Jean Marc Zingg

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint Non-antioxidant activities of vitamin E
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Curr Med Chem 11:1113-33. 2004
  2. ncbi request reprint Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation
    Esra Ogru
    Department of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, Bern 3012, Switzerland
    Ann N Y Acad Sci 1031:405-11. 2004
  3. ncbi request reprint HIV protease inhibitors-induced atherosclerosis: prevention by alpha-tocopherol
    Adelina Munteanu
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    IUBMB Life 56:629-31. 2004
  4. ncbi request reprint Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway
    Petra Kempna
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    J Biol Chem 279:50700-9. 2004
  5. ncbi request reprint Vitamin E mediates cell signaling and regulation of gene expression
    Angelo Azzi
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Ann N Y Acad Sci 1031:86-95. 2004
  6. ncbi request reprint Isoelectric point mobility shift assay for rapid screening of charged and uncharged ligands bound to proteins
    Petra Kempna
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    IUBMB Life 55:103-7. 2003
  7. ncbi request reprint Antagonistic effects of oxidized low density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor-gamma
    Adelina Munteanu
    Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    J Biol Chem 281:6489-97. 2006
  8. ncbi request reprint CD36 overexpression in ritonavir-treated THP-1 cells is reversed by alpha-tocopherol
    Adelina Munteanu
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Free Radic Biol Med 38:1047-56. 2005
  9. ncbi request reprint Novel 5' exon of scavenger receptor CD36 is expressed in cultured human vascular smooth muscle cells and atherosclerotic plaques
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Biology, University of Bern, Bern, Switzerland
    Arterioscler Thromb Vasc Biol 22:412-7. 2002
  10. doi request reprint Characterization of three human sec14p-like proteins: alpha-tocopherol transport activity and expression pattern in tissues
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Biochimie 90:1703-15. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Non-antioxidant activities of vitamin E
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Curr Med Chem 11:1113-33. 2004
    ....
  2. ncbi request reprint Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation
    Esra Ogru
    Department of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, Bern 3012, Switzerland
    Ann N Y Acad Sci 1031:405-11. 2004
    ..In nonstimulated THP-1 cells, alpha-tocopherol had only very weak effects on these events...
  3. ncbi request reprint HIV protease inhibitors-induced atherosclerosis: prevention by alpha-tocopherol
    Adelina Munteanu
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    IUBMB Life 56:629-31. 2004
    ..These findings suggest that ARPI combined with early alpha-tocopherol supplementation may decrease the drug-induced atherosclerotic risk...
  4. ncbi request reprint Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway
    Petra Kempna
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    J Biol Chem 279:50700-9. 2004
    ..Inhibition of proliferation and PKB signaling in HMC-1 cells by vitamin E suggests a role in preventing diseases with mast cell involvement, such as allergies, atherosclerosis, and tumorigenesis...
  5. ncbi request reprint Vitamin E mediates cell signaling and regulation of gene expression
    Angelo Azzi
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Ann N Y Acad Sci 1031:86-95. 2004
    ..The antioxidant-responsive element (ARE) and the TGF-beta-responsive element (TGF-beta-RE) appear in some cases to be implicated as well...
  6. ncbi request reprint Isoelectric point mobility shift assay for rapid screening of charged and uncharged ligands bound to proteins
    Petra Kempna
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    IUBMB Life 55:103-7. 2003
    ..Competition of bound charged ligands with uncharged ones reverses the mobility shift, so that the relative affinities of the two ligands to the protein can be estimated...
  7. ncbi request reprint Antagonistic effects of oxidized low density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor-gamma
    Adelina Munteanu
    Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    J Biol Chem 281:6489-97. 2006
    ..The activation of CD36 expression by PKB suggests that both lipid biosynthesis and fatty acid uptake are stimulated by PKB...
  8. ncbi request reprint CD36 overexpression in ritonavir-treated THP-1 cells is reversed by alpha-tocopherol
    Adelina Munteanu
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Free Radic Biol Med 38:1047-56. 2005
    ..CD36 overexpression is caused by inhibition of proteasome activity by ritonavir, which is efficiently restored by alpha-tocopherol...
  9. ncbi request reprint Novel 5' exon of scavenger receptor CD36 is expressed in cultured human vascular smooth muscle cells and atherosclerotic plaques
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Biology, University of Bern, Bern, Switzerland
    Arterioscler Thromb Vasc Biol 22:412-7. 2002
    ..The antisense to exon 1b does not affect CD36 in cell lines not expressing the new exon. The possibility of a novel antiatherosclerotic therapy and the use of exon 1b as a marker of atherosclerosis are discussed...
  10. doi request reprint Characterization of three human sec14p-like proteins: alpha-tocopherol transport activity and expression pattern in tissues
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Biochimie 90:1703-15. 2008
    ..Thus, the three hTAPs may mediate lipid uptake, secretion, presentation, and sub-cellular localization in a tissue-specific manner, possibly using organelle- and enzyme-specific docking sites...
  11. ncbi request reprint Cloning of novel human SEC14p-like proteins: ligand binding and functional properties
    Petra Kempna
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
    Free Radic Biol Med 34:1458-72. 2003
    ..It is possible that other phosphatidylinositol- and phosphatidylcholine-dependent signaling pathways are modulated by hTAPs and tocopherols, possibly by transporting and presenting these ligands to the corresponding enzymes...
  12. ncbi request reprint Regulation of gene expression by alpha-tocopherol
    Angelo Azzi
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
    Biol Chem 385:585-91. 2004
    ..Here we review recent results of the search for molecular mechanisms underpinning the central signaling mechanism...
  13. ncbi request reprint The effect of gamma-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cells
    Elika Samandari
    Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland
    Biochem Biophys Res Commun 342:1329-33. 2006
    ..It is concluded that alpha5 and beta1 integrin expression and surface appearance are not sufficient to explain all the observations and that other integrins or in general other factors may be associated with these events...
  14. ncbi request reprint The 80th anniversary of vitamin E: beyond its antioxidant properties
    Roberta Ricciarelli
    Institute of Biochemistry and Molecular Biology, University of Berne, Switzerland
    Biol Chem 383:457-65. 2002
    ..This review focuses on novel non-antioxidant functions of alpha-tocopherol and discusses the possibility that many of the effects previously attributed to the antioxidant functions can also be explained by non-antioxidant mechanisms...
  15. ncbi request reprint Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes
    M Clara De Pascale
    Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Arch Biochem Biophys 447:97-106. 2006
    ..Vitamin E treatment also led to increased expression of a known PPARgamma target gene involved in terminal keratinocytes differentiation, the transglutaminase-1...
  16. ncbi request reprint Modulation of proteasome activity by vitamin E in THP-1 monocytes
    Adelina Munteanu
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    IUBMB Life 59:771-80. 2007
    ....
  17. ncbi request reprint Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells
    Elke Reiter
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Biofactors 30:67-77. 2007
    ..The combination of phytochemicals with relatively broad specificity on enzymes involved in signal transduction and gene expression may increase their activity in disease prevention by modulating several different molecular targets...
  18. ncbi request reprint Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)
    Angelo Azzi
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, CH 3012 Bern, Switzerland
    FEBS Lett 519:8-10. 2002
    ..alpha-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression...
  19. ncbi request reprint Vitamin E: an overview of major research directions
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Mol Aspects Med 28:400-22. 2007
    ..This review is giving a brief introduction about vitamin E by following the major research directions since its discovery with a historical perspective...
  20. ncbi request reprint Vitamin E and mast cells
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland
    Vitam Horm 76:393-418. 2007
    ..In this chapter, the possibility that vitamin E can prevent diseases with mast cells involvement by modulating signal transduction and gene expression is evaluated...
  21. ncbi request reprint Recombinant SEC14-like proteins (TAP) possess GTPase activity
    Daniel Habermehl
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Biochem Biophys Res Commun 326:254-9. 2005
    ..However, these motifs are located in close proximity in the TAP structure and may therefore form an active site for GTP-binding and hydrolysis...
  22. ncbi request reprint Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation
    Adelina Munteanu
    Institute of Biochemistry and Molecular Biology, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Biochem Biophys Res Commun 318:311-6. 2004
    ..Alternatively, a direct effect of the phosphate ester on specific cell targets may be considered...
  23. ncbi request reprint Molecular and cellular activities of vitamin E analogues
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Mini Rev Med Chem 7:543-58. 2007
    ..In this review, the different natural vitamin E analogues and synthetic derivatives are compiled in relation to their major molecular and cellular activities...
  24. ncbi request reprint Modulation of signal transduction by vitamin E
    Jean Marc Zingg
    Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrasse 28, 3012 Bern, Switzerland
    Mol Aspects Med 28:481-506. 2007
    ..The elucidation of the molecular and cellular events affected by vitamin E could reveal novel strategies and molecular targets for developing similarly acting compounds...
  25. doi request reprint Antifibrotic effects of tocotrienols on human Tenon's fibroblasts
    Christoph Tappeiner
    Department of Ophthalmology, Inselspital, University of Bern, 3010 Bern, Switzerland
    Graefes Arch Clin Exp Ophthalmol 248:65-71. 2010
    ..To compare the antifibrotic effect of vitamin E isoforms alpha-, gamma-, and delta-tocotrienol on human Tenon's fibroblasts (hTf) to the antimetabolite mitomycin C...
  26. doi request reprint Vitamin E: Textbooks require updating
    Angelo Azzi
    Institute of Biochemistry and Molecular Biology, University of Bern, 3012 Bern, Switzerland
    Biochem Mol Biol Educ 33:184-7. 2005
    ..In almost all books the existence of vitamin E deficiency diseases is ignored. Recent findings on vitamin E molecular functions and its related diseases are described in this article...
  27. ncbi request reprint Molecular mechanism of alpha-tocopheryl-phosphate transport across the cell membrane
    Yesim Negis
    Vascular Biology Laboratory, The Jean Mayer USDA Human Nutrition Center at Tufts University, Boston, MA 02111, USA
    Biochem Biophys Res Commun 359:348-53. 2007
    ..Due to the protection by glibenclamide and probenecid on the alpha-TP induced cell growth inhibition it appears that alpha-TP acts after its uptake inside cells...
  28. ncbi request reprint The European perspective on vitamin E: current knowledge and future research
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Am J Clin Nutr 76:703-16. 2002
    ..Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of vitamin E have...
  29. ncbi request reprint Alpha-tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-alpha-mediated downregulation in human smooth muscle cells
    Luis Villacorta
    Department of Medical Biochemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro RJ, Brazil
    Circ Res 92:104-10. 2003
    ..Because CTGF stimulates the synthesis of extracellular matrix, the normalization of CTGF gene expression by alpha-tocopherol may accelerate wound repair and tissue regeneration during atherosclerosis...
  30. doi request reprint Genetic polymorphisms as determinants for disease-preventive effects of vitamin E
    Jean Marc Zingg
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Nutr Rev 66:406-14. 2008
    ....
  31. ncbi request reprint Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbits
    Nesrin Kartal Ozer
    Department of Biochemistry, Faculty of Medicine, Marmara University, 34668 Haydarpasa, Istanbul, Turkey
    Atherosclerosis 184:15-20. 2006
    ..The effects observed at the level of CD36 scavenger receptor expression in vivo suggest an involvement of reduced foam cell formation in the protective effect of Vitamin E against atherosclerosis...
  32. ncbi request reprint Tocotrienol inhibits proliferation of human Tenon's fibroblasts in vitro: a comparative study with vitamin E forms and mitomycin C
    Alexander Meyenberg
    Departement of Ophthalmology, University of Berne, Switzerland
    Graefes Arch Clin Exp Ophthalmol 243:1263-71. 2005
    ..To evaluate the potential of the vitamin E compound alpha-tocotrienol as antifibrotic agent in vitro...
  33. ncbi request reprint Vitamin E
    Angelo Azzi
    IUBMB Life 55:495-6. 2003
  34. ncbi request reprint The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet
    Yesim Negis
    Department of Biochemistry, Faculty of Medicine, Marmara University, 81326 Haydarpasa, Istanbul, Turkey
    Arch Biochem Biophys 450:63-6. 2006
    ..alpha-Tocopheryl phosphate was also more potent in diminishing the expression of CD36 than the acetate derivative...
  35. ncbi request reprint Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention
    Adelina Munteanu
    Physiology Department, Faculty of Medicine, University of Medicine and Pharmacy Bucharest, Romania
    Mol Aspects Med 28:538-90. 2007
    ..In addition to that, the cellular effects of alpha-tocopheryl phosphate and of EPC-K1, a composite molecule between alpha-tocopheryl phosphate and l-ascorbic acid, are summarized...
  36. ncbi request reprint CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's disease
    Roberta Ricciarelli
    Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
    Free Radic Biol Med 36:1018-24. 2004
    ..In line with this observation, we found an increased presence of nitrated proteins in brains showing Abeta loads and CD36 overexpression, independent of the occurrence of Alzheimer's disease pathologic features...
  37. ncbi request reprint Regulatory role of vitamins E and C on extracellular matrix components of the vascular system
    Luis Villacorta
    Cardiovascular Research Center, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Mol Aspects Med 28:507-37. 2007
    ....
  38. ncbi request reprint Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    J Allergy Clin Immunol 119:1398-407. 2007
    ..TGF-beta and its downstream mediator connective tissue growth factor (CTGF) are playing a key role in these processes, resulting in irreversible airway remodelling...
  39. ncbi request reprint Alpha-tocopheryl phosphate: a novel, natural form of vitamin E
    Robert Gianello
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia
    Free Radic Biol Med 39:970-6. 2005
    ..The results show that alpha-tocopheryl phosphate is a natural form of vitamin E. The discovery of endogenous alpha-tocopheryl phosphate has implications for the expanding knowledge of the roles of alpha-tocopherol in biological systems...
  40. ncbi request reprint Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells
    Jiri Neuzil
    Apoptosis Research Group, School of Medical Science, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 343:1113-7. 2006
    ..We suggest that TAP1 may act as an intracellular shuttle for alpha-TOS, promoting apoptosis initiated by this vitamin E analogue, as shown here for MM cells...
  41. ncbi request reprint On the existence of cellular tocopheryl phosphate, its synthesis, degradation and cellular roles: a hypothesis
    Yesim Negis
    Department of Biochemistry, Marmara University, Istanbul, Turkey
    IUBMB Life 57:23-5. 2005
    ..A possible mechanism of action of other tocopherol esters (succinate and maleate) is also hypothesized...