Xiao Yan Zhong

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Maternal smoking: effect on circulating cell-free fetal and total DNA levels in maternal plasma from the second trimester
    Olav Lapaire
    University of Basel, Department of Obstetrics and Gynecology, Basel, Switzerland
    Obstet Gynecol 110:1358-63. 2007
  2. ncbi request reprint Inability to clonally expand fetal progenitors from maternal blood
    Bernhard Zimmermann
    Department of Obstetrics and Gynaecology, University of Basel, Switzerland
    Fetal Diagn Ther 17:97-100. 2002
  3. doi request reprint Assessing the value of CAN-gene mutations using MALDI-TOF MS
    Corina Kohler
    Laboratory for Gynecological Oncology, Women s Hospital Department Research, Department of Biomedicine, University of Basel, Hebelstrasse 20, Room Nr 420, 4031 Basel, Switzerland
    J Cancer Res Clin Oncol 137:1239-44. 2011
  4. pmc Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer
    Ramin Radpour
    Laboratory for Gynecological Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 6:e16080. 2011
  5. doi request reprint Epigenetics of ovarian cancer: from the lab to the clinic
    Reza Asadollahi
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel CH 4031, Switzerland
    Gynecol Oncol 118:81-7. 2010
  6. pmc Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer
    Peng Xia
    Department of Surgical Oncology, First Affiliated Hospital of Medical College, Xi an Jiaotong University, 710061 Xi an, PR China
    BMC Cancer 9:454. 2009
  7. ncbi request reprint Quantitative analysis of intact fetal cells in maternal plasma by real-time PCR
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Experimental Oncology, Department of Obstetrics and Gynecology, University of Basel, Spitalstrasse 21, CH 4031 Basel, Switzerland
    Eur J Obstet Gynecol Reprod Biol 133:20-4. 2007
  8. ncbi request reprint Elevated level of cell-free plasma DNA is associated with breast cancer
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Gynaecological Oncology, Department of Obstetrics and Gynaecology, University of Basel, Basel, Switzerland
    Arch Gynecol Obstet 276:327-31. 2007
  9. ncbi request reprint Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender, age and frequency of blood donations?
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Experimental Oncology, Department of Obstetrics and Gynecology, University of Basel, Basel, Switzerland
    Ann Hematol 86:139-43. 2007
  10. ncbi request reprint Direct quantification of fetal cells in maternal blood by real-time PCR
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Experimental Oncology, Department of Research, University Women s Hospital Basel, Basel, Switzerland
    Prenat Diagn 26:850-4. 2006

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Maternal smoking: effect on circulating cell-free fetal and total DNA levels in maternal plasma from the second trimester
    Olav Lapaire
    University of Basel, Department of Obstetrics and Gynecology, Basel, Switzerland
    Obstet Gynecol 110:1358-63. 2007
    ..To estimate whether potential clinical applications of cell-free fetal and total DNA in the field of noninvasive prenatal diagnosis need to be adjusted for maternal smoking status...
  2. ncbi request reprint Inability to clonally expand fetal progenitors from maternal blood
    Bernhard Zimmermann
    Department of Obstetrics and Gynaecology, University of Basel, Switzerland
    Fetal Diagn Ther 17:97-100. 2002
    ..To confirm the recent report of the culture of single clones of fetal progenitor cells from maternal blood...
  3. doi request reprint Assessing the value of CAN-gene mutations using MALDI-TOF MS
    Corina Kohler
    Laboratory for Gynecological Oncology, Women s Hospital Department Research, Department of Biomedicine, University of Basel, Hebelstrasse 20, Room Nr 420, 4031 Basel, Switzerland
    J Cancer Res Clin Oncol 137:1239-44. 2011
    ..140 CAN-genes were found in breast cancer, which in turn contained overall 334 mutations. These mutations could prove useful for diagnostic and therapeutic purposes...
  4. pmc Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer
    Ramin Radpour
    Laboratory for Gynecological Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 6:e16080. 2011
    ..Aberrant DNA methylation patterns might be used as a biomarker for diagnosis and management of cancer patients...
  5. doi request reprint Epigenetics of ovarian cancer: from the lab to the clinic
    Reza Asadollahi
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel CH 4031, Switzerland
    Gynecol Oncol 118:81-7. 2010
    ..Among different mechanisms, the present article reviews the importance of epigenetic changes in ovarian cancer...
  6. pmc Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer
    Peng Xia
    Department of Surgical Oncology, First Affiliated Hospital of Medical College, Xi an Jiaotong University, 710061 Xi an, PR China
    BMC Cancer 9:454. 2009
    ..We sought to investigate whether mtDNA content in the peripheral blood of breast cancer patients is associated with clinical and pathological parameters...
  7. ncbi request reprint Quantitative analysis of intact fetal cells in maternal plasma by real-time PCR
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Experimental Oncology, Department of Obstetrics and Gynecology, University of Basel, Spitalstrasse 21, CH 4031 Basel, Switzerland
    Eur J Obstet Gynecol Reprod Biol 133:20-4. 2007
    ..In this study, we quantitatively analysed the intact fetal cells existing in maternal plasma, which would be a special method of NIPD...
  8. ncbi request reprint Elevated level of cell-free plasma DNA is associated with breast cancer
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Gynaecological Oncology, Department of Obstetrics and Gynaecology, University of Basel, Basel, Switzerland
    Arch Gynecol Obstet 276:327-31. 2007
    ..We analysed cell-free DNA (cfDNA) in the plasma of patients with both malignant and benign breast lesions by real-time quantitative PCR to determine whether the finding may have diagnostic and prognostic implications...
  9. ncbi request reprint Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender, age and frequency of blood donations?
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Experimental Oncology, Department of Obstetrics and Gynecology, University of Basel, Basel, Switzerland
    Ann Hematol 86:139-43. 2007
    ..Frequent blood donation did not affect the quantity of circulatory cf-DNA. The explanation for the latter most likely is the short half-life time of free fetal DNA in maternal circulation...
  10. ncbi request reprint Direct quantification of fetal cells in maternal blood by real-time PCR
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine and Experimental Oncology, Department of Research, University Women s Hospital Basel, Basel, Switzerland
    Prenat Diagn 26:850-4. 2006
    ..We developed a simple, robust TaqMan real-time PCR assay to directly quantify male fetal cells in maternal blood using the multi-copy DYS14, without the need for any additional enrichment procedure...
  11. doi request reprint Umbilical cord blood stem cells: what to expect
    Xiao Yan Zhong
    Laboratory for Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    Ann N Y Acad Sci 1205:17-22. 2010
    ..However, new strategies and novel developments are expected to improve engraftment and reconstitution, and to enable in utero transplantation for early therapy, as well as to allow the therapy for a wide spectrum of human diseases...
  12. doi request reprint Significant correlation between maternal body mass index at delivery and in the second trimester, and second trimester circulating total cell-free DNA levels
    Olav Lapaire
    Department of Obstetrics and Gynecology, University of Basel, Basel, Switzerland
    Reprod Sci 16:274-9. 2009
    ..The use of cell-free fetal deoxyribonucleic acid (DNA) requires the knowledge of variables that may influence the levels of cell-free DNA, such as maternal body mass index (BMI)...
  13. pmc Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
    Corina Kohler
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    Mol Cancer 8:105. 2009
    ..In this connection, circulating cell-free DNA (ccf DNA) seems to be a promising candidate. Altered levels of ccf nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) have been found in several cancer types and might have a diagnostic value...
  14. ncbi request reprint Minimal alteration in the ratio of circulatory fetal DNA to fetal corticotropin-releasing hormone mRNA level in preeclampsia
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine Department of Research, University Women s Hospital, University of Basel, Switzerland
    Fetal Diagn Ther 21:246-9. 2006
    ..Hence, we examined whether these ratios varied in maternal plasma samples taken from normotensive and preeclamptic pregnancies in vivo...
  15. pmc Methylation signature of lymph node metastases in breast cancer patients
    Zeinab Barekati
    Laboratory for Gynecological Oncology, Women s Hospital Department of Biomedicine, University of Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    BMC Cancer 12:244. 2012
    ....
  16. ncbi request reprint Mutations of mitochondrial DNA as potential biomarkers in breast cancer
    Feng Feng Cai
    University Women s Hospital, Department of Biomedicine, University of Basel, Hebelstrasse 20, Room 420, Basel, CH 4031, Switzerland
    Anticancer Res 31:4267-71. 2011
    ..Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease...
  17. doi request reprint Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer
    Alex Xiu Cheng Fan
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Hebelstrasse 20, Room Nr 416, 4031 Basel, Switzerland
    J Cancer Res Clin Oncol 135:983-9. 2009
    ..We develop a multiplex quantitative real-time PCR for synchronized analysis of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) to investigate relative mtDNA abundance in paired normal and cancerous breast tissues...
  18. ncbi request reprint Comparison of activin A and cell-free fetal DNA levels in maternal plasma from patients at high risk for preeclampsia
    Claude Henri Diesch
    Laboratory for Prenatal Medicine and Gynaecological Oncology, Department of Obstetrics and Gynecology, University of Basel, Switzerland
    Prenat Diagn 26:1267-70. 2006
    ..We examined the concentration of activin A in a prospective manner before the clinical manifestation of preeclampsia and compared the data with those of cell-free fetal DNA in the maternal plasma...
  19. doi request reprint Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Mod Pathol 23:763-72. 2010
    ..Thus, telomere shortening and promoter hypermethylation of related genes both might serve as breast cancer biomarkers...
  20. ncbi request reprint Circulating cell-free DNA as a potential biomarker for minimal and mild endometriosis
    Rebecca Zachariah
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital, Department of Biomedicine, University of Basel, Switzerland
    Reprod Biomed Online 18:407-11. 2009
    ..The finding of significantly increased concentrations of ccf nDNA in plasma of patients with endometriosis suggests that ccf nDNA might be a potential biomarker for developing non-invasive diagnostic test in endometriosis...
  21. ncbi request reprint Inability to detect cell free fetal DNA in the urine of normal pregnant women nor in those affected by preeclampsia associated HELLP syndrome
    Ying Li
    Laboratory for Prenatal Medicine, University Women s Hospital Department of Biomedical Research, University of Basel, Spitalstrasse 21, CH 4031 Basel, Switzerland
    J Soc Gynecol Investig 10:503-8. 2003
    ..Recent reports have indicated that cell-free fetal DNA can be detected in the urine of pregnant women. We attempted to reproduce those data...
  22. ncbi request reprint Parallel assessment of circulatory fetal DNA and corticotropin-releasing hormone mRNA in early- and late-onset preeclampsia
    Xiao Yan Zhong
    University Women s Hospital Department of Research, University Hospital Basel, Basel, Switzerland
    Clin Chem 51:1730-3. 2005
  23. doi request reprint Antitumor properties of salinomycin on cisplatin-resistant human ovarian cancer cells in vitro and in vivo: involvement of p38 MAPK activation
    Bei Zhang
    Laboratory for Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, CH 4031 Basel, Switzerland
    Oncol Rep 29:1371-8. 2013
    ..These findings suggested that salinomycin efficiently inhibits the cisplatin-resistant human ovarian cancer cell line growth through the induction of apoptosis, potentially associated with the p38 MAPK activation...
  24. pmc Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment
    Ramin Radpour
    Laboratory for Gynecological Oncology, Department of Biomedicine Women s Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 6:e27355. 2011
    ..Since these epigenetic alterations are reversible, it became of interest to determine the effects of the 5-aza-2'-deoxycytidine (DAC) demethylation therapy in breast cancer at different molecular levels...
  25. doi request reprint High throughput non-invasive determination of foetal Rhesus D status using automated extraction of cell-free foetal DNA in maternal plasma and mass spectrometry
    Simon Grill
    Department Biomedicine, University Women s Hospital, Basel, Switzerland
    Arch Gynecol Obstet 279:533-7. 2009
    ..To examine the potential high throughput capability and efficiency of an automated DNA extraction system in combination with mass spectrometry for the non-invasive determination of the foetal Rhesus D status...
  26. ncbi request reprint Positive correlation of cell-free DNA in plasma/serum in patients with malignant and benign breast disease
    Rosanna Zanetti-Dällenbach
    Department of Obstetrics and Gynecology, University Hospital, Basel, Switzerland
    Anticancer Res 28:921-5. 2008
    ..Circulating cell-free (ccf) DNA is measurable in healthy individuals and in higher concentration in patients with benign and malignant breast disease (BD)...
  27. ncbi request reprint Circulating fetal DNA in maternal plasma is increased in pregnancies at high altitude and is further enhanced by preeclampsia
    Xiao Yan Zhong
    University Women s Hospital Department of Research, University of Basel, Basel, Switzerland
    Clin Chem 50:2403-5. 2004
  28. doi request reprint The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers
    Weijie Chen
    Laboratory for Gynecological Oncology, University Women s Hospital, Department of Biomedicine, University of Basel, Hebelstrasse 20, CH4031, Basel, Switzerland
    Tumour Biol 34:455-62. 2013
    ..3 %. Our data suggest that circulating miRNA-10b and miRNA-373 are potential biomarkers for detecting the lymph node status of breast cancer...
  29. doi request reprint High-throughput hacking of the methylation patterns in breast cancer by in vitro transcription and thymidine-specific cleavage mass array on MALDI-TOF silico-chip
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Mol Cancer Res 6:1702-9. 2008
    ..Each individual contributed a breast cancer specimen and corresponding adjacent normal tissue. We evaluated the accuracy of the approach and implemented critical improvements in experimental design...
  30. ncbi request reprint Proteomics and biomarkers for ovarian cancer diagnosis
    Bei Zhang
    Department of Biomedicine, Women s Hospital, University of Basel, Basel, Switzerland
    Ann Clin Lab Sci 40:218-25. 2010
    ..This article reviews recently published data on the diagnosis of ovarian cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development...
  31. doi request reprint Methylation profile of TP53 regulatory pathway and mtDNA alterations in breast cancer patients lacking TP53 mutations
    Zeinab Barekati
    Laboratory for Gynecological Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    Hum Mol Genet 19:2936-46. 2010
    ..Additionally, release of significant aberrant methylated PTEN in matched serum samples might represent a promising biomarker for breast cancer...
  32. doi request reprint A selected pre-amplification strategy for genetic analysis using limited DNA targets
    Peng Xia
    Women s Hospital, Department of Biomedicine, University of Basel, Basel, Switzerland
    Clin Chem Lab Med 47:288-93. 2009
    ..Limited DNA resources or limited DNA targets in predominant backgrounds for genetic tests can lead to misdiagnosis. We developed a strategy to selectively increase the amount of minor targets through a specific pre-amplification procedure...
  33. ncbi request reprint Increased concentrations of antibody-bound circulatory cell-free DNA in rheumatoid arthritis
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine, University Women s Hospital, Department of Research, University Hospital Basel, Basel, Switzerland
    Clin Chem 53:1609-14. 2007
    ..Evidence from in vitro and animal experiments suggests that DNA may play a role in the pathogenesis of rheumatoid arthritis (RA)...
  34. doi request reprint Isolation of cell-free RNA from maternal plasma
    Xiao Yan Zhong
    Laboratory of Prenatal Medicine, University Women s Hospital Department of Research, Basel, Switzerland
    Methods Mol Biol 444:269-73. 2008
    ..This method is also amenable to the simultaneous extraction of cell-free RNA from many different samples, by use of the QIAGEN Vacuum Manifold QIAvac 24 Plus...
  35. doi request reprint Isolation of cell-free DNA from maternal plasma using manual and automated systems
    Dorothy J Huang
    Laboratory of Prenatal Medicine, University Women s Hospital Department of Research, Basel, Switzerland
    Methods Mol Biol 444:203-8. 2008
    ..Use of the methods described here will help to ensure maximum yield and purity of cell-free fetal DNA extracted from maternal plasma samples for downstream analyses...
  36. ncbi request reprint Genetic communication between fetus and mother: short- and long-term consequences
    Wolfgang Holzgreve
    Department of Obstetrics and Gynecology, University of Basel, Basel, Switzerland
    Am J Obstet Gynecol 196:372-81. 2007
  37. doi request reprint Size fractionation of cell-free DNA in maternal plasma improves the detection of a paternally inherited beta-thalassemia point mutation by MALDI-TOF mass spectrometry
    Ying Li
    University Women s Hospital, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Fetal Diagn Ther 25:246-9. 2009
    ..We have now examined the use of size fractionation in conjunction with mass spectrometry for the detection of a paternally inherited codon 39 mutation of the beta-globin gene...
  38. doi request reprint Effects of salinomycin on human ovarian cancer cell line OV2008 are associated with modulating p38 MAPK
    Bei Zhang
    Laboratory for Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Tumour Biol 33:1855-62. 2012
    ..The data suggested that salinomycin-induced apoptosis in OV2008 might be associated with activating p38 MAPK and merits further investigations...
  39. doi request reprint New trends in molecular biomarker discovery for breast cancer
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Genet Test Mol Biomarkers 13:565-71. 2009
    ..This review highlights the new trends and approaches in breast cancer biomarker discovery, which could be potentially used for early diagnosis, development of new therapeutic approaches, and follow-up of patients...
  40. doi request reprint Comparison of serum VEGF and its soluble receptor sVEGFR1 with serum cell-free DNA in patients with breast tumor
    Shereen El Tarhouny
    Laboratory for Prenatal Medicine and Gynaecologic Oncology, Women s Hospital Department Research, University of Basel, Room 416, Hebelstrasse 20, CH4031 Basel, Switzerland
    Cytokine 44:65-9. 2008
    ..We wanted to find out whether VEGF, VEGFR1 or cfDNA is a biomarker for breast cancer...
  41. ncbi request reprint Examination of maternal plasma erythropoietin and activin A concentrations with regard to circulatory erythroblast levels in normal and preeclamptic pregnancies
    Carolyn Troeger
    University Women s Hospital and Department of Research, University Hospital, Basel, Switzerland
    Fetal Diagn Ther 21:156-60. 2006
    ..We examined the relationship between circulatory erythroblast levels with maternal plasma concentrations of erythropoietin and activin A...
  42. doi request reprint PLAC4 and beta-HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21
    Irina Banzola
    Laboratory for Prenatal Medicine and Gyn Oncology, Department of Biomedicine and University Hospital, Basel, Switzerland
    Prenat Diagn 28:1262-7. 2008
    ..Here we investigated whether the levels of beta-HCG-, PAPP-A- and PLAC4 mRNA could be able to discriminate pregnancies whose fetus is affected by trisomy 21...
  43. ncbi request reprint Circulatory nucleosome levels are significantly increased in early and late-onset preeclampsia
    Xiao Yan Zhong
    University Women s Hospital Department of Research, University of Basel, Switzerland
    Prenat Diagn 25:700-3. 2005
    ..Recent reports have indicated that circulatory nucleosome levels are elevated in the periphery of cancer patients. We have now examined whether circulatory nucleosome levels are similarly elevated in cases with preeclampsia...
  44. ncbi request reprint Cell-free foetal DNA in maternal plasma does not appear to be derived from the rich pool of cell-free foetal DNA in amniotic fluid
    Xiao Yan Zhong
    Department of Research, Laboratory for Prenatal Medicine, University Women s Hospital, Spitalstrasse 21, 4031, Basel, Switzerland
    Arch Gynecol Obstet 273:221-6. 2006
    ..Large quantities of cell-free foetal DNA have been detected in amniotic fluid, and it has been proposed that this material may contribute to the pool of cell-free foetal DNA in maternal plasma...
  45. ncbi request reprint Macrophage migration inhibition factor is elevated in pregnancy, but not to a greater extent in preeclampsia
    Sashka Hristoskova
    Laboratory for Prenatal Medicine, University Women s Hospital Department of Research, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland
    Arch Gynecol Obstet 274:25-8. 2006
    ..For this reason we attempted to independently verify this report...
  46. doi request reprint Simultaneous isolation of DNA, RNA, and proteins for genetic, epigenetic, transcriptomic, and proteomic analysis
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    J Proteome Res 8:5264-74. 2009
    ..This methodological improvement enables to execute such experiments that were not performable with standard procedure, and ensures reproducible outcome...
  47. ncbi request reprint The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia
    Xiao Yan Zhong
    Department of Obstetrics and Gynaecology, University of Basel, Schanzenstrasse 46, CH 4031 Basel, Switzerland
    Hypertens Pregnancy 21:77-83. 2002
    ..As we have recently performed a prospective study to examine fetal cell traffic in pregnancies at risk for developing preeclampsia, we now quantify cell free fetal DNA concentrations in these samples...
  48. ncbi request reprint Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine, Department of Obstetrics and Gynecology, University of Basel, Schanzenstrasse 46, CH 4031, Switzerland
    Mol Hum Reprod 8:864-70. 2002
    ..Furthermore, it appears that the release of cell-free fetal DNA from this cell type is affected by pathological placental conditions which are not associated with an increase in fetal cell trafficking...
  49. ncbi request reprint Can circulatory fetal DNA be used to study placentation at high altitude?
    Xiao Yan Zhong
    University Women s Hospital Department of Research, University of Basel, Basel, Switzerland
    Ann N Y Acad Sci 1022:124-8. 2004
    ..Our data, therefore, suggest that pregnancy at high altitude is associated with an increased liberation of cell-free fetal DNA and that no major ethnic differences are apparent...
  50. ncbi request reprint Circulatory corticotropin-releasing hormone mRNA concentrations are increased in women with preterm delivery but not in those who respond to tocolytic treatment
    Xiao Yan Zhong
    Laboratory for Prenatal Medicine, University Women s Hospital, Department of Research, University Hospital Basel, Basel, Switzerland
    Clin Chem 51:635-6. 2005
  51. doi request reprint Current understanding of mitochondrial DNA in breast cancer
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecology Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel CH 4031, Switzerland
    Breast J 15:505-9. 2009
    ....
  52. ncbi request reprint Cell-free DNA in the circulation as a potential cancer biomarker
    Corina Kohler
    Laboratory for Gynecological Oncology, Women s Hospital, Department of Research, University of Basel, Switzerland
    Anticancer Res 31:2623-8. 2011
    ..This review evaluates the potential of ccf-DNA alterations as a biomarker for cancer management by addressing the question of how large the gap between ccf-DNA and the ideal cancer biomarker is...
  53. ncbi request reprint Single cell PCR in laser capture microscopy
    Sinuhe Hahn
    Laboratory for Prenatal Medicine, Department of Obstetrics and Gynecology, University of Basel, CH 4031 Basel, Switzerland
    Methods Enzymol 356:295-301. 2002
  54. ncbi request reprint Detection of donor-specific DNA polymorphisms in the urine of renal transplant recipients
    Ying Li
    University Women s Hospital Department of Research, University of Basel, Switzerland
    Clin Chem 49:655-8. 2003
  55. doi request reprint Identification of a critical novel mutation in the exon 1 of androgen receptor gene in 2 brothers with complete androgen insensitivity syndrome
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Medicine, University of Basel, Basel, Switzerland
    J Androl 30:230-2. 2009
    ..We conclude that the novel Y514X mutation in the androgen receptor is the cause of complete androgen insensitivity syndrome in this family...
  56. doi request reprint Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncolocy, Women s Hospital Department of Medicine, University of Basel, Switzerland
    J Androl 29:506-13. 2008
    ..Around 10% of obstructive azoospermia is congenital and due to mutations in the CF gene. This review highlights the relationship of mutations in the CFTR gene with CBAVD and CAUV...
  57. doi request reprint Recent progress in non-invasive prenatal diagnosis
    Sinuhe Hahn
    University Women s Hospital Department of Biomedicine, University Hospital Basel, Switzerland
    Semin Fetal Neonatal Med 13:57-62. 2008
    ..Additionally, an exiting recent development is that it might be feasible to detect Down syndrome via the quantitative assessment of placentally derived cell-free mRNA of chromosome-21-specific genes such as PLAC4...
  58. doi request reprint Strategies of reducing input sample volume for extracting circulating cell-free nuclear DNA and mitochondrial DNA in plasma
    Weijie Chen
    Laboratory for Gynecological Oncology, Department of Biomedicine, University Women s Hospital, University of Basel, Basel, Switzerland
    Clin Chem Lab Med 50:261-5. 2012
    ..This study explored several strategies for an efficient DNA extraction to increase DNA amount from limited plasma input...
  59. doi request reprint An overview of biomarkers for the ovarian cancer diagnosis
    Bei Zhang
    Laboratory for Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Eur J Obstet Gynecol Reprod Biol 158:119-23. 2011
    ..Before biomarker tests are translated for routine use, more researches, such as retrospective and prospective clinical trials, are needed to evaluate the overall clinical utility of the tests...
  60. pmc Epigenetic therapy for breast cancer
    Feng Feng Cai
    Laboratory for Gynecological Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Hebelstrasse 20, Room 420, Basel, CH 4031, Switzerland E Mails F F C C K B Z W J C
    Int J Mol Sci 12:4465-87. 2011
    ..Therefore, the uses of epigenetic targets are believed to have great potential as a lasting favorable approach in treating breast cancer...
  61. ncbi request reprint Maternal and neonatal infections and obstetrical outcome in water birth
    Rosanna A Zanetti-Daellenbach
    Women s University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    Eur J Obstet Gynecol Reprod Biol 134:37-43. 2007
    ..The goal of our study was to assess the effect of water birth on obstetrical outcome, the maternal and neonatal infection rate in a selected low risk collective...
  62. doi request reprint A rapid and accurate approach to identify single nucleotide polymorphisms of mitochondrial DNA using MALDI-TOF mass spectrometry
    Alex Xiu-Cheng Fan
    Department of Research, University of Basel, Basel, Switzerland
    Clin Chem Lab Med 46:299-305. 2008
    ..We developed a rapid, accurate, highly sensitive and high-throughput approach with low cost to identify mtDNA SNPs...
  63. ncbi request reprint High levels of circulatory erythroblasts and cell-free DNA prior to intrauterine fetal death
    Xiao Yan Zhong
    Prenat Diagn 26:1272-3. 2006
  64. ncbi request reprint Real-time quantitative polymerase chain reaction measurement of male fetal DNA in maternal plasma
    Bernhard Zimmermann
    University Women s Hospital Department of Research, University Hospital Basel, Switzerland
    Methods Mol Med 132:43-9. 2007
    ..This chapter presents the basic methodology used in this noninvasive analysis...