Affiliation: University of Lausanne
- Distinct population of hair cell progenitors can be isolated from the postnatal mouse cochlea using side population analysisEtienne Savary
Institute of Neuroscience, INSERM U 583, Montpellier, France
Stem Cells 25:332-9. 2007..Our observation that these SP cells are capable of differentiating into HC-like cells implies a possible use for such cells (i.e., the replacement of lost auditory HCs within damaged cochlea)...
- Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner earA Zine
Institute of Physiology, University of Lausanne, 1005 Lausanne, Switzerland
J Neurosci 21:4712-20. 2001..These data indicate that Hes1 and Hes5 participate together for the control of inner ear hair cell production, likely through the negative regulation of Math1...
- Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant miceAzel Zine
Institute of Physiology, University of Lausanne, 7 rue du Bugnon, CH 1005, Lausanne, Switzerland
Hear Res 170:22-31. 2002..Our study suggests complex specific relationships between Notch signaling, Math1 and Hes1/Hes5 in the control of hair cell differentiation in the developing organ of Corti...
- Notch signaling regulates the pattern of auditory hair cell differentiation in mammalsA Zine
Institute of Physiology, University of Lausanne, Switzerland
Development 127:3373-83. 2000..Our data suggest that the Notch1 signaling pathway is involved in a complex interplay between the consequences of different ligand-Notch1 combinations during cochlear morphogenesis and the phases of hair cell differentiation...
- Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochleaAzel Zine
Universite de Montpellier I, Institute des Neurosciences de Montpellier, INSERM U583, 34090 Montpellier, France
Mol Neurobiol 27:223-38. 2003....
- D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation traumaAdrien A Eshraghi
Department of Otolaryngology, University of Miami Ear Institute, Miami, Florida 33136-1015, USA
Otol Neurotol 27:504-11. 2006..CONCLUSION: Hearing loss caused by cochlear implant electrode insertion trauma in guinea pigs has both acute and delayed components. The delayed component can be prevented by treating the cochlea with D-JNKI-1...