...
  39. doi request reprint Effects of FP15, a peroxynitrite decomposition catalyst on cardiac and pulmonary function after cardiopulmonary bypass
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 41:391-6. 2012
    ....
  40. ncbi request reprint Effect of recombinant aprotinin on postoperative blood loss and coronary vascular function in a canine model of cardiopulmonary bypass
    Gabor Veres
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 32:340-5. 2007
    ....
  41. ncbi request reprint Mesenteric complications after hypothermic cardiopulmonary bypass with cardiac arrest: underlying mechanisms
    Terézia Bogdana Andrási
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Artif Organs 26:943-6. 2002
    ..01). Endothelial dysfunction, conversion from aerobic to anaerobic metabolism, and intestinal cell necrosis seem to be responsible for intestinal complications associated with CPB...
  42. ncbi request reprint Investigation of retrospective respiratory gating techniques for acquisition of thin-slice 4D-Multidetector-computed Tomorgraphy (MDCT) of the lung: Feasibility study in a large animal model
    Sebastian Ley
    Department of Radiology E010, German Cancer Research Center DKFZ, Heidelberg, Germany
    Exp Lung Res 32:395-412. 2006
    ..Both gating devices allowed for reliable 4D-MDCT image acquisition. No differences were found for calculated LV and MLD, whereas the respiratory cycle was more precisely detected using the laser based gating device...
  43. ncbi request reprint Poly(ADP-Ribose) polymerase inhibition improves endothelial dysfunction induced by hypochlorite
    Tamas Radovits
    The Laboratory of Cardiac Surgery Department of Cardiac Surgery, University of Heidelberg, 69120 Heidelberg, Germany
    Exp Biol Med (Maywood) 232:1204-12. 2007
    ..Our results demonstrate that PARP activation contributes to the pathogenesis of hypochlorite-induced endothelial dysfunction, which can be prevented by PARP inhibitors...
  44. pmc Effects of inosine on reperfusion injury after cardiopulmonary bypass
    Gabor Veres
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Cardiothorac Surg 5:106. 2010
    ..In the present pre-clinical study, we investigated the effects of inosine on cardiac function during reperfusion in an experimental model of cardioplegic arrest and extracorporal circulation...
  45. doi request reprint Tetrahydrobiopterin improves cardiac and pulmonary function after cardiopulmonary bypass
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 40:695-700. 2011
    ..In the present preclinical study, we investigated the effects of BH4 on cardiac and pulmonary function during early reperfusion in an experimental model of cardioplegic arrest and extracorporal circulation...
  46. ncbi request reprint Contractile dysfunction in experimental cardiac allograft rejection: role of the poly (ADP-ribose) polymerase pathway
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Transpl Int 19:506-13. 2006
    ..Thus, contractile and vasomotor dysfunction occur in a typical time dependent manner during cardiac rejection, which can be reduced by PARP-inhibition...
  47. ncbi request reprint Are there surgical implications to aortic root motion?
    Carsten J Beller
    Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany
    J Heart Valve Dis 14:610-5. 2005
    ..The study aim was to evaluate the influence of five common cardiac conditions on the magnitude of aortic root displacement in cardiac patients...
  48. ncbi request reprint Opposite effects of vascular irradiation on inflammatory response and apoptosis induction in the vessel wall layers via the peroxynitrite-poly(ADP-ribose) polymerase pathway
    Carsten J Beller
    Department of Cardiac Surgery, University of Heidelberg, INF 326, 69120 Heidelberg, Germany
    Clin Res Cardiol 96:8-16. 2007
    ..We investigated in a surgical rat model of vascular injury the potential role of the peroxynitrite - poly(ADPribose) polymerase (PARP) pathway in inflammatory response and apoptosis induction after vascular gamma irradiation...
  49. doi request reprint Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326 2 OG, 69120 Heidelberg, Germany
    J Thorac Cardiovasc Surg 139:1048-56. 2010
    ..On the basis of this solution, the novel Custodiol-N was developed. The present study investigated the effects of Custodiol-N in a rat model of heart transplantation...
  50. doi request reprint Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury
    Eniko Barnucz
    Laboratory of Cardiac Surgery, Department of Cardiac Surgery, University of Heidelberg, INF 326, 69120 Heidelberg, Germany
    J Pharmacol Exp Ther 345:25-31. 2013
    ..Inhibition of PHDs could therefore be a new therapeutic avenue for protecting endothelium and vascular muscle cells against IR injury...
  51. ncbi request reprint The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, INF 326 OG 2, 69120 Heidelberg, Germany
    Mech Ageing Dev 128:173-81. 2007
    ..Pharmacological decomposition of peroxynitrite by FP15 may represent a novel therapeutic utility to improve cardiac and vascular dysfunction associated with ageing...
  52. pmc Acute ethanol exposure increases the susceptibility of the donor hearts to ischemia/reperfusion injury after transplantation in rats
    Shiliang Li
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e49237. 2012
    ..The aims of this work were 1) to evaluate in rats the time-course cardiac effects of acute ethanol-exposure and 2) to explore how its abuse by donors might affect recipients in cardiac pump function after transplantation...
  53. ncbi request reprint Activation of the peroxynitrite-poly(adenosine diphosphate-ribose) polymerase pathway during neointima proliferation: a new target to prevent restenosis after endarterectomy
    Carsten J Beller
    Department of Cardiac Surgery, University of Heidelberg, Germany
    J Vasc Surg 43:824-30. 2006
    ....
  54. doi request reprint Endothelial dysfunction after hypoxia-reoxygenation: do in vitro models work?
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, OG 2, INF 326, 69120 Heidelberg, Germany
    Vascul Pharmacol 51:37-43. 2009
    ..Therefore the experimental model of in vitro vascular H/R is not suited for reliable investigation of pharmacological attempts...
  55. doi request reprint Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-alpha-acetyl-L-histidine
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Heart Lung Transplant 27:208-16. 2008
    ..This screening study tested the effects of iron chelator supplementation in different histidine-tryptophan-ketoglutarate (HTK) organ preservation solutions on endothelial function in a long-term storage model of the isolated rat aorta...
  56. ncbi request reprint Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro
    Tamas Radovits
    Laboratory of Cardiac Surgery, Department of Cardiac Surgery, University of Heidelberg, OG 2, 69120 Heidelberg, Germany
    Eur J Pharmacol 564:158-66. 2007
    ..Our results demonstrate that PARP activation contributes to the pathogenesis of H(2)O(2)-induced endothelial dysfunction, which can be prevented by PARP inhibitors...
  57. doi request reprint Quantification of lung volume at different tidal volumes and positive end-expiratory pressures in a porcine model by using retrospective respiratory gated 4D-computed tomography
    Julia Ley-Zaporozhan
    Department of Radiology E010, German Cancer Research Center, Heidelberg, Germany
    Invest Radiol 43:461-9. 2008
    ..For this purpose, the influence of different tidal volumes and positive end-expiratory pressure (PEEP) on quantitative assessment of lung volumes (LVs) and lung compartments was analyzed...
  58. ncbi request reprint Myocardial protection after systemic application of L-arginine during reperfusion
    Pal Soos
    Department of Cardiac Surgery, University of Heidelberg, Germany
    J Cardiovasc Pharmacol 43:782-8. 2004
    ..Considerably rapid elimination of plasma L-arginine was demonstrated during early reperfusion...
  59. doi request reprint Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus
    Tamas Radovits
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Am J Physiol Heart Circ Physiol 297:H125-33. 2009
    ..Based on the sophisticated method of P-V analysis, different characteristics of type 1 and type 2 diabetic cardiac dysfunction can be demonstrated...
  60. pmc Improvement of aging-associated cardiovascular dysfunction by the orally administered copper(II)-aspirinate complex
    Tamas Radovits
    Experimental Laboratory of Cardiac Surgery, Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Rejuvenation Res 11:945-56. 2008
    ..In this study we investigated the effects of CuAsp on aging-associated myocardial and endothelial dysfunction...
  61. doi request reprint Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury
    Sevil Korkmaz
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Circulation 120:677-86. 2009
    ..We investigated the effects of cinaciguat on myocardial infarction induced by isoproterenol in rats...
  62. doi request reprint The novel synthetic serine protease inhibitor CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Thorac Cardiovasc Surg 139:732-40. 2010
    ..After the "aprotinin era," we investigated the efficacy of the novel synthetic serine protease inhibitors CU-2010 with improved coagulatory and anti-inflammatory profile on blood loss and reperfusion injury in a canine model...
  63. ncbi request reprint Tricuspid valve endocarditis with septic pulmonary emboli in a drug addict
    Alexander Weymann
    Department of Cardiac Surgery, Heart Center University of Heidelberg, Germany
    Ann Thorac Cardiovasc Surg 18:481-4. 2012
    ..The infected tricuspid valve was replaced with a mechanical heart valve, and the patient recovered uneventfully from surgery...
  64. doi request reprint In vivo Gd-DTPA concentration for MR lung perfusion measurements: assessment with computed tomography in a porcine model
    Michael Puderbach
    Department of Radiology, German Cancer Research Center, Heidelberg, Germany
    Eur Radiol 18:2102-7. 2008
    ..The CA dose for quantification of lung perfusion with time-resolved MR studies must be chosen carefully since even with low doses (0.05 mmol/kg) the CAC may exceed the range of linearity in the AIF...
  65. doi request reprint Assessment of thoracic aortic dimensions in an experimental setting: comparison of different unenhanced magnetic resonance angiography techniques with electrocardiogram-gated computed tomography angiography for possible application in the pediatric popula
    Julia Ley-Zaporozhan
    Department of Radiology E010, German Cancer Research Center, Heidelberg, Germany
    Invest Radiol 43:179-86. 2008
    ..To compare different unenhanced magnetic resonance angiography (MRA) techniques for quantitative evaluation of vessel lumen in an experimental setting in young pigs whose dimensions allow for a comparison with a pediatric population...
  66. ncbi request reprint Thromboembolus crossing patent foramen ovale: appearance in multislice computed tomography and echocardiography
    Alexander Weymann
    Department of Cardiac Surgery, Heart Center, University of Heidelberg, INF 110, 69120 Heidelberg, Germany
    Ann Thorac Cardiovasc Surg 18:256-8. 2012
    ..Furthermore, a highly mobile mass trapped in her patent foramen ovale was identified. She underwent emergency cardiac embolectomy and was discharged from our hospital with conventional anticoagulant therapy...
  67. ncbi request reprint Adjunct brachytherapy: a new concept to prevent intimal hyperplasia after surgical endarterectomy?
    Carsten J Beller
    Department of Cardiac Surgery, University of Heidelberg, INF 110, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 29:334-42. 2006
    ..The mid-term results are compromised by restenosis due to neointima formation. The aim of this study was to evaluate a new treatment concept - endarterectomy with consecutive gamma-irradiation - in a rat model...
  68. ncbi request reprint Development and evaluation of a perfusion decellularization porcine heart model--generation of 3-dimensional myocardial neoscaffolds
    Alexander Weymann
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326 OG 2, 69120 Heidelberg, Germany
    Circ J 75:852-60. 2011
    ..The aim of this study was to evaluate the potential of a perfusion decellularization model for whole heart tissue engineering...
  69. ncbi request reprint ET(A) receptor blockade protects the small intestine against ischaemia/reperfusion injury in dogs via an enhancement of antioxidant defences
    Terézia B Andrási
    Department of Cardiovascular Surgery, Semmelweis University, Városmajor út 68, H 1122 Budapest, Hungary
    Clin Sci (Lond) 103:59S-63S. 2002
    ..1+/-2.9)x10(6) relative light units]. Thus ET-1 is involved in I/R-induced disturbances in the intestine. LU135252 seems to counteract these changes, in part by increasing the antioxidant capacity of the mesenterium...
  70. ncbi request reprint Mesenteric vascular dysfunction after cardiopulmonary bypass with cardiac arrest is aggravated by coexistent heart failure
    Terézia B Andrási
    Departments of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary
    Shock 23:324-9. 2005
    ....
  71. ncbi request reprint Increased aortic wall stress in aortic insufficiency: clinical data and computer model
    Carsten J Beller
    Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany
    Eur J Cardiothorac Surg 27:270-5. 2005
    ..The study was aimed at determining which cardiac pathologies are associated with increased longitudinal stress in the aorta and therefore may be responsible for the intimal transverse tears seen in aortic dissections...
  72. ncbi request reprint Inhaled nitric oxide inhibits platelet-leukocyte interactions in patients with acute respiratory distress syndrome
    Andre Gries
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    Crit Care Med 31:1697-704. 2003
    ..Therefore, the aim of this work was to investigate the formation of platelet-leukocyte aggregates (PLAs) and platelet and leukocyte cell surface receptor expression during NO therapy in patients with acute respiratory distress syndrome...
  73. ncbi request reprint Free-breathing three-dimensional computed tomography of the lung using prospective respiratory gating: charge-coupled device camera and laser sensor device in an animal experiment
    Julia Zaporozhan
    Department of Radiology, E010, German Cancer Research Center, Heidelberg, Germany
    Invest Radiol 41:468-75. 2006
    ..The aim was to investigate the feasibility and image quality of prospective respiratory gating for 3-D computed tomography (CT) of the lung...
  74. doi request reprint Left ventricular outflow tract: intraoperative measurement and changes caused by mitral valve surgery
    Christian Rosendal
    University of Heidelberg, Department of Anesthesiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Am Soc Echocardiogr 25:166-72. 2012
    ..In this study, LVOT area and shape were assessed before and after mitral valve surgery...
  75. ncbi request reprint Lung herniation after minimally invasive cardiothoracic surgery
    Alexander Weymann
    University of Heidelberg, Heidelberg, Germany
    N Engl J Med 365:e19. 2011
    ..Lung herniation is a rare complication of minimally invasive cardiothoracic surgery. In . . ...