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Genomes and GenesSpecies | Jean Marc ZinggSummaryAffiliation: University of Bern Country: Switzerland Publications
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Publications
Non-antioxidant activities of vitamin EJean Marc Zingg
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
Curr Med Chem 11:1113-33. 2004....- Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathwayPetra Kempna
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
J Biol Chem 279:50700-9. 2004..Inhibition of proliferation and PKB signaling in HMC-1 cells by vitamin E suggests a role in preventing diseases with mast cell involvement, such as allergies, atherosclerosis, and tumorigenesis... - Isoelectric point mobility shift assay for rapid screening of charged and uncharged ligands bound to proteinsPetra Kempna
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
IUBMB Life 55:103-7. 2003..Competition of bound charged ligands with uncharged ones reverses the mobility shift, so that the relative affinities of the two ligands to the protein can be estimated... - Antagonistic effects of oxidized low density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor-gammaAdelina Munteanu
Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
J Biol Chem 281:6489-97. 2006..The activation of CD36 expression by PKB suggests that both lipid biosynthesis and fatty acid uptake are stimulated by PKB... - Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammationEsra Ogru
Department of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, Bern 3012, Switzerland
Ann N Y Acad Sci 1031:405-11. 2004..In nonstimulated THP-1 cells, alpha-tocopherol had only very weak effects on these events... - Vitamin E mediates cell signaling and regulation of gene expressionAngelo Azzi
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
Ann N Y Acad Sci 1031:86-95. 2004..The antioxidant-responsive element (ARE) and the TGF-beta-responsive element (TGF-beta-RE) appear in some cases to be implicated as well... - Regulation of gene expression by alpha-tocopherolAngelo Azzi
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
Biol Chem 385:585-91. 2004..Here we review recent results of the search for molecular mechanisms underpinning the central signaling mechanism... - Cloning of novel human SEC14p-like proteins: ligand binding and functional propertiesPetra Kempna
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
Free Radic Biol Med 34:1458-72. 2003..It is possible that other phosphatidylinositol- and phosphatidylcholine-dependent signaling pathways are modulated by hTAPs and tocopherols, possibly by transporting and presenting these ligands to the corresponding enzymes... - Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytesM Clara De Pascale
Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
Arch Biochem Biophys 447:97-106. 2006..Vitamin E treatment also led to increased expression of a known PPARgamma target gene involved in terminal keratinocytes differentiation, the transglutaminase-1... - Modulation of proteasome activity by vitamin E in THP-1 monocytesAdelina Munteanu
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
IUBMB Life 59:771-80. 2007.... - Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cellsElke Reiter
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
Biofactors 30:67-77. 2007..The combination of phytochemicals with relatively broad specificity on enzymes involved in signal transduction and gene expression may increase their activity in disease prevention by modulating several different molecular targets... - Vitamin E: an overview of major research directionsJean Marc Zingg
Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
Mol Aspects Med 28:400-22. 2007..This review is giving a brief introduction about vitamin E by following the major research directions since its discovery with a historical perspective... - Vitamin E and mast cellsJean Marc Zingg
Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland
Vitam Horm 76:393-418. 2007..In this chapter, the possibility that vitamin E can prevent diseases with mast cells involvement by modulating signal transduction and gene expression is evaluated... - Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)Angelo Azzi
Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
FEBS Lett 519:8-10. 2002..alpha-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression... - Molecular and cellular activities of vitamin E analoguesJean Marc Zingg
Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
Mini Rev Med Chem 7:543-58. 2007..In this review, the different natural vitamin E analogues and synthetic derivatives are compiled in relation to their major molecular and cellular activities... - Modulation of signal transduction by vitamin EJean Marc Zingg
Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
Mol Aspects Med 28:481-506. 2007..The elucidation of the molecular and cellular events affected by vitamin E could reveal novel strategies and molecular targets for developing similarly acting compounds... 
Antifibrotic effects of tocotrienols on human Tenon's fibroblastsChristoph Tappeiner
Department of Ophthalmology, Inselspital, University of Bern, 3010 Bern, Switzerland
Graefes Arch Clin Exp Ophthalmol 248:65-71. 2010..To compare the antifibrotic effect of vitamin E isoforms alpha-, gamma-, and delta-tocotrienol on human Tenon's fibroblasts (hTf) to the antimetabolite mitomycin C...- Characterization of three human sec14p-like proteins: alpha-tocopherol transport activity and expression pattern in tissuesJean Marc Zingg
Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
Biochimie 90:1703-15. 2008..Thus, the three hTAPs may mediate lipid uptake, secretion, presentation, and sub-cellular localization in a tissue-specific manner, possibly using organelle- and enzyme-specific docking sites... - Vitamin E: Textbooks require updatingAngelo Azzi
Institute of Biochemistry and Molecular Biology, University of Bern, 3012 Bern, Switzerland
Biochem Mol Biol Educ 33:184-7. 2005..In almost all books the existence of vitamin E deficiency diseases is ignored. Recent findings on vitamin E molecular functions and its related diseases are described in this article... - Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbitsNesrin Kartal Ozer
Department of Biochemistry, Faculty of Medicine, Marmara University, 34668 Haydarpasa, Istanbul, Turkey
Atherosclerosis 184:15-20. 2006..The effects observed at the level of CD36 scavenger receptor expression in vivo suggest an involvement of reduced foam cell formation in the protective effect of Vitamin E against atherosclerosis... - The 80th anniversary of vitamin E: beyond its antioxidant propertiesRoberta Ricciarelli
Institute of Biochemistry and Molecular Biology, University of Berne, Switzerland
Biol Chem 383:457-65. 2002..This review focuses on novel non-antioxidant functions of alpha-tocopherol and discusses the possibility that many of the effects previously attributed to the antioxidant functions can also be explained by non-antioxidant mechanisms... - The European perspective on vitamin E: current knowledge and future researchRegina Brigelius-Flohe
German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
Am J Clin Nutr 76:703-16. 2002..Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of vitamin E have... - Genetic polymorphisms as determinants for disease-preventive effects of vitamin EJean Marc Zingg
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Nutr Rev 66:406-14. 2008.... - Alpha-tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-alpha-mediated downregulation in human smooth muscle cellsLuis Villacorta
Department of Medical Biochemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro-RJ, Brazil
Circ Res 92:104-10. 2003..Because CTGF stimulates the synthesis of extracellular matrix, the normalization of CTGF gene expression by alpha-tocopherol may accelerate wound repair and tissue regeneration during atherosclerosis... - The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol dietYesim Negis
Department of Biochemistry, Faculty of Medicine, Marmara University, 81326 Haydarpasa, Istanbul, Turkey
Arch Biochem Biophys 450:63-6. 2006..alpha-Tocopheryl phosphate was also more potent in diminishing the expression of CD36 than the acetate derivative... - Vitamin EAngelo Azzi
IUBMB Life 55:495-6. 2003 - Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammationAdelina Munteanu
Institute of Biochemistry and Molecular Biology, University of Bern, , 3012 Bern, Switzerland
Biochem Biophys Res Commun 318:311-6. 2004..Alternatively, a direct effect of the phosphate ester on specific cell targets may be considered... - Novel 5' exon of scavenger receptor CD36 is expressed in cultured human vascular smooth muscle cells and atherosclerotic plaquesJean-Marc Zingg
Institute of Biochemistry and Molecular Biology, University of Bern, Bern, Switzerland
Arterioscler Thromb Vasc Biol 22:412-7. 2002..The antisense to exon 1b does not affect CD36 in cell lines not expressing the new exon. The possibility of a novel antiatherosclerotic therapy and the use of exon 1b as a marker of atherosclerosis are discussed... - Molecular mechanism of alpha-tocopheryl-phosphate transport across the cell membraneYesim Negis
Vascular Biology Laboratory, The Jean Mayer USDA Human Nutrition Center at Tufts University, Boston, MA 02111, USA
Biochem Biophys Res Commun 359:348-53. 2007..Due to the protection by glibenclamide and probenecid on the alpha-TP induced cell growth inhibition it appears that alpha-TP acts after its uptake inside cells... - Tocotrienol inhibits proliferation of human Tenon's fibroblasts in vitro: a comparative study with vitamin E forms and mitomycin CAlexander Meyenberg
Departement of Ophthalmology, University of Berne, Switzerland
Graefes Arch Clin Exp Ophthalmol 243:1263-71. 2005..In this in vitro study, antiproliferative effects of mitomycin C were stronger than those of alpha-tocotrienol... - HIV protease inhibitors-induced atherosclerosis: prevention by alpha-tocopherolAdelina Munteanu
Institute of Biochemistry and Molecular Biology, University of Bern, , 3012 Bern, Switzerland
IUBMB Life 56:629-31. 2004..These findings suggest that ARPI combined with early alpha-tocopherol supplementation may decrease the drug-induced atherosclerotic risk... - Alpha-tocopheryl phosphate: a novel, natural form of vitamin ERobert Gianello
Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia
Free Radic Biol Med 39:970-6. 2005..The results show that alpha-tocopheryl phosphate is a natural form of vitamin E. The discovery of endogenous alpha-tocopheryl phosphate has implications for the expanding knowledge of the roles of alpha-tocopherol in biological systems... - The effect of gamma-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cellsElika Samandari
Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland
Biochem Biophys Res Commun 342:1329-33. 2006..It is concluded that alpha5 and beta1 integrin expression and surface appearance are not sufficient to explain all the observations and that other integrins or in general other factors may be associated with these events... - CD36 overexpression in ritonavir-treated THP-1 cells is reversed by alpha-tocopherolAdelina Munteanu
Institute of Biochemistry and Molecular Biology, University of Bern, , 3012 Bern, Switzerland
Free Radic Biol Med 38:1047-56. 2005..CD36 overexpression is caused by inhibition of proteasome activity by ritonavir, which is efficiently restored by alpha-tocopherol... - Cellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionAdelina Munteanu
Physiology Department, Faculty of Medicine, University of Medicine and Pharmacy Bucharest, Romania
Mol Aspects Med 28:538-90. 2007..In addition to that, the cellular effects of alpha-tocopheryl phosphate and of EPC-K1, a composite molecule between alpha-tocopheryl phosphate and l-ascorbic acid, are summarized... - On the existence of cellular tocopheryl phosphate, its synthesis, degradation and cellular roles: a hypothesisYesim Negis
Department of Biochemistry, Marmara University, Istanbul, Turkey
IUBMB Life 57:23-5. 2005..A possible mechanism of action of other tocopherol esters (succinate and maleate) is also hypothesized... - Regulatory role of vitamins E and C on extracellular matrix components of the vascular systemLuis Villacorta
Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Mol Aspects Med 28:507-37. 2007.... - CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's diseaseRoberta Ricciarelli
Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
Free Radic Biol Med 36:1018-24. 2004..In line with this observation, we found an increased presence of nitrated proteins in brains showing Abeta loads and CD36 overexpression, independent of the occurrence of Alzheimer's disease pathologic features... - Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cellsJiri Neuzil
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
Biochem Biophys Res Commun 343:1113-7. 2006..We suggest that TAP1 may act as an intracellular shuttle for alpha-TOS, promoting apoptosis initiated by this vitamin E analogue, as shown here for MM cells... - Recombinant SEC14-like proteins (TAP) possess GTPase activityDaniel Habermehl
Institute of Biochemistry and Molecular Biology, University of Bern, , 3012 Bern, Switzerland
Biochem Biophys Res Commun 326:254-9. 2005..However, these motifs are located in close proximity in the TAP structure and may therefore form an active site for GTP-binding and hydrolysis... - Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodelingSteffen Kunzmann
University Children s Hospital, Wurzburg, Germany
J Allergy Clin Immunol 119:1398-407. 2007..TGF-beta and its downstream mediator connective tissue growth factor (CTGF) are playing a key role in these processes, resulting in irreversible airway remodelling...