Konstantinos N Syrigos

Summary

Publications

  1. pmc Role of vitamin d in the prevention of pancreatic cancer
    Pubudu Bulathsinghala
    Department of Internal Medicine, Danbury Hospital, 24 Hospital Avenue, Danbury, CT 06810, USA
    J Nutr Metab 2010:721365. 2010
  2. pmc The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma: A Case Series
    Muhammad W Saif
    Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY 10032 3784, USA
    J Oncol 2011:125467. 2011
  3. pmc Metastatic cervical carcinoma to the thyroid gland: a case report and review of the literature
    Elena Karapanagiotou
    Oncology Unit, Third Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    Yale J Biol Med 79:165-8. 2006
  4. pmc CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy
    Muhammad Wasif Saif
    Clinical Medicine, The GI Oncology Section of the Division of Hematology Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, Milstein Hospital, 177 Fort Washington Avenue, Suite 6 435, NY 10032, USA
    J Oncol 2010:934359. 2010
  5. pmc Cerebrovascular accidents associated with sorafenib in hepatocellular carcinoma
    Muhammad W Saif
    Division of Hematology, Oncology, Department of Medicine, Columbia University, NY 10027, USA
    Gastroenterol Res Pract 2011:616080. 2011
  6. doi request reprint Pulmonary blastoma with submandibular, scrotum and adrenal metastases: case report
    Kostas N Syrigos
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens University School of Medicine, Athens, Greece
    Respiration 83:83-6. 2012
  7. pmc High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology
    Valsamo K Anagnostou
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:186. 2010
  8. pmc Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model
    Aristotelis Bamias
    Department of Clinical Therapeutics, Athens University, Medical School, Athens, Greece
    BMC Cancer 10:45. 2010
  9. ncbi request reprint A phase-II study of liposomal doxorubicin and docetaxel in patients with advanced pancreatic cancer
    K N Syrigos
    Oncology Unit, 3rd Department of Medicine, Athens Medical School, Building Z, Sotiria General Hospital, Mesogion 152, 115 26 Athens, Greece
    Anticancer Res 22:3583-8. 2002
  10. ncbi request reprint Colonoscopy in asymptomatic individuals with a family history of colorectal cancer
    K N Syrigos
    Department of Clinical Oncology, Imperial College of Science Technology and Medicine, Hammersmith Hospital Campus, London, UK
    Ann Surg Oncol 9:439-43. 2002

Detail Information

Publications93

  1. pmc Role of vitamin d in the prevention of pancreatic cancer
    Pubudu Bulathsinghala
    Department of Internal Medicine, Danbury Hospital, 24 Hospital Avenue, Danbury, CT 06810, USA
    J Nutr Metab 2010:721365. 2010
    ..Future studies will verify the role of vitamin D in the prevention and therapy of pancreatic cancer and will lead to guidelines on adequate sun exposure and vitamin D dietary intake...
  2. pmc The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma: A Case Series
    Muhammad W Saif
    Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY 10032 3784, USA
    J Oncol 2011:125467. 2011
    ..We conclude that EGFR inhibitors may play a vital role in the treatment of anal cancer and we suggest that large trials are be conducted in order to clarify their efficacy and to improve therapeutic management...
  3. pmc Metastatic cervical carcinoma to the thyroid gland: a case report and review of the literature
    Elena Karapanagiotou
    Oncology Unit, Third Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    Yale J Biol Med 79:165-8. 2006
    ..We conclude that patients who present swelling or palpable nodules in the thyroid side and have a history of a previous malignancy must be considered for metastatic disease...
  4. pmc CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy
    Muhammad Wasif Saif
    Clinical Medicine, The GI Oncology Section of the Division of Hematology Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, Milstein Hospital, 177 Fort Washington Avenue, Suite 6 435, NY 10032, USA
    J Oncol 2010:934359. 2010
    ..This review presents the emerging role of CoFactor in colorectal and nongastrointestinal malignancies...
  5. pmc Cerebrovascular accidents associated with sorafenib in hepatocellular carcinoma
    Muhammad W Saif
    Division of Hematology, Oncology, Department of Medicine, Columbia University, NY 10027, USA
    Gastroenterol Res Pract 2011:616080. 2011
    ..Sorafenib was discontinued in both cases. Physicians should monitor patients receiving sorafenib for neurologic symptoms, and in the absence of other etiology, prompt discontinuation of this drug should be considered...
  6. doi request reprint Pulmonary blastoma with submandibular, scrotum and adrenal metastases: case report
    Kostas N Syrigos
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens University School of Medicine, Athens, Greece
    Respiration 83:83-6. 2012
    ..Treatment strategy in pulmonary blastoma should be defined by a multidisciplinary team, and surgical treatment should be considered as quickly as possible when such a tumor is suspected...
  7. pmc High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology
    Valsamo K Anagnostou
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:186. 2010
    ..Bcl-2 has been investigated as a prognostic factor in non small cell lung cancer (NSCLC) patients with conflicting results...
  8. pmc Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model
    Aristotelis Bamias
    Department of Clinical Therapeutics, Athens University, Medical School, Athens, Greece
    BMC Cancer 10:45. 2010
    ..We studied the prognostic significance of baseline characteristics and we compared the risk stratification with the established Memorial Sloan Kettering Cancer Center (MSKCC) model...
  9. ncbi request reprint A phase-II study of liposomal doxorubicin and docetaxel in patients with advanced pancreatic cancer
    K N Syrigos
    Oncology Unit, 3rd Department of Medicine, Athens Medical School, Building Z, Sotiria General Hospital, Mesogion 152, 115 26 Athens, Greece
    Anticancer Res 22:3583-8. 2002
    ..We have conducted a Phase-II study in order to evaluate the tolerance and efficacy of their combination as front-line treatment in patients with APC...
  10. ncbi request reprint Colonoscopy in asymptomatic individuals with a family history of colorectal cancer
    K N Syrigos
    Department of Clinical Oncology, Imperial College of Science Technology and Medicine, Hammersmith Hospital Campus, London, UK
    Ann Surg Oncol 9:439-43. 2002
    ..This study was performed to evaluate the use of total colonoscopy as the optimal screening test in asymptomatic individuals with a family history of colorectal cancer (CRC)...
  11. doi request reprint Prognostic and predictive factors in a randomized phase III trial comparing cisplatin-pemetrexed versus cisplatin-gemcitabine in advanced non-small-cell lung cancer
    K N Syrigos
    Oncology Unit, Department of Medicine, Athens School of Medicine, Athens, Greece
    Ann Oncol 21:556-61. 2010
    ..Histology has recently been identified in multiple NSCLC phase III trials as a predictive factor for survival in patients receiving pemetrexed regimens...
  12. doi request reprint Targeted therapy for oesophageal cancer: an overview
    K N Syrigos
    Oncology Unit, Third Department of Medicine, Athens University School of Medicine, Sotiria General Hospital, Athens, Greece
    Cancer Metastasis Rev 27:273-88. 2008
    ....
  13. ncbi request reprint Biweekly administration of docetaxel and gemcitabine as adjuvant therapy for stage II and IIIA non-small cell lung cancer: a phase II study
    Konstantinos N Syrigos
    Athens University School of Medicine, Head, Oncology Unit, Third Department of Medicine, Athens School of Medicine, Building Z, Sotiria General Hospital, Mesogion 152, 115 27 Athens, Greece
    Anticancer Res 27:2887-92. 2007
    ....
  14. ncbi request reprint Prostate cancer in the elderly
    Konstantinos N Syrigos
    Oncology Unit, Third Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece
    Anticancer Res 25:4527-33. 2005
    ..Physicians treating aged prostate cancer patients should be trained in an individualized approach, based on clinical performance status and comorbitities...
  15. ncbi request reprint Bi-weekly administration of docetaxel and gemcitabine as first-line therapy for non-small cell lung cancer: a phase II study
    Konstantinos N Syrigos
    Oncology Unit, Third Department of Medicine, University of Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    Anticancer Res 25:3489-93. 2005
    ..The bi-weekly administration of docetaxel and gemcitabine for advanced NSCLC was evaluated in a phase II study (objective response rate, median survival, median duration of response and safety)...
  16. ncbi request reprint Skin cancer in the elderly
    Konstantinos N Syrigos
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Athens, Greece
    In Vivo 19:643-52. 2005
    ..Physicians treating elderly patients should be trained in an individualized approach to these patients and encouraged to participate in programs for the early detection of suspicious skin lesions...
  17. ncbi request reprint Biweekly administration of docetaxel and gemcitabine for elderly patients with advanced non-small cell lung cancer: a phase II study
    K N Syrigos
    Third Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    J Chemother 19:438-43. 2007
    ..Hence, this two-drug combination appears promising and warrants further evaluation...
  18. ncbi request reprint The clinical significance of molecular markers to bladder cancer
    Konstantinos N Syrigos
    Oncology Unit, 3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece
    Hybrid Hybridomics 23:335-42. 2004
    ..Clinical studies are in progress for the assessment of other biological molecules with prognostic potential, such as the E-cadherin, the protein p120, and the telomerase...
  19. ncbi request reprint Circulating soluble E-cadherin levels are of prognostic significance in patients with multiple myeloma
    K N Syrigos
    Oncology Unit, 3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece
    Anticancer Res 24:2027-31. 2004
    ..We examined whether the circulating levels of soluble E-Cad in newly diagnosed patients with multiple myeloma (MM) are of prognostic significance...
  20. ncbi request reprint Prognostic significance of soluble adhesion molecules in Hodgkin's disease
    K N Syrigos
    Oncology Haematology Unit, 3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece
    Anticancer Res 24:1243-7. 2004
    ..We evaluated the serum concentration of four adhesion molecules and their prognostic significance in patients with Hodgkin's Disease (HD)...
  21. ncbi request reprint Adhesion molecules as targets for the treatment of neoplastic diseases
    Konstantinos N Syrigos
    Oncology Unit, 3rd Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    Curr Pharm Des 12:2849-61. 2006
    ..This review presents the perspectives of specific anti-adhesion molecule targeting as a possible therapeutic approach in neoplastic diseases...
  22. ncbi request reprint Cytotoxic therapy of gastroenteropancreatic (GEP) tumors
    K N Syrigos
    3rd Department of Medicine, Sotiria General Hospital, Athens Medical School, Greece
    Anticancer Res 22:1311-4. 2002
    ..Nevertheless, it is widely recognized that chemotherapy has some role in the management of Neuroendocrine Pancreatic Tumors (NPTs); while in Metastatic Carcinoid Tumors (MCTs) it has only a minimal effect...
  23. ncbi request reprint The need for third-line treatment in non-small cell lung cancer: an overview of new options
    Kostas N Syrigos
    Oncology Unit, Sotiria General Hospital, Athens School of Medicine, Athens, Greece
    Anticancer Res 31:649-59. 2011
    ..In an effort to prolong survival while maintaining quality of life, large prospective studies are needed to examine the effectiveness and safety of third-line regimens in these patients...
  24. ncbi request reprint Mucins as immunogenic targets in cancer
    K N Syrigos
    Department of Clinical Oncology, Imperial College of Science Technology and Medicine, London, U K
    Anticancer Res 19:5239-44. 1999
    ..We concluded that the provocation of an anti-MUC1 immune response may be used for the development of a vaccine strategy, which holds promise for therapeutic antineoplastic interventions...
  25. ncbi request reprint Prognostic significance of autoantibodies against tropomyosin in patients with colorectal adenocarcinoma
    K N Syrigos
    3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Greece
    Hybridoma 18:543-6. 1999
    ..The difference between the two groups was statistically significant (p < 0.01). Anti-tropomyosin antibodies could be used as biological markers of prognosis in colon cancer patients...
  26. ncbi request reprint Epithelial mucin expression in bladder cancer: correlation with pathological and clinical parameters
    K N Syrigos
    Kifisias 40 and Arkadias, Athens, Greece
    Urol Res 28:241-5. 2000
    ..We conclude that PEM is frequently overexpressed by bladder cancer cells and HMFG1 is the antibody of choice to be used as a carrier of a cytotoxic agent for application of intravesical targeted therapy of bladder cancer...
  27. pmc Prolonged survival after splenectomy in Wiskott-Aldrich syndrome: a case report
    Kostas N Syrigos
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece
    Ital J Pediatr 37:42. 2011
    ....
  28. ncbi request reprint The prognostic significance of autoantibodies against dsDNA in patients with colorectal adenocarcinoma
    K N Syrigos
    Oncology Unit, 3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece
    Anticancer Res 20:4351-3. 2000
    ..The goal of this study was to correlate the presence of the anti-dsDNA autoantibodies in the serum of patients with colorectal adenocarcinoma suffering from the prognosis of their disease...
  29. ncbi request reprint Primary malignant melanoma of the esophagus: report of two cases and review of the literature
    K N Syrigos
    Laboratory of Molecular Immunology, Hippokration Hospital, Athens Medical School, Greece
    In Vivo 13:421-2. 1999
    ..We reported two cases of primary malignant melanoma of the esophagus, treated with interpositioning of the left colon subcutaneously over the sternum. We also reviewed the world literature on this rare but fatal disease...
  30. ncbi request reprint The development of monoclonal antibody therapy in leukemias
    K N Syrigos
    Oncology Unit, 3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece
    Hybridoma 20:145-8. 2001
    ..Considering the preliminary data, MAb therapy appears to be a new, promising weapon in the oncologist's armentarium...
  31. ncbi request reprint Safety and efficacy of the new bisphosphonate ibandronate in the management of bone metastasis following rapid infusion
    Konstantinos N Syrigos
    Oncology Haematology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens Medical School, Athens, Greece
    In Vivo 16:361-3. 2002
    ..We evaluated the safety and efficacy of the new BP ibandronate, given as a rapid infusion...
  32. ncbi request reprint Safety and efficacy of zoledronic acid rapid infusion in lung cancer patients with bone metastases: a single institution experience
    Elias Kotteas
    Athens University School of Medicine, Oncology Unit, Third Department of Medicine, Sotiria General Hospital, Building Z, 152 Mesogion Avenue, 115 27 Athens, Greece
    Anticancer Res 28:529-33. 2008
    ..We conclude that the rapid infusion of zoledronic acid is safe and convenient for lung cancer patients even after the 3rd and 6th months follow-up...
  33. ncbi request reprint Preclinical research in treatment of pancreatic cancer
    Evangelia Skoura
    Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital Athens, Greece
    JOP 14:384-7. 2013
    ..The third study presents the effectiveness of the novel cell division cycle 7 (Cdc7) kinase inhibitor, MSK-777 (Abstract #e15059). All studies demonstrated promising results and further investigation is ongoing. ..
  34. doi request reprint Effects of taxane-based chemotherapy on inhibin B and gonadotropins as biomarkers of spermatogenesis
    Eleftherios Chatzidarellis
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Athens, Greece
    Fertil Steril 94:558-63. 2010
    ..To assess the effects of taxane-based chemotherapy on the male reproductive axis, and, therefore, its impact on spermatogenesis and fertility...
  35. ncbi request reprint Rapid infusion of ibandronate in lung cancer patients with bone metastases
    Maria Kiagia
    Oncology Unit, Third Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    Anticancer Res 26:3133-6. 2006
    ..Ibandronate is a new generation of bisphosphonates (BPs) with demonstrated clinical benefit in breast and prostate cancer patients with bone metastases...
  36. doi request reprint Locally advanced pancreatic cancer
    Georgios M Oikonomopoulos
    Second Oncology Clinic, St Savvas Anticancer Hospital, Athens, Greece
    JOP 14:126-8. 2013
    ..A discussion is presented about the different chemotherapy or chemoradiotherapy regimens, that move away from gemcitabine-based treatment, and the effort to find less toxic, but efficient therapeutic combinations...
  37. ncbi request reprint The use of radiolabeled somatostatin analog scintigraphy in the staging of small cell lung cancer patients
    Ifigeneia A Tzannou
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens, Greece
    Am J Clin Oncol 30:503-6. 2007
    ..We evaluated the role of somatostatin receptor scintigraphy (SRS) in the diagnosis and initial staging of SCLC in comparison with the conventional staging procedure...
  38. ncbi request reprint Pegylated Liposomal Doxorubicin HCL (Caelyx) in combination with Sandostatin LAR as salvage therapy in patients with small-cell lung cancer
    Adrianni Charpidou
    Oncology Unit, Third Department of Medicine, Athens School of Medicine, Greece
    In Vivo 20:553-7. 2006
    ..The aim of the present study was to evaluate the efficacy of Pegylated Liposomal Doxorubicin (Caelyx) combined with Sandostatin LAR as salvage treatment of small cell lung cancer (SCLC) in platinum-pretreated patients...
  39. pmc XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer: a Hellenic Cooperative Oncology Group phase III trial with collateral biomarker analysis
    Dimitrios Pectasides
    Oncology Section, Second Department of Internal Medicine, Hippokration Hospital, University of Athens School of Medicine, Athens, Greece
    BMC Cancer 12:271. 2012
    ..The aim was to compare two standard chemotherapy regimens combined with bevacizumab as first-line treatment in patients with metastatic colorectal cancer...
  40. doi request reprint Carboplatin plus pemetrexed as first-line treatment of patients with malignant pleural mesothelioma: a phase II study
    Nikolaos Katirtzoglou
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Athens, Greece
    Clin Lung Cancer 11:30-5. 2010
    ..Treatment options are limited, and response to chemotherapy is poor. The aim of this phase II study was to evaluate the activity of the carboplatin/pemetrexed combination as first-line chemotherapy in patients with unresectable MPM...
  41. doi request reprint Second-line therapy in pancreatic cancer
    Evangelia Skoura
    Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
    JOP 14:133-4. 2013
    ....
  42. ncbi request reprint Review. EGFR mutations in non-small cell lung cancer--clinical implications
    Andriani Charpidou
    Oncology Unit, Third Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    In Vivo 22:529-36. 2008
    ....
  43. ncbi request reprint Translational research in pancreatic cancer. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011
    Alexios S Strimpakos
    Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital Athens, Greece
    JOP 12:120-2. 2011
    ..Finally, enhanced selective targeting of pancreatic tumors was achieved by combining antibody-drug conjugates (ADC) with radioimmunotherapy (Abstract #206)...
  44. doi request reprint Novel agents in the treatment of pancreatic adenocarcinoma
    Anastasios Dimou
    Department of Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA
    JOP 14:138-40. 2013
    ..Further studying of FG-3019 and ASG-5ME will show the potential activity if any of these compounds in patients with pancreatic cancer...
  45. doi request reprint Multimodal treatment strategies for elderly patients with head and neck cancer
    Evangelos G Sarris
    Oncology Unit GPP, Sotiria General Hospital, Athens Medical School, Building Z, 152 Mesogion Av, 115 27 Athens, Greece
    Cancer Treat Rev 40:465-75. 2014
    ..The aim of this review article is to investigate the multimodal treatment approaches for elderly patients with head and neck cancer. ..
  46. doi request reprint The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer (NSCLC)
    Eleni M Karapanagiotou
    Third Department of Medicine, Oncology Unit, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    Lung Cancer 61:391-7. 2008
    ..Only serum resistin levels were associated with weight loss. Despite no direct involvement of leptin and adiponectin, resistin as a proinflammatory cytokine may play a role in the pathogenesis of weight loss in NSCLC patients...
  47. doi request reprint Thymoma and radiation therapy: a systematic review of medical treatment
    Alexandra Giannopoulou
    Department of Radiation Therapy, Attikon University General Hospital, Athens, Greece
    Expert Rev Anticancer Ther 13:759-66. 2013
    ..In conclusion, high technology (3D radiotherapy, 4D radiotherapy, intensity-modulated radiotherapy, image-guided radiotherapy and computed tomography fusion with PET scan) optimizes tumor target definition and provides dose escalation...
  48. doi request reprint Key molecular mechanisms in lung cancer invasion and metastasis: a comprehensive review
    Fotis Perlikos
    12th Pulmonary Medicine Department, Sotiria General Hospital, Athens School of Medicine, Greece
    Crit Rev Oncol Hematol 87:1-11. 2013
    ..Improving of understanding of the underlying molecular and cellular mechanisms remains an urgent and essential issue, in order to develop new more effective strategies in preventing and treating lung cancer...
  49. doi request reprint Pancreatic cancer: updates on translational research and future applications
    Evangelos G Sarris
    Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
    JOP 14:145-8. 2013
    ..Lastly, in Abstract #164, the diagnostic utility of YKL-40 and IL-6 in pancreatic cancer patients is investigated...
  50. ncbi request reprint Translational research in pancreatic cancer. Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010
    Alexios S Strimpakos
    Oncology Unit, Sotiria General Hospital, University of Athens, Athens, Greece
    JOP 11:124-7. 2010
    ..In this paper we present details and comment on these works...
  51. ncbi request reprint Clinical significance of heat shock protein-70 expression in bladder cancer
    Konstantinos N Syrigos
    Laboratory of Molecular Oncology, 3rd Department of Internal Medicine, Sotiria General Hospital, Athens University School of Medicine, Athens, Greece
    Urology 61:677-80. 2003
    ..To investigate the expression of heat shock protein-70 (HSP-70) in transitional cell bladder cancer and correlate it with normal and inflammatory bladder tissue samples...
  52. ncbi request reprint Pancreatic neuroendocrine tumors: role of novel agents. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011
    Alexios S Strimpakos
    Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital Athens, Greece
    JOP 12:117-9. 2011
    ..Another agent with promising activity in PNET which will be discussed in this review is sunitinib, a biological agent with multikinase inhibitor properties (Abstract #244)...
  53. ncbi request reprint Treatment for refractory pancreatic cancer. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011
    Nektaria Makrilia
    Oncology Unit, Third Department of Medicine, Sotiria General Hospital, Athens Medical School Athens, Greece
    JOP 12:110-3. 2011
    ....
  54. ncbi request reprint Biodistribution and pharmacokinetics of 111In-dTPA-labelled pegylated liposomes after intraperitoneal injection
    Konstantinos N Syrigos
    Cancer Research UK Targeted Therapy Laboratory, Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Acta Oncol 42:147-53. 2003
    ..6-fold). small intestine (1.5-fold). colon (1.2-fold), gallbladder (5.1-fold) and adrenal gland (2.1-fold). These data support the development of i.p. liposomal chemotherapy for the treatment of intraperitoneal malignant disease...
  55. ncbi request reprint Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery
    D Alexiou
    First Department of Surgery, University of Athens, Medical School, Athens, Greece
    Eur J Cancer 37:2392-7. 2001
    ..Since these markers are linked to CEA levels, it is uncertain whether their measurement will prove cost-effective in colorectal cancer management...
  56. doi request reprint Multiplexed analysis of angiogenesis and lymphangiogenesis factors predicts outcome for non-small cell lung cancer patients
    Valsamo K Anagnostou
    Third Department of Medicine, Sotiria General Hospital, Athens, Greece
    Virchows Arch 458:331-40. 2011
    ..Angiogenic and lymphangiogenic biomarkers studied define subgroups of patients at high risk and may be useful for prognostic stratification of NSCLC patients especially those with early stage disease...
  57. ncbi request reprint Programmed death ligand-1 expression in non-small cell lung cancer
    Vamsidhar Velcheti
    Solid Tumor, Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
    Lab Invest 94:107-16. 2014
    ..Expression of PD-L1 protein or mRNA is associated with better outcome. Further studies are required to determine the value of this marker in prognosis and prediction of response to treatments targeting this pathway. ..
  58. doi request reprint Soluble ICAM-1 levels in small-cell lung cancer: prognostic value for survival and predictive significance for response during chemotherapy
    Elias A Kotteas
    Oncology Unit GPP, Sotiria General Hospital, Athens School of Medicine, 152, Mesogeion av, 115 27, Athens, Greece
    Med Oncol 30:662. 2013
    ..Also, a possible role for soluble ICAM-1 may exist as a predictive marker for objective response during chemotherapy for patients with extensive disease (p = 0.001). ..
  59. ncbi request reprint Liposomally targeted cytotoxic drugs for the treatment of cancer
    Kevin J Harrington
    Cancer Research UK Targeted Therapy Laboratory, Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    J Pharm Pharmacol 54:1573-600. 2002
    ..In this review, we will trace the development of those liposomes that are currently undergoing (or are about to undergo) clinical evaluation...
  60. pmc Circulating VEGF levels in the serum of gastric cancer patients: correlation with pathological variables, patient survival, and tumor surgery
    Anastasios J Karayiannakis
    Second Department of Surgery, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
    Ann Surg 236:37-42. 2002
    ..To evaluate the clinical usefulness of serum vascular endothelial growth factor (VEGF) levels in gastric cancer patients...
  61. ncbi request reprint Serum vascular endothelial growth factor levels in pancreatic cancer patients correlate with advanced and metastatic disease and poor prognosis
    Anastasios J Karayiannakis
    Second Department of Surgery, Democritus University of Thrace, Medical School, 6 I Kaviri Street, Alexandroupolis 68 100, Greece
    Cancer Lett 194:119-24. 2003
    ..These findings suggest that serum VEGF concentrations may reflect pancreatic cancer progression and that their determination may be clinically useful...
  62. ncbi request reprint Expression patterns of alpha-, beta- and gamma-catenin in pancreatic cancer: correlation with E-cadherin expression, pathological features and prognosis
    A J Karayiannakis
    Second Department of Surgery, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
    Anticancer Res 21:4127-34. 2001
    ..The E-cadherin-catenin cell adhesion complex has been implicated in tumour invasion and metastasis. In this study, we evaluated the clinical significance of E-cadherin and catenin expression in pancreatic cancer...
  63. ncbi request reprint Serum E-cadherin concentrations and their response during laparoscopic and open cholecystectomy
    A J Karayiannakis
    Second Department of Surgery, Democritus University of Thrace, Medical School, 6 I Kaviri Street, 68 100 Alexandroupolis, Greece
    Surg Endosc 16:1551-4. 2002
    ..Elevated serum levels of the cell adhesion molecule E-cadherin have been associated with the presence of tissue injury and inflammation. We compared soluble E-cadherin response during laparoscopic and open cholecystectomy...
  64. ncbi request reprint Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients
    A J Karayiannakis
    Second Department of Surgery, Democritus Thrace University, Medical School, 68100 Alexandroupolis, Greece
    Anticancer Res 21:1355-8. 2001
    ..In this study we evaluated serum levels of TNF-alpha in pancreatic cancer patients and investigated their relationships to cachexia...
  65. ncbi request reprint Clinical pharmacogenetics in oncology: the paradigm of molecular targeted therapies
    Giannis Mountzios
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens Medical School, Building Z, 152 Mesogion Avenue, 115 27 Athens, Greece
    Curr Pharm Des 16:2184-93. 2010
    ..The true clinical utility of these applications remains to be proven in future prospective, randomized clinical trials in large patient cohorts of all different ethnic backgrounds...
  66. ncbi request reprint Clinical significance of soluble c-erbB-2 levels in the serum and urine of patients with gastric cancer
    Christos Tsigris
    First Department of Surgery, University of Athens, Medical School, Athens, Greece
    Anticancer Res 22:3061-5. 2002
    ..This study measured serum and urinary c-erbB-2 levels in patients with gastric cancer, assessing their role in cancer-specific survival and the effects of resectional surgery...
  67. ncbi request reprint Prognostic significance of erythropoietin expression in human renal cell carcinoma
    Agniezka Michael
    Department of Oncology, St George s Hospital Medical School, London, UK
    BJU Int 100:291-4. 2007
    ..g. liver, uterus, central nervous system, vascular endothelial cells and solid tumours...
  68. ncbi request reprint Thyroid autoantibodies and thyroid function in patients with pancreatic adenocarcinoma
    I Fyssas
    Department of Propaedeutic Surgery, Athens Medical School, Hippokration Hospital, Greece
    Acta Oncol 36:65-8. 1997
    ..The difference between the PA patients and either of the control groups was statistically significant (p < 0.05). The production of autoantibodies could be attributed to impaired immunoregulation caused by the malignant cells...
  69. ncbi request reprint Immune responses in advanced colorectal cancer following repeated intradermal vaccination with the anti-CEA murine monoclonal antibody, PR1A3: results of a phase I study
    A P Zbar
    Academic Department of Colorectal Surgery, Hammersmith Hospital, London, UK
    Int J Colorectal Dis 20:403-14. 2005
    ..The aim was to determine the toxicity, clinical and immune responses to the murine monoclonal anti-carcinoembryonic antigen (CEA) antibody, PR1A3, in patients with advanced colorectal cancer...
  70. ncbi request reprint Targeted therapies for non-small cell lung cancer
    G S Papaetis
    Oncology Unit, 3rd Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    Curr Pharm Des 13:2810-31. 2007
    ..Multi-targeted therapy still remains the most attractive avenue for future treatment strategies...
  71. pmc Gefitinib (ZD1839, Iressa) as palliative treatment in recurrent or metastatic head and neck cancer
    A M Kirby
    Head and Neck Unit, Royal Marsden Hospital, 203 Fulham Road, London, UK
    Br J Cancer 94:631-6. 2006
    ....
  72. ncbi request reprint Overexpression of hnRNPA2/B1 in bronchoscopic specimens: a potential early detection marker in lung cancer
    S Katsimpoula
    Sixth Department of Pneumology, Sotiria General Hospital, Athens, Greece
    Anticancer Res 29:1373-82. 2009
    ..The aim of this study was to determine the utility of its detection in bronchoscopic specimens...
  73. doi request reprint The VEGF pathway in lung cancer
    Michalis Alevizakos
    Oncology Unit GPP, Sotiria General Hospital, Athens School of Medicine, Athens, Greece
    Cancer Chemother Pharmacol 72:1169-81. 2013
    ..Thus, a new class of drugs has emerged, targeting its pathway, which has offered substantial, albeit small, improvements in patient prognosis...
  74. doi request reprint Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence
    Vassilis S Ramfidis
    Oncology Unit, 251 General Hospital of Airforce, Athens, Greece
    JOP 14:158-60. 2013
    ....
  75. doi request reprint Intraductal papillary mucinous neoplasms of the pancreas (IPMNs): epidemiology, diagnosis and future aspects
    Froso Konstantinou
    Oncology Unit, Third Department of Medicine, Athens School of Medicine, Sotiria General Hospital, Athens, Greece
    JOP 14:141-4. 2013
    ..Herein, the authors summarize the data presented at the 2013 ASCO Gastrointestinal Cancers Symposium regarding incidence and clinicopathological characteristics of IPMN (Abstracts #324, #187 and #179)...
  76. pmc Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway
    Katie Twigger
    Division of Cancer Biology Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    BMC Cancer 12:368. 2012
    ..In particular, we analysed the role of EGFR/Ras signalling in determining virus-mediated cytotoxicity in SCCHN...
  77. ncbi request reprint Endoscopic and endobronchial ultrasound-guided needle aspiration in the mediastinal staging of non-small cell lung cancer
    Thomas Raptakis
    Ierapetra General Hospital, Crete, Greece
    Anticancer Res 33:2369-76. 2013
    ....
  78. pmc Therapeutic effect of sodium iodide symporter gene therapy combined with external beam radiotherapy and targeted drugs that inhibit DNA repair
    Mohan Hingorani
    Targeted Therapy Team, The Institute of Cancer Research, London, UK
    Mol Ther 18:1599-605. 2010
    ..Therefore, combining NIS gene therapy and EBRT represents an ideal strategy to exploit the therapeutic benefits of novel radiosensitizers...
  79. ncbi request reprint Abnormal expression of the E-cadherin-catenin complex in dysplastic Barrett's oesophagus
    J P Seery
    Department of Gastroenterology, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, London, UK
    Acta Oncol 38:945-8. 1999
    ..Our results indicate that altered subcellular distribution of beta-catenin occurs frequently in dysplastic Barrett's oesophagus and possibly reflects the signalling function of this molecule...
  80. ncbi request reprint Pegylated liposome-encapsulated doxorubicin and cisplatin enhance the effect of radiotherapy in a tumor xenograft model
    K J Harrington
    Oncology Unit, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    Clin Cancer Res 6:4939-49. 2000
    ..This study is the first to demonstrate the value of pegylated liposomes as vehicles for the delivery of radiosensitizing drugs in CCRT strategies...
  81. pmc Expression of CC chemokine receptor 7 in tonsillar cancer predicts cervical nodal metastasis, systemic relapse and survival
    L Pitkin
    Thomas Tatum Head and Neck Unit, St George s Hospital, London, UK
    Br J Cancer 97:670-7. 2007
    ..These data demonstrated that CCR7 expression was associated with cervical nodal and systemic metastases from tonsillar cancers. High levels of CCR7 expression predicted a poor prognosis...
  82. doi request reprint Role of positron emission tomography in the early prediction of response to chemotherapy in patients with non--small-cell lung cancer
    Evangelia Skoura
    Nuclear Medicine Department, Evangelismos Hospital, Athens, Greece
    Clin Lung Cancer 13:181-7. 2012
    ..Finally, it evaluates the usefulness of [(18)F]fluorothymidine, a PET tracer for imaging tumor proliferation, in predicting response to therapy in patients with lung cancer...
  83. ncbi request reprint Sex hormone levels in the serum of patients with pancreatic adenocarcinoma
    I Fyssas
    1st Department of Propaedeutic Surgery, Hippokration Hospital, Athens Medical School, Greece
    Horm Metab Res 29:115-8. 1997
    ..001), compared with group of healthy volunteers. Our data provide evidence of a generalised dysfunction of the hypothalamic-hypophysial-gonadal axis in pancreatic cancer patients...
  84. pmc Targeted radiosensitisation by pegylated liposome-encapsulated 3', 5'-O-dipalmitoyl 5-iodo-2'-deoxyuridine in a head and neck cancer xenograft model
    K J Harrington
    ICRF Oncology Unit, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, and Cancer Research UK Targeted Therapy Laboratory, Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Br J Cancer 91:366-73. 2004
    ..Immunohistochemistry with a specific anti-IUdR monoclonal antibody confirmed greater levels of tumour staining in tumours from animals treated with PLIUdR compared with those treated with unencapsulated IUdR...
  85. ncbi request reprint Intravesical administration of radiolabelled tumour-associated monoclonal antibody in bladder cancer
    K N Syrigos
    Department of Clinical Oncology, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, London, England
    Acta Oncol 38:379-82. 1999
    ..81 +/- 1.23, at 2 h and 2.17 +/- 0.42 at 24 h. No radioactivity was detected in the blood. We conclude that HMFG1 could be used intravesically for the successful delivery of a cytotoxic agent...
  86. pmc Biodistribution and pharmacokinetics of 111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model: implications for novel targeting strategies
    K J Harrington
    ICFR Oncology Unit, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    Br J Cancer 83:232-8. 2000
    ..The potential applications of pegylated liposomes in the arena of targeted therapy of solid cancers are discussed...
  87. doi request reprint Pharmacogenetics and biomarkers in colorectal cancer
    A S Strimpakos
    Department of Medicine, Royal Marsden Hospital, Sutton, UK
    Pharmacogenomics J 9:147-60. 2009
    ..Here, we review the main genetic alterations observed in familial and sporadic CRC and their associations with the metabolism, efficacy and toxicities of drugs used in this disease...
  88. ncbi request reprint Gastrointestinal bleeding as initial presentation of melanoma of unknown primary origin: report of a case and review of the literature
    E A Kotteas
    Third Department of Medicine, Athens School of Medicine, Athens, Greece
    In Vivo 23:487-9. 2009
    ..The thorough physical and paraclinical examination did not reveal any lesions or nodules as a primary site of the disease. The literature concerning this rare presentation of melanoma is also reviewed...
  89. ncbi request reprint The effect of irradiation on the biodistribution of radiolabeled pegylated liposomes
    K J Harrington
    ICRF Oncology Unit, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    Int J Radiat Oncol Biol Phys 50:809-20. 2001
    ....
  90. ncbi request reprint High pretreatment interleukin-10 is an independent predictor of poor failure-free survival in patients with Hodgkin's lymphoma
    Eleanna V Salgami
    Haematology Oncology Unit, Third University Department of Medicine, Sotiria Hospital, 152 Mesogion Avenue, Athens 11527, Greece
    Haematologia (Budap) 32:377-87. 2002
    ..The aim of this study was to investigate the relationship of pretreatment serum IL-10 (sIL-10) levels with known prognostic factors and with failure-free survival (FFS) in patients with Hodgkin's lymphoma (HL)...
  91. ncbi request reprint Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer patients
    Dimitrios Alexiou
    First Department of Surgery, University of Athens, Medical School, Greece
    Am J Gastroenterol 98:478-85. 2003
    ..Our objectives were to correlate these levels with clinicopathological features, established tumor markers, and patient survival, and to assess changes in serum levels of cell adhesion molecules after tumor surgery...
  92. ncbi request reprint Clinical significance of preoperative serum vascular endothelial growth factor levels in patients with colorectal cancer and the effect of tumor surgery
    Anastasios J Karayiannakis
    Second Department of Surgery, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
    Surgery 131:548-55. 2002
    ..In this study we evaluated the clinical usefulness of preoperative serum VEGF concentrations in patients with colorectal cancer. The changes in serum VEGF levels after tumor surgery were also evaluated...
  93. ncbi request reprint Clinical significance of serum and urinary c-erbB-2 levels in colorectal cancer
    Christos Tsigris
    First Department of Surgery, University of Athens, Medical School, Athens 115 27, Greece
    Cancer Lett 184:215-22. 2002
    ..These findings suggest that serum assessment of c-erbB-2 concentration may be valuable in defining colorectal cancer prognosis...