Andre Ziegler

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Thermodynamics of sodium dodecyl sulfate partitioning into lipid membranes
    Anmin Tan
    Department of Biophysical Chemistry, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Biophys J 83:1547-56. 2002
  2. ncbi request reprint The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence
    Andre Ziegler
    Department of Biophysical Chemistry, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Biochemistry 44:138-48. 2005
  3. doi request reprint Contributions of glycosaminoglycan binding and clustering to the biological uptake of the nonamphipathic cell-penetrating peptide WR9
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 50 70, Basel, Switzerland
    Biochemistry 50:4650-64. 2011
  4. ncbi request reprint Thermodynamic studies and binding mechanisms of cell-penetrating peptides with lipids and glycosaminoglycans
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Adv Drug Deliv Rev 60:580-97. 2008
  5. ncbi request reprint Size-exclusion chromatography of heparin oligosaccharides at high and low pressure
    Andre Ziegler
    Proteoglycan and Glycosaminoglycan Structure Laboratory, Mass Spectrometry Resource, Boston University, 715 Albany Street, Boston, MA 02118, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 837:76-86. 2006
  6. pmc Binding and clustering of glycosaminoglycans: a common property of mono- and multivalent cell-penetrating compounds
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, 4056 Basel, Switzerland
    Biophys J 94:2142-9. 2008
  7. ncbi request reprint Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Biochemistry 42:9185-94. 2003
  8. pmc Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Basel, Switzerland
    Biophys J 86:254-63. 2004
  9. ncbi request reprint High affinity of the cell-penetrating peptide HIV-1 Tat-PTD for DNA
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Kingelbergstrasse 50 70, 4056 Basel, Switzerland
    Biochemistry 46:8138-45. 2007
  10. doi request reprint Thermodynamics of lipid interactions with cell-penetrating peptides
    Reto Sauder
    Department of Biophysical Chemistry, Biozentrum of the University of Basel, Basel, Switzerland
    Methods Mol Biol 683:129-55. 2011

Detail Information

Publications13

  1. pmc Thermodynamics of sodium dodecyl sulfate partitioning into lipid membranes
    Anmin Tan
    Department of Biophysical Chemistry, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Biophys J 83:1547-56. 2002
    ..3 mol SDS per mol lipid and the equilibrium SDS concentration is C (sat)(D,F)approximately equal 2.2 mM +/- 0.6 mM. SDS translocation across the bilayer is slow at ambient temperature but increases at high temperatures...
  2. ncbi request reprint The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence
    Andre Ziegler
    Department of Biophysical Chemistry, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Biochemistry 44:138-48. 2005
    ..In contrast, no recovery to baseline values was observed after repeated exposures to the CPP, suggesting that the CPP is toxic in long-term applications...
  3. doi request reprint Contributions of glycosaminoglycan binding and clustering to the biological uptake of the nonamphipathic cell-penetrating peptide WR9
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 50 70, Basel, Switzerland
    Biochemistry 50:4650-64. 2011
    ..The results suggest that GAG binding without and with GAG clustering induce two different pathways of CPP uptake...
  4. ncbi request reprint Thermodynamic studies and binding mechanisms of cell-penetrating peptides with lipids and glycosaminoglycans
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Adv Drug Deliv Rev 60:580-97. 2008
    ..In contrast, no direct translocation at these conditions is observed for non-amphipathic CPPs. Finally, CPPs bind GAGs at low micromolar concentrations with potential consequences for endocytotic pathways...
  5. ncbi request reprint Size-exclusion chromatography of heparin oligosaccharides at high and low pressure
    Andre Ziegler
    Proteoglycan and Glycosaminoglycan Structure Laboratory, Mass Spectrometry Resource, Boston University, 715 Albany Street, Boston, MA 02118, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 837:76-86. 2006
    ..Optimized SEC affords separation of characteristic heparin trisaccharides that contain uronic acid at the reducing end and suggest cellular storage of heparin as a free glycan...
  6. pmc Binding and clustering of glycosaminoglycans: a common property of mono- and multivalent cell-penetrating compounds
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, 4056 Basel, Switzerland
    Biophys J 94:2142-9. 2008
    ..Because the binding and clustering of GAGs were found to be a common denominator of all CPCs tested, these properties might be helpful to identify further CPCs...
  7. ncbi request reprint Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Biochemistry 42:9185-94. 2003
    ..TAT-PTD has a much lower affinity for lipid membranes than for glycosaminoglycans, making the latter interaction a more probable pathway for CPP binding to biological membranes...
  8. pmc Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Basel, Switzerland
    Biophys J 86:254-63. 2004
    ....
  9. ncbi request reprint High affinity of the cell-penetrating peptide HIV-1 Tat-PTD for DNA
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Kingelbergstrasse 50 70, 4056 Basel, Switzerland
    Biochemistry 46:8138-45. 2007
    ....
  10. doi request reprint Thermodynamics of lipid interactions with cell-penetrating peptides
    Reto Sauder
    Department of Biophysical Chemistry, Biozentrum of the University of Basel, Basel, Switzerland
    Methods Mol Biol 683:129-55. 2011
    ..This suggests that the mechanism for cytosolic CPP delivery (and potential toxicity) differs among CPPs despite their common name...
  11. ncbi request reprint Postresuscitation stunning: postfibrillatory myocardial dysfunction caused by reduced myofilament Ca2+ responsiveness after ventricular fibrillation-induced myocyte Ca2+ overload
    Christian E Zaugg
    Department of Research, University Hospital Basel, Switzerland
    J Cardiovasc Electrophysiol 13:1017-24. 2002
    ..We tested whether this dysfunction can be caused by reduced myofilament Ca2+ responsiveness after VF-induced myocyte Ca2+ overload. We also tested whether electrical defibrillation shocks contribute to this dysfunction...
  12. ncbi request reprint Non-invasive measurements of myocardial carbon metabolism using in vivo 13C NMR spectroscopy
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Switzerland
    NMR Biomed 15:222-34. 2002
    ..In conclusion, it is demonstrated that 13C NMR spectroscopy of the heart in intact rats is feasible and provides new quantitative insight into myocardial substrate uptake, preference and metabolism in vivo...
  13. ncbi request reprint Specific binding of Ro 09-0198 (cinnamycin) to phosphatidylethanolamine: a thermodynamic analysis
    Gia Machaidze
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Biochemistry 41:1965-71. 2002
    ..This reorganization of the lipid matrix is not limited to PE but also includes other lipids...