Christian Zweifel

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi request reprint Continuous time-domain monitoring of cerebral autoregulation in neurocritical care
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Department of Clinical Neurosciences, Cambridge, United Kingdom Department of Neurosurgery, University Hospital of Basel, Basel, Switzerland Electronic address
    Med Eng Phys 36:638-45. 2014
  2. ncbi request reprint Reliability of the blood flow velocity pulsatility index for assessment of intracranial and cerebral perfusion pressures in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurgery 71:853-61. 2012
  3. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
  4. doi request reprint Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    J Neurotrauma 27:1951-8. 2010
  5. doi request reprint Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Stroke 41:1963-8. 2010
  6. doi request reprint A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Neurol Res 32:425-8. 2010
  7. doi request reprint Transcranial Doppler pulsatility index: what it is and what it isn't
    Nicolas de Riva
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Box 167, Cambridge, CB2 0QQ, UK
    Neurocrit Care 17:58-66. 2012
  8. doi request reprint The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations
    Jennifer Diedler
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Anesth Analg 113:849-57. 2011
  9. pmc Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury
    Emmanuel Carrera
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    J Neurotrauma 28:889-96. 2011
  10. doi request reprint Plateau waves in head injured patients requiring neurocritical care
    Gianluca Castellani
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neurocrit Care 11:143-50. 2009

Detail Information

Publications18

  1. doi request reprint Continuous time-domain monitoring of cerebral autoregulation in neurocritical care
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Department of Clinical Neurosciences, Cambridge, United Kingdom Department of Neurosurgery, University Hospital of Basel, Basel, Switzerland Electronic address
    Med Eng Phys 36:638-45. 2014
    ..Furthermore, we will demonstrate how reactivity indices can show transient changes of cerebral autoregulation and can be used to optimize management of arterial blood pressure (ABP) and cerebral perfusion pressure (CPP). ..
  2. ncbi request reprint Reliability of the blood flow velocity pulsatility index for assessment of intracranial and cerebral perfusion pressures in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurgery 71:853-61. 2012
    ..It has been postulated that the Gosling pulsatility index (PI) assessed with transcranial Doppler (TCD) has a diagnostic value for noninvasive estimation of intracranial pressure (ICP) and cerebral perfusion pressure (CPP)...
  3. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
    ..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown...
  4. doi request reprint Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    J Neurotrauma 27:1951-8. 2010
    ..THx may be of diagnostic value to optimize therapy oriented toward restoration and continuity of cerebrovascular reactivity, especially in patients for whom direct ICP monitoring is not feasible...
  5. doi request reprint Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Stroke 41:1963-8. 2010
    ..In this study, we compared near-infrared spectroscopy-based indices of cerebral autoregulation (TOx) with Mx in patients with subarachnoid hemorrhage...
  6. doi request reprint A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Neurol Res 32:425-8. 2010
    ....
  7. doi request reprint Transcranial Doppler pulsatility index: what it is and what it isn't
    Nicolas de Riva
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Box 167, Cambridge, CB2 0QQ, UK
    Neurocrit Care 17:58-66. 2012
    ..We sought to evaluate the relationship between PI and CVR in situations, where CVR increases (mild hypocapnia) and decreases (plateau waves of intracranial pressure-ICP)...
  8. doi request reprint The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations
    Jennifer Diedler
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Anesth Analg 113:849-57. 2011
    ..In the current study, we investigated the role of slow oscillations of total hemoglobin for NIRS-based cerebrovascular reactivity monitoring...
  9. pmc Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury
    Emmanuel Carrera
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    J Neurotrauma 28:889-96. 2011
    ..Further studies are needed to determine whether monitoring of arterial and CSF compartment compliances may detect and prevent an adverse ischemic event during hyperventilation...
  10. doi request reprint Plateau waves in head injured patients requiring neurocritical care
    Gianluca Castellani
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neurocrit Care 11:143-50. 2009
    ..The aim of this study was to analyze the occurrence of plateau waves in head injured patients requiring neurocritical care, their relation with cerebral autoregulation and impact on outcome...
  11. doi request reprint Growth hormone and outcome in patients with intracerebral hemorrhage: a pilot study
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Switzerland
    Biomarkers 16:511-6. 2011
    ..Within this pilot study, we evaluated the prognostic value of GH in patients with acute intracerebral hemorrhage (ICH)...
  12. doi request reprint The monitoring of relative changes in compartmental compliances of brain
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK Department of Engineering, University of Cambridge, Cambridge, UK
    Physiol Meas 30:647-59. 2009
    ..Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space...
  13. doi request reprint Slow vasogenic fluctuations of intracranial pressure and cerebral near infrared spectroscopy--an observational study
    Ruwan A Weerakkody
    University of Cambridge, Addenbrooke s Hospital, UK
    Acta Neurochir (Wien) 152:1763-9. 2010
    ..In this study, we attempted to describe synchronisation between slow waves of ICP and of near-infrared spectroscopy (NIRS) variables during controlled elevation of ICP...
  14. doi request reprint What shapes pulse amplitude of intracranial pressure?
    Emmanuel Carrera
    Academic Neurosurgical Unit, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Neurotrauma 27:317-24. 2010
    ..Further clinical studies will reveal whether AMP(ICP) is a better indicator of clinical severity and outcome than mICP in TBI and NPH patients...
  15. doi request reprint Near infrared spectroscopy as possible non-invasive monitor of slow vasogenic ICP waves
    Ruwan Alwis Weerakkody
    University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 114:181-5. 2012
    ..Correlating changes in Hb and HbO(2) may be of use as a method of non-invasive detection of vasogenic ICP waves...
  16. doi request reprint Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Neurosurg Focus 25:E2. 2008
    ..A cerebrovascular pressure reactivity index (PRx) can be determined as the moving correlation coefficient between mean intracranial pressure (ICP) and mean arterial blood pressure...
  17. doi request reprint Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects
    Emmanuel Carrera
    Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    J Neuroimaging 21:121-5. 2011
    ..However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown...
  18. doi request reprint Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    J Am Coll Cardiol 56:1045-53. 2010
    ..The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke...