Cs Szabó

Summary

Publications

  1. pmc Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury
    Katalin Módis
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Int J Mol Med 31:437-46. 2013
  2. pmc Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro
    Katalin Erdélyi
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 1102, USA
    Int J Mol Med 32:339-46. 2013
  3. pmc Identification of pharmacological modulators of HMGB1-induced inflammatory response by cell-based screening
    Domokos Gero
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 8:e65994. 2013
  4. pmc Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
    Csaba Szabo
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 110:12474-9. 2013
  5. ncbi request reprint Potential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shock
    Ciro Coletta
    Department of Anesthesiology, The University of Texas Medical Branch, 601 Harborside Drive, Galveston, TX 77555 1102, USA
    Curr Vasc Pharmacol 11:208-21. 2013
  6. pmc Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction
    Domokos Gero
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, USA
    Diabetes 62:953-64. 2013
  7. doi request reprint Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
    Katalin Módis
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    FASEB J 27:601-11. 2013
  8. doi request reprint The outsiders: emerging roles of ectonucleotidases in inflammation
    Csaba Szabo
    Department of Anesthesiology, Medical Branch, University of Texas, Galveston, TX 77555, USA
    Sci Transl Med 4:146ps14. 2012
  9. doi request reprint Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications
    Csaba Szabo
    Department of Anesthesiology, The University of Texas Medical Branch at Galveston, 601 Harborside Drive, Galveston, TX 77555, USA
    Antioxid Redox Signal 17:68-80. 2012
  10. pmc Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care
    Florian Wagner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästehsiologie, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Crit Care 13:213. 2009

Collaborators

Detail Information

Publications51

  1. pmc Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury
    Katalin Módis
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Int J Mol Med 31:437-46. 2013
    ..The present study supports the view that testing of inosine for protection against various forms of warm and cold liver ischemia is relevant...
  2. pmc Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro
    Katalin Erdélyi
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 1102, USA
    Int J Mol Med 32:339-46. 2013
    ....
  3. pmc Identification of pharmacological modulators of HMGB1-induced inflammatory response by cell-based screening
    Domokos Gero
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 8:e65994. 2013
    ..The current study unveils several drug-like modulators of HMGB1-mediated inflammatory responses and offers pharmacological directions for the therapeutic suppression of inflammatory responses in HMGB1-dependent diseases. ..
  4. pmc Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
    Csaba Szabo
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 110:12474-9. 2013
    ..The current findings identify CBS-derived H2S as a tumor growth factor and anticancer drug target. ..
  5. ncbi request reprint Potential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shock
    Ciro Coletta
    Department of Anesthesiology, The University of Texas Medical Branch, 601 Harborside Drive, Galveston, TX 77555 1102, USA
    Curr Vasc Pharmacol 11:208-21. 2013
    ..In addition, we outline the potential means by which modulation of H2S (pharmacological inhibition of its biosynthesis or therapeutic donation) may affect the outcome in circulatory shock...
  6. pmc Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction
    Domokos Gero
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, USA
    Diabetes 62:953-64. 2013
    ....
  7. doi request reprint Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
    Katalin Módis
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    FASEB J 27:601-11. 2013
    ..This pathway may serve a physiological role in the maintenance of mitochondrial electron transport and cellular bioenergetics...
  8. doi request reprint The outsiders: emerging roles of ectonucleotidases in inflammation
    Csaba Szabo
    Department of Anesthesiology, Medical Branch, University of Texas, Galveston, TX 77555, USA
    Sci Transl Med 4:146ps14. 2012
    ....
  9. doi request reprint Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications
    Csaba Szabo
    Department of Anesthesiology, The University of Texas Medical Branch at Galveston, 601 Harborside Drive, Galveston, TX 77555, USA
    Antioxid Redox Signal 17:68-80. 2012
    ..Diabetes and its complications represent a major socioeconomic problem...
  10. pmc Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care
    Florian Wagner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästehsiologie, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Crit Care 13:213. 2009
    ....
  11. ncbi request reprint Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
    Csaba Szabo
    Department of Surgery, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, University Heights, Newark, New Jersey 07103 2714, USA
    Nat Rev Drug Discov 6:662-80. 2007
    ..These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases...
  12. pmc Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction
    Csaba Szabo
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 0833, USA
    Br J Pharmacol 156:713-27. 2009
    ..Reactive species generation and PARP play key roles in the pathogenesis of 'glucose memory' and in the development of injury in endothelial cells exposed to alternating high/low glucose concentrations...
  13. pmc Gaseotransmitters: new frontiers for translational science
    Csaba Szabo
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 1102, USA
    Sci Transl Med 2:59ps54. 2010
    ..Discussed here are the chemical and pharmacological properties that present challenges for the translation of these potentially toxic molecules...
  14. pmc Novel modulators of poly(ADP-ribose) polymerase
    Csaba Szabo
    Department of Surgery, University of Medicine and Dentistry, New Jersey Medical School, 185 South Orange Avenue, University Heights Newark, NJ 07103, USA
    Trends Pharmacol Sci 27:626-30. 2006
    ..Several tetracycline antibiotics are also potent PARP-1 inhibitors. In this article, we present an overview of novel PARP-1 modulators...
  15. pmc Hydrogen sulphide and angiogenesis: mechanisms and applications
    Csaba Szabo
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, 77555 1102, USA
    Br J Pharmacol 164:853-65. 2011
    ..Accordingly, topical administration of H(2)S promotes wound healing, whereas genetic ablation of CSE attenuates it. Pharmacological modulation of H(2)S-mediated angiogenic pathways may open the door for novel therapeutic approaches...
  16. ncbi request reprint Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions
    Csaba Szabo
    Inotek Pharmaceuticals Corporation, Beverly, MA 01915, USA
    Curr Vasc Pharmacol 3:301-3. 2005
    ....
  17. ncbi request reprint Multiple pathways of peroxynitrite cytotoxicity
    Csaba Szabo
    Inotek Pharmaceuticals Corporation, 100 Cummings Center, Suite 419E, Beverly, MA 01915, USA
    Toxicol Lett 140:105-12. 2003
    ....
  18. doi request reprint Pathophysiological roles of peroxynitrite in circulatory shock
    Csaba Szabo
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas, USA
    Shock 34:4-14. 2010
    ..Neutralization of peroxynitrite with potent peroxynitrite decomposition catalysts provides cytoprotective and beneficial effects in rodent and large-animal models of circulatory shock...
  19. ncbi request reprint Pathophysiological aspects of cellular pyridine nucleotide metabolism: focus on the vascular endothelium. Review
    Cs Szabó
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Acta Physiol Hung 90:175-93. 2003
    ..A separate section describes how these mechanisms apply to the pathogenesis of endothelial cell injury in selected cardiovascular pathophysiological conditions...
  20. ncbi request reprint Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor
    Chun Yang Xiao
    Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    J Pharmacol Exp Ther 310:498-504. 2004
    ..Overall, the current results demonstrate the importance of the PARP pathway in diabetic rats subjected to myocardial infarction and demonstrate the role of PARP in regulating AIF translocation in MI/R...
  21. ncbi request reprint Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase
    Rita Benko
    Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    Life Sci 75:1255-61. 2004
    ....
  22. pmc Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation
    Csaba Szabo
    Inotek Pharmaceuticals Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    Mol Med 10:28-35. 2004
    ....
  23. ncbi request reprint Cardioprotective effects of poly(ADP-ribose) polymerase inhibition
    Csaba Szabo
    Inotek Pharmaceuticals Corporation, Beverly, MA 01915, USA
    Pharmacol Res 52:34-43. 2005
    ..The current article provides an overview of the experimental evidence implicating PARP as a pathophysiological modulator of cardiac myocyte injury in vitro and in vivo...
  24. ncbi request reprint Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications
    Csaba Szabo
    Inotek Pharmaceuticals Corporation, Suite 419 E, 100 Cummings Center, Beverly, MA 01915, USA
    Pharmacol Res 52:60-71. 2005
    ..The current review provides an overview of the experimental evidence implicating PARP as a causative factor in the pathogenesis of diabetes and diabetic complications in vitro and in vivo...
  25. ncbi request reprint Poly(ADP-ribose) polymerase activation by reactive nitrogen species--relevance for the pathogenesis of inflammation
    Csaba Szabo
    Department of Human Physiology and Clinical Experimental Research, Semmelweis University Medical School, Budapest, Hungary
    Nitric Oxide 14:169-79. 2006
    ..Here we review the role of reactive nitrogen species in the process of PARP activation, followed by the effect of pharmacological inhibition or genetic inactivation of PARP on the course of various forms of inflammation...
  26. ncbi request reprint Poly (ADP-ribose) polymerase activation and circulatory shock
    Csaba Szabo
    Department of Surgery, UMD NJ New Jersey Medical School, Newark, NJ 07103, USA
    Novartis Found Symp 280:92-103; discussion 103-7, 160-4. 2007
    ..Oestrogen, by providing a baseline inhibitory effect on PARP activation, may be partially responsible for this gender difference...
  27. ncbi request reprint Poly(ADP-ribose) polymerase and renal hypothermic preservation injury
    Martin J Mangino
    Department of Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
    Am J Physiol Renal Physiol 286:F838-47. 2004
    ..ROS are sufficient but not necessary to activate PARP under these conditions...
  28. doi request reprint Poly(ADP-ribose) polymerase: a new therapeutic target?
    Domokos Gero
    CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary
    Curr Opin Anaesthesiol 21:111-21. 2008
    ..To overview the emerging data in the literature showing the role of poly(ADP-ribose) polymerase (PARP) in the pathogenesis of critical illness...
  29. ncbi request reprint Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis
    Babu V Naidu
    Division of Cardiothoracic Surgery, Department of Surgery, University of Washington, Box 356310, 1959 NE Pacific St, Seattle, WA 98195, USA
    Exp Mol Pathol 75:12-7. 2003
    ..The peroxynitrite decomposition catalyst, FP-15, is protective when administered daily and warrants investigation into its potential clinical utility...
  30. pmc Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity
    Dirk M Maybauer
    Department of Anesthesiology, Investigational Intensive Care Unit, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, 301 University Blvd, Galveston, TX 77555 0833, USA
    Biochem Biophys Res Commun 377:786-91. 2008
    ..These findings suggest that ONOO(-) plays a pivotal role in the pathology of IL-2-induced pulmonary VLS, and that WW-85 may become a useful treatment option...
  31. ncbi request reprint Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status
    Attila Szijarto
    Department of Surgery, Semmelweis University, Budapest, Hungary
    J Surg Res 142:72-80. 2007
    ....
  32. pmc Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia
    Eszter M Horvath
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103 2714, USA
    Life Sci 82:205-9. 2008
    ..The current findings may have significant implications in the context of the emerging concept of tight glycemic control and insulin treatment for critically ill patients...
  33. pmc Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes
    Emese Toth-Zsamboki
    Cardiovascular Research Group of the Hungarian Academy of Sciences and Semmelweis University and National Health Center, Budapest, Hungary
    Mol Med 12:221-8. 2006
    ..These results represent the first direct demonstration of PARP activation in human myocardial infarction. Future work is required to test whether pharmacological inhibition of PARP may offer myocardial protection during primary PCI...
  34. ncbi request reprint Role of peroxynitrite anion in renal hypothermic preservation injury
    Martin J Mangino
    Department of Surgery, University of Wisconsin Medical School, Madison, WI, USA
    Transplantation 80:1455-60. 2005
    ..Peroxynitrite anions may play a role in normothermic renal ischemia and reperfusion. The purpose of this study was to determine if endogenous peroxynitrite anion is involved in renal preservation injury...
  35. ncbi request reprint Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep
    Katsumi Shimoda
    Department of Anesthesiology, The University of Texas Medical Branch, Shriners Burns Hospital, Galveston, Texas 77555 0833, USA
    Am J Physiol Lung Cell Mol Physiol 285:L240-9. 2003
    ..We conclude that PARS inhibition attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury...
  36. ncbi request reprint Poly(ADP-ribose) polymerase as a drug target for cardiovascular disease and cancer: an update
    Eszter M Horvath
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103 2714, USA
    Drug News Perspect 20:171-81. 2007
    ..In addition, potent PARP inhibitors have entered the stage of clinical testing. The current review provides an update on the most recent developments in the area of PARP...
  37. ncbi request reprint Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury
    Alexander S Farivar
    Department of Surgery, University of Washington Medical Center, Seattle, Washington 98195, USA
    Ann Thorac Surg 77:1938-43. 2004
    ..This study determined its efficacy when administered intratracheally (IT)...
  38. ncbi request reprint Critical role of reactive nitrogen species in lung ischemia-reperfusion injury
    Babu V Naidu
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    J Heart Lung Transplant 22:784-93. 2003
    ..The purpose of the study was to examine the role of this reactive nitrogen species in lung ischemia-reperfusion injury...
  39. ncbi request reprint Short-term alanyl-glutamine dipeptide pretreatment in liver ischemia-reperfusion model: effects on microcirculation and antioxidant status in rats
    Attila Szijarto
    1st Department of Surgery, Semmelweis University, Budapest, Hungary
    Clin Nutr 26:640-8. 2007
    ..The aim of our study was to examine the effect of glutamine (Gln) supplementation--adminstered in alanyl-glutamine dipeptide form--on liver function, immuno/histopathology and the oxidative state of the liver after injury...
  40. ncbi request reprint Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay
    Domokos Gero
    CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary
    Int J Mol Med 20:749-61. 2007
    ..The current experimental setting can be employed for cell-based high-throughput screening of various compound libraries...
  41. doi request reprint Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation
    Anton S McCourtie
    Department of Surgery, Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, WA 98195, USA
    Exp Mol Pathol 84:141-4. 2008
    ..These studies attempted to characterize the effects of PARS on AM activation in response to oxidative stress...
  42. doi request reprint Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation
    Aimalohi Esechie
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Sci (Lond) 115:91-7. 2008
    ..In conclusion, these results suggest that H2S exerts protective effects in acute lung injury, at least in part through the activation of anti-inflammatory and antioxidant pathways...
  43. doi request reprint Intra-mitochondrial poly(ADP-ribosyl)ation: potential role for alpha-ketoglutarate dehydrogenase
    Eszter Pankotai
    Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Mitochondrion 9:159-64. 2009
    ..The KGDH enzyme may, therefore, have a novel function as a PARP-like enzyme, which may play a role in regulating intramitochondrial NAD(+) and poly(ADP-ribose) homeostasis, with possible roles in physiology and pathophysiology...
  44. pmc Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis
    Katalin Módis
    CellScreen Applied Research Center, Semmelweis University Medical School, Budapest, Hungary
    Br J Pharmacol 158:1565-78. 2009
    ..We have established an in vitro model of acute tubular necrosis in rat kidney tubular cells, using combined oxygen-glucose deprivation (COGD) and screened a library of 1280 pharmacologically active compounds for cytoprotective effects...
  45. ncbi request reprint Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass
    Basel Ramlawi
    Division of Cardiothoracic Surgery, Department of Surgery, Beth Israel Deaconess MedicalCenter, LMOB 2A, 110 Francis St, Boston, Massachusetts 02215, USA
    Circulation 114:I257-63. 2006
    ..We studied key apoptotic mediators via the caspase-dependent and intrinsic pathways as well as poly(ADP)-ribosylating protein (PARP) activity in myocardial and peripheral tissues after CA and cardiopulmonary bypass (CBP)...
  46. ncbi request reprint Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide
    Attila Csordas
    Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Life Sci 80:633-7. 2007
    ..These results indicate that mitochondria do not produce physiologically relevant quantities of NO in the heart and are unlikely to have any physiological importance as NO donors, nor do they contain a recognizable mtNOS enzyme...
  47. ncbi request reprint Prevalence of underweight, overweight and obesity on the basis of body mass index and body fat percentage in Hungarian schoolchildren: representative survey in metropolitan elementary schools
    Magda Antal
    National Institute for Food and Nutrition Science, Budapest, Hungary
    Ann Nutr Metab 54:171-6. 2009
    ..The purpose of the survey was to assess the age- and gender-specific anthropometric data of children between the ages of 7 and 14 years who attended elementary schools in Budapest...
  48. pmc Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury
    Fiona D Saunders
    Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Lung Cell Mol Physiol 298:L427-36. 2010
    ....
  49. ncbi request reprint Lifestyle of school children: representative survey in metropolitan elementary schools. Part one
    Szabolcs Péter
    National Institute of Food Safety and Nutrition, Budapest, Hungary
    Ann Nutr Metab 51:448-53. 2007
    ..Obesity is multifactorial and depends on lifestyle as well as genetic components. The purpose of the survey was to investigate the lifestyle of 7- to 14-year-old children attending elementary schools in Budapest...
  50. doi request reprint Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition
    Levente Kiss
    Department of Surgery, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, University Heights, Newark, NJ 07103 2714, USA
    Life Sci 83:589-94. 2008
    ..The aim of our study was to elucidate the potential mechanisms responsible for the effects of H(2)S on vascular tone...

Research Grants27

  1. Novel preservation fluid for organ transplantation
    Jon Mabley; Fiscal Year: 2003
    ..abstract_text> ..
  2. PARS and peroxynitrite induced cell death
    Csaba Szabo; Fiscal Year: 2009
    ..4 To establish the role of Bel family proteins in the regulation of calcium homeostasis during peroxynitrite-induced cell death. The studies proposed here have broad pathophysiological relevance. ..
  3. PARS and peroxynitrite induced cell death
    Csaba Szabo; Fiscal Year: 2006
    ..4 To establish the role of Bel family proteins in the regulation of calcium homeostasis during peroxynitrite-induced cell death. The studies proposed here have broad pathophysiological relevance. ..
  4. Peroxynitrate neutralizing agents for stroke therapy
    Csaba Szabo; Fiscal Year: 2003
    ....
  5. Ultrapotent PARS inhibitor for CNS trauma
    Csaba Szabo; Fiscal Year: 2003
    ..Estimated worldwide revenues after market entry and maturation (ca. 4 years after FDA approval)=$750 million (annual). ..
  6. Poly(ADP-ribose) synthetase inhibition and diabetes
    Csaba Szabo; Fiscal Year: 2004
    ....
  7. Doxorubicin cardiotoxicity:protection by peroxynitrite
    Csaba Szabo; Fiscal Year: 2002
    ..abstract_text> ..
  8. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2004
    ..Further, based on exciting preliminary data, the final, fifth aim is focusing in establishing the role of PARS in myocardial preconditioning. ..
  9. Adenosine-3 agonists for the suppression of arthritis
    Csaba Szabo; Fiscal Year: 2003
    ..A novel A3 receptor agonist may represent a useful anti-inflammatory adjunct to current therapeutic regimens; funding of the current SBIR Phase II will allow for starting human safety trials in 2 years. ..
  10. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2002
    ..Further, based on exciting preliminary data, the final, fifth aim is focusing in establishing the role of PARS in myocardial preconditioning. ..
  11. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2003
    ..Further, based on exciting preliminary data, the final, fifth aim is focusing in establishing the role of PARS in myocardial preconditioning. ..
  12. Poly(ADP-ribose)and diabetic erectile dysfunction
    FANGMING ZUO; Fiscal Year: 2004
    ..If these studies confirm that Inotek's PARP inhibitor is effective in improving erectile function in diabetes, a Phase II component will be triggered, which will focus on formal preclinical safety testing. ..
  13. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2005
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  14. PARS and peroxynitrite induced cell death
    Csaba Szabo; Fiscal Year: 2007
    ..4 To establish the role of Bel family proteins in the regulation of calcium homeostasis during peroxynitrite-induced cell death. The studies proposed here have broad pathophysiological relevance. ..
  15. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2004
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  16. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2003
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  17. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2002
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  18. POLY (ADP-RIBOSE) SYNTHETASE AND REPERFUSION INJURY
    Csaba Szabo; Fiscal Year: 1999
    ..The principal investigator will also investigate the changes in endothelial function during myocardial reperfusion injury, and the role of PARS in these changes. ..
  19. PARS INHIBITOR FOR THE THERAPY OF CIRCULATORY SHOCK
    Ludmila Belayev; Fiscal Year: 2003
    ..The current project will enable the applicants to move forward in two years, near to the level of the beginning of Phase II efficacy trial in septic patients. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  20. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2005
    ..Further, based on exciting preliminary data, the final, fifth aim is focusing in establishing the role of PARS in myocardial preconditioning. ..
  21. POLY (ADP-RIBOSE) SYNTHETASE AND REPERFUSION INJURY
    Csaba Szabo; Fiscal Year: 2000
    ..The principal investigator will also investigate the changes in endothelial function during myocardial reperfusion injury, and the role of PARS in these changes. ..
  22. Poly(ADP-ribose)Polymerase & Doxorubicin Cardiotoxicity
    Jon Mabley; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: The annual anticipated revenues for an effective therapeutic to prevent anti-cancer-drug induced cardiodepression is over $100 million in the US alone. ..