Yves Wespi

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study
    H M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, Switzerland
    Br J Cancer 94:231-8. 2006
  2. pmc Remarkable change in age-specific breast cancer incidence in the Swiss canton of Geneva and its possible relation with the use of hormone replacement therapy
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205 Geneva, Switzerland
    BMC Cancer 6:78. 2006
  3. ncbi Undertreatment strongly decreases prognosis of breast cancer in elderly women
    Christine Bouchardy
    Geneva Cancer Registry, 55 Boulevard de la Cluse 55, 1205 Geneva, Switzerland
    J Clin Oncol 21:3580-7. 2003
  4. ncbi Older female cancer patients: importance, causes, and consequences of undertreatment
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, Geneva, Switzerland
    J Clin Oncol 25:1858-69. 2007
  5. pmc Recent increase of breast cancer incidence among women under the age of forty
    C Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, 55, Bd de la Cluse, 1205 Geneva, Switzerland
    Br J Cancer 96:1743-6. 2007
  6. ncbi Metabolic genetic polymorphisms and susceptibility to lung cancer
    C Bouchardy
    Geneva Cancer Registry, Boulevard de la Cluse 55, 1205 Geneva, Switzerland
    Lung Cancer 32:109-12. 2001
  7. ncbi Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract
    C Bouchardy
    Geneva Cancer Registry, Geneva, Switzerland
    Int J Cancer 87:734-40. 2000
  8. doi Increased risk of second cancer among patients with ovarian borderline tumors
    Christine Bouchardy
    Geneva Cancer Registry, Institute of Social and Preventive Medicine, Geneva University, Geneva, Switzerland
    Gynecol Oncol 109:210-4. 2008
  9. doi Impact of a positive family history on diagnosis, management, and survival of breast cancer: different effects across socio-economic groups
    H M Verkooijen
    Geneva Cancer Registry, Geneva University, Geneva, Switzerland
    Cancer Causes Control 20:1689-96. 2009
  10. ncbi Increased risk of acute myeloid leukaemia after treatment for breast cancer
    R Renella
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, 55 Boulevard de la Cluse, 1205 Geneva, Switzerland
    Breast 15:614-9. 2006

Detail Information

Publications54

  1. pmc Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study
    H M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, Switzerland
    Br J Cancer 94:231-8. 2006
    ..Owing to the limited number of patients in this study, these results should be used only to generate hypotheses...
  2. pmc Remarkable change in age-specific breast cancer incidence in the Swiss canton of Geneva and its possible relation with the use of hormone replacement therapy
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205 Geneva, Switzerland
    BMC Cancer 6:78. 2006
    ..This article aims to explain the reasons for the remarkable change in age of breast cancer occurrence in the Swiss canton of Geneva...
  3. ncbi Undertreatment strongly decreases prognosis of breast cancer in elderly women
    Christine Bouchardy
    Geneva Cancer Registry, 55 Boulevard de la Cluse 55, 1205 Geneva, Switzerland
    J Clin Oncol 21:3580-7. 2003
    ..Treatments are influenced by unclear standards and are usually less aggressive. This study aims to evaluate determinants and effect of treatment choice on breast cancer prognosis among elderly patients...
  4. ncbi Older female cancer patients: importance, causes, and consequences of undertreatment
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, Geneva, Switzerland
    J Clin Oncol 25:1858-69. 2007
    ..Treatments are still influenced by unclear standards and have to be adapted to the older patient's general health status, but should also offer the best chance of cure...
  5. pmc Recent increase of breast cancer incidence among women under the age of forty
    C Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, 55, Bd de la Cluse, 1205 Geneva, Switzerland
    Br J Cancer 96:1743-6. 2007
    ..Using data from the Geneva Cancer Registry, we found that in 2002-2004, breast cancer incidence in women aged 25-39 years increased by 46.7% per year (95% CI: 7.1-74.0, P=0.015), which surveillance or detection bias may not fully explain...
  6. ncbi Metabolic genetic polymorphisms and susceptibility to lung cancer
    C Bouchardy
    Geneva Cancer Registry, Boulevard de la Cluse 55, 1205 Geneva, Switzerland
    Lung Cancer 32:109-12. 2001
    ..This article summarizes the state of knowledge on metabolic polymorphisms and lung cancer susceptibility, and opens the discussion on the future direction of this promising way of research...
  7. ncbi Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract
    C Bouchardy
    Geneva Cancer Registry, Geneva, Switzerland
    Int J Cancer 87:734-40. 2000
    ..Our study suggests that CYP2E1 genotype modifies the risk of UAT cancers, but due to the low frequency of CYP2E1 variant alleles, large-scale studies are needed to confirm our findings...
  8. doi Increased risk of second cancer among patients with ovarian borderline tumors
    Christine Bouchardy
    Geneva Cancer Registry, Institute of Social and Preventive Medicine, Geneva University, Geneva, Switzerland
    Gynecol Oncol 109:210-4. 2008
    ..Such risk has not been investigated for ovarian borderline tumors. We aim to evaluate the risk of subsequent cancer occurrence among patients with borderline ovarian tumors in a population-based setting...
  9. doi Impact of a positive family history on diagnosis, management, and survival of breast cancer: different effects across socio-economic groups
    H M Verkooijen
    Geneva Cancer Registry, Geneva University, Geneva, Switzerland
    Cancer Causes Control 20:1689-96. 2009
    ..This study aims to investigate whether increased awareness of breast cancer, due to a positive family history (FH), reduces diagnostic, therapeutic, and survival differences between women of low versus high socio-economic status (SES)...
  10. ncbi Increased risk of acute myeloid leukaemia after treatment for breast cancer
    R Renella
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, 55 Boulevard de la Cluse, 1205 Geneva, Switzerland
    Breast 15:614-9. 2006
    ..Due to the relatively low number of women treated with chemotherapy without radiotherapy and due to the infrequency of the disease, the question of whether chemotherapy alone increases this risk of AML cannot yet be answered...
  11. doi Hormonal therapy for oestrogen receptor-negative breast cancer is associated with higher disease-specific mortality
    A Merglen
    Geneva Cancer Registry, Institute of Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Ann Oncol 20:857-61. 2009
    ..Without proven benefits, tamoxifen is occasionally prescribed for women with ER-negative disease. This population-based study aims to estimate the impact of tamoxifen on the outcome of ER-negative disease...
  12. ncbi Set-up of a population-based familial breast cancer registry in Geneva, Switzerland: validation of first results
    H M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, Geneva
    Ann Oncol 15:350-3. 2004
    ..This article evaluates the accuracy of family history of breast and ovarian cancer among first-degree relatives of breast cancer patients, retrospectively collected during the setting up of a population-based family breast cancer registry...
  13. doi Excess of cardiovascular mortality among node-negative breast cancer patients irradiated for inner-quadrant tumors
    C Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Switzerland
    Ann Oncol 21:459-65. 2010
    ..Radiotherapy of inner quadrants can be associated with greater heart irradiation, but no study has evaluated the effect of inner-quadrant irradiation on cardiovascular mortality...
  14. doi Changing pattern of age-specific breast cancer incidence in the Swiss canton of Geneva
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland
    Breast Cancer Res Treat 120:519-23. 2010
    ....
  15. pmc Adjuvant chemotherapy for colon carcinoma with positive lymph nodes: use and benefit in routine health care practice
    C Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, 55 Boulevard de la Cluse, Geneva, 1205, Switzerland
    Br J Cancer 85:1251-7. 2001
    ..Strong beneficial effect of adjuvant chemotherapy on stage III CC can be achieved in routine practice. However, this study shows that it is probably not optimally utilised in Switzerland, particularly among the elderly...
  16. ncbi Hormone replacement therapy, mammography screening and changing age-specific incidence rates of breast cancer: an ecological study comparing two European populations
    H M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, Geneva 1205, Switzerland
    Breast Cancer Res Treat 107:389-95. 2008
    ....
  17. ncbi N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk
    C Bouchardy
    Geneva Cancer Registry, Switzerland
    Pharmacogenetics 8:291-8. 1998
    ..No significant association was found between NAT2 genotype and lung cancer. The NAT1 polymorphism may thus be an important modifier of individual susceptibility to smoking-induced lung cancer...
  18. doi Estimated dose to the rectum and colon in prostate cancer patients treated with exclusive radiation therapy presenting a secondary colorectal malignancy
    D C Weber
    Department of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland
    Clin Oncol (R Coll Radiol) 21:687-94. 2009
    ..To estimate the dose to colorectal structures after external beam radiation therapy (EBRT) delivered to prostate cancer patients who developed secondary colorectal cancers (sCRC)...
  19. ncbi Management of women with ductal carcinoma in situ of the breast: a population-based study
    H M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Ann Oncol 13:1236-45. 2002
    ..This multidisciplinary study investigates therapeutic modalities of DCIS in daily practice and provides recommendations on how to increase quality of care...
  20. ncbi Characteristics and outcome of prostate cancer with PSA <4 ng/ml at diagnosis: a population-based study
    M Bonet
    Division of Radiation Oncology, Geneva University Hospitals, Geneva, Switzerland
    Clin Transl Oncol 11:312-7. 2009
    ..After adjustment for other prognostic factors, prostate cancer-specific mortality was similar for both groups (hazard ratio: 1.1; 95%CI: 0.6-2.2). Conclusion We conclude that cancer with low PSA values at diagnosis is not indolent...
  21. doi Increased risk of colon cancer after external radiation therapy for prostate cancer
    Elisabetta Rapiti
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Int J Cancer 123:1141-5. 2008
    ..This study shows a significant increase of colon but not rectum cancer after radiotherapy for prostate cancer. The risk of second cancer after irradiation, although probably small, needs nevertheless to be carefully monitored...
  22. ncbi Important increase of invasive lobular breast cancer incidence in Geneva, Switzerland
    Helena Marieke Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Int J Cancer 104:778-81. 2003
    ..Contrary to ductal cancer, trends for lobular cancer are unlikely to be explained by increased use of screening mammography. Other explanations must be researched, in particular the role played by hormone replacement therapy...
  23. ncbi Surveys on mammography frequency in Geneva
    J M Lutz
    J Med Screen 7:111-3. 2000
    ..The two year coverage rate for mammography among the 50 to 69 age group is estimated at 38%, which means that about 20,000 women within this target population in Geneva still escape screening...
  24. doi Lung cancer mortality risk among breast cancer patients treated with anti-estrogens
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Cancer 117:1288-95. 2011
    ..If this is true, use of anti-estrogens should be associated with decreased lung cancer mortality risk. The authors compared lung cancer incidence and mortality among breast cancer patients with and without anti-estrogen therapy...
  25. doi Risk of second breast cancer according to estrogen receptor status and family history
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, 55 Boulevard de la Cluse, 1205 Geneva, Switzerland
    Breast Cancer Res Treat 127:233-41. 2011
    ..Surveillance and prevention of second cancer occurrence should consider both ER status of the first tumor and family history...
  26. ncbi Social class is an important and independent prognostic factor of breast cancer mortality
    Christine Bouchardy
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Switzerland
    Int J Cancer 119:1145-51. 2006
    ..While waiting for the outcome of other researches, we should consider socioeconomic status as an independent prognostic factor and provide intensified support and surveillance to women of low social class...
  27. ncbi Cancer risk by occupation and socioeconomic group among men--a study by the Association of Swiss Cancer Registries
    Christine Bouchardy
    Geneva Cancer Registry, Institute of Social and Preventive Medicine, University of Geneva, Switzerland
    Scand J Work Environ Health 28:1-88. 2002
  28. ncbi Family history of breast or ovarian cancer modifies the risk of secondary leukemia after breast cancer: results from a population-based study
    Helena M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, Geneva, Switzerland
    Int J Cancer 122:1114-7. 2008
    ..This excess risk is largely due to the increased risk of secondary chronic leukemia...
  29. ncbi Tumor location of the lower-inner quadrant is associated with an impaired survival for women with early-stage breast cancer
    Séverine Sarp
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Ann Surg Oncol 14:1031-9. 2007
    ..As these metastases are not investigated, patients with lower-inner quadrant tumors have an increased risk of being under-staged and under-treated and may therefore have a higher risk of death from breast cancer...
  30. ncbi Breast-conserving surgery has equivalent effect as mastectomy on stage I breast cancer prognosis only when followed by radiotherapy
    Elisabetta Rapiti
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Bd de la Cluse 55, CH 1205 Geneva, Switzerland
    Radiother Oncol 69:277-84. 2003
    ..Early-stage breast cancer is increasing and consequently the use of breast-conserving surgery (BCS). We examined the effect of mastectomy and BCS on overall and breast cancer survival in routine health care in Geneva, Switzerland...
  31. ncbi Survival of young and older breast cancer patients in Geneva from 1990 to 2001
    Elisabetta Rapiti
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Switzerland
    Eur J Cancer 41:1446-52. 2005
    ..We conclude that age is not an independent prognostic factor when accounting for breast tumor characteristics and treatment...
  32. pmc Positive peritoneal cytology in early-stage endometrial cancer does not influence prognosis
    P M Tebeu
    Fondation pour Recherches Medicales, University of Geneva, Switzerland
    Br J Cancer 91:720-4. 2004
    ..Based on the present and previous studies, FIGO (Fédération Internationale de Gynécologie et d'Obstétrique) might consider reviewing its classification system...
  33. doi Impact of socioeconomic status on prostate cancer diagnosis, treatment, and prognosis
    Elisabetta Rapiti
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Cancer 115:5556-65. 2009
    ....
  34. ncbi Diagnostic changes as a reason for the increase in papillary thyroid cancer incidence in Geneva, Switzerland
    Helena M Verkooijen
    Geneva Cancer Registry Institute for Social and Preventive Medicine, University of Geneva, Switzerland
    Cancer Causes Control 14:13-7. 2003
    ..This study examines if these artificial factors explain the increased papillary thyroid cancer incidence in the Swiss canton of Geneva...
  35. pmc Patients' refusal of surgery strongly impairs breast cancer survival
    Helena M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, Switzerland
    Ann Surg 242:276-80. 2005
    ..To compare patient and tumor characteristics and survival between women who refused and women who accepted surgery for breast cancer...
  36. ncbi Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis
    Elisabetta Rapiti
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva
    J Clin Oncol 24:2743-9. 2006
    ..In this population-based study, we evaluate the impact of local surgery on survival of patients with metastatic breast cancer at diagnosis...
  37. ncbi Short- and long-term mortality with localized prostate cancer
    Arnaud Merglen
    Geneva Cancer Registry, Institute of Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205 Geneva, Switzerland
    Arch Intern Med 167:1944-50. 2007
    ..We assessed the effect of treatment on prostate cancer-specific mortality considering the determinants of treatment and prognosis...
  38. ncbi Survival after bilateral breast cancer: results from a population-based study
    Helena M Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 bd de la Cluse, CH 1205, Geneva, Switzerland
    Breast Cancer Res Treat 105:347-57. 2007
    ..Controversy exists on the impact of bilaterality of breast cancer on survival. We used population-based data to compare survival of women with unilateral versus bilateral breast cancer...
  39. doi Prognostic value of nodal ratios in node-positive breast cancer: a compiled update
    Vincent Vinh-Hung
    Geneva University Hospitals, Geneva, Switzerland
    Future Oncol 5:1585-603. 2009
    ....
  40. doi Impact of obesity on diagnosis and treatment of breast cancer
    Carole Deglise
    Geneva Cancer Registry, Institute of Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland
    Breast Cancer Res Treat 120:185-93. 2010
    ..Specific strategies are needed to optimize the care of obese women with or at risk of breast cancer...
  41. ncbi Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk
    Anne Feyler
    Unit of Cancer Epidemiology INSERM U521, Gustave Roussy Institute, 94805 Villejuif, France
    Cancer Epidemiol Biomarkers Prev 11:1550-4. 2002
    ..68 (95% CI: 0.5-0.93). However, because of the heterogeneity in individual study results, additional large case-control studies are warranted to provide a more definitive conclusion...
  42. ncbi Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy
    Jerry Polesel
    Epidemiology and Biostatics Unit, Aviano Cancer Center, Aviano, Italy
    AIDS 22:301-6. 2008
    ..To assess the long-term effect of HAART on non-Hodgkin lymphoma (NHL) incidence in people with HIV (PHIV)...
  43. ncbi No major impact of mammography screening on the age specific incidence rates of breast cancer in the Netherlands
    Helena M Verkooijen
    Int J Cancer 119:2988; author reply 2989-90. 2006
  44. ncbi Use of conservative surgery for stage I breast cancer falls dramatically for women aged 80 and older
    Elisabetta Rapiti
    J Am Geriatr Soc 51:1506-7. 2003
  45. ncbi Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States)
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 14:339-46. 2003
    ....
  46. ncbi Pleural mesothelioma incidence in Europe: evidence of some deceleration in the increasing trends
    Fabio Montanaro
    Mesothelioma Registry of Liguria, Unit of Environmental Epidemiology and Applied Biostatistics, National Cancer Research Institute IST, Genova, Italy
    Cancer Causes Control 14:791-803. 2003
    ....
  47. ncbi Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 159:1-16. 2004
    ..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field...
  48. doi Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers
    Patrick Danoy
    Centre National de Genotypage, Evry, France
    Int J Cancer 123:457-63. 2008
    ..The 3 genes are key players for regulating the efficiency of DSB repair. Large-scale studies are needed to show if any of these 3 variants are truly associated with an increased risk of cancer...
  49. ncbi [Collaboration patients-health care providers]
    Angela Grezet-Bento de Carvalho
    Association Savoir Patient Réseau cancer du sein, Bd de la Cluse, Geneve
    Rev Med Suisse 3:2418-20, 2422-3. 2007
    ..Focusing on very concrete problems highlighted from patients' expertise also improves research, medical training, and health policy standards...
  50. ncbi [Role of surgery for metastatic breast cancer at diagnosis]
    Georges Vlastos
    Unité de sénologie et oncogynécologie, Service de Gynecologie, Département de gynécologie et d obstétrique chirurgicales, HUG, Geneve
    Rev Med Suisse 3:2413-6. 2007
    ..As these studies have been adjusted for factors that may induce biais, only a prospective clinical randomized trial may confirm the role of surgery in the management of metastatic breast cancer...
  51. ncbi Risk factors for the development of second primary tumors among men after laryngeal and hypopharyngeal carcinoma
    Rajesh P Dikshit
    Gene Environment Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Cancer 103:2326-33. 2005
    ..However, to the authors' knowledge little is known regarding the risk factors for developing SPTs or about the strategy to be followed to avoid them...
  52. ncbi Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis
    Emanuela Taioli
    University of Pittsburgh, Cancer Institute, Pittsburgh, Pensylvania 15232, USA
    Genet Med 9:67-73. 2007
    ..The myeloperoxidase G-463A polymorphism was significantly protective in "ever" smokers but not in "never" smokers. Myeloperoxidase is a key enzyme in tobacco-induced carcinogenesis...
  53. ncbi Lifestyle habits as prognostic factors in survival of laryngeal and hypopharyngeal cancer: a multicentric European study
    Rajesh P Dikshit
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 117:992-5. 2005
    ..Our results support the hypothesis that there is a role for dietary intervention to improve survival of laryngeal and hypopharyngeal cancer patients...
  54. doi Multiple ADH genes are associated with upper aerodigestive cancers
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Nat Genet 40:707-9. 2008
    ..0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology...