Research Topics
Genomes and Genes
| Rolf ZellerSummaryAffiliation: University of Basel Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Shh and Gremlin1 chromosomal landscapes in development and diseaseRolf Zeller
Developmental Genetics, DBM Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
Curr Opin Genet Dev 17:428-34. 2007..While most of the transacting factors remain unknown, Hoxd proteins have been shown to bind to the far upstream Shh cis-regulatory elements and activate their expression in limb buds...
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signalingPascal te Welscher
Department of Developmental Biology, Faculty of Biology, Utrecht University, 3584CH Utrecht, The Netherlands
Genes Dev 16:421-6. 2002..These interactions polarize the nascent limb bud mesenchyme prior to SHH signaling...
The temporal dynamics of vertebrate limb development, teratogenesis and evolutionRolf Zeller
Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, Basel, Switzerland
Curr Opin Genet Dev 20:384-90. 2010..Finally, the adaptive diversification or loss of modern tetrapod limbs in particular phyla or species appear to be a consequence of evolutionary tampering with the regulatory systems that control distal progression of limb development...- It takes time to make a pinky: unexpected insights into how SHH patterns vertebrate digitsRolf Zeller
Developmental Genetics, Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
Sci STKE 2004:pe53. 2004..In addition, a fraction of cells changes their SHH responsiveness progressively during limb bud pattering, which is indicative of local nonlinear modulation of cell fate specification... - Vertebrate limb bud development: moving towards integrative analysis of organogenesisRolf Zeller
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Nat Rev Genet 10:845-58. 2009..The resulting integrative model provides insights into how the specification and proliferative expansion of the anteroposterior and proximodistal limb bud axes are coordinately controlled in time and space... - A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterningJean Denis Bénazet
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Science 323:1050-3. 2009..This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways... - Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud developmentAntonella Galli
Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
PLoS Genet 6:e1000901. 2010..Our study uncovers essential components of the transcriptional machinery and key interactions that set-up limb bud asymmetry upstream of establishing the SHH signaling limb bud organizer... - GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesisJavier Lopez-Rios
Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
Dev Cell 22:837-48. 2012..Thus, Gli3 is a negative regulator of the proliferative expansion of digit progenitors and acts as a gatekeeper for the exit to chondrogenic differentiation... - Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesisOdysse Michos
Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
Development 134:2397-405. 2007.... - Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryosAlexandre Gonçalves
Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Basel, Switzerland
PLoS ONE 6:e19370. 2011..Therefore, we investigated whether BMP7 in turn also participates in inhibiting ureteric bud outgrowth during the initiation of metanephric kidney development... - Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesisOdysse Michos
Developmental Genetics, Dept of Clinical Biological Sciences DKBW University of Basel Medical School, c o Anatomy Institute, Pestalozzistrasse 20, CH 4056 Basel, Switzerland
Development 131:3401-10. 2004..As a consequence, the metanephric mesenchyme is eliminated by apoptosis, in the same way as the core mesenchymal cells of the limb bud... - Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signallingLia Panman
Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
Development 133:3419-28. 2006.... - Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb budsJean Denis Bénazet
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland
Development 139:4250-60. 2012..In summary, our analysis reveals that SMAD4 is required to initiate: (1) formation of the Sox9-positive digit ray primordia; and (2) aggregation and chondrogenic differentiation of all limb skeletal elements... - Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb budsAimee Zuniga
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058, Basel, Switzerland
BMC Dev Biol 12:23. 2012..abstract:.. - Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning systemJean Denis Bénazet
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Cold Spring Harb Perspect Biol 1:a001339. 2009..Vertebrate limb-bud development is controlled by a 4-dimensional (4D) patterning system integrating positive and negative regulatory feedback loops, rather than thresholds set by morphogen gradients... - SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signallingSimone Probst
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Development 138:1913-23. 2011..In summary, SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module... - Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expressionAimee Zuniga
Developmental Genetics, Department of Clinical Biological Sciences, University of Basel Medical School, CH 4056 Basel, Switzerland
Genes Dev 18:1553-64. 2004..Our studies reveal the large genomic landscape harboring this GCR, which is required for tissue-specific coexpression of two structurally and functionally unrelated genes... - Dual RMCE for efficient re-engineering of mouse mutant allelesMarco Osterwalder
Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
Nat Methods 7:893-5. 2010..dRMCE is a scalable, flexible tool to introduce tags, reporters and mutant coding regions into an endogenous locus of interest in an easy and highly efficient manner... - Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar developmentCatherine Vaillant
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland
Development 134:1745-54. 2007..We propose that PN-1 contributes to shaping the cerebellum by promoting cell cycle exit... - Tissue remodelling through branching morphogenesisMarkus Affolter
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Nat Rev Mol Cell Biol 10:831-42. 2009..Recent experiments suggest that cell competition and cell rearrangements might be conserved key features in branch formation and might be controlled by local cell signalling... - Making sense-data-based simulations of vertebrate limb developmentDagmar Iber
Computational Biology, Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH 4058 Basel, Switzerland
Curr Opin Genet Dev 22:570-7. 2012..Such in silico genetic approaches will permit the simulation of complex mutant phenotypes tedious or impossible to generate using mouse molecular genetics... - Progression of vertebrate limb development through SHH-mediated counteraction of GLI3Pascal te Welscher
Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, NL 3584 CH Utrecht, Netherlands
Science 298:827-30. 2002..Our genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development... - Ultraconserved non-coding sequence element controls a subset of spatiotemporal GLI3 expressionZissis Paparidis
Institute of Human Genetics, Philipps University, Bahnhofstrasse 7, D35037 Marburg, Germany
Dev Growth Differ 49:543-53. 2007..Time, location, and quantity of reporter gene expression are congruent with part of the pattern previously reported for endogenous GLI3 transcription... - Genetic interaction of Gli3 and Alx4 during limb developmentLia Panman
Department of Developmental Biology, Utrecht University, Utrecht, The Netherlands
Int J Dev Biol 49:443-8. 2005..Most interestingly, the loss of the severe preaxial polydactyly characteristic of Gli3-/- limbs in double mutant embryos establishes that this type of polydactyly requires Alx4 function... - Patterning the limb before and after SHH signallingLia Panman
Department of Developmental Biology, Utrecht University, Padualaan 8, NL-3584 CH Utrecht, The Netherlands
J Anat 202:3-12. 2003..We also discuss recent results showing that differential mesenchymal responsiveness to SHH signalling is established prior to its expression by the polarizing region... - Developmental biology: first come, first servedRolf Zeller
Nature 420:138-9. 2002 - Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesisAimee Zuniga
Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Mech Dev 114:51-9. 2002..Finally, Twist function, most likely by regulating FGF signalling, is required for cell survival as apoptotic cells are detected in posterior and distal limb bud mesenchyme... - FGF2 signaling is required for the development of neuronal circuits regulating blood pressureRosanna Dono
Department of Developmental Biology, Faculty of Biology, Utrecht University, Utrecht, The Netherlands
Circ Res 90:E5-E10. 2002..The full text of this article is available at http://www.circresaha.org...