C A Wagner

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. doi request reprint The SLC34 family of sodium-dependent phosphate transporters
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Winterthurerstrasse, Zurich, 190 8057, Switzerland
    Pflugers Arch 466:139-53. 2014
  2. doi request reprint Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice
    Andrea Di Giacopo
    Institute of Physiology Zurich Center for Integrative Human Physiology ZIHP University of Zurich, Winterthurerstrasse 190, CH 8075 Zurich, Switzerland
    Am J Physiol Renal Physiol 305:F1645-55. 2013
  3. doi request reprint The calcium-sensing receptor directly regulates proximal tubular functions
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 84:228-30. 2013
  4. pmc Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men
    Sandro Manuel Mueller
    Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland
    J Int Soc Sports Nutr 10:16. 2013
  5. doi request reprint The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Cell Physiol Biochem 28:497-504. 2011
  6. pmc Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts
    Carsten A Wagner
    Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA
    Cell Physiol Biochem 28:513-20. 2011
  7. ncbi request reprint Urinary pH and stone formation
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, Zurich, University of Zurich, Switzerland
    J Nephrol 23:S165-9. 2010
  8. doi request reprint The rhesus protein RhCG: a new perspective in ammonium transport and distal urinary acidification
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 79:154-61. 2011
  9. ncbi request reprint New roles for renal potassium channels
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 23:5-8. 2010
  10. ncbi request reprint Hydrogen sulfide: a new gaseous signal molecule and blood pressure regulator
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 22:173-6. 2009

Collaborators

  • J Biber
  • H Murer
  • Olivier Devuyst
  • Pascal Houillier
  • Ian C Forster
  • Hannelore Daniel
  • Manuel Palacin
  • Ferruh Artunc
  • Dennis Brown
  • O W Moe
  • N Hernando
  • A E Busch
  • Florian Lang
  • E Hummler
  • D Markovich
  • Andrea Di Giacopo
  • Sandro Manuel Mueller
  • A Albers
  • Christian Winter
  • J Kovacikova
  • D Bacic
  • R P Lifton
  • K E Finberg
  • Saskia Maria Gehrig
  • Isabelle Frey-Wagner
  • Ellen I Closs
  • Marco Toigo
  • Gerti Stange
  • Giovambattista Capasso
  • Rexhep Rexhepaj
  • Sebastian Frese
  • Urs Boutellier
  • Nilufar Mohebbi
  • Alessandra Cantone
  • Virginia Nunes
  • Isabel Rubio-Aliaga
  • Nicole Gehring
  • Isabel Jaenecke
  • Mariona Font-Llitjos
  • A N Smith
  • J P Geibel
  • Paul A Stehberger
  • Luca Vedovelli
  • Teodor G Paunescu
  • Florina Rothenberger
  • Nicole B Kampik
  • Hubert John
  • A Bröer
  • J Loffing
  • C Winter
  • B Kaissling
  • M LeHir
  • D Loffing-Cueni
  • B Rossier
  • Y Su
  • J Gloeckner
  • C Schmidt
  • R Caroppo
  • P A Lang
  • M A Devonald
  • F E Karet
  • K Radebold
  • I Setiawan
  • L Manuelidis
  • I Qureshi
  • P Kirchhoff
  • T Eggermann
  • S Lahme
  • K Zerres
  • K H Bichler
  • E U Kranz
  • C M Hartmann
  • V Ganapathy
  • K S Dimmer
  • N Brookes
  • S Broer

Detail Information

Publications24

  1. doi request reprint The SLC34 family of sodium-dependent phosphate transporters
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Winterthurerstrasse, Zurich, 190 8057, Switzerland
    Pflugers Arch 466:139-53. 2014
    ..The physiological relevance of the three members of the SLC34 family is underlined by rare Mendelian disorders causing phosphaturia, hypophosphatemia, or ectopic organ calcifications. ..
  2. doi request reprint Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice
    Andrea Di Giacopo
    Institute of Physiology Zurich Center for Integrative Human Physiology ZIHP University of Zurich, Winterthurerstrasse 190, CH 8075 Zurich, Switzerland
    Am J Physiol Renal Physiol 305:F1645-55. 2013
    ..These observations indicate that transporters located in distal segments of the kidney and/or metabolic pathways may partially compensate for Slc7a9 loss of function. ..
  3. doi request reprint The calcium-sensing receptor directly regulates proximal tubular functions
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 84:228-30. 2013
    ..These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions. ..
  4. pmc Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men
    Sandro Manuel Mueller
    Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, Zurich, Switzerland
    J Int Soc Sports Nutr 10:16. 2013
    ..The purpose was to investigate the effects of one dose of NaHCO3 per day for five consecutive days on cycling time-to-exhaustion (Tlim) at 'Critical Power' (CP) and acid-base parameters in endurance athletes...
  5. doi request reprint The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Cell Physiol Biochem 28:497-504. 2011
    ..This review summarizes recent findings on the role and regulation of pendrin in the context of the kidneys role in acid-base homeostasis in health and disease...
  6. pmc Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts
    Carsten A Wagner
    Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA
    Cell Physiol Biochem 28:513-20. 2011
    ..In summary, angiotensin II stimulates H(+)-ATPases in CNT/CCD intercalated cells, and may contribute to the regulation of chloride absorption and bicarbonate secretion in this nephron segment...
  7. ncbi request reprint Urinary pH and stone formation
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, Zurich, University of Zurich, Switzerland
    J Nephrol 23:S165-9. 2010
    ..This review will discuss a few aspects that relate to the capacity of the kidney to regulate pH and its impact on the excretion of solutes that participate in the formation or prevention of stones...
  8. doi request reprint The rhesus protein RhCG: a new perspective in ammonium transport and distal urinary acidification
    Carsten A Wagner
    Institute of Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 79:154-61. 2011
    ..Similarly, crystal structures of human RhCG and the homologous bacterial AmtB protein suggest that these proteins may form gas channels...
  9. ncbi request reprint New roles for renal potassium channels
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 23:5-8. 2010
    ..Moreover, defects of 2 different potassium channels expressed on opposing membrane domains of the same cells cause distinct symptoms...
  10. ncbi request reprint Hydrogen sulfide: a new gaseous signal molecule and blood pressure regulator
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 22:173-6. 2009
    ..These data establish H2S as a new and important biologic signal molecule and as a new regulator of vascular blood flow and blood pressure...
  11. doi request reprint Regulated acid-base transport in the collecting duct
    Carsten A Wagner
    Zurich Center for Human Integrative Physiology, University of Zurich, Switzerland
    Pflugers Arch 458:137-56. 2009
    ..Dysregulation of intercalated cell function or abundance causes various syndromes of distal renal tubular acidosis underlining the importance of these processes for acid-base homeostasis...
  12. ncbi request reprint How much is blood pressure in the general population determined by rare mutations in renal salt-transporting proteins?
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich Switzerland
    J Nephrol 21:632-4. 2008
    ..The frequency of such alleles may be much higher in the general population than previously anticipated and may explain at least in part the complex genetics of human hypertension...
  13. doi request reprint When proton pumps go sour: Urinary acidification and kidney stones
    C A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 73:1103-5. 2008
    ..The pathomechanisms by which these mutations affect pump activity are only poorly understood. Common polymorphisms may impair pump activity and may link the pump to a higher risk for alkaline urine and the development of kidney stones...
  14. ncbi request reprint The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase
    J Kovacikova
    1Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 70:1706-16. 2006
    ..Thus, functional expression of ENaC channels in the CNT is sufficient for furosemide-stimulated urinary acidification and identifies the CNT as a major segment in electrogenic urinary acidification...
  15. pmc NaPi-IIa and interacting partners
    N Hernando
    Institute of Physiology, Zurich University, CH 8057, Zurich, Switzerland
    J Physiol 567:21-6. 2005
    ..Biochemical and morphological, as well as functional, analyses have allowed us to obtain insights into the physiological roles of such interactions, although our present knowledge is still far from complete...
  16. ncbi request reprint Transport characteristics of a murine renal Na/Pi-cotransporter
    C M Hartmann
    University of Zurich, Institute of Physiology, Zurich, Switzerland
    Pflugers Arch 430:830-6. 1995
    ..The effect of Pi and Na concentration on the apparent Km values for Na or Pi, respectively, provides evidence for an ordered interaction of "cosubstrate" (Na first) and "substrate" (Pi or arsenate second)...
  17. ncbi request reprint The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone
    D Bacic
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 69:495-503. 2006
    ....
  18. ncbi request reprint Function and structure of heterodimeric amino acid transporters
    C A Wagner
    Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    Am J Physiol Cell Physiol 281:C1077-93. 2001
    ....
  19. ncbi request reprint The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion
    J P Geibel
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06511, USA
    J Biol Chem 276:39549-52. 2001
    ..These studies present the first example of a member of the divalent cation receptors modulating a plasma membrane transport protein and may lead to new insights into the regulation of gastric acid secretion...
  20. pmc Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway
    Christian Winter
    Institute of Physiology, Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zürich Switzerland
    Am J Physiol Cell Physiol 301:C1251-61. 2011
    ..PKA and cAMP appear to have a modulatory effect. The rapid nongenomic action of aldosterone may participate in the regulation of H(+)-ATPase activity and contribute to final urinary acidification...
  21. ncbi request reprint [Molecular biology of cystinuria]
    A Albers
    ,
    Fortschr Med Orig 119:49-50. 2001
    ..Furthermore, first steps towards a molecular genetic testing have been carried out replacing the so far diagnostic procedure which are stressing for the patients. The results of these testings make an individual therapy possible...
  22. ncbi request reprint Molecular cloning and characterization of Atp6n1b: a novel fourth murine vacuolar H+-ATPase a-subunit gene
    A N Smith
    Department of Medical Genetics, Cambridge Institute for Medical Research, Box 139 Addenbrooke s Hospital, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 276:42382-8. 2001
    ....
  23. ncbi request reprint The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux
    A Bröer
    Physiologisches Institut der Universitat, Tubingen, Germany
    J Neurochem 73:2184-94. 1999
    ..However, the relative contribution of this pathway to glutamine release from cells in vivo or in vitro remains to be determined...
  24. ncbi request reprint Na+ transport by the neural glutamine transporter ATA1
    A Albers
    , Gmelinstr. 5, , Germany
    Pflugers Arch 443:92-101. 2001
    ..A decrease of the intracellular pH similarly inhibited glutamine transport via ATA1, suggesting that the pH dependence was an allosteric effect on the transporter...