C Weissmann

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Bovine spongiform encephalopathy and early onset variant Creutzfeldt-Jakob disease
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Zurich, Switzerland
    Curr Opin Neurobiol 7:695-700. 1997
  2. ncbi request reprint The Ninth Datta Lecture. Molecular biology of transmissible spongiform encephalopathies
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    FEBS Lett 389:3-11. 1996
  3. ncbi request reprint Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice
    E Flechsig
    Institut fur Molekularbiologie, Abteilung I, Universitat Zurich, Switzerland
    Neuron 27:399-408. 2000
  4. ncbi request reprint PrP-deficient mice are resistant to scrapie
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Ann N Y Acad Sci 724:235-40. 1994
  5. pmc Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system
    S Brandner
    Institute of Neuropathology, University Hospital, Zurich, Switzerland
    Proc Natl Acad Sci U S A 93:13148-51. 1996
  6. pmc Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1
    H Ruffner
    Institut für Molekularbiologie I, University of Zurich, Switzerland
    Proc Natl Acad Sci U S A 90:11503-7. 1993
  7. pmc High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene
    H Bueler
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Mol Med 1:19-30. 1994
  8. ncbi request reprint Mice devoid of PrP are resistant to scrapie
    H Bueler
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Cell 73:1339-47. 1993
  9. ncbi request reprint Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions
    D Shmerling
    Institut fur Molekularbiologie, Abteilung I, Universitat Zurich, Switzerland
    Cell 93:203-14. 1998
  10. ncbi request reprint Neuroinvasion of prions: insights from mouse models
    S Brandner
    Institute of Neuropathology, Department of Pathology, University Hospital, Zurich, Switzerland
    Exp Physiol 85:705-12. 2000

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Bovine spongiform encephalopathy and early onset variant Creutzfeldt-Jakob disease
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Zurich, Switzerland
    Curr Opin Neurobiol 7:695-700. 1997
    ..Recent evidence links the appearance of new variant Creutzfeldt-Jakob disease in humans to consumption of BSE-contaminated cattle-derived products...
  2. ncbi request reprint The Ninth Datta Lecture. Molecular biology of transmissible spongiform encephalopathies
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    FEBS Lett 389:3-11. 1996
    ....
  3. ncbi request reprint Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice
    E Flechsig
    Institut fur Molekularbiologie, Abteilung I, Universitat Zurich, Switzerland
    Neuron 27:399-408. 2000
    ..Thus, while the region comprising the octarepeats is not essential for mediating pathogenesis and prion replication, it modulates the extent of these events and of disease presentation...
  4. ncbi request reprint PrP-deficient mice are resistant to scrapie
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Ann N Y Acad Sci 724:235-40. 1994
    ..These experiments show that PrPC, possibly at close to normal levels, is required for the usual susceptibility to scrapie and that lack of homology between incoming prions and the host's PrP genes retards disease...
  5. pmc Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system
    S Brandner
    Institute of Neuropathology, University Hospital, Zurich, Switzerland
    Proc Natl Acad Sci U S A 93:13148-51. 1996
    ..Again, intraocular inoculation did not lead to disease in the PrP-producing graft. These results demonstrate that PrP is necessary for prion spread along neural pathways...
  6. pmc Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1
    H Ruffner
    Institut für Molekularbiologie I, University of Zurich, Switzerland
    Proc Natl Acad Sci U S A 90:11503-7. 1993
    ....
  7. pmc High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene
    H Bueler
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Mol Med 1:19-30. 1994
    ..We showed previously that mice devoid of PrPC (Prn-p0/0) are completely resistant to scrapie. We now report on the unexpected response of heterozygous (Prn-p0/+) mice to scrapie infection...
  8. ncbi request reprint Mice devoid of PrP are resistant to scrapie
    H Bueler
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Cell 73:1339-47. 1993
    ..These experiments show that PrPC, possibly at close to normal levels, is required for the usual susceptibility to scrapie and that lack of homology between incoming prions and the host's PrP genes retards disease...
  9. ncbi request reprint Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions
    D Shmerling
    Institut fur Molekularbiologie, Abteilung I, Universitat Zurich, Switzerland
    Cell 93:203-14. 1998
    ..The defect was completely abolished by introducing one copy of a wild-type PrP gene. We speculate that these truncated PrPs may be nonfunctional and compete with some other molecule with a PrP-like function for a common ligand...
  10. ncbi request reprint Neuroinvasion of prions: insights from mouse models
    S Brandner
    Institute of Neuropathology, Department of Pathology, University Hospital, Zurich, Switzerland
    Exp Physiol 85:705-12. 2000
    ..The latter studies have allowed us to clarify some of the mechanisms of prion spread and disease pathogenesis...
  11. ncbi request reprint Normal host prion protein necessary for scrapie-induced neurotoxicity
    S Brandner
    Department of Pathology, University Hospital, Zurich, Switzerland
    Nature 379:339-43. 1996
    ..Therefore, in addition to being resistant to scrapie infection, brain tissue devoid of PrPC is not damaged by exogenous PrPSc...
  12. ncbi request reprint Susceptibility to scrapie in mice is dependent on PrPC
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 343:431-3. 1994
    ..These experiments show that PrPC, possibly at close to normal levels, is required for the usual susceptibility to scrapie and that lack of homology between incoming prions and the host's PrP genes retards disease...
  13. ncbi request reprint No propagation of prions in mice devoid of PrP
    A Sailer
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Cell 77:967-8. 1994
  14. pmc Studies on prion replication in spleen
    A J Raeber
    Institute of Neuropathology, University Hospital, Zurich, Switzerland
    Dev Immunol 8:291-304. 2001
    ..These results imply that splenic lymphocytes can acquire prions, possibly from FDC's, but only if they express PrP...
  15. ncbi request reprint Transgenic and knockout mice in research on prion diseases
    A J Raeber
    Institute of Neuropathology, Department of Pathology, University Hospital, Zurich, Switzerland
    Brain Pathol 8:715-33. 1998
    ..Such studies have shed new light onto the mechanisms of prion spread and disease pathogenesis...
  16. ncbi request reprint Role of the PrP gene in transmissible spongiform encephalopathies
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Intervirology 35:164-75. 1993
    ..Prn-p0/0, Prn-p+/+ and Prn-p0/+ mice were inoculated with scrapie agent; the clinical response as well as the prion titer at different time points are being determined...
  17. pmc Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
    Y L Yang
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    EMBO J 14:6095-106. 1995
    ..Thus, PKR is not directly essential for responses to pIC, and a pIC-responsive system independent of PKR is induced by IFN. No evidence of the tumor suppressor activity of PKR was demonstrated...
  18. ncbi request reprint A 'unified theory' of prion propagation
    C Weissmann
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Nature 352:679-83. 1991
    ..Can the two views be reconciled?..
  19. ncbi request reprint Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
    H Bueler
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Nature 356:577-82. 1992
    ..It is now feasible to determine whether mice devoid of PrPC can propagate prions and are susceptible to scrapie pathogenesis...
  20. ncbi request reprint Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene
    U Muller
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Cell 79:755-65. 1994
    ..The brain contained shortened beta APP-specific protein at a low level. Mutant mice were severely impaired in spatial learning and exploratory behavior and showed increased incidence of agenesis of the corpus callosum...
  21. pmc Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes
    L F Reis
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    EMBO J 13:4798-806. 1994
    ..There was also no impairment in the response of type I IFN-inducible genes. Therefore, IRF-1 is not essential for these processes in vivo...
  22. ncbi request reprint PrP knock-out and PrP transgenic mice in prion research
    C Weissmann
    MRC Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, London, UK
    Br Med Bull 66:43-60. 2003
    ..In addition, the availability of PrP knock-out mice provided an approach to carry out reverse genetics on PrP, both in regard to prion disease and to its physiological role...
  23. pmc B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice
    F Montrasio
    Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:4034-7. 2001
    ..We conclude that splenic B lymphocytes are not prion-replication competent and that they acquire prions from other cells, most likely follicular dendritic cells with which they closely associate and whose maturation depends on them...
  24. ncbi request reprint Molecular genetics of transmissible spongiform encephalopathies
    C Weissmann
    Institut für Molekularbiologie der Universität Zürich, Abteilung I, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 274:3-6. 1999
  25. ncbi request reprint The role of PrP in health and disease
    E Flechsig
    Institut fur Virologie und Immunbiologie, Versbacherstrasse 7, D 97078 Wurzburg, Germany
    Curr Mol Med 4:337-53. 2004
    ..Many questions regarding the role of PrP in susceptibility to prions have been elucidated, however the physiological role of PrP and the pathological mechanisms of neurodegeneration in prion diseases are still elusive...
  26. ncbi request reprint Perspectives: neurobiology. PrP's double causes trouble
    C Weissmann
    MRC Prion Unit Neurogenetics, Imperial College School of Medicine at St Mary s, London W2 1PG, UK
    Science 286:914-5. 1999
  27. ncbi request reprint Ethical issues in human prion diseases
    S J Tabrizi
    Department of Neurodegenerative Disease MRC Prion Unit, Institute of Neurology, London, UK
    Br Med Bull 66:305-16. 2003
    ..In this chapter, we outline ethical questions posed by research, diagnostic procedures and therapy in the field of prion diseases...
  28. pmc Structure and expression of cloned murine IFN-alpha genes
    G D Shaw
    Nucleic Acids Res 11:555-73. 1983
    ..coli under the control of the ampicillinase promoter. MuIFN-alpha 1 had no detectable activity on human cells, while MuIFN-alpha 2 was 20% as active on human as on mouse cells...
  29. pmc A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions
    P C Klöhn
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 100:11666-71. 2003
    ..SC assays performed in a more time-consuming end point titration format extend the sensitivity and show that infectivity titers measured in tissue culture and in the mouse are similar...
  30. ncbi request reprint Transmission of prions
    C Weissmann
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Infect Dis 186:S157-65. 2002
    ..This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture...
  31. pmc Transmission of prions
    C Weissmann
    Medical Research Council Prion Unit, Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 99:16378-83. 2002
    ..This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals and in cell culture...
  32. pmc Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie
    M Fischer
    Institut für Molekularbiologie der Universität Zürich, Switzerland
    EMBO J 15:1255-64. 1996
    ....
  33. pmc Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain
    D Rossi
    MRC Prion Unit Neurogenetics, Imperial College School of Medicine at St Mary s, London W2 1PG, UK
    EMBO J 20:694-702. 2001
    ..Zürich II mice transgenic for a PRND:-containing cosmid expressed Dpl at twice the level and became ataxic approximately 5 months earlier. Thus, Dpl levels in brain and onset of the ataxic syndrome are inversely correlated...
  34. pmc Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie
    A J Raeber
    Institut fur Molekularbiologie, Abteilung I, University of Zurich, H onggerberg, 8093 Z urich, Switzerland
    EMBO J 16:6057-65. 1997
    ..Interestingly, mice expressing the same transgenes but also endogenous murine PrP genes propagated infectivity without developing disease...