Affiliation: University of Basel
- The T-cell receptor signalosome: a dynamic structure with expanding complexityGuy Werlen
Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, CH 4031, Basel, Switzerland
Curr Opin Immunol 14:299-305. 2002..This review describes how 'vertical' displacement mechanisms and lateral coalescence of lipid-raft-associated scaffold proteins combine to form distinct signalosomes, which control signal specificity...
- Signaling life and death in the thymus: timing is everythingGuy Werlen
Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, CH 4031 Basel, Switzerland
Science 299:1859-63. 2003..Understanding the logic of TCR signaling may eventually explain how thymocytes and T cells distinguish self from nonself, a phenomenon that has fascinated immunologists for 50 years...
- Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingMark A Daniels
Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
Nature 444:724-9. 2006....
- Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase responseMatthew Lovatt
Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, London NW71AA, United Kingdom
Mol Cell Biol 26:8655-65. 2006..Finally, we show that signals through Lck are essential for the development of T-cell-effector potential, particularly for effective cytokine transcription...