Bernhard Wehrle-Haller

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant mice
    B Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, Geneva 4, 1211, Switzerland
    Dev Biol 210:71-86. 1999
  2. ncbi The inner lives of focal adhesions
    Bernhard Wehrle-Haller
    Dept of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 4, Geneve, Switzerland
    Trends Cell Biol 12:382-9. 2002
  3. ncbi Analysis of integrin dynamics by fluorescence recovery after photobleaching
    Bernhard Wehrle-Haller
    Department of Cellular Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    Methods Mol Biol 370:173-202. 2007
  4. pmc The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells
    Caroline Cluzel
    Department of Pathology and Immunlogy, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    J Cell Biol 171:383-92. 2005
  5. pmc Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior
    C Ballestrem
    Department of Pathology, , Geneva, Switzerland
    J Cell Biol 155:1319-32. 2001
  6. ncbi The role of Kit-ligand in melanocyte development and epidermal homeostasis
    Bernhard Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, Geneve, Switzerland
    Pigment Cell Res 16:287-96. 2003
  7. ncbi Actin, microtubules and focal adhesion dynamics during cell migration
    Bernhard Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 4, Geneva, Switzerland
    Int J Biochem Cell Biol 35:39-50. 2003
  8. ncbi Stem cell factor presentation to c-Kit. Identification of a basolateral targeting domain
    B Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 276:12667-74. 2001
  9. ncbi A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface
    Frédérique Paulhe
    Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 279:55545-55. 2004
  10. ncbi Membrane-bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche
    Séverine Tabone-Eglinger
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    FASEB J 26:3738-53. 2012

Collaborators

Detail Information

Publications27

  1. ncbi Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant mice
    B Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, Geneva 4, 1211, Switzerland
    Dev Biol 210:71-86. 1999
    ....
  2. ncbi The inner lives of focal adhesions
    Bernhard Wehrle-Haller
    Dept of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 4, Geneve, Switzerland
    Trends Cell Biol 12:382-9. 2002
    ....
  3. ncbi Analysis of integrin dynamics by fluorescence recovery after photobleaching
    Bernhard Wehrle-Haller
    Department of Cellular Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    Methods Mol Biol 370:173-202. 2007
    ....
  4. pmc The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells
    Caroline Cluzel
    Department of Pathology and Immunlogy, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    J Cell Biol 171:383-92. 2005
    ..Thus, integrin clustering requires the formation of the ternary complex consisting of activated integrins, immobilized ligands, talin, and PI(4,5)P2. The dynamic remodeling of this ternary complex controls cell motility...
  5. pmc Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior
    C Ballestrem
    Department of Pathology, , Geneva, Switzerland
    J Cell Biol 155:1319-32. 2001
    ....
  6. ncbi The role of Kit-ligand in melanocyte development and epidermal homeostasis
    Bernhard Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, Geneve, Switzerland
    Pigment Cell Res 16:287-96. 2003
    ..In addition, recent studies evoked the importance of Kitl misexpression in some hyperpigmented lesions that may open the avenue for Kitl-dependent treatment of pathological skin conditions...
  7. ncbi Actin, microtubules and focal adhesion dynamics during cell migration
    Bernhard Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 4, Geneva, Switzerland
    Int J Biochem Cell Biol 35:39-50. 2003
    ..We discuss here the cross-talk of the actin cytoskeleton with the microtubule network and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration...
  8. ncbi Stem cell factor presentation to c-Kit. Identification of a basolateral targeting domain
    B Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 276:12667-74. 2001
    ..Our findings therefore present mono-leucines as a novel type of protein sorting motif for transmembrane growth factors...
  9. ncbi A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface
    Frédérique Paulhe
    Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 279:55545-55. 2004
    ..It is responsible for the capture of Kitl at coat protein complex II-coated ER exit sites, leading to subsequent cell surface transport under physiological conditions...
  10. ncbi Membrane-bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche
    Séverine Tabone-Eglinger
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    FASEB J 26:3738-53. 2012
    ....
  11. doi Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation
    Perrine Pinon
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Medical School, Geneva, Switzerland
    Pigment Cell Melanoma Res 24:282-94. 2011
    ..The gained information will help to understand melanocyte behavior in pathological situations such as melanoma growth and metastasis formation...
  12. pmc New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering
    Frederic Saltel
    Department of Cellular Physiology and Metabolism, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
    J Cell Biol 187:715-31. 2009
    ..This interaction shields the beta-integrin tail from reassociation with its alpha subunit, thereby maintaining the integrin in a substrate-binding and clustering-competent form...
  13. doi Structure and function of focal adhesions
    Bernhard Wehrle-Haller
    University of Geneva, Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Curr Opin Cell Biol 24:116-24. 2012
    ....
  14. pmc An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features
    Sophie Cornillon
    Département de Physiologie Cellulaire et Métabolisme, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    EMBO Rep 7:617-21. 2006
    ..This study sheds light on the molecular mechanisms controlling cell adhesion and their establishment during evolution...
  15. doi Assembly and disassembly of cell matrix adhesions
    Bernhard Wehrle-Haller
    University of Geneva, Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Curr Opin Cell Biol 24:569-81. 2012
    ..The aim of this review is to provide insight into the mechanisms leading to the progressive assembly of focal adhesions, how they are modulated in response to mechanical challenges and which mechanisms are used for their disassembly...
  16. doi Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain
    Frédérique Paulhe
    Department of Cellular Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    FASEB J 23:3037-48. 2009
    ..Thus, transmembrane-mediated association of membrane-anchored growth factors consists of a novel mechanism to improve paracrine signaling and morphogenesis...
  17. ncbi Integrin-dependent pathologies
    Bernhard Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Pathol 200:481-7. 2003
    ..Here we explain how integrins mediate cell migration and how genetic defects of integrins and their adaptors lead to cellular dysfunction and generate pathological situations...
  18. pmc Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy
    Anne Angelillo-Scherrer
    Division of Angiology and Hemostasis, Department of Internal Medicine, Faculty of Medicine and University Hospitals of Geneva, Geneva, Switzerland
    J Clin Invest 115:237-46. 2005
    ..Blocking the Gas6-R-alphaIIbbeta3 integrin cross-talk might be a novel approach to the reduction of thrombosis...
  19. pmc Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts
    Boris Hinz
    Department of Pathology, Centre Medical Universitaire, University of Geneva, Switzerland
    Mol Biol Cell 14:2508-19. 2003
    ..We conclude that the formation and stability of supermature FAs depends on a high alpha-SMA-mediated contractile activity of myofibroblast stress fibers...
  20. ncbi Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    FASEB J 22:194-206. 2008
    ..Our results demonstrate that SYTVII is expressed on insulin granules and that only SYTVII alpha is implicated in exocytosis under physiological conditions...
  21. ncbi Molecular identification of distinct neurogenic and melanogenic neural crest sublineages
    Rushu Luo
    Neurobiotechnology Center and Department of Neuroscience, Ohio State University, 105 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    Development 130:321-30. 2003
    ....
  22. ncbi Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion
    Dirk Lehnert
    Department of Biology, University of Konstanz, Universitaetstrasse 10, 78457 Konstanz, Germany
    J Cell Sci 117:41-52. 2004
    ..Knowledge of these geometrical limits is essential for an understanding of cell adhesion and migration, and for the design of artificial surfaces that optimally interact with cells in a living tissue...
  23. ncbi Cell-matrix adhesion complexes: master control machinery of cell migration
    John G Lock
    Karolinska Institutet, Department of Biosciences and Nutrition, Novum, Huddinge, Sweden
    Semin Cancer Biol 18:65-76. 2008
    ....
  24. pmc CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts
    Anne Chabadel
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Ecole Normale Superieure de Lyon, 69364 Lyon, France
    Mol Biol Cell 18:4899-910. 2007
    ..However, although CD44 signals are sufficient to form a SZ, the presence of WIP is indispensable for the formation of a fully functional SZ...
  25. ncbi Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins
    Jutta Petzinger
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    Cell Commun Adhes 14:137-55. 2007
    ..Hence, uPAR-mediated cell adhesion on VN relies on the formation of a unique cellular structure that we have termed "detergent-insoluble adhesion patch" (DIAP)...
  26. ncbi Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function
    Eric Marthinet
    Pediatric Endocrinology and Diabetology, Children s Hospital, 6, rue Willy Donze, CH 1211 Geneva, Switzerland
    J Clin Endocrinol Metab 90:5401-6. 2005
    ..A loss of function of K(ATP) channels causes depolarization of beta-cells and congenital hyperinsulinism (CHI), a disease presenting with severe hypoglycemia in the newborn period...
  27. ncbi Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1 alpha precursor on cell motility
    Faten Merhi-Soussi
    Division of Rheumatology, Department of Internal Medicine, University Hospital of Geneva, 26 avenue de Beau Séjour, 1211 Geneva 14, Switzerland
    Cytokine 32:163-70. 2005
    ..In conclusion, NIL-1alpha propiece increases ECV304 cell motility and icIL-1Ra1 exerts intracellular functions regulating this stimulatory effect...