Anna Wirz-Justice

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 32:1-5. 2002
  2. ncbi A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Wilhelm Klein Strasse 27, CH 4012 Basel, Switzerland
    J Clin Psychiatry 72:986-93. 2011
  3. pmc Temporal organization as a therapeutic target
    Anna Wirz-Justice
    Professor Emeritus, Centre for Chronobiology, Psychiatric Hospitals, University of Basel, Basel, Switzerland
    Dialogues Clin Neurosci 14:335-7. 2012
  4. ncbi Disturbed circadian rest-activity cycles in schizophrenia patients: an effect of drugs?
    A Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Schizophr Bull 27:497-502. 2001
  5. ncbi Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 36:192-4. 2004
  6. ncbi Biological rhythm disturbances in mood disorders
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Int Clin Psychopharmacol 21:S11-5. 2006
  7. pmc Diurnal variation of depressive symptoms
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Dialogues Clin Neurosci 10:337-43. 2008
  8. doi The circadian rest-activity cycle in Korsakoff psychosis
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospital of University Basel, Basel, Switzerland
    Am J Geriatr Psychiatry 18:33-41. 2010
  9. ncbi Circadian modulation of sequence learning under high and low sleep pressure conditions
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, University of Basel, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 151:167-76. 2004
  10. ncbi Age-related attenuation of the evening circadian arousal signal in humans
    Mirjam Munch
    Centre for Chronobiology, University Psychiatric Hospitals, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Neurobiol Aging 26:1307-19. 2005

Collaborators

Detail Information

Publications56

  1. ncbi No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 32:1-5. 2002
    ..This study's failure to find significant delays to a single administration does not negate other positive findings with multiple doses, which may be necessary for a 'weak zeitgeber'...
  2. ncbi A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Wilhelm Klein Strasse 27, CH 4012 Basel, Switzerland
    J Clin Psychiatry 72:986-93. 2011
    ..Affective disorder during pregnancy is a common condition requiring careful judgment to treat the depression while minimizing risk to the fetus. Following up on promising pilot trials, we studied the efficacy of light therapy...
  3. pmc Temporal organization as a therapeutic target
    Anna Wirz-Justice
    Professor Emeritus, Centre for Chronobiology, Psychiatric Hospitals, University of Basel, Basel, Switzerland
    Dialogues Clin Neurosci 14:335-7. 2012
    ..This issue on biological rhythms contains articles on a variety of different frequencies not included in the usual definition of chronobiology, but which open up interesting approaches to time and illness...
  4. ncbi Disturbed circadian rest-activity cycles in schizophrenia patients: an effect of drugs?
    A Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Schizophr Bull 27:497-502. 2001
    ..This is the first documentation of circadian rest-activity cycle disturbances in schizophrenia related to class of drug...
  5. ncbi Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 36:192-4. 2004
    ..Melatonin suppression is not necessary for a phase shift by light, and melatonin is not a 'weak' Zeitgeber relative to bright light when ambient lighting is strictly controlled...
  6. ncbi Biological rhythm disturbances in mood disorders
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Int Clin Psychopharmacol 21:S11-5. 2006
    ..Chronobiology has provided efficacious non-pharmaceutical treatments for mood disorders (such as sleep deprivation or light therapy) as well as novel approaches to new drugs (e.g. agomelatine)...
  7. pmc Diurnal variation of depressive symptoms
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Dialogues Clin Neurosci 10:337-43. 2008
    ..The implications for treatment are to stabilize mood state by enhancing synchronization of the sleep-wake cycle with the biological clock (eg, with light therapy)...
  8. doi The circadian rest-activity cycle in Korsakoff psychosis
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospital of University Basel, Basel, Switzerland
    Am J Geriatr Psychiatry 18:33-41. 2010
    ..This pilot study investigated the rest-activity cycle of KP to see whether there were sleep-wake cycle disturbances similar to those that the authors had observed in patients with AD...
  9. ncbi Circadian modulation of sequence learning under high and low sleep pressure conditions
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, University of Basel, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 151:167-76. 2004
    ..Our data indicate that sequence learning is modulated by circadian phase, and the neurophysiological medium required for this type of learning is related to sleep...
  10. ncbi Age-related attenuation of the evening circadian arousal signal in humans
    Mirjam Munch
    Centre for Chronobiology, University Psychiatric Hospitals, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Neurobiol Aging 26:1307-19. 2005
    ..Thus, our data indicate that age-related changes in sleep propensity are clearly related to a reduced circadian signal opposing the homeostatic drive for sleep...
  11. doi Young women with major depression live on higher homeostatic sleep pressure than healthy controls
    Sylvia Frey
    Centre for Chronobiology, Psychiatric Hospital of University of Basel, Basel, Switzerland
    Chronobiol Int 29:278-94. 2012
    ..This finding may have important repercussions on the treatment of the illness as such that a selective suppression of EEG slow-wave activity could promote acute mood improvement...
  12. ncbi High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    J Clin Endocrinol Metab 90:1311-6. 2005
    ....
  13. doi Subjective well-being is modulated by circadian phase, sleep pressure, age, and gender
    Angelina Birchler-Pedross
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    J Biol Rhythms 24:232-42. 2009
    ..The results demonstrate age- and/or gender-related modifications of well-being related to sleep deprivation and circadian phase and thus point to specific biological components of mood vulnerability...
  14. ncbi Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 32:59-62. 2002
    ..There was a distinct increase in staining intensity in all AD cases indicating an up-regulation of the receptor, possibly as a compensatory response to impaired melatonin levels in order to augment melatonin's neuroprotective effects...
  15. ncbi Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions
    Katharina Blatter
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 168:312-7. 2006
    ..Not only sleepiness and circadian phase, but also age and gender are major factors that may contribute to attentional failures in extended work shifts and during nighttime work shifts...
  16. ncbi Age-related changes in the circadian and homeostatic regulation of human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Chronobiol Int 23:461-74. 2006
    ..Our data suggest that manipulations of the circadian timing system, rather than the sleep homeostat, may offer a potential strategy to alleviate age-related decrements in sleep and daytime alertness levels...
  17. ncbi Age-related changes in the circadian modulation of sleep-spindle frequency during nap sleep
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Hospitals, Wilhelm Kleinstr, Basel, Switzerland
    Sleep 28:1093-101. 2005
    ..We investigated whether this circadian modulation of spindle characteristics changes with age...
  18. ncbi Evidence that the lunar cycle influences human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, 4012 Basel, Switzerland
    Curr Biol 23:1485-8. 2013
    ..This is the first reliable evidence that a lunar rhythm can modulate sleep structure in humans when measured under the highly controlled conditions of a circadian laboratory study protocol without time cues. ..
  19. ncbi Challenging the sleep homeostat does not influence the thermoregulatory system in men: evidence from a nap vs. sleep-deprivation study
    Kurt Krauchi
    Psychiatric University Clinics, Centre for Chronobiology, Wilhelm Klein Strasse 27, H4025 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1052-61. 2006
    ..In summary, the thermoregulatory system seems to be independent of the sleep homeostat, but the circadian modulation of sleepiness and sleep inertia is clearly associated with thermoregulatory changes...
  20. doi Sleep-wake cycles and cognitive functioning in schizophrenia
    Vivien Bromundt
    Centre for Chronobiology, Psychiatric Hospital, University of Basel, Switzerland
    Br J Psychiatry 198:269-76. 2011
    ..Irregular sleep-wake cycles and cognitive impairment are frequently observed in schizophrenia, however, how they interact remains unclear...
  21. doi Estimation of human circadian phase via a multi-channel ambulatory monitoring system and a multiple regression model
    Vitaliy Kolodyazhniy
    Department of Clinical Psychology and Psychotherapy, Faculty for Psychology, University of Basel, Basel, Switzerland
    J Biol Rhythms 26:55-67. 2011
    ..The proposed noninvasive measurement method could find applications in sleep medicine or in other domains where knowing the exact endogenous circadian phase is important (e.g., for the timing of light therapy)...
  22. pmc Higher frontal EEG synchronization in young women with major depression: a marker for increased homeostatic sleep pressure?
    Angelina Birchler-Pedross
    Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Basel, Switzerland
    Sleep 34:1699-706. 2011
    ..Major depressive disorder (MDD) is often associated with disturbances in circadian and/or sleep-wake dependent processes, which both regulate daytime energy and sleepiness levels...
  23. ncbi Encoding difficulty promotes postlearning changes in sleep spindle activity during napping
    Christina Schmidt
    Centre for Chronobiology, Psychiatric University Clinics, CH 4025 Basel, Switzerland
    J Neurosci 26:8976-82. 2006
    ..Furthermore, we demonstrate here that the nature of the learning material is a determinant factor for sleep-related alterations after declarative learning...
  24. ncbi Thermoregulatory effects of melatonin in relation to sleepiness
    Kurt Krauchi
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    Chronobiol Int 23:475-84. 2006
    ..Besides the role of melatonin as "nature's soporific", it can also serve as nature's nocturnal vascular modulator...
  25. ncbi Waking up properly: is there a role of thermoregulation in sleep inertia?
    Kurt Krauchi
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Sleep Res 13:121-7. 2004
    ..In order to directly test our hypothesis, further studies with thermophysiological interventions (e.g. cooling the extremities) are needed...
  26. ncbi Distribution of melatonin MT1 receptor immunoreactivity in human retina
    Egemen Savaskan
    Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    J Histochem Cytochem 50:519-26. 2002
    ..In AD cases photoreceptor cells were degenerated and showed low MT1 expression...
  27. ncbi Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment
    Stephanie Vollenweider
    Psychiatric University Clinics, Thermophysiological Chronobiology, Centre for Chronobiology, Wilhelm Klein Strasse 27, Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 294:R630-8. 2008
    ..2 h; P = 0.01). Similar phase shifts were observed in CBT, DPG, and KSS ratings. In conclusion, WVD exhibit a phase delay of the endogenous circadian system with respect to their habitual sleep-wake cycle, which could be a cause of DIS...
  28. pmc Is homeostatic sleep regulation under low sleep pressure modified by age?
    Mirjam Munch
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Sleep 30:781-92. 2007
    ..Here, we investigated age-related changes in homeostatic sleep regulation under low sleep pressure conditions, with respect to regional EEG differences and their dynamics...
  29. ncbi Thermophysiologic aspects of the three-process-model of sleepiness regulation
    Kurt Krauchi
    Psychiatric University Clinic, Centre for Chronobiology, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    Clin Sports Med 24:287-300, ix. 2005
    ..Sleep per se has no further thermoregulatory effect. Taken together, a thermophysiologic approach may provide a successful strategy to treat sleep-onset insomnia and alleviate sleep inertia...
  30. ncbi Sleep loss-related decrements in planning performance in healthy elderly depend on task difficulty
    Katharina Blatter
    Centre for Chronobiology, University Psychiatric Clinics, Basel, Switzerland
    J Sleep Res 14:409-17. 2005
    ..These results indicate that sleep loss-related decrements in planning performance depend on difficulty level, and that apparently insensitive tasks can turn out to be sensitive to sleep loss and circadian variation...
  31. doi Validation of a single item to assess daytime sleepiness for the Swiss Transplant Cohort Study
    Hanna Burkhalter
    University of Basel, Switzerland University Hospital Basel, Switzerland
    Prog Transplant 23:220-8. 2013
    ..Thus there is a need to assess daytime sleepiness in clinical practice and transplant registries...
  32. doi Daytime sleepiness in renal transplant recipients is associated with immunosuppressive non-adherence: a cross-sectional, multi-center study
    Hanna Burkhalter
    Institute of Nursing Science, University of Basel, Basel, Switzerland Division of Transplant Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Clin Transplant 28:58-66. 2014
    ....
  33. ncbi Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men
    Mirjam Munch
    Centre for Chronobiology, Psychiatric Univ Clinics, University of Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1421-8. 2006
    ..Our results can be interpreted in terms of an induction of a circadian phase delay and/or repercussions of a stronger alerting effect after blue light, persisting into the sleep episode...
  34. ncbi Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly
    Paola Fontana Gasio
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Exp Gerontol 38:207-16. 2003
    ..Increasing zeitgeber strength is an important strategy for improving sleep quality and timing in dementia, and DDS light therapy may provide one of the appropriate means to do so...
  35. ncbi Alteration of internal circadian phase relationships after morning versus evening carbohydrate-rich meals in humans
    Kurt Krauchi
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    J Biol Rhythms 17:364-76. 2002
    ..Food may be a zeitgeber in humans for the food-entrainable peripheral oscillators, but melatonin data do not support such a conclusion for the light-entrainable oscillator in the suprachiasmatic nucleus...
  36. doi Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance
    Christian Cajochen
    Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Basel, Switzerland
    J Appl Physiol (1985) 110:1432-8. 2011
    ..The challenge will be to design a computer screen with a spectral profile that can be individually programmed to add timed, essential light information to the circadian system in humans...
  37. ncbi Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, University of Basel, CH 4025 Basel, Switzerland
    Eur J Neurosci 23:1082-6. 2006
    ..The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders...
  38. ncbi Circadian and wake-dependent modulation of fastest and slowest reaction times during the psychomotor vigilance task
    Peter Graw
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025, Basel, Switzerland
    Physiol Behav 80:695-701. 2004
    ..On the other hand, decrements in PVT performance which were related to circadian phase did not depend significantly on any categorization (such as percentiles of the RTs)...
  39. pmc Self-reported sleep disturbances in renal transplant recipients
    Hanna Burkhalter
    Institute of Nursing Science, University of Basel, Basel, Switzerland
    BMC Nephrol 14:220. 2013
    ..Poor sleep quality (SQ) and daytime sleepiness (DS) are common in renal transplant (RTx) recipients; however, related data are rare. This study describes the prevalence and frequency of self-reported sleep disturbances in RTx recipients...
  40. ncbi Colour vision deficiencies in Alzheimer's disease
    Mona Pache
    University Eye Clinic, Mittlere Strasse 91, CH 4012 Basel, Switzerland
    Age Ageing 32:422-6. 2003
    ..In this study, colour vision of Alzheimer's disease patients was tested using the Ishihara test and the PV-16 choice test. The latter test, primarily designed for children, was chosen in order to avoid problems due to cognitive decline...
  41. ncbi The frontal predominance in human EEG delta activity after sleep loss decreases with age
    Mirjam Munch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, 4025 Basel, Switzerland
    Eur J Neurosci 20:1402-10. 2004
    ..These findings provide quantitative evidence for the hypothesis that frontal brain regions are particularly vulnerable to the effects of elevated sleep pressure ('prefrontal tiredness') and ageing ('frontal ageing')...
  42. ncbi Human sleep spindle characteristics after sleep deprivation
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Clin Neurophysiol 114:2258-67. 2003
    ..The effect of a 40 h sleep deprivation (SD) on spindle characteristics along the antero-posterior axis was investigated...
  43. ncbi Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Basel, Switzerland
    Gerontology 49:380-3. 2003
    ..Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol...
  44. pmc Serum factors in older individuals change cellular clock properties
    Lucia Pagani
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, CH 4012 Basel, Switzerland
    Proc Natl Acad Sci U S A 108:7218-23. 2011
    ..Thus, even though the molecular machinery of peripheral circadian clocks does not change with age, some age-related circadian dysfunction observed in vivo might be of hormonal origin and therefore might be pharmacologically remediable...
  45. ncbi Regional differences in the circadian modulation of human sleep spindle characteristics
    Vera Knoblauch
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str 27, 4025 Basel, Switzerland
    Eur J Neurosci 18:155-63. 2003
    ..Our data provide evidence that the circadian pacemaker actively promotes low-frequency sleep spindles during the biological night with a parietal predominance...
  46. ncbi Orexins and their receptors in the human retina
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Pathobiology 71:211-6. 2004
    ..In the human retina, however, immunohistochemical localization of orexins and their receptors, OX-R1 and OX-R2, has not been ascertained...
  47. ncbi Validity of 2 sleep quality items to be used in a large cohort study of kidney transplant recipients
    Hanna Burkhalter
    University of Basel, Center for Chronobiology, Switzerland
    Prog Transplant 21:27-35. 2011
    ..Poor sleep quality and poor daytime functioning affect many kidney transplant patients...
  48. ncbi Effect of melatonin on vascular responses of porcine ciliary arteries
    Mona Pache
    Basel University Eye Clinic, Basel, Switzerland
    Curr Eye Res 24:313-7. 2002
    ..To investigate the effect of melatonin on isolated porcine ciliary arteries...
  49. ncbi Chronotherapeutics (light and wake therapy) as a class of interventions for affective disorders
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Clinics, University of Basel, Switzerland
    Handb Clin Neurol 106:697-713. 2012
    ..Here, we consider light exposure and sleep deprivation (more positively known as "wake therapy") as first-line treatments for major depression, and we provide guidelines for use...
  50. ncbi Brightening depression
    Anna Wirz-Justice
    Science 303:467-9. 2004
  51. ncbi Life between clocks: daily temporal patterns of human chronotypes
    Till Roenneberg
    Center for Chronobiology, Institute for Medical Psychology, Munich, Germany
    J Biol Rhythms 18:80-90. 2003
    ..The implications are far ranging concerning learning, memory, vigilance, performance, and quality of life...
  52. ncbi Melatonin reduces arousal and startle responsiveness without influencing startle habituation or affective startle modulation in young women
    Hartmut Schachinger
    Clinical Physiology, Graduate School of Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
    Horm Behav 54:258-62. 2008
    ..We conclude that melatonin reduces arousal and startle responsiveness. However, no evidence for a direct emotion-modulating effect of melatonin was found in this healthy cohort...
  53. ncbi Is sleep per se a zeitgeber in humans?
    Konstantin V Danilenko
    Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, 630003 Novosibirsk, Russia
    J Biol Rhythms 18:170-8. 2003
    ..02) and by 0.27 +/- 0.14 h for melatonin rhythms (p = 0.09). However, this advance was small to medium according to effect size. Sleep per se may feed back onto the circadian pacemaker, but it appears to be a weak zeitgeber in humans...
  54. ncbi Chronobiology and psychiatry
    Anna Wirz-Justice
    Sleep Med Rev 11:423-7. 2007
  55. ncbi Chronotherapeutics (light and wake therapy) in affective disorders
    Anna Wirz-Justice
    Psychol Med 35:939-44. 2005
    ..3) Given the urgent need for new strategies to treat patients with residual depressive symptoms, clinical trials of wake therapy and/or adjuvant light therapy, coupled with follow-up studies of long-term recurrence, are a high priority...
  56. ncbi Rutger Wever: an appreciation
    Anna Wirz-Justice
    J Biol Rhythms 20:554-5. 2005