Rolf Zinkernagel

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Protective 'immunity' by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called 'immunological memory'
    Rolf M Zinkernagel
    University Hospital Zurich, Institute of Experimental Immunology, Zurich, Switzerland
    Immunol Rev 211:310-9. 2006
  2. ncbi request reprint On 'reactivity' versus 'tolerance'
    Rolf M Zinkernagel
    Institute of Experimental Immunology, University of Zurich, 8091, Switzerland
    Immunol Cell Biol 82:343-52. 2004
  3. ncbi request reprint On immunity against infections and vaccines: credo 2004
    R M Zinkernagel
    Institute of Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Scand J Immunol 60:9-13. 2004
  4. ncbi request reprint On observing and analyzing disease versus signals
    Rolf Zinkernagel
    Institute of Experimental Immunology, University of Zurich, CH 8091 Zurich, Switzerland
    Nat Immunol 8:8-10. 2007
  5. ncbi request reprint Responses to Cohn's discussion on the Zinkernagel-Hengartner 'Credo 2004'
    R Zinkernagel
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Scand J Immunol 62:195-201. 2005
  6. ncbi request reprint Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 10:187-92. 2004
  7. ncbi request reprint Marginal zone macrophages and immune responses against viruses
    Stephan Oehen
    Institute for Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 169:1453-8. 2002
  8. ncbi request reprint Living donor liver transplantation and tolerance: a potential strategy in cholangiocarcinoma
    Zakiyah Kadry
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Switzerland
    Transplantation 76:1003-6. 2003
  9. pmc Identification of an N-terminal trimeric coiled-coil core within arenavirus glycoprotein 2 permits assignment to class I viral fusion proteins
    Bruno Eschli
    Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Virol 80:5897-907. 2006
  10. pmc "Viral déjà vu" elicits organ-specific immune disease independent of reactivity to self
    Doron Merkler
    Department of Neuropathology, Georg August Universitat, Goettingen, Germany
    J Clin Invest 116:1254-63. 2006

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Protective 'immunity' by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called 'immunological memory'
    Rolf M Zinkernagel
    University Hospital Zurich, Institute of Experimental Immunology, Zurich, Switzerland
    Immunol Rev 211:310-9. 2006
    ....
  2. ncbi request reprint On 'reactivity' versus 'tolerance'
    Rolf M Zinkernagel
    Institute of Experimental Immunology, University of Zurich, 8091, Switzerland
    Immunol Cell Biol 82:343-52. 2004
    ..Ideas are important in immunology, but are often rather demagogically handled and therefore may cost us very dearly indeed. Evaluating immunity to infections and tumours in vivo should help prevent us from getting lost in immunology...
  3. ncbi request reprint On immunity against infections and vaccines: credo 2004
    R M Zinkernagel
    Institute of Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Scand J Immunol 60:9-13. 2004
    ..T cells not only play an essential role in maintaining T-help-dependent memory antibody titres, but also in controlling the many infections that persist in a host at rather low levels (such as tuberculosis, measles and HIV)...
  4. ncbi request reprint On observing and analyzing disease versus signals
    Rolf Zinkernagel
    Institute of Experimental Immunology, University of Zurich, CH 8091 Zurich, Switzerland
    Nat Immunol 8:8-10. 2007
    ..Immune responses must be appropriate to allow survival of both the individual and the species. These responses involve complex interactions that often go unmeasured...
  5. ncbi request reprint Responses to Cohn's discussion on the Zinkernagel-Hengartner 'Credo 2004'
    R Zinkernagel
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Scand J Immunol 62:195-201. 2005
  6. ncbi request reprint Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 10:187-92. 2004
    ....
  7. ncbi request reprint Marginal zone macrophages and immune responses against viruses
    Stephan Oehen
    Institute for Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 169:1453-8. 2002
    ..This shows that the early innate immune system provides an important preparatory phase to the adaptive immune system and is particularly important for antiviral protection...
  8. ncbi request reprint Living donor liver transplantation and tolerance: a potential strategy in cholangiocarcinoma
    Zakiyah Kadry
    Department of Visceral and Transplantation Surgery, University Hospital Zurich, Switzerland
    Transplantation 76:1003-6. 2003
    ..The following is a description of a living donor liver transplantation for a hilar cholangiocarcinoma in a previous recipient of an allogeneic bone marrow transplant...
  9. pmc Identification of an N-terminal trimeric coiled-coil core within arenavirus glycoprotein 2 permits assignment to class I viral fusion proteins
    Bruno Eschli
    Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Virol 80:5897-907. 2006
    ..Our results clearly demonstrate that the arenavirus GP is a trimer and must be considered a member of the class I viral fusion protein family...
  10. pmc "Viral déjà vu" elicits organ-specific immune disease independent of reactivity to self
    Doron Merkler
    Department of Neuropathology, Georg August Universitat, Goettingen, Germany
    J Clin Invest 116:1254-63. 2006
    ..Thus the concept of "viral déjà vu" demonstrates how 2 related but independently encountered viral infections can cause organ-specific immune disease without molecular mimicry of self and without breaking self tolerance...
  11. ncbi request reprint Natural IgE production in the absence of MHC Class II cognate help
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Immunity 24:329-39. 2006
    ..The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals...
  12. ncbi request reprint CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses
    Tobias Junt
    Institute of Experimental Immunology, Zurich, Switzerland
    J Immunol 175:7109-16. 2005
    ..These experiments revealed that CXCR5 is critical for the coordinated interaction of antiviral T and B cells through its impact on initial B cell expansion and the recruitment of Ag-specific B and Th cells to germinal centers...
  13. ncbi request reprint Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology
    Karl S Lang
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 175:5524-31. 2005
    ..These data underscore the in vivo efficacy and immunopathological "safety" of neutralizing antibodies...
  14. ncbi request reprint Expression of lymphotoxin beta governs immunity at two distinct levels
    Tobias Junt
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 36:2061-75. 2006
    ..ii) Expression of LTbeta on non-lymphocytes governs antiviral immunity by enhancing antigen presentation on antigen-presenting cells. This prevents cytotoxic T lymphocytes exhaustion or death of the host by uncontrolled virus spread...
  15. pmc Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread
    Lars Hangartner
    Institute of Experimental Immunology, University Hospital Zurich, 8091 Zurich, Switzerland
    J Exp Med 203:2033-42. 2006
    ..Virus variants that did not bind antibodies were not affected. We therefore conclude that nonneutralizing antibodies binding to the same antigenic site as neutralizing antibodies are biologically relevant by limiting early viral spread...
  16. ncbi request reprint Mechanisms of neonatal mucosal antibody protection
    Nicola L Harris
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    J Immunol 177:6256-62. 2006
    ..This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect...
  17. ncbi request reprint Induction of IgE and allergic-type responses in fur mite-infested mice
    Veronika Pochanke
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 36:2434-45. 2006
    ....
  18. pmc Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 116:2456-63. 2006
    ..Thus, nonspecific activation of innate immunity can drastically enhance susceptibility to immune destruction of a solid organ...
  19. doi request reprint Aggravation of viral hepatitis by platelet-derived serotonin
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzberstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 14:756-61. 2008
    ..Thus, vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology...
  20. pmc Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
    Max Löhning
    Institute of Experimental Immunology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Exp Med 205:53-61. 2008
    ..These findings demonstrate the efficiency of linear memory T cell differentiation and encourage the design of vaccines and immune cell therapies based on differentiated effector T cells...
  21. ncbi request reprint Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies
    Katja Fink
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 38:90-101. 2008
    ....
  22. pmc "Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses
    Karl S Lang
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 2:e1162. 2007
    ..Likewise, partial depletion of the CD4+ T cell compartment by using anti-CD4 antibodies enhanced protective antibodies...
  23. ncbi request reprint Extralymphatic virus sanctuaries as a consequence of potent T-cell activation
    Mike Recher
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 13:1316-23. 2007
    ..Our results suggest that sanctuary-site formation depends both on organ anatomy and on the induction of different adaptive immune effector mechanisms. Boosting T-cell responses alone may not reduce virus persistence...
  24. ncbi request reprint B cell activation state-governed formation of germinal centers following viral infection
    Katja Fink
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 179:5877-85. 2007
    ....
  25. pmc Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus
    Bruno Eschli
    Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Virol 81:11650-7. 2007
    ..Second, affinity maturation of the available low-affinity non-neutralizing antibodies is impaired...
  26. pmc A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses
    Stefan Freigang
    Institute of Experimental Immunology, Department of Pathology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:13426-31. 2007
    ..These findings impinge on vaccine strategies...
  27. ncbi request reprint MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus
    Karl S Lang
    Institutes of Experimental Immunology, Neuropathology and Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 37:2434-40. 2007
    ..Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis...
  28. ncbi request reprint Parameters governing exhaustion of rare T cell-independent neutralizing IgM-producing B cells after LCMV infection
    Raphaël M Zellweger
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 36:3175-85. 2006
    ..Upon infection, a low frequency of LCMV-nAb-producing B cells, as observed in WT mice, results in a high antigen-to-B cell ratio and is likely to lead to terminal differentiation - and elimination - of these rare B cells...
  29. pmc Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:15535-9. 2006
    ..The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease...
  30. pmc Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC
    Marianne M Martinic
    Institute of Experimental Immunology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:14435-40. 2006
    ..Thus, maturation of functional CD4+ T cell responses required MHC class II on thymic epithelium, whereas CD8+ T cells matured in the absence of TE MHC...
  31. ncbi request reprint Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses
    Katja Fink
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 36:2094-105. 2006
    ..These findings indicate that IFN-alpha-mediated augmentation of specific B cell responses is a partially TLR7- and virus dose-dependent mechanism...
  32. ncbi request reprint Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation
    Karl S Lang
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 35:738-45. 2005
    ..Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate...
  33. ncbi request reprint Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
    Nat Med 11:138-45. 2005
    ..These data identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease...
  34. pmc Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC
    Marianne M Martinic
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:1861-6. 2003
    ..Therefore, in contrast to earlier results with irradiation or thymus chimeras, these relatively undisturbed tetraparental mice reveal that the MHC of nonthymic epithelial cells efficiently selects a functional T cell repertoire...
  35. ncbi request reprint On natural and artificial vaccinations
    Rolf M Zinkernagel
    Institute for Experimental Immunology, University Hospital, Zurich CH 8091, Switzerland
    Annu Rev Immunol 21:515-46. 2003
    ....
  36. pmc Antagonistic variant virus prevents wild-type virus-induced lethal immunopathology
    Lukas Hunziker
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    J Exp Med 196:1039-46. 2002
    ..The results illustrate that a coinfecting APL-expressing virus can shift an immunopathological virus-host relationships in favor of host survival. This may play a role in poorly cytopathic long-lasting virus carrier states in humans...
  37. ncbi request reprint On cross-priming of MHC class I-specific CTL: rule or exception?
    Rolf M Zinkernagel
    Institute for Experimental Immunology, University Hospital, Zurich, Switzerland
    Eur J Immunol 32:2385-92. 2002
  38. ncbi request reprint Uncertainties - discrepancies in immunology
    Rolf M Zinkernagel
    Institute for Experimental Immunology, University Hospital, Zurich, Switzerland
    Immunol Rev 185:103-25. 2002
    ....
  39. ncbi request reprint On differences between immunity and immunological memory
    Rolf M Zinkernagel
    Institute for Experimental Immunology, University Hospital, Zurich, Switzerland
    Curr Opin Immunol 14:523-36. 2002
    ..Although experimental immunological memory is largely maintained antigen-independently, protective immunity is antigen-dependent...
  40. ncbi request reprint Arterial inflammation and atherosclerosis
    Burkhard Ludewig
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Zurich, Switzerland
    Trends Cardiovasc Med 12:154-9. 2002
    ..The evidence to date suggests that the mutual chronic perpetuation of immune mediated vascular inflammation and cholesterol-induced atherosclerosis is a key step in atherogenesis...
  41. ncbi request reprint Antiviral immune responses in the absence of organized lymphoid T cell zones in plt/plt mice
    Tobias Junt
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    J Immunol 168:6032-40. 2002
    ....
  42. ncbi request reprint Antiinfection immunity and autoimmunity
    Rolf M Zinkernagel
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Ann N Y Acad Sci 958:3-6. 2002
    ..If we know the infection, we call the disease immunopathologically mediated; if we do not recognize or know it, we call the disease autoimmune...
  43. ncbi request reprint Immunity, immunopathology and vaccines against HIV?
    Rolf M Zinkernagel
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Vaccine 20:1913-7. 2002
    ....
  44. pmc Effects of promyelocytic leukemia protein on virus-host balance
    Weldy V Bonilla
    Institute of Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    J Virol 76:3810-8. 2002
    ..These in vivo observations corroborated our results showing more virus production in PML(-/-) fibroblasts. Thus, PML is a contributor to innate immunity, defining host susceptibility to viral infections and to immunopathology...
  45. pmc Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production
    Stefan Muller
    Department of Pathology, University of Bern, Murtenstrasse 31, CH 3010 Bern, Switzerland
    J Virol 76:2375-83. 2002
    ....
  46. ncbi request reprint Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
    Lukas Hunziker
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 4:343-9. 2003
    ..This nonspecific B cell activation may contribute to antibody-mediated autoimmunity...
  47. ncbi request reprint Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections
    Beatrice M Senn
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Switzerland
    Eur J Immunol 33:950-61. 2003
    ..Thus, in T11 mu MT mice combinatorial L chain variability alone is able to build up a sufficiently complex B cell repertoire to mount protective immunoglobulin responses against a variety of pathogens...
  48. pmc Kinetics of protective antibodies are determined by the viral surface antigen
    Daniel D Pinschewer
    Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 114:988-93. 2004
    ..They further suggest that structural features of viral GPs or coevolutionary adaptation of the virus's GP to the host's naive B cell repertoire, or both, may critically limit nAb kinetics and improvement of vaccine efficacy...
  49. ncbi request reprint Deliberate removal of T cell help improves virus-neutralizing antibody production
    Mike Recher
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 5:934-42. 2004
    ..These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found...
  50. ncbi request reprint Do thymically and strictly extrathymically developing T cells generate similar immune responses?
    Marie Eve Blais
    Guy Bernier Research Center, Maisonneuve Rosemont Hospital, Montreal, QC, Canada
    Blood 103:3102-10. 2004
    ..Our data indicate that the site of development impinges on T-cell quality and function and that extrathymic T cells functionally cannot substitute for classical thymic T cells...
  51. ncbi request reprint Exhaustion of cytotoxic T cells during adoptive immunotherapy of virus carrier mice can be prevented by B cells or CD4+ T cells
    Lukas Hunziker
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 32:374-82. 2002
    ..These findings have implications for improving adoptive immunotherapy for persistent human viral infections...
  52. ncbi request reprint Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key
    Martin F Bachmann
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    Eur J Immunol 34:317-26. 2004
    ..See accompanying article http://dx.doi.org/10.1002/eji.200324844..
  53. pmc Public versus personal serotypes of a viral quasispecies
    Lukas Hunziker
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:6015-20. 2003
    ..Together, these mutants form a generally recognized "public" serotype. These findings may help to explain aspects of human infections and Ab responses against hepatitis B virus, hepatitis C virus, and HIV...
  54. ncbi request reprint Specific cytotoxic T cells eliminate cells producing neutralizing antibodies
    Oliver Planz
    Nature 426:474. 2003
  55. pmc Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies
    Lars Hangartner
    Institute of Experimental Immunology, Department of Pathology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:12883-8. 2003
    ..However, despite these high naïve titers, de novo activation of naïve CD4+ T and B cells was not blocked. Therefore, B cells giving rise to natural antibodies do not participate in virus-induced antibody responses...
  56. ncbi request reprint Role of TCR-restricting MHC density and thymic environment on selection and survival of cells expressing low-affinity T cell receptors
    Marianne M Martinic
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 34:1041-9. 2004
    ....
  57. doi request reprint Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008
    ....
  58. pmc Science and sensibility: an interview with Professor Rolf M. Zinkernagel, Nobel Prize Winner for Medicine 1996. Interview by Hrishikesh Satish Kulkarni and Ajit H. Goenka
    Rolf M Zinkernagel
    MedGenMed 9:28. 2007
  59. pmc Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire
    Weldy V Bonilla
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    J Clin Invest 116:156-62. 2006
    ....
  60. ncbi request reprint Antiviral antibody responses: the two extremes of a wide spectrum
    Lars Hangartner
    Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Nat Rev Immunol 6:231-43. 2006
    ..Issues of antibody specificity, affinity and avidity, maturation and escape are discussed in the context of co-evolution of the host and viruses...
  61. pmc Induced prion protein controls immune-activated retroviruses in the mouse spleen
    Marius Lötscher
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    PLoS ONE 2:e1158. 2007
    ..The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP...
  62. pmc Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming
    Stefan Freigang
    Institute of Experimental Immunology, University Hospital, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:13477-82. 2003
    ....
  63. ncbi request reprint The challenges of an HIV vaccine enterprise
    Rolf M Zinkernagel
    Science 303:1294-7; author reply 1294-7. 2004
  64. ncbi request reprint Identification and characterization of a novel antigen from the nematode Nippostrongylus brasiliensis recognized by specific IgE
    Veronika Pochanke
    Institute for Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 37:1275-84. 2007
    ..Here, we show that even such low levels of parasite-specific IgE are sufficient to prime mast cells in vivo and mediate degranulation...
  65. pmc Allogeneic beta-islet cells correct diabetes and resist immune rejection
    Marcus Pericin
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:8203-6. 2002
    ..Such strictly extralymphatic cell grafts that are immunologically largely ignored should be applicable clinically...