Wang H, Iezzi M, Theander S, Antinozzi P, Gauthier B, Halban P, et al. Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. Diabetologia. 2005;48:720-31 pubmed
Wang H, Gauthier B, Hagenfeldt Johansson K, Iezzi M, Wollheim C. Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J Biol Chem. 2002;277:17564-70 pubmed
..These results suggest that Foxa2 is a vital transcription factor evolved to control the expression of genes essential for maintaining beta-cell glucose sensing and glucose homeostasis. ..
Wang H, Wollheim C. ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells. J Biol Chem. 2002;277:32746-52 pubmed
..These unprecedented results suggest that ChREBP rather than USF mediates glucose-promoted L-PK expression in insulin-secreting cells. ..
Wang H, Maechler P, Antinozzi P, Herrero L, Hagenfeldt Johansson K, Bjorklund A, et al. The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction. J Biol Chem. 2003;278:16622-9 pubmed
..However, 2-day exposure to these agents promoted SREBP-1c processing. Therefore, the SREBP-1c maturation could be implicated in the pathogenesis of beta-cell glucolipotoxicity. ..