Research Topics
| R W PeelingSummaryAffiliation: World Health Organization Country: Switzerland Publications
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Detail Information
Publications
Detection of gonococcal infection : pros and cons of a rapid testPeter Vickerman
London School of Hygiene and Tropical Medicine, London, UK
Mol Diagn 9:175-9. 2005..Their optimal use in these settings requires the development of simpler and cheaper rapid tests...
The pathogenesis of syphilis: the Great Mimicker, revisitedRosanna W Peeling
Diagnostics Research and Development, UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, The World Health Organization, Geneva, Switzerland
J Pathol 208:224-32. 2006..Understanding of the molecular targets of these immune responses may facilitate the development of vaccines for syphilis...
Evaluation of rapid diagnostic tests: malariaDavid Bell
Malaria, and other Vector-borne and Parasitic Diseases, World Health Organization-Regional Office for the Western Pacific, PO Box 2932, Manila, Philippines
Nat Rev Microbiol 4:S34-8. 2006
A guide for diagnostic evaluationsRosanna W Peeling
UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
Nat Rev Microbiol 4:S2-6. 2006..Misdiagnosis leading to failure to treat a serious infection or wasting expensive treatment on people who are not infected remains a serious obstacle to health...
A guide for diagnostic evaluationsRosanna W Peeling
UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
Nat Rev Microbiol 6:S2-6. 2008..Misdiagnosis leading to failure to treat a serious infection or wasting expensive treatment on people who are not infected remains a serious obstacle to health...
Avoiding HIV and dying of syphilisRosanna W Peeling
Diagnostics Research and Development, UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, WHO, CH-1211 Geneva 27, Switzerland
Lancet 364:1561-3. 2004
Why do we need quality-assured diagnostic tests for sexually transmitted infections?Rosanna W Peeling
WHO TDR Sexually Transmitted Diseases Diagnostics Initiative SDI, UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
Nat Rev Microbiol 4:S7-19. 2006....
Diagnostic tools for preventing and managing maternal and congenital syphilis: an overviewRosanna W Peeling
Sexually Transmitted Diseases Diagnostics Initiative SDI, UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, World Health Organization, Geneva, Switzerland
Bull World Health Organ 82:439-46. 2004..The development of a non-invasive rapid treponemal test that distinguishes between active and past infections remains a high priority in areas where syphilis is endemic...
Rapid tests for sexually transmitted infections (STIs): the way forwardR W Peeling
Sexually Transmitted Diseases Diagnostics Initiative SDI, UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, 20 Avenue Appia, Geneva, Switzerland
Sex Transm Infect 82:v1-6. 2006....
SyphilisR W Peeling
WHO, Geneva, Switzerland
Nat Rev Microbiol 2:448-9. 2004
A guide for diagnostic evaluationsRosanna W Peeling
UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
Nat Rev Microbiol 4:S2-6. 2006..Misdiagnosis leading to failure to treat a serious infection or wasting expensive treatment on people who are not infected remains a serious obstacle to health...
A guide for diagnostic evaluationsRosanna W Peeling
UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
Nat Rev Microbiol 8:S2-6. 2010..Misdiagnosis leading to failure to treat a serious infection or wasting expensive treatment on people who are not infected remains a serious obstacle to health...
The value of mass screening for chlamydia control in high prevalence communitiesS Hodgins
Nunavik Board of Health, Kuujjuaq, Quebec, Canada
Sex Transm Infect 78:i64-8. 2002..trachomatis infection under these circumstances. It is particularly important to target men in settings such as this where women are routinely screened in antenatal and family planning clinics...
Why do we need quality-assured diagnostic tests for sexually transmitted infections?Rosanna W Peeling
WHO TDR Sexually Transmitted Diseases Diagnostics Initiative SDI, UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
Nat Rev Microbiol 4:909-21. 2006....
Diagnostic tests for infectious diseases in the developing world: two sides of the coinTikki Pang
Research Policy and Cooperation, World Health Organization, Ave Appia, 1211, Geneva 27, Switzerland
Trans R Soc Trop Med Hyg 101:856-7. 2007....
Evaluation of a rapid point-of-care test for the detection of gonococcal infection among female sex workers in BeninM Alary
Population Health Research Unit, Centre Hospitalier Affilie Universitaire De Quebec, Quebec, Canada
Sex Transm Infect 82:v29-32. 2006..To assess the validity of the PATH (Seattle, Washington, USA) GC-Check rapid test, a point-of-care immunochromatographic strip test, in the detection of gonococcal infection among female sex workers (FSWs) in Benin...
Mass treatment with single-dose azithromycin for trachomaAnthony W Solomon
Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
N Engl J Med 351:1962-71. 2004..Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment for trachoma are based on a mathematical model...
Reducing the burden of HIV/AIDS in infants: the contribution of improved diagnosticsJulia E Aledort
RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90407-2138, USA
Nature 444:19-28. 2006
Distribution study of Chlamydia trachomatis serovars among high-risk women in China performed using PCR-restriction fragment length polymorphism genotypingXing Gao
Department of STD Epidemiology, National Center for STD Control, 12 Jiangwangmiao Street, Nanjing 210042, China
J Clin Microbiol 45:1185-9. 2007..trachomatis, revealing exposure to multiple sources of infection. Although the scope for generalizations is limited by our small sample size, our results showing clinical correlations with genotypes are informative...
Evaluation of diagnostic tests for infectious diseases: general principlesShabir Banoo
Medicines Control Council of South Africa, Pretoria, South Africa
Nat Rev Microbiol 4:S20-32. 2006
Evaluation of rapid diagnostic tests: syphilisAlan Herring
Veterinary School, University of Bristol, Langford House, Langford, North Somerset, BS40 5DN, UK
Nat Rev Microbiol 4:S33-40. 2006
Reducing the burden of sexually transmitted infections in resource-limited settings: the role of improved diagnosticsJulia E Aledort
RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90407-2138, USA
Nature 444:59-72. 2006
Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the PhilippinesJennifer S Smith
International Agency for Research on Cancer, F 69372 Lyon Cedex 08, France
J Infect Dis 185:324-31. 2002..C. trachomatis infection was found to be a possible cofactor of HPV in the etiology of squamous cervical cancer, and its effect may be mediated by chronic inflammation...
School based HIV prevention in Zimbabwe: feasibility and acceptability of evaluation trials using biological outcomesFrances M Cowan
Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, London, UK
AIDS 16:1673-8. 2002..However, self-reported behavioural outcomes will probably be biased, emphasizing the importance of using externally validated biological outcome measures to determine effectiveness...
Evaluation of rapid diagnostic tests: chlamydia and gonorrhoeaAlan Herring
Veterinary School, University of Bristol, Langford House, Langford, North Somerset, BS40 5DN, UK
Nat Rev Microbiol 4:S41-8. 2006
Strategies for control of trachoma: observational study with quantitative PCRAnthony W Solomon
London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
Lancet 362:198-204. 2003..Success of antibiotic distribution programmes could depend on these groups receiving effective treatment...
Diagnostics for the developing worldDavid Mabey
Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7H, UK
Nat Rev Microbiol 2:231-40. 2004
Syphilis control--a continuing challengeEdward W Hook
Department of Medicine, University of Alabama at Birmingham, USA
N Engl J Med 351:122-4. 2004
Diagnosis and assessment of trachomaAnthony W Solomon
Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
Clin Microbiol Rev 17:982-1011, table of contents. 2004..There is an urgent need for a rapid, reliable test for C. trachomatis to assist in measuring progress towards the elimination of trachoma...
Evaluation of antimicrobial resistance and treatment failures for Chlamydia trachomatis: a meeting reportSusan A Wang
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 191:917-23. 2005..Evaluating C. trachomatis clinical treatment failures, interpreting laboratory findings, and correlating the 2 clearly remain extremely challenging undertakings...
Chlamydia trachomatis infection in female partners of circumcised and uncircumcised adult menXavier Castellsague
Cancer Epidemiology and Registration Unit, Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, L Hospitalet de Llobregat, Barcelona, Spain
Am J Epidemiol 162:907-16. 2005..These findings suggest that male circumcision could reduce the risk of C. trachomatis infection in female sexual partners...
Validation of syndromic algorithm for the management of genital ulcer diseases in ChinaQian-Qiu Wang
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China
Int J STD AIDS 13:469-74. 2002..More than 97% of patients followed up responded clinically to treatment. CONCLUSION: Further validation and revision of the WHO flowchart for GUD are needed...
Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?Francois Chappuis
Travel and Migration Medicine Unit, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Nat Rev Microbiol 5:873-82. 2007..New diagnostic tools and new treatment strategies will only have an impact if they are made widely available to patients...
Risk factors for syphilis infection among pregnant women: results of a case-control study in Shenzhen, ChinaHua Zhou
Institute of Dermatology, Shenzhen Chronic Disease Hospital, Shenzhen, China
Sex Transm Infect 83:476-80. 2007..01 cases per 100,000 live births in 1991 to 19.7 cases per 100,000 live births in 2005. Detailed studies of risk factors for syphilis in pregnant women are needed to inform new preventive interventions...
Chlamydial heat-shock protein-60 antibody and correlation with Chlamydia pneumoniae in atherosclerotic plaquesIgnatius W Fong
Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
J Infect Dis 186:1469-73. 2002..pneumoniae antigen, versus 5.7+/-6.1 mg/L in those without (P=.556). Immune response to CHSP-60 may play a role in atherogenesis, but CRP serum levels does not appear to be related to C. pneumoniae infection...
Pelvic inflammatory disease in the People's Republic of China: aetiology and managementShang Hong
The First Clinical College, China Medical University, Shenyang, 110001, China
Int J STD AIDS 13:568-72. 2002..Symptoms had resolved completely in 64 (47%), and had improved in 68 (50%). There was no improvement in five (4%). CONCLUSIONS: The management protocol for female lower abdominal pain recommended by WHO is effective in this setting...
Evaluation of diagnostic tests for infectious diseases: general principlesShabir Banoo
Nat Rev Microbiol 4:S21-31. 2006
Infection with Chlamydia pneumoniae and risk of multiple sclerosisKassandra L Munger
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Epidemiology 14:141-7. 2003..CONCLUSIONS: These results support a positive association between Cpn infection and progressive MS...
Impact of mass distribution of azithromycin on the antibiotic susceptibilities of ocular Chlamydia trachomatisAnthony W Solomon
Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
Antimicrob Agents Chemother 49:4804-6. 2005..No clinically or programmatically significant increase in azithromycin or tetracycline resistance was observed...
Chlamydia trachomatis and invasive cervical cancer: a pooled analysis of the IARC multicentric case-control studyJennifer S Smith
International Agency for Research on Cancer, Lyon, France
Int J Cancer 111:431-9. 2004..0; 95% CI = 0.53-1.9) in HPV DNA-positive women. An association of C. trachomatis with squamous cell ICC was found among all cases and control women with or without adjustment for HPV...
Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and preventionXavier Castellsague
Institut d Investigacio Biomedica de Bellvitge, Cancer Epidemiology and Registration Unit, Institut Català d Oncologia L Hospitalet de Llobregat, Barcelona, Spain
J Natl Cancer Inst 98:303-15. 2006..The extent to which human papillomavirus (HPV) infection and cofactors may explain this differential trend is unclear...
