L Vutskits

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint [Do anesthetics impair brain development?]
    L Vutskits
    Département d Anesthésiologie, Pharmacologie et Soins Intensifs, Hopital Cantonal Universitaire de Geneve, 24, rue, Micheli du Crest, 1211 Geneve, Suisse
    Arch Pediatr 13:777-9. 2006
  2. ncbi request reprint Anesthesia management in a young child with aromatic l-amino acid decarboxylase deficiency
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Geneva, Switzerland
    Paediatr Anaesth 16:82-4. 2006
  3. ncbi request reprint Clinically relevant concentrations of propofol but not midazolam alter in vitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Switzerland
    Anesthesiology 102:970-6. 2005
  4. ncbi request reprint Effect of ketamine on dendritic arbor development and survival of immature GABAergic neurons in vitro
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Toxicol Sci 91:540-9. 2006
  5. ncbi request reprint Low concentrations of ketamine initiate dendritic atrophy of differentiated GABAergic neurons in culture
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Toxicology 234:216-26. 2007
  6. doi request reprint Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial
    Laszlo Vutskits
    Division of Anesthesiology, University Hospitals of Geneva, 24, Rue Micheli du Crest, CH 1211, Geneva 14, Switzerland
    Neurochem Res 33:1325-31. 2008
  7. doi request reprint Adverse effects of methylene blue on the central nervous system
    Laszlo Vutskits
    Division of Anesthesiology, University Hospitals of Geneva, and Department of Neuroscience, Faculty of Medicine, Geneva University, Geneva, Switzerland
    Anesthesiology 108:684-92. 2008
  8. ncbi request reprint Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro
    E Gascon
    Department of Neuroscience, University of Geneva Medical School, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    Eur J Neurosci 21:69-80. 2005
  9. doi request reprint New pool of cortical interneuron precursors in the early postnatal dorsal white matter
    O Riccio
    Department of Mental Health and General Psychiatry, University Hospital of Geneva, CH 1211 Geneva 4, Switzerland
    Cereb Cortex 22:86-98. 2012
  10. ncbi request reprint Differential neurotoxic effects of propofol on dissociated cortical cells and organotypic hippocampal cultures
    I Spahr-Schopfer
    Department of Anesthesiology, University Medical Center, University Hospital of Geneva, Geneva, Switzerland
    Anesthesiology 92:1408-17. 2000

Collaborators

Detail Information

Publications27

  1. ncbi request reprint [Do anesthetics impair brain development?]
    L Vutskits
    Département d Anesthésiologie, Pharmacologie et Soins Intensifs, Hopital Cantonal Universitaire de Geneve, 24, rue, Micheli du Crest, 1211 Geneve, Suisse
    Arch Pediatr 13:777-9. 2006
  2. ncbi request reprint Anesthesia management in a young child with aromatic l-amino acid decarboxylase deficiency
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Geneva, Switzerland
    Paediatr Anaesth 16:82-4. 2006
    ..Our experience suggests that, with appropriate anticipation of the potential autonomic disturbances, anesthesia, at least for minor surgical and diagnostic procedures, can be conducted safely in patients with AADC deficiency...
  3. ncbi request reprint Clinically relevant concentrations of propofol but not midazolam alter in vitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Switzerland
    Anesthesiology 102:970-6. 2005
    ..The authors addressed this issue by evaluating the effect of propofol on dendritic growth and arbor expansion of developing gamma-aminobutyric acid-positive (GABAergic) interneurons...
  4. ncbi request reprint Effect of ketamine on dendritic arbor development and survival of immature GABAergic neurons in vitro
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Toxicol Sci 91:540-9. 2006
    ....
  5. ncbi request reprint Low concentrations of ketamine initiate dendritic atrophy of differentiated GABAergic neurons in culture
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Toxicology 234:216-26. 2007
    ..These results raise the possibility that chronic exposure to low, subanesthetic concentrations of ketamine, while not affecting cell survival, could still impair neuronal morphology and thus might lead to dysfunctions of neural networks...
  6. doi request reprint Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial
    Laszlo Vutskits
    Division of Anesthesiology, University Hospitals of Geneva, 24, Rue Micheli du Crest, CH 1211, Geneva 14, Switzerland
    Neurochem Res 33:1325-31. 2008
    ..These data suggest that in males undergoing elective minor surgery, BDNF plasma concentrations show a specific pattern that is influenced by the anesthetic technique and, possibly, by the duration of surgery...
  7. doi request reprint Adverse effects of methylene blue on the central nervous system
    Laszlo Vutskits
    Division of Anesthesiology, University Hospitals of Geneva, and Department of Neuroscience, Faculty of Medicine, Geneva University, Geneva, Switzerland
    Anesthesiology 108:684-92. 2008
    ..Hence, the aim of the current study was to investigate the potentially neurotoxic effects of MB using a combination of in vivo and in vitro experimental approaches...
  8. ncbi request reprint Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro
    E Gascon
    Department of Neuroscience, University of Geneva Medical School, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    Eur J Neurosci 21:69-80. 2005
    ....
  9. doi request reprint New pool of cortical interneuron precursors in the early postnatal dorsal white matter
    O Riccio
    Department of Mental Health and General Psychiatry, University Hospital of Geneva, CH 1211 Geneva 4, Switzerland
    Cereb Cortex 22:86-98. 2012
    ..These results altogether reveal that at postnatal ages, the dorsal white matter contains a pool of interneuron precursors that divide and migrate into the aCC...
  10. ncbi request reprint Differential neurotoxic effects of propofol on dissociated cortical cells and organotypic hippocampal cultures
    I Spahr-Schopfer
    Department of Anesthesiology, University Medical Center, University Hospital of Geneva, Geneva, Switzerland
    Anesthesiology 92:1408-17. 2000
    ..We investigated this issue by comparing the effects of long-term propofol treatment on two models of brain cultures: dissociated neonatal cortical cell cultures and organotypic slice cultures...
  11. ncbi request reprint Potentially toxic effects of anaesthetics on the developing central nervous system
    E Gascon
    University of Geneva Medical School, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva, Switzerland
    Eur J Anaesthesiol 24:213-24. 2007
    ..While clinicians should clearly not withhold anaesthesia based on current animal studies, these observations should urge more laboratory and clinical research to further elucidate this issue...
  12. ncbi request reprint Local gamma-aminobutyric acid and glutamate circuit control of hypophyseotrophic corticotropin-releasing factor neuron activity in the paraventricular nucleus of the hypothalamus
    V Bartanusz
    Department of Morphology, University of Geneva Medical School, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    Eur J Neurosci 19:777-82. 2004
    ..Suppression of GABAergic transmission appears to have a permissive role for inducing an increased secretory activity of CRF neurons that is driven by an excitatory glutamatergic network via AMPA/kainate receptors...
  13. ncbi request reprint The role of neural cell adhesion molecules in plasticity and repair
    J Z Kiss
    Department of Morphology, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 4, Geneva, Switzerland
    Brain Res Brain Res Rev 36:175-84. 2001
    ..Animal models have been developed to assess the role of these molecules in functional recovery after lesions...
  14. pmc Excess of serotonin affects neocortical pyramidal neuron migration
    O Riccio
    Department of Mental Health and Psychiatry, University Hospital of Geneva, Geneva, Switzerland
    Transl Psychiatry 1:e47. 2011
    ..These findings support the hypothesis that developmental dysregulation of serotonin homeostasis has detrimental effects on neocortical circuit formation and contributes to increased vulnerability to psychiatric disorders...
  15. doi request reprint General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt
    C M Lacoh
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, 1211 Geneva, Switzerland
    Br J Anaesth 110:i10-8. 2013
    ..As general anaesthetics are powerful modulators of neuronal activity, the purpose of this study was to explore how these drugs affect KCC2 expression during the brain growth spurt...
  16. ncbi request reprint Removal of PSA from NCAM affects the survival of magnocellular vasopressin- and oxytocin-producing neurons in organotypic cultures of the paraventricular nucleus
    L Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Geneva, Switzerland
    Eur J Neurosci 17:2119-26. 2003
    ..These results suggest that, in addition to its role in neuro-glial plasticity, PSA-NCAM might also influence the trophic factor responsiveness of hypothalamic VP and OT neurosecretory cells...
  17. ncbi request reprint Acute differential modulation of synaptic transmission and cell survival during exposure to pulsed and continuous radiofrequency energy
    Alex Cahana
    Interventional Pain Program, Department of Anesthesiology, Geneva University Hospital, Geneva, Switzerland
    J Pain 4:197-202. 2003
    ..This model might help elucidate the importance of various parameters for the clinical application of radiofrequency lesioning and might open new horizons for the role of pulsed radiofrequency lesioning in cases of neuropathic pain...
  18. ncbi request reprint A role for atm in E-cadherin-mediated contact inhibition in epithelial cells
    Geneviève Vaudan Vutskits
    Division of Oncology, Geneva Medical School, Geneva 4, Switzerland
    Breast Cancer Res Treat 99:143-53. 2006
    ..Altogether, these results suggest that atm could participate in a molecular pathway linking extracellular signalling to cell cycle control and may help further clarify the role of Atm in epithelial cell biology and carcinogenesis...
  19. doi request reprint Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6
    O Riccio
    Department of Adult Psychiatry, University Hospital of Geneva, Geneva, Switzerland
    Mol Psychiatry 14:280-90. 2009
    ....
  20. doi request reprint Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesis
    Adrian Briner
    Department of Anesthesiology, University Hospital of Geneva, Geneva, Switzerland
    Anesthesiology 112:546-56. 2010
    ....
  21. ncbi request reprint Effects of ketamine on the developing central nervous system
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Geneva, Switzerland
    Ideggyogy Sz 60:109-12. 2007
    ....
  22. ncbi request reprint The polysialylated neural cell adhesion molecule promotes neurogenesis in vitro
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Geneva, Switzerland
    Neurochem Res 31:215-25. 2006
    ..These results suggest that, in addition to its role in the migration of neuronal progenitors, PSA-NCAM is required for the adequate survival of these cells...
  23. ncbi request reprint Neuronal-induced and glutamate-dependent activation of glial glutamate transporter function
    Carol L Poitry-Yamate
    Department of Physiology, University of Geneva Medical School CMU, Geneva, Switzerland
    J Neurochem 82:987-97. 2002
    ..Together, these results suggest an activity-dependent neuronal feedback system for rapid astroglial glutamate transporter regulation where neuron-derived glutamate is the physiological signal that triggers transporter function...
  24. ncbi request reprint Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons
    Eduardo Gascon
    Department of Neuroscience, University of Geneva Medical School, 1, rue Michel Servet, CH 1211, Geneva, Switzerland
    Brain Res Rev 56:101-18. 2007
    ..In this review, we discuss the role and mode of actions of PSA-NCAM in structural plasticity as well as its potential link to cognitive processes...
  25. pmc Anesthetics rapidly promote synaptogenesis during a critical period of brain development
    Mathias De Roo
    Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    PLoS ONE 4:e7043. 2009
    ..Importantly, they also raise concern about the potential impact of these drugs on human practice, when applied during critical periods of development in infants...
  26. pmc VEGF is a chemoattractant for FGF-2-stimulated neural progenitors
    Huanxiang Zhang
    Department of Morphology, University Medical Center, University of Geneva Medical School, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Cell Biol 163:1375-84. 2003
    ..These results demonstrate that VEGF is an attractive guidance cue for the migration of undifferentiated neural progenitors and offer a mechanistic link between neurogenesis and angiogenesis in the nervous system...
  27. ncbi request reprint PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival
    Eduardo Gascon
    Department of Neuroscience, University of Geneva Medical School, CH 1211 Geneva, Switzerland
    Development 134:1181-90. 2007
    ..We propose that PSA-NCAM may promote survival by controlling the expression of the p75 receptor in developing neurons...