Research Topics
| Andreas WagnerSummaryAffiliation: University of Zurich Country: Switzerland Publications
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Detail Information
Publications
Neutral network sizes of biological RNA molecules can be computed and are not atypically smallThomas Jörg
Inria Saclay, Ile de France, INRIA, Parc Orsay Université 4, Orsay Cedex, France
BMC Bioinformatics 9:464. 2008..Unfortunately, any one neutral set contains generally only a tiny fraction of genotype space. Thus, current methods cannot measure neutral set sizes accurately, except in the smallest genotype spaces...- Rapid detection of positive selection in genes and genomes through variation clustersAndreas Wagner
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Genetics 176:2451-63. 2007..I also identify multiple new human-chimpanzee orthologs subject to positive selection, among them genes that are involved in reproductive functions, immune defense, and the nervous system... - From bit to it: how a complex metabolic network transforms information into living matterAndreas Wagner
Department of Biochemistry, University of Zurich, Building Y27, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
BMC Syst Biol 1:33. 2007..A metabolic network transforms nutrients into biomass. The better it uses information on available nutrient availability, the faster it will allow a cell to divide... - Robustness and evolvability: a paradox resolvedAndreas Wagner
Department of Biochemistry, University of Zurich, 8057 Zurich, Switzerland
Proc Biol Sci 275:91-100. 2008..My observations may apply to other genetic systems where many connected genotypes produce the same phenotypes... - A survey of bacterial insertion sequences using IScanAndreas Wagner
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 27 J 54, CH 8057 Zurich, Switzerland
Nucleic Acids Res 35:5284-93. 2007..Applied to the thousands of genomes that will soon be available, IScan could be used for many purposes, such as mapping the evolutionary history and horizontal transfer patterns of different ISs... 
Gene duplications, robustness and evolutionary innovationsAndreas Wagner
University of Zurich, Department of Biochemistry, Bldg Y27, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Bioessays 30:367-73. 2008..These include the role of gene duplications in the vertebrate radiation, flowering plant evolution and heart development, which encompass some of the most striking innovations in the evolution of life...- Distant horizontal gene transfer is rare for multiple families of prokaryotic insertion sequencesAndreas Wagner
Department of Biochemistry, University of Zurich, Bldg Y27, Winterthurerstrasse 190, 8057, Zurich, Switzerland
Mol Genet Genomics 280:397-408. 2008..If true also for other, non-mobile DNA, the rarity of distant horizontal transfer increases the odds of reliable phylogenetic inference from sequence data... - Evolutionary constraints permeate large metabolic networksAndreas Wagner
University of Zurich, Dept of Biochemistry, CH 8057 Zurich, Switzerland
BMC Evol Biol 9:231. 2009..These observations, together with the continual discovery of new microbial metabolic pathways and enzymes, raise the possibility that metabolic networks are only weakly constrained in changing their complement of enzymatic reactions... - The evolvability of programmable hardwareKarthik Raman
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
J R Soc Interface 8:269-81. 2011..They also point to generic ways to generate fault-tolerant, adaptable and evolvable electronic circuitry... - A comparison of genotype-phenotype maps for RNA and proteinsEvandro Ferrada
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland
Biophys J 102:1916-25. 2012..We compare this property to evidence from natural RNA and protein molecules, and conclude that RNA genotype space may be more conducive to the evolution of new structure phenotypes... - Superessential reactions in metabolic networksAditya Barve
Institutes of Evolutionary Biology and Environmental Studies, University of Zurich, CH 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 109:E1121-30. 2012..Our work also shows how analyses of large network ensembles can help understand the evolution of complex and robust metabolic networks... - Evolutionary plasticity and innovations in complex metabolic reaction networksJoão F Matias Rodrigues
Department of Biochemistry, University of Zurich, Zurich, Switzerland
PLoS Comput Biol 5:e1000613. 2009..Our approach has broad implications for the evolution of metabolic networks, for our understanding of mutational robustness, for the design of antimetabolic drugs, and for metabolic engineering... - Evolutionary innovations and the organization of protein functions in genotype spaceEvandro Ferrada
Department of Biochemistry, University of Zurich, Zurich, Switzerland
PLoS ONE 5:e14172. 2010..Whether a protein with a given function can evolve specific new functions is thus determined by the protein's location in sequence space... - Genotype networks, innovation, and robustness in sulfur metabolismJoão F Matias Rodrigues
Institute of Evolutionary Biology and Environmental Studies Bldg, Y27, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
BMC Syst Biol 5:39. 2011..We here focus on the element sulfur. We study properties of the space of all possible metabolic genotypes in sulfur metabolism by analyzing random metabolic genotypes that are viable on different numbers of sulfur sources... - Metabolic networks and their evolutionAndreas Wagner
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland
Adv Exp Med Biol 751:29-52. 2012..Reaction addition also provides a window into the evolution of metabolic innovations, the ability of a metabolism to sustain life on new sources of energy and of chemical elements... - Evolvability and robustness in a complex signalling circuitKarthik Raman
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Mol Biosyst 7:1081-92. 2011..Our approach points a way towards mapping genotype spaces in complex circuitry, and it exposes some challenges such mapping faces... 
Pervasive indels and their evolutionary dynamics after the fish-specific genome duplicationBaocheng Guo
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland
Mol Biol Evol 29:3005-22. 2012..Our observations are consistent across all five fish species. Taken together, they suggest a general pattern of duplicate gene evolution in which indels are important driving forces of evolutionary change...- Environmental change exposes beneficial epistatic interactions in a catalytic RNAEric J Hayden
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland
Proc Biol Sci 279:3418-25. 2012..Our results suggest that such change can facilitate adaptive evolution by exposing new peaks of a fitness landscape. They highlight a prominent role for genotype-environment interactions in doing so... - BEL/Pao retrotransposons in metazoan genomesNicole de la Chaux
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
BMC Evol Biol 11:154. 2011..No comprehensive characterization of these elements is available so far. The aim of this study was to describe all BEL/Pao elements in a set of 62 sequenced metazoan genomes, and to analyze their phylogenetic relationship... - Evolutionary dynamics of the LTR retrotransposons roo and rooA inferred from twelve complete Drosophila genomesNicole de la Chaux
Department of Biochemistry, University of Zurich, Zurich, Switzerland
BMC Evol Biol 9:205. 2009..We here study the phylogenetic distribution and evolution of roo, and its highly diverged relative rooA in 12 completely sequenced genomes of the genus Drosophila... - Efficient characterization of high-dimensional parameter spaces for systems biologyElías Zamora-Sillero
Department of Biochemistry, University of Zurich, Zurich, Switzerland
BMC Syst Biol 5:142. 2011..This hampers explorations of the viable space based on "brute force" or Gaussian sampling... - Exhaustive identification of steady state cycles in large stoichiometric networksJeremiah Wright
Department of Biochemistry, University of Zurich, Zurich, Switzerland
BMC Syst Biol 2:61. 2008..Unfortunately, our ability to identify cycles in stoichiometric networks, such as signal transduction and genome-scale metabolic networks, has been hampered by the computational complexity of the methods currently used... - Cooperation is fleeting in the world of transposable elementsAndreas Wagner
Department of Biochemistry, University of Zurich, Zurich, Switzerland
PLoS Comput Biol 2:e162. 2006..Because such cooperation does not pay in the long run, the vehicles of such survival will eventually disappear again. My analysis demonstrates that game theory can help explain behavioral strategies even for mobile DNA... - Specialization can drive the evolution of modularityCarlos Espinosa-Soto
Department of Biochemistry, University of Zurich, Zurich, Switzerland
PLoS Comput Biol 6:e1000719. 2010..We also show how modularity can facilitate co-option, the utilization of existing gene activity to build new gene activity patterns, a frequent feature of evolutionary innovations... - Energy costs constrain the evolution of gene expressionAndreas Wagner
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Exp Zool B Mol Dev Evol 308:322-4. 2007..In small organisms with large effective population sizes, the evolution of transcription and translation rates are thus not evolutionarily neutral processes... - The low cost of recombination in creating novel phenotypes: Recombination can create new phenotypes while disrupting well-adapted phenotypes much less than mutationAndreas Wagner
Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland
Bioessays 33:636-46. 2011..A better understanding might shed light on the evolution of recombination and help improve evolutionary strategies in biochemical engineering... - The molecular origins of evolutionary innovationsAndreas Wagner
University of Zurich Institute of Evolutionary Biology and Environmental Studies, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Trends Genet 27:397-410. 2011..Both features emerge from a common cause, the robustness of phenotypes to perturbations, whose origins are linked to life in changing environments... - Design constraints on a synthetic metabolismTugce Bilgin
Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland
PLoS ONE 7:e39903. 2012..The constraints we identify prescribe broad boundary conditions that can help to guide synthetic metabolism design... - Differences in cell division rates drive the evolution of terminal differentiation in microbesJoão F Matias Rodrigues
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland
PLoS Comput Biol 8:e1002468. 2012..This may explain why plants engage in symbiotic interactions with diazotrophic bacteria... - Genotype networks shed light on evolutionary constraintsAndreas Wagner
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Y27 J 54, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Trends Ecol Evol 26:577-84. 2011..Furthermore, they can explain important consequences of constraints, such as punctuated stasis and canalization... - The Systems Biology Research Tool: evolvable open-source softwareJeremiah Wright
Department of Biochemistry, University of Zurich, Zurich, Switzerland
BMC Syst Biol 2:55. 2008..Software must also be used to implement mathematical models and algorithms required for simulation and theoretical predictions on the system-level... - The early phase of a bacterial insertion sequence infectionManuel Bichsel
Department of Biochemistry, University of Zurich, CH 8057 Zurich, Switzerland
Theor Popul Biol 78:278-88. 2010..We conclude that horizontal gene transfer is strong enough to allow the persistence of insertion sequences, although infection is an erratic and slow process... - Transposable elements as genomic diseasesAndreas Wagner
University of Zurich, Dept of Biochemistry, Bldg Y27, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Mol Biosyst 5:32-5. 2009.... - Phenotypic plasticity can facilitate adaptive evolution in gene regulatory circuitsCarlos Espinosa-Soto
University of Zurich, Dept of Biochemistry, Zurich, Switzerland
BMC Evol Biol 11:5. 2011..Phenotypic plasticity allows a genotype to produce different - alternative - phenotypes after non-genetic perturbations that include gene expression noise, environmental change, or epigenetic modification... - Protein robustness promotes evolutionary innovations on large evolutionary time-scalesEvandro Ferrada
Department of Biochemistry, University of Zurich, Building Y27, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Proc Biol Sci 275:1595-602. 2008..Significant associations among structural designability, folding rate and intrinsic disorder also exist, underlining the complex relationship of the structural factors that affect protein evolution... - Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzymeEric J Hayden
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland
Nature 474:92-5. 2011..Our observations show that cryptic variation contains new genotypes pre-adapted to a changed environment. Our results highlight the positive role that robustness and epistasis can have in adaptive evolution... - Evolution of viral proteins originated de novo by overprintingNiv Sabath
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland
Mol Biol Evol 29:3767-80. 2012..Some of the oldest de novo genes evolve under stronger selection pressure than the ancestral gene they overlap, suggesting an evolutionary tug of war between the ancestral and the de novo gene... - Estimating the fitness effect of an insertion sequenceManuel Bichsel
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zuerich, Switzerland
J Math Biol 66:95-114. 2013..Occasional beneficial effects may thus have played an important role in the fast spreading of insertion sequences like IS5... - The role of robustness in phenotypic adaptation and innovationAndreas Wagner
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Y27 J 54 Winterthurerstrasse 190, 8057 Zurich, Switzerland
Proc Biol Sci 279:1249-58. 2012..In addition, robustness can help avoid an important evolutionary conflict between the interests of individuals and populations-a conflict that can impede evolutionary adaptation... - Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populationsBing Chen
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, 8057 Zurich, Switzerland
BMC Evol Biol 12:25. 2012..It is unknown whether observations from such laboratory experiments are relevant in the wild... - The predominantly selfing plant Arabidopsis thaliana experienced a recent reduction in transposable element abundance compared to its outcrossing relative Arabidopsis lyrataNicole de la Chaux
Molecular Evolution and Evolutionary Systems Biology, Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland
Mob DNA 3:2. 2012..abstract:.. - Convergent evolution of gene circuitsGavin C Conant
Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, New Mexico 87131, USA
Nat Genet 34:264-6. 2003..Specifically, we show that multiple types of transcriptional regulation circuitry in Escherichia coli and the yeast Saccharomyces cerevisiae have evolved independently and not by duplication of one or a few ancestral circuits... - How the global structure of protein interaction networks evolvesAndreas Wagner
Department of Biology, University of New Mexico, 167A Castetter Hall, Albuquerque, NM 817131 1091, USA
Proc Biol Sci 270:457-66. 2003.... - Asymmetric functional divergence of duplicate genes in yeastAndreas Wagner
Department of Biology, University of New Mexico, Albuquerque, USA
Mol Biol Evol 19:1760-8. 2002..I propose a model that can explain this divergence pattern if asymmetrically diverging duplicate gene pairs show increased robustness to deleterious mutations... - GenomeHistory: a software tool and its application to fully sequenced genomesGavin C Conant
Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, NM 87131, USA
Nucleic Acids Res 30:3378-86. 2002..In contrast, a weakly negative such correlation is seen in multicellular eukaryotes... - Molecular evolution in the yeast transcriptional regulation networkAnnette M Evangelisti
Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
J Exp Zoolog B Mol Dev Evol 302:392-411. 2004..On the other hand, the number of transcription factors that bind to highly diverged duplicates is significantly greater than would be expected if loss of binding played the only role in the divergence of duplicate genes... - Influence of metabolic network structure and function on enzyme evolutionDennis Vitkup
Center for Computational Biology and Bioinformatics, Department of Biomedical Informatics, Columbia University, Russ Berrie Pavilion, St Nicholas Avenue, New York, NY 10032, USA
Genome Biol 7:R39. 2006..The ability to consider fluxes in a metabolic network allows us to relate the functional role of each enzyme in a network to its rate of evolution... - Energy constraints on the evolution of gene expressionAndreas Wagner
Department of Biology, The University of New Mexico, NM, USA
Mol Biol Evol 22:1365-74. 2005..They are under active selection opposing them. My estimates are based on genome-scale information of gene expression in the yeast S. cerevisiae as well as information on the energy cost of biosynthesizing amino acids and nucleotides... - Alternative routes and mutational robustness in complex regulatory networksAndreas Wagner
Department of Biology, MSC03 2020, The University of New Mexico, Albuquerque, NM 87131 0001, USA
Biosystems 88:163-72. 2007..Our results underscore the importance of systems biology approaches to understand functional and evolutionary constraints on genes and proteins... - Molecular evolution in large genetic networks: does connectivity equal constraint?Matthew W Hahn
Department of Biology, Box 90338, Duke University, Durham, NC 27708, USA mwhahn ucdavis edu
J Mol Evol 58:203-11. 2004..The finding that highly connected proteins can tolerate just as many amino acid substitutions as other proteins leads us to conclude that power-laws in cellular networks do not reflect selection for mutational robustness... - Periodic extinctions of transposable elements in bacterial lineages: evidence from intragenomic variation in multiple genomesAndreas Wagner
Department of Biology, The University of New Mexico, USA
Mol Biol Evol 23:723-33. 2006..This is also suggested by the highly skewed and patchy distribution of insertion sequences among genomes. In sum, one can think of insertion sequences as slow-acting infectious diseases of cell lineages... - Enriching for direct regulatory targets in perturbed gene-expression profilesSusannah G Tringe
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Genome Biol 5:R29. 2004..When applied to experimental data the reconstruction procedure preferentially retains direct transcription factor-target relationships... - Robustness, evolvability, and neutralityAndreas Wagner
Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, NM 87131, USA
FEBS Lett 579:1772-8. 2005.... - Structure and evolution of protein interaction networks: a statistical model for link dynamics and gene duplicationsJohannes Berg
Institut fur Theoretische Physik, Universitat zu Koln, Zülpicherstr, 77, 50937 Koln, Germany
BMC Evol Biol 4:51. 2004..Understanding the underlying evolutionary dynamics is crucial for discerning random parts of the network from biologically important properties shaped by natural selection... - A fast algorithm for determining the best combination of local alignments to a query sequenceGavin C Conant
Department of Biology, The University of New Mexico, Albuquerque, NM, USA
BMC Bioinformatics 5:62. 2004..Recombination perturbs this order. An algorithm that can reconstruct sequence similarity despite rearrangement would be helpful for reconstructing the evolutionary history of recombined sequences... - Reconstructing pathways in large genetic networks from genetic perturbationsAndreas Wagner
University of New Mexico, Department of Biology, Albuquerque, NM 817131 1091, USA
J Comput Biol 11:53-60. 2004..The algorithm is able to distinguish a large fraction of direct regulatory interactions from indirect interactions, even if the accuracy of its input data is substantially compromised... - Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genesJason G Bragg
Biology Department, University of New Mexico, Albuquerque, NM 87131, USA
Proc Biol Sci 274:1063-70. 2007..Taken together, our results contribute to the emerging view that protein atomic composition influences genome and transcriptome evolution... - Robustness can evolve gradually in complex regulatory gene networks with varying topologyStefano Ciliberti
Laboratoire de Physique Théoique et Modèles Statistiques, Universite Paris Sud, Orsay, France
PLoS Comput Biol 3:e15. 2007..In addition, it exists also for RNA and protein structures, and may thus be a general organizational principle of all biological systems... - New structural variation in evolutionary searches of RNA neutral networks- Sumedha
Univ Paris Sud, LPTMS, UMR8626, CNRS, Orsay F 91405, France
Biosystems 90:475-85. 2007..Our findings underscore the role of neutral networks in evolutionary innovation, and the role that high robustness can play in diminishing the potential for such innovation... - A statistical framework for combining and interpreting proteomic datasetsMichael A Gilchrist
Department of Biology, University of New Mexico, Albuquerque 87106, USA
Bioinformatics 20:689-700. 2004..AVAILABILITY: A suite of simple programs to accomplish some of the above tasks is available at www.unm.edu/~compbio/software/DatasetAssess.. - Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegansGavin C Conant
Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, NM 87131, USA
Proc Biol Sci 271:89-96. 2004..We discuss the different causes of mutational robustness in single-copy and duplicate genes, as well as its evolutionary origin... - Asymmetric sequence divergence of duplicate genesGavin C Conant
Department of Biology, The University of New Mexico, Albuquerque, New Mexico 87131, USA
Genome Res 13:2052-8. 2003..The method is also more sensitive in detecting positive selection (Ka/Ks > 1) than models relying only on pairwise gene comparisons... - Selection and gene duplication: a view from the genomeAndreas Wagner
Department of Biology, University of New Mexico, 167A Castetter Hall, Albuquerque, NM 817131 1091, USA
Genome Biol 3:reviews1012. 2002.... - Trimeric membrane-anchored gp41 inhibits HIV membrane fusionOliver Lenz
European Molecular Biology Laboratory EMBL, 6, rue Jules Horowitz, 38042 Grenoble, France
J Biol Chem 280:4095-101. 2005..Our data suggest that liposome-anchored gp41ctm exerts its inhibitory action outside of the initial fusion contact site, and its implications for the fusion reaction are discussed... - Direct time-of-flight for quantitative, real-time in-beam PET: a concept and feasibility studyPaulo Crespo
Forschungszentrum Dresden Rossendorf, Institute of Radiation Physics, Bautzner Landstr 128, PO Box 510119, 01314 Dresden, Germany
Phys Med Biol 52:6795-811. 2007..The latter greatly alleviates the installation of in-beam PET at radiotherapeutic sites... - Estimating coarse gene network structure from large-scale gene perturbation dataAndreas Wagner
University of New Mexico and The Santa Fe Institute, University of New Mexico, Department of Biology, Albuquerque, New Mexico 87131 1091, USA
Genome Res 12:309-15. 2002..The network comprises >100 independent subnetworks... - Multifunctionality and robustness trade-offs in model genetic circuitsOlivier C Martin
Univ Paris Sud, UMR8120, Laboratoire de Genetique Vegetale du Moulon, INRA, and CNRS, Gif sur Yvette, F 91190, France
Biophys J 94:2927-37. 2008..As long as there are many alternative network structures, each of which can fulfill all required functions, multiple functions may acquire high robustness through gradual Darwinian evolution... - [Effects of a computer-assisted system for nursing care documentation on quality and quantity of nursing care documentation]Cornelia Mahler
Projektleitung PIK, , Vossstrasse 2, D-69115 Heidelberg
Pflege 16:144-52. 2003..The content of the documentation as well as the individualization of the nursing care plan still need to be improved... - Distributed robustness versus redundancy as causes of mutational robustnessAndreas Wagner
Department of Biology, University of New Mexico, 167A Castetter Hall, Albuquerque, NM 87131 1091, USA
Bioessays 27:176-88. 2005..I also ask whether one can quantify the extent to which redundancy or distributed robustness contribute to mutational robustness... - Does selection mold molecular networks?Andreas Wagner
University of New Mexico, Department of Biology, 167A Castetter Hall, Albuquerque, NM 817131 1091, USA
Sci STKE 2003:PE41. 2003..I illustrate the importance of thorough studies of network evolution with two recent examples, one from genome-scale networks, the other from small transcriptional regulation circuits... - Risk management in biological evolutionAndreas Wagner
Department of Biology, University of New Mexico, 167A Castetter Hall, Albuquerque, NM 817131 1091, USA
J Theor Biol 225:45-57. 2003.... - The rarity of gene shuffling in conserved genesGavin C Conant
Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland
Genome Biol 6:R50. 2005..However, surprisingly little is known about its incidence on a genome-wide scale... - Circuit topology and the evolution of robustness in two-gene circadian oscillatorsAndreas Wagner
Department of Biology, University of New Mexico, 167A Castetter Hall, Albuquerque, NM 87131 1091, USA
Proc Natl Acad Sci U S A 102:11775-80. 2005..The regulatory interlocking of several oscillating gene products in biological circadian oscillators may exist because it provides robustness... - A model of protein translation including codon bias, nonsense errors, and ribosome recyclingMichael A Gilchrist
Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, 37996, USA
J Theor Biol 239:417-34. 2006..These results indirectly validate our underlying model assumptions and confirm that nonsense errors can play an important role in shaping codon usage bias... - Perspective: Evolution and detection of genetic robustnessJ Arjan G M de Visser
Department of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
Evolution 57:1959-72. 2003.... - Enhanced protein loading into liposomes by the multiple crossflow injection techniqueAndreas Wagner
Institute of Applied Microbiology, University of Agricultural Sciences, A 1190 Vienna, Austria
J Liposome Res 12:271-83. 2002..Vesicle size distribution and encapsulation efficiency remain constant. Furthermore, special attention is paid on reproducibility of prepared liposomes, scale-up and on long term stability of the lipid vesicles... - Experimental design for in vitro skin penetration study of liposomal superoxide dismutaseEdith Braun
Institute of Applied Microbiology, Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna, Austria
J Pharm Biomed Anal 40:1187-97. 2006..Analysis of variance showed that the size and the cholesterol content of liposomes as well as the duration of the penetration studies have a statistically significant influence on the amount of protein found in deeper skin layers...