Research Topics
Genomes and Genes | Bernhard Wehrle-HallerSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Detail Information
Publications
Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant miceB Wehrle-Haller
Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, Geneva 4, 1211, Switzerland
Dev Biol 210:71-86. 1999....- The inner lives of focal adhesionsBernhard Wehrle-Haller
Dept of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 4, Geneve, Switzerland
Trends Cell Biol 12:382-9. 2002.... - Analysis of integrin dynamics by fluorescence recovery after photobleachingBernhard Wehrle Haller
Department of Cellular Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
Methods Mol Biol 370:173-202. 2007.... - Stem cell factor presentation to c-Kit. Identification of a basolateral targeting domainB Wehrle-Haller
Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
J Biol Chem 276:12667-74. 2001..Our findings therefore present mono-leucines as a novel type of protein sorting motif for transmembrane growth factors... - Actin, microtubules and focal adhesion dynamics during cell migrationBernhard Wehrle-Haller
Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 4, Geneva, Switzerland
Int J Biochem Cell Biol 35:39-50. 2003..We discuss here the cross-talk of the actin cytoskeleton with the microtubule network and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration... - The role of Kit-ligand in melanocyte development and epidermal homeostasisBernhard Wehrle-Haller
Department of Pathology, Centre Medical Universitaire, Geneve, Switzerland
Pigment Cell Res 16:287-96. 2003..In addition, recent studies evoked the importance of Kitl misexpression in some hyperpigmented lesions that may open the avenue for Kitl-dependent treatment of pathological skin conditions... - A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surfaceFrédérique Paulhe
Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
J Biol Chem 279:55545-55. 2004..It is responsible for the capture of Kitl at coat protein complex II-coated ER exit sites, leading to subsequent cell surface transport under physiological conditions... 
Membrane-bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial nicheSéverine Tabone-Eglinger
Department of Cell Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
FASEB J 26:3738-53. 2012....- Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferationPerrine Pinon
Department of Cell Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Medical School, Geneva, Switzerland
Pigment Cell Melanoma Res 24:282-94. 2011..The gained information will help to understand melanocyte behavior in pathological situations such as melanoma growth and metastasis formation... 
New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clusteringFrederic Saltel
Department of Cellular Physiology and Metabolism, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
J Cell Biol 187:715-31. 2009..This interaction shields the beta-integrin tail from reassociation with its alpha subunit, thereby maintaining the integrin in a substrate-binding and clustering-competent form...- Structure and function of focal adhesionsBernhard Wehrle-Haller
University of Geneva, Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Curr Opin Cell Biol 24:116-24. 2012.... - The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cellsCaroline Cluzel
Department of Pathology and Immunlogy, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
J Cell Biol 171:383-92. 2005..Thus, integrin clustering requires the formation of the ternary complex consisting of activated integrins, immobilized ligands, talin, and PI(4,5)P2. The dynamic remodeling of this ternary complex controls cell motility... - An adhesion molecule in free-living Dictyostelium amoebae with integrin beta featuresSophie Cornillon
Département de Physiologie Cellulaire et Métabolisme, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
EMBO Rep 7:617-21. 2006..This study sheds light on the molecular mechanisms controlling cell adhesion and their establishment during evolution... - Integrin-dependent pathologiesBernhard Wehrle-Haller
Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
J Pathol 200:481-7. 2003..Here we explain how integrins mediate cell migration and how genetic defects of integrins and their adaptors lead to cellular dysfunction and generate pathological situations... - Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domainFrédérique Paulhe
Department of Cellular Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
FASEB J 23:3037-48. 2009..Thus, transmembrane-mediated association of membrane-anchored growth factors consists of a novel mechanism to improve paracrine signaling and morphogenesis... - Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosisBenoit R Gauthier
Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
FASEB J 22:194-206. 2008..Our results demonstrate that SYTVII is expressed on insulin granules and that only SYTVII alpha is implicated in exocytosis under physiological conditions... - Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapyAnne Angelillo-Scherrer
Division of Angiology and Hemostasis, Department of Internal Medicine, Faculty of Medicine and University Hospitals of Geneva, Geneva, Switzerland
J Clin Invest 115:237-46. 2005..Blocking the Gas6-R-alphaIIbbeta3 integrin cross-talk might be a novel approach to the reduction of thrombosis... - Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblastsBoris Hinz
Department of Pathology, Centre Medical Universitaire, University of Geneva, Switzerland
Mol Biol Cell 14:2508-19. 2003..We conclude that the formation and stability of supermature FAs depends on a high alpha-SMA-mediated contractile activity of myofibroblast stress fibers... - Molecular identification of distinct neurogenic and melanogenic neural crest sublineagesRushu Luo
Neurobiotechnology Center and Department of Neuroscience, Ohio State University, 105 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
Development 130:321-30. 2003.... - CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclastsAnne Chabadel
Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Ecole Normale Superieure de Lyon, 69364 Lyon, France
Mol Biol Cell 18:4899-910. 2007..However, although CD44 signals are sufficient to form a SZ, the presence of WIP is indispensable for the formation of a fully functional SZ... - Cell-matrix adhesion complexes: master control machinery of cell migrationJohn G Lock
Karolinska Institutet, Department of Biosciences and Nutrition, Novum, Huddinge, Sweden
Semin Cancer Biol 18:65-76. 2008.... - Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesionDirk Lehnert
Department of Biology, University of Konstanz, Universitaetstrasse 10, 78457 Konstanz, Germany
J Cell Sci 117:41-52. 2004..Knowledge of these geometrical limits is essential for an understanding of cell adhesion and migration, and for the design of artificial surfaces that optimally interact with cells in a living tissue... - Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrinsJutta Petzinger
Institute for Biochemistry, Justus Liebig University, Giessen, Germany
Cell Commun Adhes 14:137-55. 2007..Hence, uPAR-mediated cell adhesion on VN relies on the formation of a unique cellular structure that we have termed "detergent-insoluble adhesion patch" (DIAP)... - Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and functionEric Marthinet
Pediatric Endocrinology and Diabetology, Children s Hospital, 6, rue Willy Donze, CH 1211 Geneva, Switzerland
J Clin Endocrinol Metab 90:5401-6. 2005..A loss of function of K(ATP) channels causes depolarization of beta-cells and congenital hyperinsulinism (CHI), a disease presenting with severe hypoglycemia in the newborn period... - Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1 alpha precursor on cell motilityFaten Merhi-Soussi
Division of Rheumatology, Department of Internal Medicine, University Hospital of Geneva, 26 avenue de Beau Séjour, 1211 Geneva 14, Switzerland
Cytokine 32:163-70. 2005..In conclusion, NIL-1alpha propiece increases ECV304 cell motility and icIL-1Ra1 exerts intracellular functions regulating this stimulatory effect...