G Williamson

Summary

Country: Switzerland

Publications

  1. ncbi In vitro biological properties of flavonoid conjugates found in vivo
    G Williamson
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000, Lausanne, 26, Switzerland
    Free Radic Res 39:457-69. 2005
  2. ncbi A critical review of the bioavailability of glucosinolates and related compounds
    Birgit Holst
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Nat Prod Rep 21:425-47. 2004
  3. ncbi Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes
    Vanessa Crespy
    Nestle Research Center, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Free Radic Res 38:1025-31. 2004
  4. ncbi How should we assess the effects of exposure to dietary polyphenols in vitro?
    Paul A Kroon
    Nutrition Division, Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 80:15-21. 2004
  5. ncbi Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription
    Karen A O'Leary
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Mutat Res 551:245-54. 2004
  6. pmc Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes
    Pascale Anderle
    ISREC, Swiss Institute for Experimental Cancer Research, 1066 Epalinges s Lausanne, Switzerland
    BMC Genomics 6:69. 2005
  7. ncbi Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    Gary Williamson
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 81:243S-255S. 2005
  8. ncbi Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2)
    Gary Williamson
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Drug Metab Dispos 35:1262-8. 2007
  9. ncbi Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate
    Karen A Cooper
    Nestle Research Center, CH 1000 Lausanne 26, Switzerland
    J Agric Food Chem 55:2841-7. 2007
  10. ncbi Transport and metabolism of ferulic acid through the colonic epithelium
    Laure Poquet
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Drug Metab Dispos 36:190-7. 2008

Collaborators

Detail Information

Publications68

  1. ncbi In vitro biological properties of flavonoid conjugates found in vivo
    G Williamson
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000, Lausanne, 26, Switzerland
    Free Radic Res 39:457-69. 2005
    ..In addition to the biological properties of the conjugates, the partition coefficients and methods of synthesis are also presented...
  2. ncbi A critical review of the bioavailability of glucosinolates and related compounds
    Birgit Holst
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Nat Prod Rep 21:425-47. 2004
    ..This includes liberation from the plant material, absorption from the digestive system, distribution around the body, metabolism and excretion...
  3. ncbi Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes
    Vanessa Crespy
    Nestle Research Center, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Free Radic Res 38:1025-31. 2004
    ..The low glucuronidation rates could partially explain why these flavanols are present in plasma as unconjugated forms...
  4. ncbi How should we assess the effects of exposure to dietary polyphenols in vitro?
    Paul A Kroon
    Nutrition Division, Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 80:15-21. 2004
    ..1-10 micromol/L. For correct interpretation of results, future efforts to define biological activities of polyphenols must make use of the available data concerning bioavailability and metabolism in humans...
  5. ncbi Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription
    Karen A O'Leary
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Mutat Res 551:245-54. 2004
    ..Flavonoid modulation of COX-2 transcription may therefore be an important mechanism in anti-carcinogenesis...
  6. pmc Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes
    Pascale Anderle
    ISREC, Swiss Institute for Experimental Cancer Research, 1066 Epalinges s Lausanne, Switzerland
    BMC Genomics 6:69. 2005
    ....
  7. ncbi Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    Gary Williamson
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 81:243S-255S. 2005
    ..The length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols...
  8. ncbi Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2)
    Gary Williamson
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Drug Metab Dispos 35:1262-8. 2007
    ....
  9. ncbi Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate
    Karen A Cooper
    Nestle Research Center, CH 1000 Lausanne 26, Switzerland
    J Agric Food Chem 55:2841-7. 2007
    ..Finally, the (-)-catechin content is not predictable from the epicatechin content, and it is concluded that this is the main form of polyphenol that varies according to manufacturing conditions and cocoa origin...
  10. ncbi Transport and metabolism of ferulic acid through the colonic epithelium
    Laure Poquet
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Drug Metab Dispos 36:190-7. 2008
    ..These results show that the form of ferulic acid available to the blood after passage across the colonic barrier would be mainly the free form, together with only a small percentage of conjugated and reduced ferulic acid...
  11. doi Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD
    W Seefelder
    Quality and Safety Assurance Department, Nestle Research Center, Nestec Ltd, CH 1000 Lausanne 26, Switzerland
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:391-400. 2008
    ..Further work on the bioavailability, metabolism and possible toxicity of chloroesters per se is warranted...
  12. ncbi Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism
    Mathieu Renouf
    Nestle Research Center, Nestec Limited, Vers chez les Blanc, Lausanne, Switzerland
    Mol Nutr Food Res 54:760-6. 2010
    ..This study confirms that the small intestine is a significant site for absorption of PA, but shows for the first time that the colon/microflora play the major role in absorption and metabolism of CGAs and PA from coffee...
  13. doi Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry
    Philippe A Guy
    Nestle Research Center, Nestec Ltd, P O Box 44, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3965-74. 2009
    ..Using this method, we determined plasma levels in humans and measured the efficiency of deconjugation using our enzymatic cocktail...
  14. ncbi Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium
    Myriam Richelle
    Nestle Research Center, Nestec Ltd, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Br J Nutr 96:227-38. 2006
    ..Even for compounds that have been studied well in other organs, information on skin is relatively sparse. Gaps in knowledge are identified and suggestions made for future research...
  15. doi Simultaneous measurement of 13C- and 15N-isotopic enrichments of threonine by mass spectrometry
    Jean Philippe Godin
    Nestle Research Center, Nestec Ltd, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Rapid Commun Mass Spectrom 23:1109-15. 2009
    ..05). This new GC/MS method offers the possibility to measure (13)C- and (15)N-isotopic enrichments with higher throughput, and using a lower amount of sample, than using GC/C/IRMS...
  16. ncbi Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase
    Elena Lo Piparo
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000 Lausanne 26, Switzerland
    J Med Chem 51:3555-61. 2008
    ..Our findings show that certain naturally occurring flavonoids act as inhibitors of human alpha-amylase, which makes them promising candidates for controlling the digestion of starch and postprandial glycemia...
  17. doi Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants
    Birgit Holst
    BioAnalytical Science Department, Nestle Research Center, Nestec Ltd, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Curr Opin Biotechnol 19:73-82. 2008
    ....
  18. ncbi Interactions affecting the bioavailability of dietary polyphenols in vivo
    Susanne Scholz
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Int J Vitam Nutr Res 77:224-35. 2007
    ..Information derived from such experiments could be useful for the optimal design of future bioefficacy studies...
  19. doi Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma
    Mathieu Renouf
    Nestle Research Center, Vers chez les Blancs, 1000 Lausanne 26, Switzerland
    J Nutr 140:259-63. 2010
    ..As a conclusion, adding whole milk did not alter the overall bioavailability of coffee phenolic acids, whereas sugar and nondairy creamer affected the T(max) and C(max) but not the appearance of coffee phenolics in plasma...
  20. ncbi Lycopene isomerisation takes place within enterocytes during absorption in human subjects
    Myriam Richelle
    Nestle Research Center, Nestec Ltd, Lausanne, Switzerland
    Br J Nutr 103:1800-7. 2010
    ..Although there is a huge inter-individual variability of total lycopene absorption reported both in in vitro intestinal cell lines as well as in human chylomicrons, the lycopene isomer profile is quite similar...
  21. doi Monocomponent hexa- and dodecaethylene glycol succinyl-tocopherol esters: self-assembly structures, cellular uptake and sensitivity to enzyme hydrolysis
    Britta M Folmer
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Biochem Pharmacol 78:1464-74. 2009
    ..The in silico prediction is consistent with the in vitro data, since a longer chain length is predicted to favour hydrolysis of the ester bond between the succinate and polyethylene glycol moieties...
  22. ncbi Investigation of the metabolic fate of dihydrocaffeic acid
    Laure Poquet
    Nestle Research Centre, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Biochem Pharmacol 75:1218-29. 2008
    ..As a conclusion, the main form of dihydrocaffeic acid circulating in plasma after its ingestion is a mixture of different primary and secondary metabolites...
  23. ncbi Regional variations in ABC transporter expression along the mouse intestinal tract
    David M Mutch
    Nestle Research Center, CH 1000 Lausanne 26, Switzerland
    Physiol Genomics 17:11-20. 2004
    ....
  24. ncbi Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress
    Heike Steiling
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Free Radic Biol Med 43:752-62. 2007
    ....
  25. ncbi Predictive relationship between polyphenol and nonfat cocoa solids content of chocolate
    Karen A Cooper
    Nestle Research Centre, Lausanne, Switzerland
    J Agric Food Chem 56:260-5. 2008
    ..40), but these relationships were independent of the nature of the chocolate type, indicating that they might still have some predictive capabilities...
  26. doi Effect of dihydrocaffeic acid on UV irradiation of human keratinocyte HaCaT cells
    Laure Poquet
    Nestle Research Centre, Vers chez les Blanc, 1000 Lausanne 26, Switzerland School of Biomedical and Molecular Sciences, The University of Surrey, Guildford, Surrey GU2 7XH, UK
    Arch Biochem Biophys 476:196-204. 2008
    ..The data obtained suggest that dihydrocaffeic acid is a potential candidate for photo-protection by interfering with the events initiated after UV exposure in keratinocytes...
  27. ncbi Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial
    Inge Lise F Nielsen
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Nutr 136:404-8. 2006
    ..This may affect future interventions concerning the health benefits of citrus flavonoids...
  28. ncbi Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
    Walter Brand
    Nestle Research Center, Nestec Ltd, Vers chez les Blanc, PO Box 44, 1000 Lausanne 26, Switzerland
    Biomed Pharmacother 60:508-19. 2006
    ....
  29. ncbi Review of the factors affecting bioavailability of soy isoflavones in humans
    Inge Lise Finné Nielsen
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Nutr Cancer 57:1-10. 2007
    ..In conclusion, it is important to consider the factors affecting bioavailability of isoflavones when designing intervention studies...
  30. doi Catechin glucosides: occurrence, synthesis, and stability
    Thomas Raab
    Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Agric Food Chem 58:2138-49. 2010
    ..The results show the potential of catechin glucosides, especially C3'G, as more stable prescursors of catechin...
  31. ncbi A review of the health effects of green tea catechins in in vivo animal models
    Vanessa Crespy
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    J Nutr 134:3431S-3440S. 2004
    ..Further investigations on mechanisms, the nature of the active compounds, and appropriate dose levels are needed...
  32. ncbi Cocoa and health: a decade of research
    Karen A Cooper
    Nestle Research Center, Vers chez les Blanc, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Br J Nutr 99:1-11. 2008
    ..However, after 10 years of research, what is known about the potential health benefits of cocoa and what are the important next steps in understanding this decadent source of antioxidants?..
  33. ncbi Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers
    Walter Brand
    Division of Toxicology, Wageningen University, Wageningen, The Netherlands
    Drug Metab Dispos 36:1794-802. 2008
    ..1-fold increased (p <or= 0.001). These findings elucidate a novel pathway of hesperetin metabolism and transport and show that BCRP-mediated transport could be a limiting step for hesperetin bioavailability...
  34. ncbi Bioavailability and metabolism
    Wilhelm Stahl
    Institut fur Physiologische Chemie I, Dusseldorf, Germany
    Mol Aspects Med 23:39-100. 2002
  35. ncbi (+)-Catechin is more bioavailable than (-)-catechin: relevance to the bioavailability of catechin from cocoa
    Jennifer L Donovan
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    Free Radic Res 40:1029-34. 2006
    ..Our findings provide an explanation for the poor bioavailability of catechin when consumed in chocolate or other cocoa containing products...
  36. ncbi Specific characterization of substrate and inhibitor binding sites of a glycosyl hydrolase family 11 xylanase from Aspergillus niger
    Tariq A Tahir
    Institute of Food Research IFR, Norwich Research Park, United Kingdom
    J Biol Chem 277:44035-43. 2002
    ..A close inspection of the three-dimensional structure of A. niger xylanase suggests that the binding site of XIP-I is located at the conserved "thumb" hairpin loop of family 11 xylanases...
  37. ncbi Intact glucosinolate analysis in plant extracts by programmed cone voltage electrospray LC/MS: performance and comparison with LC/MS/MS methods
    Fred A Mellon
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Anal Biochem 306:83-91. 2002
    ..Data obtained on a variety of plant extracts confirmed that the methodology was robust and reliable...
  38. doi Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
    Gary Williamson
    Chair of Functional Food, Procter Department of Food Science, University of Leeds, Leeds LS2 9JT, UK
    Br J Nutr 99:S55-8. 2008
    ..We are heading in the right direction towards a DRI, but bioavailability and dose-effects, including toxic levels, need to be established before DRIs can be considered...
  39. ncbi Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans
    M Susan DuPont
    Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA United Kingdom
    J Nutr 132:172-5. 2002
    ..These data show that polyphenols are taken up from cider, that phloretin is excreted in the urine and suggest that low doses of quercetin are extensively methylated in humans...
  40. ncbi Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects
    Laurent Y Rios
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 77:912-8. 2003
    ..In vitro and in vivo studies using pure compounds as substrates suggest that proanthocyanidins and the related catechin monomers may be degraded into more bioavailable low-molecular-weight phenolic acids by the microflora in the colon...
  41. ncbi Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract
    Kelly M Cornish
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, UK
    Free Radic Biol Med 33:63-70. 2002
    ..The results indicate dietary quercetin and metabolites are active in inhibiting oxidative damage in the lens and thus could play a role in prevention of cataract formation...
  42. ncbi Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
    ..Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols...
  43. pmc Substrate (aglycone) specificity of human cytosolic beta-glucosidase
    Jean Guy Berrin
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK
    Biochem J 373:41-8. 2003
    ..Taken together with the three-dimensional model, these mutation studies identified the amino-acid residues in the aglycone-binding subsite of hCBG that are essential for flavonoid glucoside binding and catalysis...
  44. ncbi The dual nature of the wheat xylanase protein inhibitor XIP-I: structural basis for the inhibition of family 10 and family 11 xylanases
    Francoise Payan
    Architecture et Fonction de Macromolecules Biologiques, UMR 6098, CNRS et Universités d Aix Marseille I et II, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Biol Chem 279:36029-37. 2004
    ..The biological role of the xylanase inhibitors is discussed in light of the present structural data...
  45. ncbi Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo
    Niclas Petri
    Department of Pharmacy, Biopharmaceutics Research Group Uppsala University, Uppsala, Sweden
    Drug Metab Dispos 31:805-13. 2003
    ..These results show that food components have the potential to modify drug metabolism in the human enterocyte in vivo very rapidly...
  46. ncbi Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy
    Elizabeth L Adams
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
    Carbohydr Res 339:579-90. 2004
    ..The experimental data demonstrates the potential for using inactivated enzymes and AFM to probe the structural heterogeneity of individual polysaccharide molecules...
  47. ncbi Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo
    Sonia de Pascual-Teresa
    Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    J Nutr 134:552-7. 2004
    ..The results show that a single high dose of the flavonoid quercetin from onions does not change COX-2 mRNA expression in human lymphocytes in vivo even though this change occurred in vitro and ex vivo...
  48. ncbi Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells
    Graham P Basten
    Institute of Food Research, Norwich Research Park, Conley Lane, Norwich, NR4 7UA, UK
    Carcinogenesis 23:1399-404. 2002
    ....
  49. ncbi The activity of barley alpha-amylase on starch granules is enhanced by fusion of a starch binding domain from Aspergillus niger glucoamylase
    Nathalie Juge
    Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Biochim Biophys Acta 1764:275-84. 2006
    ..9 for rAMY1. Remarkably, at low concentration (2 nM), AMY1-SBD hydrolysed barley starch granules 15-fold faster than rAMY1, while higher amounts of AMY-SBD caused molecular overcrowding of the starch granule surface...
  50. ncbi Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes
    James R Bacon
    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Carcinogenesis 24:1903-11. 2003
    ....
  51. ncbi Cocoa procyanidins are stable during gastric transit in humans
    Laurent Y Rios
    Institute of Food Research, Norwich Research Park, Norwich, United Kingdom
    Am J Clin Nutr 76:1106-10. 2002
    ..Degradation of procyanidins under simulated gastric conditions at pH 2.0 has been reported in vitro...
  52. pmc Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat
    Ruth Flatman
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, U K
    Biochem J 365:773-81. 2002
    ..niger and A. nidulans xylanase are due to a 200-fold lower dissociation rate k(off) for the latter, with only a small difference in association rate k(on)...
  53. ncbi Bioavailability of phyto-oestrogens
    Ian Rowland
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
    Br J Nutr 89:S45-58. 2003
    ..Factors influencing absorption and metabolism of phyto-oestrogens include diet and gut microflora...
  54. ncbi Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation
    Jinsong Zhang
    Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Carcinogenesis 24:497-503. 2003
    ..These results demonstrate that synergy can result from a combination of induction at the levels of transcription and translation...
  55. ncbi Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells
    Vanda Svehlíková
    Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Carcinogenesis 25:1629-37. 2004
    ....
  56. ncbi A family 11 xylanase from Penicillium funiculosum is strongly inhibited by three wheat xylanase inhibitors
    Caroline S M Furniss
    Nutrition and Consumer Sciences Division, Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    Biochim Biophys Acta 1598:24-9. 2002
    ..This is the first report describing a xylanase that is inhibited by all three wheat xylanase inhibitor proteins described to date...
  57. ncbi Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver
    David M Mutch
    Nutrient Bioavailability, Nestlé Research Center Vers Chez Les Blanc, Lausanne 26, Switzerland
    Am J Physiol Gastrointest Liver Physiol 291:G63-72. 2006
    ....
  58. ncbi Divergent effects of quercetin conjugates on angiogenesis
    Sandra Donnini
    Section of Pharmacology, Department of Molecular Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Br J Nutr 95:1016-23. 2006
    ..Q3G and Q3'S are the two major conjugates in plasma, but their ratio is dependent on several factors, so that inhibition or activation of angiogenesis could be subtly shifted as a result of metabolism in vivo...
  59. ncbi Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
    Karen A O'Leary
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Biochem Pharmacol 65:479-91. 2003
    ..These results show that HepG2 cells can absorb and turnover quercetin glucuronides and that human endogenous beta-glucuronidase activity could modulate the intracellular biological activities of dietary antioxidant flavonoids...
  60. ncbi AFM studies of water-soluble wheat arabinoxylans--effects of esterase treatment
    Elizabeth L Adams
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
    Carbohydr Res 340:1841-5. 2005
    ..Overnight treatment with FAEA led to a reduction in the density of branches suggesting that they may also be linked to the backbone through phenolic linkages...
  61. ncbi Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    Kitti Németh
    Institute of Food Research, Colney Lane, Norwich NR4 7 UA, UK
    Eur J Nutr 42:29-42. 2003
    ..Hence, first-pass metabolism (small intestine-liver) appears to involve a critical deglycosylation step for which the mechanisms are not known...
  62. pmc Structural analysis of xylanase inhibitor protein I (XIP-I), a proteinaceous xylanase inhibitor from wheat (Triticum aestivum, var. Soisson)
    Francoise Payan
    Architecture et Fonction des Macromolecules Biologiques, UMR6098, CNRS and Universities Aix Marseille I and II, 31 Chemin Joseph Aiguier, France
    Biochem J 372:399-405. 2003
    ..The structural differences in the inhibitor cleft structure probably account for the lack of activity of XIP-I towards chitin...
  63. ncbi Identification of the major glucosinolate (4-mercaptobutyl glucosinolate) in leaves of Eruca sativa L. (salad rocket)
    Richard N Bennett
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Phytochemistry 61:25-30. 2002
    ..This new GLS and its isothiocyanate are likely to contribute to the unique odour and flavour of E. sativa...
  64. ncbi A systematic study of carboxylic acids in negative ion mode electrospray ionisation mass spectrometry providing a structural model for ion suppression
    Mike N Clifford
    School of Biomedical and Molecular Sciences, The University of Surrey, Guildford, Surrey GU2 7XH, UK
    Rapid Commun Mass Spectrom 21:2014-8. 2007
    ....
  65. ncbi Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin
    Kerstin M Janisch
    Technical University of Munich, WZW Department of Plant Sciences, Institute of Phytopathology, Am Hochanger 2, 85350 Freising Weihenstephan, Germany
    Free Radic Res 38:877-84. 2004
    ..The data show that flavonoid intestinal and hepatic metabolism have profound effects on ability to inhibit LDL oxidation and a lesser but significant effect on binding to serum albumin...
  66. ncbi Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides
    Jean Guy Berrin
    Nutrition, Health and Consumer Sciences Division, Institute of Food Research, Norwich, UK
    Eur J Biochem 269:249-58. 2002
    ..These data indicate that human CBG hydrolyses a broad range of dietary glucosides and may play a critical role in xenobiotic metabolism...
  67. ncbi Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
    Andrea J Day
    Procter Department of Food Science, University of Leeds, Leeds LS2 9JT, UK
    Biochem Pharmacol 65:1199-206. 2003
    ..Evidently the mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercetin-3-glucoside appears to be absorbed only following hydrolysis by LPH...
  68. ncbi Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor
    Giles O Elliott
    Institute of Food Research, Norwich Research Park, Norwich, UK
    FEBS Lett 519:66-70. 2002
    ..This is the first full-length cDNA sequence that encodes a novel class of protein which inhibits the activity of endo-1,4-beta-D-xylanases...