Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergeticsKatalin Módis
1Department of Anesthesiology, The University of Texas Medical Branch at Galveston, 601 Harborside Dr, Galveston, TX 77555, USA Email
FASEB J 27:601-11. 2013
..Módis, K., Coletta, C., Erdélyi, K., Papapetropoulos, A., Szabo, C. Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics...
- Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction
Domokos Gero
Corresponding author Csaba Szabo
Diabetes 62:953-64. 2013
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- The outsiders: emerging roles of ectonucleotidases in inflammation
Csaba Szabo
Department of Anesthesiology, Medical Branch, University of Texas, Galveston, TX 77555, USA
Sci Transl Med 4:146ps14. 2012
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- Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications
Csaba Szabo
Department of Anesthesiology, The University of Texas Medical Branch at Galveston, 601 Harborside Drive, Galveston, TX 77555, USA
Antioxid Redox Signal 17:68-80. 2012
..In addition, changes in H(2)S homeostasis also play a role in the pathogenesis of endothelial injury, which develop on the basis of chronically or intermittently elevated circulating glucose levels in diabetes...
Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical careFlorian Wagner
Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästehsiologie, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
Crit Care 13:213. 2009
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- Novel modulators of poly(ADP-ribose) polymerase
Csaba Szabo
Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, 185 South Orange Avenue, University Heights Newark, NJ 07103, USA
Trends Pharmacol Sci 27:626-30. 2006
..Several tetracycline antibiotics are also potent PARP-1 inhibitors. In this article, we present an overview of novel PARP-1 modulators...
Peroxynitrite: biochemistry, pathophysiology and development of therapeuticsCsaba Szabo
Department of Surgery, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, University Heights, Newark, New Jersey 07103 2714, USA
Nat Rev Drug Discov 6:662-80. 2007
..These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases...
- Gaseotransmitters: new frontiers for translational science
Csaba Szabo
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 1102, USA
Sci Transl Med 2:59ps54. 2010
..Discussed here are the chemical and pharmacological properties that present challenges for the translation of these potentially toxic molecules...
- Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction
Csaba Szabo
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 0833, USA
Br J Pharmacol 156:713-27. 2009
..Reactive species generation and PARP play key roles in the pathogenesis of 'glucose memory' and in the development of injury in endothelial cells exposed to alternating high/low glucose concentrations...
- Pathophysiological roles of peroxynitrite in circulatory shock
Csaba Szabo
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas, USA
Shock 34:4-14. 2010
..Neutralization of peroxynitrite with potent peroxynitrite decomposition catalysts provides cytoprotective and beneficial effects in rodent and large-animal models of circulatory shock...
- Hydrogen sulphide and angiogenesis: mechanisms and applications
Csaba Szabo
Department of Anesthesiology, University of Texas Medical Branch, Galveston, 77555 1102, USA
Br J Pharmacol 164:853-65. 2011
..Accordingly, topical administration of H(2)S promotes wound healing, whereas genetic ablation of CSE attenuates it. Pharmacological modulation of H(2)S-mediated angiogenic pathways may open the door for novel therapeutic approaches...
- Poly(ADP-ribose) polymerase activation by reactive nitrogen species--relevance for the pathogenesis of inflammation
Csaba Szabo
Department of Human Physiology and Clinical Experimental Research, Semmelweis University Medical School, Budapest, Hungary
Nitric Oxide 14:169-79. 2006
..Here we review the role of reactive nitrogen species in the process of PARP activation, followed by the effect of pharmacological inhibition or genetic inactivation of PARP on the course of various forms of inflammation...
- Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions
Csaba Szabo
Inotek Pharmaceuticals Corporation, Beverly, MA 01915, USA
Curr Vasc Pharmacol 3:301-3. 2005
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- Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications
Csaba Szabo
Inotek Pharmaceuticals Corporation, Suite 419 E, 100 Cummings Center, Beverly, MA 01915, USA
Pharmacol Res 52:60-71. 2005
..The current review provides an overview of the experimental evidence implicating PARP as a causative factor in the pathogenesis of diabetes and diabetic complications in vitro and in vivo...
- Cardioprotective effects of poly(ADP-ribose) polymerase inhibition
Csaba Szabo
Inotek Pharmaceuticals Corporation, Beverly, MA 01915, USA
Pharmacol Res 52:34-43. 2005
..The current article provides an overview of the experimental evidence implicating PARP as a pathophysiological modulator of cardiac myocyte injury in vitro and in vivo...
- Multiple pathways of peroxynitrite cytotoxicity
Csaba Szabo
Inotek Pharmaceuticals Corporation, 100 Cummings Center, Suite 419E, Beverly, MA 01915, USA
Toxicol Lett 140:105-12. 2003
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- Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase
Rita Benko
Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
Life Sci 75:1255-61. 2004
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- Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation
Csaba Szabo
Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
Mol Med 10:28-35. 2004
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- Pathophysiological aspects of cellular pyridine nucleotide metabolism: focus on the vascular endothelium. Review
Cs Szabó
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
Acta Physiol Hung 90:175-93. 2003
..A separate section describes how these mechanisms apply to the pathogenesis of endothelial cell injury in selected cardiovascular pathophysiological conditions...
- Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor
Chun Yang Xiao
Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
J Pharmacol Exp Ther 310:498-504. 2004
..Overall, the current results demonstrate the importance of the PARP pathway in diabetic rats subjected to myocardial infarction and demonstrate the role of PARP in regulating AIF translocation in MI/R...
- Poly (ADP-ribose) polymerase activation and circulatory shock
Csaba Szabo
Department of Surgery, UMD NJ New Jersey Medical School, Newark, NJ 07103, USA
Novartis Found Symp 280:92-103; discussion 103-7, 160-4. 2007
..Oestrogen, by providing a baseline inhibitory effect on PARP activation, may be partially responsible for this gender difference...
- Poly(ADP-ribose) polymerase and renal hypothermic preservation injury
Martin J Mangino
Department of Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
Am J Physiol Renal Physiol 286:F838-47. 2004
..ROS are sufficient but not necessary to activate PARP under these conditions...
- Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis
Babu V Naidu
Division of Cardiothoracic Surgery, Department of Surgery, University of Washington, Box 356310, 1959 NE Pacific St, Seattle, WA 98195, USA
Exp Mol Pathol 75:12-7. 2003
..The peroxynitrite decomposition catalyst, FP-15, is protective when administered daily and warrants investigation into its potential clinical utility...
- Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity
Dirk M Maybauer
Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, 301 University Blvd, Galveston, TX 77555 0833, USA
Biochem Biophys Res Commun 377:786-91. 2008
..These findings suggest that ONOO(-) plays a pivotal role in the pathology of IL-2-induced pulmonary VLS, and that WW-85 may become a useful treatment option...
- Poly(ADP-ribose) polymerase: a new therapeutic target?
Domokos Gero
CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary
Curr Opin Anaesthesiol 21:111-21. 2008
..To overview the emerging data in the literature showing the role of poly(ADP-ribose) polymerase (PARP) in the pathogenesis of critical illness...
- Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia
Eszter M Horvath
Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103 2714, USA
Life Sci 82:205-9. 2008
..The current findings may have significant implications in the context of the emerging concept of tight glycemic control and insulin treatment for critically ill patients...
- Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes
Emese Toth-Zsamboki
Cardiovascular Research Group of the Hungarian Academy of Sciences and Semmelweis University and National Health Center, Budapest, Hungary
Mol Med 12:221-8. 2006
..These results represent the first direct demonstration of PARP activation in human myocardial infarction. Future work is required to test whether pharmacological inhibition of PARP may offer myocardial protection during primary PCI...
- Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status
Attila Szijarto
Department of Surgery, Semmelweis University, Budapest, Hungary
J Surg Res 142:72-80. 2007
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- Intra-mitochondrial poly(ADP-ribosyl)ation: potential role for alpha-ketoglutarate dehydrogenase
Eszter Pankotai
Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
Mitochondrion 9:159-64. 2009
..The KGDH enzyme may, therefore, have a novel function as a PARP-like enzyme, which may play a role in regulating intramitochondrial NAD(+) and poly(ADP-ribose) homeostasis, with possible roles in physiology and pathophysiology...
- Role of peroxynitrite anion in renal hypothermic preservation injury
Martin J Mangino
Department of Surgery, University of Wisconsin Medical School, Madison, WI, USA
Transplantation 80:1455-60. 2005
..Peroxynitrite anions may play a role in normothermic renal ischemia and reperfusion. The purpose of this study was to determine if endogenous peroxynitrite anion is involved in renal preservation injury...
- Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep
Katsumi Shimoda
Department of Anesthesiology, The University of Texas Medical Branch, Shriners Burns Hospital, Galveston, Texas 77555-0833, USA
Am J Physiol Lung Cell Mol Physiol 285:L240-9. 2003
..We conclude that PARS inhibition attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury...
- Critical role of reactive nitrogen species in lung ischemia-reperfusion injury
Babu V Naidu
Department of Surgery, University of Washington, Seattle, Washington 98195, USA
J Heart Lung Transplant 22:784-93. 2003
..The development of potent water-soluble decomposition catalysts represents a potentially useful therapeutic tool in the prevention of lung ischemia-reperfusion injury after lung transplantation...
- Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation
Anton S McCourtie
Department of Surgery, Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, WA 98195, USA
Exp Mol Pathol 84:141-4. 2008
..These studies attempted to characterize the effects of PARS on AM activation in response to oxidative stress...
- Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update
Eszter M Horvath
Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103 2714, USA
Drug News Perspect 20:171-81. 2007
..In addition, potent PARP inhibitors have entered the stage of clinical testing. The current review provides an update on the most recent developments in the area of PARP...
- Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury
Alexander S Farivar
Department of Surgery, University of Washington Medical Center, Seattle, Washington 98195, USA
Ann Thorac Surg 77:1938-43. 2004
..This study determined its efficacy when administered intratracheally (IT)...
- Short-term alanyl-glutamine dipeptide pretreatment in liver ischemia-reperfusion model: effects on microcirculation and antioxidant status in rats
Attila Szijarto
1st Department of Surgery, Semmelweis University, Budapest, Hungary
Clin Nutr 26:640-8. 2007
..The aim of our study was to examine the effect of glutamine (Gln) supplementation--adminstered in alanyl-glutamine dipeptide form--on liver function, immuno/histopathology and the oxidative state of the liver after injury...
- Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay
Domokos Gero
CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary
Int J Mol Med 20:749-61. 2007
..The current experimental setting can be employed for cell-based high-throughput screening of various compound libraries...
- Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation
Aimalohi Esechie
Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555, USA
Clin Sci (Lond) 115:91-7. 2008
..In conclusion, these results suggest that H2S exerts protective effects in acute lung injury, at least in part through the activation of anti-inflammatory and antioxidant pathways...
- Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis
Katalin Módis
CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary
Br J Pharmacol 158:1565-78. 2009
..We have established an in vitro model of acute tubular necrosis in rat kidney tubular cells, using combined oxygen-glucose deprivation (COGD) and screened a library of 1280 pharmacologically active compounds for cytoprotective effects...
- Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass
Basel Ramlawi
Division of Cardiothoracic Surgery, Department of Surgery, Beth Israel Deaconess MedicalCenter, LMOB 2A, 110 Francis St, Boston, Massachusetts 02215, USA
Circulation 114:I257-63. 2006
..CONCLUSIONS: Despite optimal current surgical myocardial protection, we found that CA with CBC induced both programmed cell death and survival signaling in myocardial tissue...
- Prevalence of underweight, overweight and obesity on the basis of body mass index and body fat percentage in Hungarian schoolchildren: representative survey in metropolitan elementary schools
Magda Antal
National Institute for Food and Nutrition Science, Budapest, Hungary
Ann Nutr Metab 54:171-6. 2009
..The purpose of the survey was to assess the age- and gender-specific anthropometric data of children between the ages of 7 and 14 years who attended elementary schools in Budapest...
- Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide
Attila Csordas
Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
Life Sci 80:633-7. 2007
..These results indicate that mitochondria do not produce physiologically relevant quantities of NO in the heart and are unlikely to have any physiological importance as NO donors, nor do they contain a recognizable mtNOS enzyme...
- Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition
Levente Kiss
Department of Surgery, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, University Heights, Newark, NJ 07103 2714, USA
Life Sci 83:589-94. 2008
..The aim of our study was to elucidate the potential mechanisms responsible for the effects of H(2)S on vascular tone...
- Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury
Fiona D Saunders
Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
Am J Physiol Lung Cell Mol Physiol 298:L427-36. 2010
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- Lifestyle of school children: representative survey in metropolitan elementary schools. Part one
Szabolcs Péter
National Institute of Food Safety and Nutrition, Budapest, Hungary
Ann Nutr Metab 51:448-53. 2007
..Obesity is multifactorial and depends on lifestyle as well as genetic components. The purpose of the survey was to investigate the lifestyle of 7- to 14-year-old children attending elementary schools in Budapest...
