Rolf Zeller

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Shh and Gremlin1 chromosomal landscapes in development and disease
    Rolf Zeller
    Developmental Genetics, DBM Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Curr Opin Genet Dev 17:428-34. 2007
  2. pmc Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling
    Pascal te Welscher
    Department of Developmental Biology, Faculty of Biology, Utrecht University, 3584CH Utrecht, The Netherlands
    Genes Dev 16:421-6. 2002
  3. ncbi request reprint It takes time to make a pinky: unexpected insights into how SHH patterns vertebrate digits
    Rolf Zeller
    Developmental Genetics, Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Sci STKE 2004:pe53. 2004
  4. doi request reprint The temporal dynamics of vertebrate limb development, teratogenesis and evolution
    Rolf Zeller
    Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, Basel, Switzerland
    Curr Opin Genet Dev 20:384-90. 2010
  5. doi request reprint Vertebrate limb bud development: moving towards integrative analysis of organogenesis
    Rolf Zeller
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nat Rev Genet 10:845-58. 2009
  6. doi request reprint A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Science 323:1050-3. 2009
  7. doi request reprint Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland
    Development 139:4250-60. 2012
  8. pmc Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development
    Antonella Galli
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS Genet 6:e1000901. 2010
  9. doi request reprint GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis
    Javier Lopez-Rios
    Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Dev Cell 22:837-48. 2012
  10. ncbi request reprint Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
    Odysse Michos
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 134:2397-405. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Shh and Gremlin1 chromosomal landscapes in development and disease
    Rolf Zeller
    Developmental Genetics, DBM Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Curr Opin Genet Dev 17:428-34. 2007
    ..While most of the transacting factors remain unknown, Hoxd proteins have been shown to bind to the far upstream Shh cis-regulatory elements and activate their expression in limb buds...
  2. pmc Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling
    Pascal te Welscher
    Department of Developmental Biology, Faculty of Biology, Utrecht University, 3584CH Utrecht, The Netherlands
    Genes Dev 16:421-6. 2002
    ..These interactions polarize the nascent limb bud mesenchyme prior to SHH signaling...
  3. ncbi request reprint It takes time to make a pinky: unexpected insights into how SHH patterns vertebrate digits
    Rolf Zeller
    Developmental Genetics, Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Sci STKE 2004:pe53. 2004
    ..In addition, a fraction of cells changes their SHH responsiveness progressively during limb bud pattering, which is indicative of local nonlinear modulation of cell fate specification...
  4. doi request reprint The temporal dynamics of vertebrate limb development, teratogenesis and evolution
    Rolf Zeller
    Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, Basel, Switzerland
    Curr Opin Genet Dev 20:384-90. 2010
    ..Finally, the adaptive diversification or loss of modern tetrapod limbs in particular phyla or species appear to be a consequence of evolutionary tampering with the regulatory systems that control distal progression of limb development...
  5. doi request reprint Vertebrate limb bud development: moving towards integrative analysis of organogenesis
    Rolf Zeller
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nat Rev Genet 10:845-58. 2009
    ..The resulting integrative model provides insights into how the specification and proliferative expansion of the anteroposterior and proximodistal limb bud axes are coordinately controlled in time and space...
  6. doi request reprint A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Science 323:1050-3. 2009
    ..This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways...
  7. doi request reprint Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland
    Development 139:4250-60. 2012
    ..In summary, our analysis reveals that SMAD4 is required to initiate: (1) formation of the Sox9-positive digit ray primordia; and (2) aggregation and chondrogenic differentiation of all limb skeletal elements...
  8. pmc Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development
    Antonella Galli
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS Genet 6:e1000901. 2010
    ..Our study uncovers essential components of the transcriptional machinery and key interactions that set-up limb bud asymmetry upstream of establishing the SHH signaling limb bud organizer...
  9. doi request reprint GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis
    Javier Lopez-Rios
    Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Dev Cell 22:837-48. 2012
    ..Thus, Gli3 is a negative regulator of the proliferative expansion of digit progenitors and acts as a gatekeeper for the exit to chondrogenic differentiation...
  10. ncbi request reprint Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
    Odysse Michos
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 134:2397-405. 2007
    ....
  11. doi request reprint The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development
    Simone Probst
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Differentiation 85:121-30. 2013
    ....
  12. pmc Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds
    Aimee Zuniga
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058, Basel, Switzerland
    BMC Dev Biol 12:23. 2012
    ..Previous analysis identified a distant cis-regulatory landscape within the neighbouring Formin1 (Fmn1) locus that is required for Grem1 expression, reminiscent of the genomic landscapes controlling HoxD and Shh expression in limb buds...
  13. pmc Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos
    Alexandre Gonçalves
    Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Basel, Switzerland
    PLoS ONE 6:e19370. 2011
    ..Therefore, we investigated whether BMP7 in turn also participates in inhibiting ureteric bud outgrowth during the initiation of metanephric kidney development...
  14. ncbi request reprint Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling
    Lia Panman
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 133:3419-28. 2006
    ....
  15. ncbi request reprint Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis
    Odysse Michos
    Developmental Genetics, Dept of Clinical Biological Sciences DKBW University of Basel Medical School, c o Anatomy Institute, Pestalozzistrasse 20, CH 4056 Basel, Switzerland
    Development 131:3401-10. 2004
    ..As a consequence, the metanephric mesenchyme is eliminated by apoptosis, in the same way as the core mesenchymal cells of the limb bud...
  16. pmc Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Cold Spring Harb Perspect Biol 1:a001339. 2009
    ..Vertebrate limb-bud development is controlled by a 4-dimensional (4D) patterning system integrating positive and negative regulatory feedback loops, rather than thresholds set by morphogen gradients...
  17. pmc SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling
    Simone Probst
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 138:1913-23. 2011
    ..In summary, SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module...
  18. pmc Dual RMCE for efficient re-engineering of mouse mutant alleles
    Marco Osterwalder
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Nat Methods 7:893-5. 2010
    ..dRMCE is a scalable, flexible tool to introduce tags, reporters and mutant coding regions into an endogenous locus of interest in an easy and highly efficient manner...
  19. pmc Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression
    Aimee Zuniga
    Developmental Genetics, Department of Clinical Biological Sciences, University of Basel Medical School, CH 4056 Basel, Switzerland
    Genes Dev 18:1553-64. 2004
    ..Our studies reveal the large genomic landscape harboring this GCR, which is required for tissue-specific coexpression of two structurally and functionally unrelated genes...
  20. doi request reprint The molecular basis of human congenital limb malformations
    Aimee Zuniga
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Wiley Interdiscip Rev Dev Biol 1:803-22. 2012
    ..This review highlights how the current understanding of the molecular gene networks and interactions that control mouse limb bud development provides insight into the etiology of human congenital limb malformations...
  21. doi request reprint Making sense-data-based simulations of vertebrate limb development
    Dagmar Iber
    Computational Biology, Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH 4058 Basel, Switzerland
    Curr Opin Genet Dev 22:570-7. 2012
    ..Such in silico genetic approaches will permit the simulation of complex mutant phenotypes tedious or impossible to generate using mouse molecular genetics...
  22. doi request reprint Tissue remodelling through branching morphogenesis
    Markus Affolter
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Nat Rev Mol Cell Biol 10:831-42. 2009
    ..Recent experiments suggest that cell competition and cell rearrangements might be conserved key features in branch formation and might be controlled by local cell signalling...
  23. ncbi request reprint Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development
    Catherine Vaillant
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland
    Development 134:1745-54. 2007
    ..We propose that PN-1 contributes to shaping the cerebellum by promoting cell cycle exit...
  24. doi request reprint Dual requirement of ectodermal Smad4 during AER formation and termination of feedback signaling in mouse limb buds
    Jean Denis Bénazet
    Department Biomedicine, Developmental Genetics, University of Basel, Mattenstrasse 28, CH 4058, Basel, Switzerland
    Genesis 51:660-6. 2013
    ..In summary, our genetic analysis reveals the temporally and functionally distinct dual requirement of ectodermal Smad4 during initiation and termination of AER signaling...
  25. ncbi request reprint Progression of vertebrate limb development through SHH-mediated counteraction of GLI3
    Pascal te Welscher
    Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, NL 3584 CH Utrecht, Netherlands
    Science 298:827-30. 2002
    ..Our genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development...
  26. ncbi request reprint Ultraconserved non-coding sequence element controls a subset of spatiotemporal GLI3 expression
    Zissis Paparidis
    Institute of Human Genetics, Philipps University, Bahnhofstrasse 7, D35037 Marburg, Germany
    Dev Growth Differ 49:543-53. 2007
    ..Time, location, and quantity of reporter gene expression are congruent with part of the pattern previously reported for endogenous GLI3 transcription...
  27. ncbi request reprint Genetic interaction of Gli3 and Alx4 during limb development
    Lia Panman
    Department of Developmental Biology, Utrecht University, Utrecht, The Netherlands
    Int J Dev Biol 49:443-8. 2005
    ..Most interestingly, the loss of the severe preaxial polydactyly characteristic of Gli3-/- limbs in double mutant embryos establishes that this type of polydactyly requires Alx4 function...
  28. pmc Patterning the limb before and after SHH signalling
    Lia Panman
    Department of Developmental Biology, Utrecht University, Padualaan 8, NL 3584 CH Utrecht, The Netherlands
    J Anat 202:3-12. 2003
    ..We also discuss recent results showing that differential mesenchymal responsiveness to SHH signalling is established prior to its expression by the polarizing region...
  29. ncbi request reprint Developmental biology: first come, first served
    Rolf Zeller
    Nature 420:138-9. 2002
  30. ncbi request reprint Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis
    Aimee Zuniga
    Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Mech Dev 114:51-9. 2002
    ..Finally, Twist function, most likely by regulating FGF signalling, is required for cell survival as apoptotic cells are detected in posterior and distal limb bud mesenchyme...
  31. ncbi request reprint FGF2 signaling is required for the development of neuronal circuits regulating blood pressure
    Rosanna Dono
    Department of Developmental Biology, Faculty of Biology, Utrecht University, Utrecht, The Netherlands
    Circ Res 90:E5-E10. 2002
    ..The full text of this article is available at http://www.circresaha.org...