Jorge Alvar

Summary

Affiliation: World Health Organization
Country: Switzerland

Publications

  1. ncbi request reprint Canine leishmaniasis
    Jorge Alvar
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Adv Parasitol 57:1-88. 2004
  2. ncbi request reprint Leishmaniasis and poverty
    Jorge Alvar
    Communicable Diseases, Neglected Tropical Diseases Control, World Health Organization, 20 Ave Appia, CH 1211 Geneva 27, Switzerland
    Trends Parasitol 22:552-7. 2006
  3. ncbi request reprint Kala-azar outbreak in Libo Kemkem, Ethiopia: epidemiologic and parasitologic assessment
    Jorge Alvar
    Department for the Control of Neglected Tropical Diseases CDS NTD IDM, Leishmaniasis Control Program, World Health Organization, 20 Avenue Appia, CH 1211 Geneva, Switzerland
    Am J Trop Med Hyg 77:275-82. 2007
  4. pmc Leishmaniasis worldwide and global estimates of its incidence
    Jorge Alvar
    Department for the Control of Neglected Tropical Diseases HTM NTD IDM, Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland
    PLoS ONE 7:e35671. 2012
  5. pmc The relationship between leishmaniasis and AIDS: the second 10 years
    Jorge Alvar
    Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Clin Microbiol Rev 21:334-59, table of contents. 2008
  6. pmc Response from Savioli and colleagues from the Department of Neglected Tropical Diseases, World Health Organization
    Lorenzo Savioli
    World Health Organization Department of Control of Neglected Tropical Diseases, Geneva, Switzerland
    PLoS Med 3:e283. 2006
  7. pmc Epidemiology of leishmaniasis in Spain based on hospitalization records (1997-2008)
    Ruth Gil-Prieto
    Department of Preventive Medicine and Public Health and Medical Immunology and Microbiology, Rey Juan Carlos University, Madrid, Spain
    Am J Trop Med Hyg 85:820-5. 2011
  8. pmc Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis
    Piero Olliaro
    UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases WHO TDR, Geneva, Switzerland
    PLoS Negl Trop Dis 7:e2130. 2013
  9. ncbi request reprint Chemotherapy in the treatment and control of leishmaniasis
    Jorge Alvar
    Department for Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia CH 1211 Geneva 27, Switzerland
    Adv Parasitol 61:223-74. 2006
  10. ncbi request reprint Relapses versus reinfections in patients coinfected with Leishmania infantum and human immunodeficiency virus type 1
    Miguel A Morales
    World Health Organization Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Madrid, Spain
    J Infect Dis 185:1533-7. 2002

Detail Information

Publications22

  1. ncbi request reprint Canine leishmaniasis
    Jorge Alvar
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Adv Parasitol 57:1-88. 2004
    ....
  2. ncbi request reprint Leishmaniasis and poverty
    Jorge Alvar
    Communicable Diseases, Neglected Tropical Diseases Control, World Health Organization, 20 Ave Appia, CH 1211 Geneva 27, Switzerland
    Trends Parasitol 22:552-7. 2006
    ..Public investment in treatment and control would decrease the leishmaniasis disease burden and help to alleviate poverty...
  3. ncbi request reprint Kala-azar outbreak in Libo Kemkem, Ethiopia: epidemiologic and parasitologic assessment
    Jorge Alvar
    Department for the Control of Neglected Tropical Diseases CDS NTD IDM, Leishmaniasis Control Program, World Health Organization, 20 Avenue Appia, CH 1211 Geneva, Switzerland
    Am J Trop Med Hyg 77:275-82. 2007
    ..Molecular typing in splenic aspirates showed L. infantum (six) and L. donovani (one). Local transmission resulted from multiple introductions, is now well established, and will be difficult to eradicate...
  4. pmc Leishmaniasis worldwide and global estimates of its incidence
    Jorge Alvar
    Department for the Control of Neglected Tropical Diseases HTM NTD IDM, Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland
    PLoS ONE 7:e35671. 2012
    ..These data should help to define control strategies and reinforce leishmaniasis advocacy...
  5. pmc The relationship between leishmaniasis and AIDS: the second 10 years
    Jorge Alvar
    Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Clin Microbiol Rev 21:334-59, table of contents. 2008
    ..Based on the previous experience of 20 years of coinfection in Europe, this review focuses on the management of Leishmania-HIV-coinfected patients in low-income countries where leishmaniasis is endemic...
  6. pmc Response from Savioli and colleagues from the Department of Neglected Tropical Diseases, World Health Organization
    Lorenzo Savioli
    World Health Organization Department of Control of Neglected Tropical Diseases, Geneva, Switzerland
    PLoS Med 3:e283. 2006
  7. pmc Epidemiology of leishmaniasis in Spain based on hospitalization records (1997-2008)
    Ruth Gil-Prieto
    Department of Preventive Medicine and Public Health and Medical Immunology and Microbiology, Rey Juan Carlos University, Madrid, Spain
    Am J Trop Med Hyg 85:820-5. 2011
    ..5 million for inpatient care alone. The economical burden of leishmaniasis is not neglectable and in the 12-year study period it represented more than $19 million...
  8. pmc Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis
    Piero Olliaro
    UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases WHO TDR, Geneva, Switzerland
    PLoS Negl Trop Dis 7:e2130. 2013
    ..The limited resources available for CL have to be concentrated in clinical studies of excellence that meet international quality standards...
  9. ncbi request reprint Chemotherapy in the treatment and control of leishmaniasis
    Jorge Alvar
    Department for Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia CH 1211 Geneva 27, Switzerland
    Adv Parasitol 61:223-74. 2006
    ..In addition, full deployment of drugs in treatment and control requires defined strategies, which can also prevent or delay the development of drug resistance...
  10. ncbi request reprint Relapses versus reinfections in patients coinfected with Leishmania infantum and human immunodeficiency virus type 1
    Miguel A Morales
    World Health Organization Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Madrid, Spain
    J Infect Dis 185:1533-7. 2002
    ..These results suggest the utility of this PCR-RFLP analysis in detecting leishmaniasis reinfection in HIV-positive patients...
  11. ncbi request reprint Amphotericin B lipid complex versus meglumine antimoniate in the treatment of visceral leishmaniasis in patients infected with HIV: a randomized pilot study
    Fernando Laguna
    Servicio de Enfermedades Infecciosas, Hospital Carlos III, Instituto de Salud Carlos III, C Sinesio Delgado 12, 28029 Madrid, Spain
    J Antimicrob Chemother 52:464-8. 2003
    ..0006). The efficacy of ABLC is similar to meglumine antimoniate, but the severity of toxicity in the treatment of HIV-VL is lower with ABLC...
  12. ncbi request reprint Liposomal amphotericin B for the treatment of visceral leishmaniasis
    Caryn Bern
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 43:917-24. 2006
    ..The public health community should work to broaden access to preferential liposomal amphotericin B pricing by public sector VL treatment programs...
  13. pmc Comparison of new diagnostic tools for management of pediatric Mediterranean visceral leishmaniasis
    Israel Cruz
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Pozuelo Majadahonda Km 2, 28220 Majadahonda, Madrid, Spain
    J Clin Microbiol 44:2343-7. 2006
    ..All of the new noninvasive techniques tested showed high diagnostic sensitivity. However, LnPCR analysis of the bone marrow was the most sensitive; this test was able to detect the persistence of parasites and predict potential relapses...
  14. ncbi request reprint Virulence and disease in leishmaniasis: what is relevant for the patient?
    Luis Rivas
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Trends Parasitol 20:297-301. 2004
  15. ncbi request reprint Leishmania/HIV co-infections in the second decade
    Israel Cruz
    WHO Collaborating Centre for Leishmaniasis, National Centre of Microbiology, Institute of Health Carlos III, Madrid, Spain
    Indian J Med Res 123:357-88. 2006
    ..An extensive review of the literature on Leishmania/HIV co-infection has allowed the inclusion of a comprehensive and updated list of bibliographical references...
  16. ncbi request reprint Evidence for a wide occurrence of proton-translocating pyrophosphatase genes in parasitic and free-living protozoa
    Jose R Perez-Castineira
    Instituto de Bioquimica Vegetal y Fotosintesis, Universidad de Sevilla CSIC, Avda Americo Vespucio s n, Sevilla 41092, Spain
    Biochem Biophys Res Commun 294:567-73. 2002
    ..Paralogous genes were found in some species suggesting the occurrence of protein isoforms. These results indicate that H(+)-PPases are more widely distributed among protozoa than previously thought...
  17. ncbi request reprint Isolation and characterization of Leishmania infantum cDNA encoding a protein homologous to eukaryotic elongation factor 1 gamma
    Carmen Cañavate
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Madrid, Spain
    Trans R Soc Trop Med Hyg 96:S41-7. 2002
    ..Southern hybridization and pulsed field gel electrophoresis showed that EF-1 gamma genes are highly conserved among members of the Leishmania genus and must be clustered in a single chromosomal locus...
  18. ncbi request reprint Canine leishmaniasis: epidemiological risk and the experimental model
    Javier Moreno
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologi a, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Spain
    Trends Parasitol 18:399-405. 2002
    ..Such studies are essential to determine the basis of the canine protective immune response and to establish a laboratory model, a significant aspect for the development of vaccines against canine leishmaniasis...
  19. doi request reprint Immunogenicity of HSP-70, KMP-11 and PFR-2 leishmanial antigens in the experimental model of canine visceral leishmaniasis
    Eugenia Carrillo
    WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, Inst de Salud Carlos III, Majadahonda, Spain
    Vaccine 26:1902-11. 2008
    ..The identification as vaccine candidates of Leishmania antigens that elicit appropriate immune responses in the canine model is a key step in the rational approach to generate a vaccine for canine visceral leishmaniasis...
  20. ncbi request reprint Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?
    Francois Chappuis
    Travel and Migration Medicine Unit, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Nat Rev Microbiol 5:873-82. 2007
    ..New diagnostic tools and new treatment strategies will only have an impact if they are made widely available to patients...
  21. ncbi request reprint Amphotericin B lipid complex versus no treatment in the secondary prophylaxis of visceral leishmaniasis in HIV-infected patients
    Rogelio Lopez-Velez
    Enfermedades Infecciosas, Hospital Ramon y Cajal, Carretera de Colmenar, Km 9 100, 28034 Madrid, Spain
    J Antimicrob Chemother 53:540-3. 2004
    ..The aim of this study was to evaluate the efficacy and safety of amphotericin B lipid complex (ABLC) in preventing VL relapses in HIV-infected patients...
  22. ncbi request reprint Semi-quantitative analysis of cytokine expression in asymptomatic canine leishmaniasis
    Cristina Chamizo
    WHO Collaborating Centre for Leishmaniasis, Parasitology Service, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
    Vet Immunol Immunopathol 103:67-75. 2005
    ..Although both Th1 and Th2 cytokines are produced, cell mediated immunity observed in these L. infantum-infected asymptomatic dogs depended on the preferential expression of Th1 cytokines...