Jozsef Zakany

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi A dual role for Hox genes in limb anterior-posterior asymmetry
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Program Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 304:1669-72. 2004
  2. ncbi The role of Hox genes during vertebrate limb development
    Jozsef Zakany
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Curr Opin Genet Dev 17:359-66. 2007
  3. ncbi Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Biol 306:883-93. 2007
  4. pmc Uncoupling time and space in the collinear regulation of Hox genes
    Patrick Tschopp
    Department of Zoology and Animal Biology, National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland
    PLoS Genet 5:e1000398. 2009
  5. pmc Distinct roles and regulations for HoxD genes in metanephric kidney development
    Nicolas Di-Poï
    Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland
    PLoS Genet 3:e232. 2007
  6. doi A function for all posterior Hoxd genes during digit development?
    Saskia Delpretti
    National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Federale, Lausanne, Switzerland
    Dev Dyn 241:792-802. 2012
  7. ncbi Hox gene function in vertebrate gut morphogenesis: the case of the caecum
    Giovanna Zacchetti
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Development 134:3967-73. 2007
  8. ncbi Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function
    Marie Kmita
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nature 435:1113-6. 2005
  9. ncbi Tinkering with constraints in the evolution of the vertebrate limb anterior-posterior polarity
    Denis Duboule
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Novartis Found Symp 284:130-7; discussion 138-41, 158-63. 2007
  10. doi A genetic basis for altered sexual behavior in mutant female mice
    Jozsef Zakany
    National Research Centre Frontiers in Genetics, Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland
    Curr Biol 22:1676-80. 2012

Collaborators

Detail Information

Publications10

  1. ncbi A dual role for Hox genes in limb anterior-posterior asymmetry
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Program Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 304:1669-72. 2004
    ..This signal is subsequently translated into digit morphological asymmetry by promoting the late expression of Hoxd genes, two collinear processes relying on opposite genomic topographies, upstream and downstream Shh signaling...
  2. ncbi The role of Hox genes during vertebrate limb development
    Jozsef Zakany
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Curr Opin Genet Dev 17:359-66. 2007
    ..With this in mind, the functional input of Hox genes during limb growth and development can now be re-assessed...
  3. ncbi Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10
    Jozsef Zakany
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Biol 306:883-93. 2007
    ..The nature of these potential interactions is discussed in the context of proximal-distal growth and patterning...
  4. pmc Uncoupling time and space in the collinear regulation of Hox genes
    Patrick Tschopp
    Department of Zoology and Animal Biology, National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Geneva, Switzerland
    PLoS Genet 5:e1000398. 2009
    ..We discuss the potential functions and evolutionary origins of these mechanisms, as well as their relationship with similar processes at work during limb development...
  5. pmc Distinct roles and regulations for HoxD genes in metanephric kidney development
    Nicolas Di-Poï
    Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland
    PLoS Genet 3:e232. 2007
    ..These insights further our knowledge of the genetic control of kidney morphogenesis and may contribute to understanding certain congenital kidney malformations, including polycystic kidney disease and renal hypoplasia...
  6. doi A function for all posterior Hoxd genes during digit development?
    Saskia Delpretti
    National Research Centre Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Federale, Lausanne, Switzerland
    Dev Dyn 241:792-802. 2012
    ..We used a combination of five small nested deletions in cis, involving from two to four consecutive genes of the Hoxd13 to Hoxd9 loci, in mice, to evaluate their combined functional importance...
  7. ncbi Hox gene function in vertebrate gut morphogenesis: the case of the caecum
    Giovanna Zacchetti
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Development 134:3967-73. 2007
    ..These results illuminate components of the genetic cascade necessary for the emergence of this gut segment, crucial for many vertebrates...
  8. ncbi Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function
    Marie Kmita
    Department of Zoology and Animal Biology and National Research Centre Frontiers in Genetics, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nature 435:1113-6. 2005
    ..Accordingly, these mutant limbs may be reminiscent of an ancestral trunk extension, related to that proposed for arthropods...
  9. ncbi Tinkering with constraints in the evolution of the vertebrate limb anterior-posterior polarity
    Denis Duboule
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Novartis Found Symp 284:130-7; discussion 138-41, 158-63. 2007
    ..This major regulatory constraint imposed a polarity to our limbs as the most parsimonious solution to grow appendages...
  10. doi A genetic basis for altered sexual behavior in mutant female mice
    Jozsef Zakany
    National Research Centre Frontiers in Genetics, Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland
    Curr Biol 22:1676-80. 2012
    ..The potential relevance to human 2q.31.1 microdeletion syndrome is discussed...