P L Olliaro
Affiliation: World Health Organization
- Mode of action and mechanisms of resistance for antimalarial drugsP Olliaro
World Health Organization, Communicable Diseases Cluster CDS, UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, CH 1211 27, Geneva, Switzerland
Pharmacol Ther 89:207-19. 2001..The use of closely related compounds has promoted the spread of multidrug resistant parasites. This review intends to collate contemporary knowledge, and also to highlight conflicting views on unresolved issues...
- Plasmodium falciparum: an electronmicroscopy study of caveolae and trafficking between the parasite and the extracellular mediumP Olliaro
UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland
Int J Parasitol 27:1007-12. 1997..They may constitute carrier vesicles containing parasite membrane transport molecules possibly involved in malaria pathogenesis and/or immunity...
- Possible modes of action of the artemisinin-type compoundsP L Olliaro
UNDP World Bank WHO Special Programme on Research and Training in Tropical Diseases, CDS Cluster, 20, Avenue Appia, CH 1211, Geneva, Switzerland
Trends Parasitol 17:122-6. 2001..However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas...
- Controlling malaria: challenges and solutionsP Olliaro
UNDP World Bank World Health Organization Special Program for Research and Training in Tropical Diseases TDR, Geneva, Switzerland
Trop Med Int Health 6:922-7. 2001..The paper describes a multilateral, multidisciplinary research project on artemisinin-based combination therapy, which offers a new and potentially highly effective way to prevent or retard the development of drug resistance...
- Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A reviewP L Olliaro
UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, CH 1211 Geneva 27, Switzerland
J Postgrad Med 50:40-4. 2004..This review will summarise current antimalarial drug developments and outline recent clinical research that aims to bring artemisinin based combinations to those that need them most...
- What role can public health institutions play in drug development for the poor? A case study of artesunateM Gomes
Special Programme for Research and Training in Tropical Diseases, TDR WHO, Geneva, Switzerland
Med Trop (Mars) 58:97-100. 1998..In essence, each and every player has rallied in the challenge to reduce the discrepancy between need and availability of a drug that can has the potential to reduce mortality form the disease...
- Pharmacokinetics of artesunate after single oral administration to ratsP L Olliaro
UNPD World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, CDS, World Health Organization, 20, avenue AppiaCH 1211 Geneva 27, Switzerland
BMC Pharmacol 1:12. 2001..In order to study the absorption phase of the kinetics of artesunate following oral administration in rats, samples were collected at baseline, and then 0.5, 2, 5, 10, 15, 30, 45, 60 and 120 minutes after a single dose of 150 mg...
- The global portfolio of new antimalarial medicines under developmentP Olliaro
UNICEF UNDP WB WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland
Clin Pharmacol Ther 85:584-95. 2009..The portfolio is discussed in terms of the novelty of the new molecules and their potential health impact in terms of addressing the requirements for the control and eventual eradication of malaria...
- Status of antimalarial drugs under developmentP L Olliaro
Steering Committee on Drugs for Malaria, UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland
Bull World Health Organ 73:565-71. 1995..Some of these drugs may become available in the next few years. It is therefore essential to find mechanisms to ensure that they are made available at an affordable price to the populations that really need them...
- Phagocytosis of hemozoin (native and synthetic malaria pigment), and Plasmodium falciparum intraerythrocyte-stage parasites by human and mouse phagocytesP Olliaro
UNDP WorldBank WHO Special Programme for Research and Training in Tropical Diseases TDR, Geneva, Switzerland
Ultrastruct Pathol 24:9-13. 2000..On the contrary, whole parasites appear to follow a classical endocytic pathway. This suggests that there may be differences between the ingestion of free particles and whole parasites in terms of modulation of phagocytes' functions...
- Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trialM F Gomes
UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland
Lancet 373:557-66. 2009..We investigated whether this intervention reduced mortality and permanent disability...