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- Wang H, Maechler P, Antinozzi P, Herrero L, Hagenfeldt Johansson K, Bjorklund A, et al. The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction. J Biol Chem. 2003;278:16622-9 pubmed..However, 2-day exposure to these agents promoted SREBP-1c processing. Therefore, the SREBP-1c maturation could be implicated in the pathogenesis of beta-cell glucolipotoxicity. ..