Guy Werlen

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint The T-cell receptor signalosome: a dynamic structure with expanding complexity
    Guy Werlen
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, CH 4031, Basel, Switzerland
    Curr Opin Immunol 14:299-305. 2002
  2. ncbi request reprint Signaling life and death in the thymus: timing is everything
    Guy Werlen
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, CH 4031 Basel, Switzerland
    Science 299:1859-63. 2003
  3. ncbi request reprint Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
    Mark A Daniels
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Nature 444:724-9. 2006
  4. pmc Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response
    Matthew Lovatt
    Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, London NW71AA, United Kingdom
    Mol Cell Biol 26:8655-65. 2006

Collaborators

Detail Information

Publications4

  1. ncbi request reprint The T-cell receptor signalosome: a dynamic structure with expanding complexity
    Guy Werlen
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, CH 4031, Basel, Switzerland
    Curr Opin Immunol 14:299-305. 2002
    ..This review describes how 'vertical' displacement mechanisms and lateral coalescence of lipid-raft-associated scaffold proteins combine to form distinct signalosomes, which control signal specificity...
  2. ncbi request reprint Signaling life and death in the thymus: timing is everything
    Guy Werlen
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, CH 4031 Basel, Switzerland
    Science 299:1859-63. 2003
    ..Understanding the logic of TCR signaling may eventually explain how thymocytes and T cells distinguish self from nonself, a phenomenon that has fascinated immunologists for 50 years...
  3. ncbi request reprint Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
    Mark A Daniels
    Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Nature 444:724-9. 2006
    ....
  4. pmc Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response
    Matthew Lovatt
    Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, London NW71AA, United Kingdom
    Mol Cell Biol 26:8655-65. 2006
    ..Finally, we show that signals through Lck are essential for the development of T-cell-effector potential, particularly for effective cytokine transcription...