R von Kanel

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Pain drawings in somatoform-functional pain
    Niklaus Egloff
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
    BMC Musculoskelet Disord 13:257. 2012
  2. doi request reprint Psychosocial stress and cardiovascular risk : current opinion
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    Swiss Med Wkly 142:w13502. 2012
  3. doi request reprint Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy
    R von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern Department of Clinical Research, University of Bern, Bern, Switzerland
    J Thromb Haemost 10:1547-55. 2012
  4. pmc Effect of Alzheimer caregiving on circulating levels of C-reactive protein and other biomarkers relevant to cardiovascular disease risk: a longitudinal study
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland
    Gerontology 58:354-65. 2012
  5. pmc Sleep in spousal Alzheimer caregivers: a longitudinal study with a focus on the effects of major patient transitions on sleep
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland
    Sleep 35:247-55. 2012
  6. pmc Effect of chronic dementia caregiving and major transitions in the caregiving situation on kidney function: a longitudinal study
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, CH 3010 Bern, Switzerland
    Psychosom Med 74:214-20. 2012
  7. pmc Algometry with a clothes peg compared to an electronic pressure algometer: a randomized cross-sectional study in pain patients
    Niklaus Egloff
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, CH 3010 Bern, Switzerland
    BMC Musculoskelet Disord 12:174. 2011
  8. pmc Effect of the G-308A polymorphism of the tumor necrosis factor (TNF)-alpha gene promoter site on plasma levels of TNF-alpha and C-reactive protein in smokers: a cross-sectional study
    Marie Louise Gander
    Department of General Internal Medicine, University Hospital, Bern, Switzerland
    BMC Cardiovasc Disord 4:17. 2004
  9. doi request reprint Momentary stress moderates procoagulant reactivity to a trauma-specific interview in patients with posttraumatic stress disorder caused by myocardial infarction
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, University of Bern, CH 3010 Bern, Switzerland
    J Psychiatr Res 44:956-63. 2010
  10. pmc Regular physical activity moderates cardiometabolic risk in Alzheimer's caregivers
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
    Med Sci Sports Exerc 43:181-9. 2011

Detail Information

Publications90

  1. pmc Pain drawings in somatoform-functional pain
    Niklaus Egloff
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
    BMC Musculoskelet Disord 13:257. 2012
    ..Our aim was to identify the most sensitive and specific graphic criteria as a tool to help identifying somatoform-functional pain...
  2. doi request reprint Psychosocial stress and cardiovascular risk : current opinion
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    Swiss Med Wkly 142:w13502. 2012
    ....
  3. doi request reprint Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy
    R von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern Department of Clinical Research, University of Bern, Bern, Switzerland
    J Thromb Haemost 10:1547-55. 2012
    ..Psychological distress might affect the international normalized ratio (INR), but effects might vary depending on oral anticoagulant (OAC) therapy...
  4. pmc Effect of Alzheimer caregiving on circulating levels of C-reactive protein and other biomarkers relevant to cardiovascular disease risk: a longitudinal study
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland
    Gerontology 58:354-65. 2012
    ..Providing care to a spouse with Alzheimer's disease (AD) may contribute to cardiovascular disease (CVD). The acute phase reactant C-reactive protein (CRP) is a well-established biomarker of an increased CVD risk...
  5. pmc Sleep in spousal Alzheimer caregivers: a longitudinal study with a focus on the effects of major patient transitions on sleep
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland
    Sleep 35:247-55. 2012
    ..We studied the longitudinal effects of dementia caregiving and major transitions in the caregiving situation on caregivers' sleep and the effect of moderating variables...
  6. pmc Effect of chronic dementia caregiving and major transitions in the caregiving situation on kidney function: a longitudinal study
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, CH 3010 Bern, Switzerland
    Psychosom Med 74:214-20. 2012
    ..To estimate the glomerular filtration rate (GFR) in relation to the chronic stress of dementia caregiving and major transitions in the caregiving situation...
  7. pmc Algometry with a clothes peg compared to an electronic pressure algometer: a randomized cross-sectional study in pain patients
    Niklaus Egloff
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, CH 3010 Bern, Switzerland
    BMC Musculoskelet Disord 12:174. 2011
    ..Clinically meaningful" was defined as a medium (r = 0.3-0.5) or high (r > 0.5) correlation coefficient according to Cohen's conventions...
  8. pmc Effect of the G-308A polymorphism of the tumor necrosis factor (TNF)-alpha gene promoter site on plasma levels of TNF-alpha and C-reactive protein in smokers: a cross-sectional study
    Marie Louise Gander
    Department of General Internal Medicine, University Hospital, Bern, Switzerland
    BMC Cardiovasc Disord 4:17. 2004
    ..We investigated whether smoking would interact with the TNF-alpha G-308A polymorphism in determining plasma levels of TNF-alpha and CRP...
  9. doi request reprint Momentary stress moderates procoagulant reactivity to a trauma-specific interview in patients with posttraumatic stress disorder caused by myocardial infarction
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, University of Bern, CH 3010 Bern, Switzerland
    J Psychiatr Res 44:956-63. 2010
    ..Procoagulant reactivity in post-MI patients with PTSD confronted with their traumatically experienced MI was observed if patients perceived high levels of momentary stress before the interview...
  10. pmc Regular physical activity moderates cardiometabolic risk in Alzheimer's caregivers
    Roland von Kanel
    Division of Psychosomatic Medicine, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
    Med Sci Sports Exerc 43:181-9. 2011
    ..Regular physical exercise reduces cardiometabolic risk, but caregivers may have less opportunity to engage in such activity. We hypothesized that regular physical activity would moderate cardiometabolic risk in dementia caregivers...
  11. doi request reprint Heart rate recovery after exercise in chronic heart failure: role of vital exhaustion and type D personality
    Roland von Kanel
    Cardiovascular Prevention and Rehabilitation, Bern University Hospital, Inselspital, and University of Bern, Switzerland
    J Cardiol 53:248-56. 2009
    ..Reduced heart rate recovery (HRR) also predicts morbidity and mortality in CHF. We hypothesized that elevated levels of vital exhaustion and type D personality are both associated with decreased HRR...
  12. doi request reprint Measures of endothelial dysfunction in plasma of patients with posttraumatic stress disorder
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Switzerland
    Psychiatry Res 158:363-73. 2008
    ..This suggests one mechanism by which posttraumatic stress could contribute to atherosclerosis...
  13. doi request reprint Relation of heart rate recovery to psychological distress and quality of life in patients with chronic heart failure
    Roland von Kanel
    Cardiovascular Prevention and Rehabilitation, Bern University Hospital, Inselspital, University of Bern, Switzerland
    Eur J Cardiovasc Prev Rehabil 16:645-50. 2009
    ..We hypothesized lower HRR with greater psychological distress and poorer QoL in CHF...
  14. doi request reprint Effects of aspirin and propranolol on the acute psychological stress response in factor VIII coagulant activity: a randomized, double-blind, placebo-controlled experimental study
    Roland von Kanel
    Department of General Internal Medicine, Swiss Cardiovascular Center, University Hospital Berne, Berne, Switzerland
    Blood Coagul Fibrinolysis 19:75-81. 2008
    ..The effect of single aspirin on the acute clotting factor VIII stress response was indistinguishable from a placebo effect...
  15. pmc Problem behavior of dementia patients predicts low-grade hypercoagulability in spousal caregivers
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, CH 3010 Bern, Switzerland
    J Gerontol A Biol Sci Med Sci 65:1004-11. 2010
    ..We hypothesized that dementia patients' problem behaviors and negative reactions of caregivers to these behaviors would relate to hypercoagulability in caregivers...
  16. ncbi request reprint Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: a randomized, double-blind, placebo-controlled study
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Bern, CH 3010 Bern, Switzerland
    Brain Behav Immun 22:150-7. 2008
    ..Aspirin but not propranolol attenuated the stress-induced increase in plasma IL-6 levels. This suggests one mechanism by which aspirin treatment might reduce the risk of atherothrombotic events triggered by acute mental stress...
  17. doi request reprint Posttraumatic stress disorder and soluble cellular adhesion molecules at rest and in response to a trauma-specific interview in patients after myocardial infarction
    Roland von Kanel
    Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland
    Psychiatry Res 179:312-7. 2010
    ..Elevated levels of circulating CAMs might help explain the psychophysiologic link of PTSD with cardiovascular risk...
  18. doi request reprint The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    J Cardiovasc Pharmacol 51:231-8. 2008
    ..This suggests that these cardiovascular drugs might exert limited protection from the development of stress-triggered coronary thrombosis...
  19. doi request reprint Stress hormones in patients with posttraumatic stress disorder caused by myocardial infarction and role of comorbid depression
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    J Affect Disord 121:73-9. 2010
    ....
  20. doi request reprint Nighttime vagal cardiac control and plasma fibrinogen levels in a population of working men and women
    Roland von Kanel
    Department of General Internal Medicine, Bern University Hospital, Inselspital, Bern, Switzerland
    Ann Noninvasive Electrocardiol 14:176-84. 2009
    ..The vagus nerve curtails inflammation via a cholinergic antiinflammatory pathway. We hypothesized that lower vagal control of the heart relates to higher plasma fibrinogen levels...
  21. pmc Autonomic function and prothrombotic activity in women after an acute coronary event
    Roland von Kanel
    Department of General Internal Medicine, University Hospital, Inselspital, CH 3010 Bern, Switzerland
    J Womens Health (Larchmt) 17:1331-7. 2008
    ..The link between decreased heart rate variability (HRV) and atherosclerosis progression is elusive. We hypothesized that reduced HRV relates to increased levels of prothrombotic factors previously shown to predict coronary risk...
  22. doi request reprint Prothrombotic changes with acute psychological stress: combined effect of hemoconcentration and genuine coagulation activation
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Inselspital, CH 3010 Bern Switzerland
    Thromb Res 123:622-30. 2009
    ..We investigated the extent to which the change in prothrombotic measures with acute stress reflects hemoconcentration and genuine activation of coagulation...
  23. ncbi request reprint [The burnout syndrome: a medical perspective]
    R von Kanel
    Kompetenzbereich für Psychosomatische Medizin, Klinik für Allgemeine Innere Medizin, Universitatsspital, Inselspital, Bern
    Praxis (Bern 1994) 97:477-87. 2008
    ..These are complemented by more specific interventions targeting job stress related factors. Relapse prevention focuses on early recognition of warning signs and is an ongoing process...
  24. doi request reprint Posttraumatic stress disorder and dyslipidemia: previous research and novel findings from patients with PTSD caused by myocardial infarction
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
    World J Biol Psychiatry 11:141-7. 2010
    ..Based on a brief systematic review suggesting dyslipidemia in posttraumatic stress disorder (PTSD), we studied, for the first time, levels of blood lipids in patients with a DSM-IV diagnosis of PTSD caused by myocardial infarction (MI)...
  25. doi request reprint Association between posttraumatic stress disorder following myocardial infarction and liver enzyme levels: a prospective study
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, and University of Bern, 3010, Bern, Switzerland
    Dig Dis Sci 55:2614-23. 2010
    ..Moreover, chronic posttraumatic stress disorder and transaminases predicted coronary heart disease...
  26. doi request reprint Accumulation of 30 min of moderately intense physical activity is a clinically meaningful treatment to reduce systolic blood pressure in prehypertension
    R von Kanel
    Psychocardiology Unit, Department of General Internal Medicine, Cardiac Prevention and Rehabilitation, Bern University Hospital Inselspital, University of Bern, Bern, Switzerland
    J Hum Hypertens 22:444-6. 2008
  27. doi request reprint Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital and University of Bern, CH 3010 Bern, Switzerland
    Neuroimmunomodulation 17:39-46. 2010
    ..We explored the association between PTSD and inflammatory biomarkers related to cardiovascular morbidity and the role of co-morbid depressive symptoms in this relationship...
  28. pmc Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    Clin Res Cardiol 100:241-7. 2011
    ..We investigated whether decreased HRV is associated with inflammatory markers in patients with coronary heart disease (CHD)...
  29. ncbi request reprint Relation of morning serum cortisol to prothrombotic activity in women with stable coronary artery disease
    Roland von Kanel
    Department of General Internal Medicine, University Hospital, Berne 3010, Switzerland
    J Thromb Thrombolysis 25:165-72. 2008
    ..We hypothesized a direct relationship between cortisol and hemostasis factors related to a prothrombotic state in coronary artery disease...
  30. ncbi request reprint Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, CH 3010 Berne, Switzerland
    Clin Sci (Lond) 109:61-7. 2005
    ..Pro-inflammatory and procoagulant changes with stress were associated. Aside from fibrinogen reactivity, IL-6 reactivity was an independent predictor of stress-induced fibrin formation...
  31. ncbi request reprint Hypercoagulability in working men and women with high levels of panic-like anxiety
    Roland von Kanel
    Institute for Behavioral Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Psychother Psychosom 73:353-60. 2004
    ..An increased clotting diathesis might subject anxious individuals to an elevated arterial thrombotic risk. We investigated whether panic-like anxiety would relate to a hypercoagulable state...
  32. ncbi request reprint Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: how strong is the evidence?
    R von Kanel
    Department of General Internal Medicine, University Hospital, CH 3010 Bern, Switzerland
    Acta Psychiatr Scand 110:163-77. 2004
    ..This study reviewed the evidence for hyperactive platelets and for effects of antidepressant drug treatment on platelet 'stickiness' in clinical depression...
  33. ncbi request reprint Relationship between overnight neuroendocrine activity and morning haemostasis in working men
    Roland von Kanel
    Institute for Behavioral Sciences, Federal Institute of Technology, Zurich, Switzerland
    Clin Sci (Lond) 107:89-95. 2004
    ..Although overnight SNS hyperactivity was associated independently with morning hypercoagulability, the relationship between the activity of HPAA and haemostasis was mediated by traditional cardiovascular risk factors...
  34. ncbi request reprint Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Switzerland
    Brain Behav Immun 20:40-8. 2006
    ..The hypothalamus-pituitary-adrenal axis may attenuate stress reactivity of IL-6. The lack of habituation in IL-6 responses to daily stress could subject at-risk individuals to higher atherosclerotic morbidity and mortality...
  35. ncbi request reprint Opposite effect of negative and positive affect on stress procoagulant reactivity
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Switzerland
    Physiol Behav 86:61-8. 2005
    ..Negative affect was associated with attenuated procoagulant reactivity to stress and the opposite was observed for positive affect. Negative affect is not likely to enhance the acute procoagulant stress response in healthy men...
  36. ncbi request reprint [Psychosomatic medicine in primary care]
    R von Kanel
    Abteilung für Psychosomatische Medizin C L Lory Haus, Klinik für Aligemeine Innere Medizin, Inselspital, Universitatsspital Bern
    Praxis (Bern 1994) 95:311-20. 2006
    ..Adopting this approach will allow the PCP to be challenged but not overburdened by, on an average, 30-50% of his patients presenting with psychosomatic symptoms...
  37. pmc Distress related to myocardial infarction and cardiovascular outcome: a retrospective observational study
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    BMC Psychiatry 11:98. 2011
    ..We hypothesized that retrospective ratings of patients' MI-related fear of dying, helplessness, or pain, all assessed within the first year post-MI, are associated with poor cardiovascular outcome...
  38. doi request reprint Effects of social support on the clinical course of Crohn's disease
    Rafael J A Cámara
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, Bern, Switzerland
    Inflamm Bowel Dis 17:1277-86. 2011
    ..We hypothesized that higher social support would predict a more favorable course of Crohn's disease (CD) directly (main effect hypothesis) and via moderating other prognostic factors (buffer hypothesis)...
  39. ncbi request reprint Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Inselspital, Freiburgstrasse 4, CH 3010 Berne, Switzerland
    J Psychiatr Res 41:744-52. 2007
    ..41, p=0.035). PTSD patients showed a low-grade systemic proinflammatory state, which, moreover, was related to PTSD symptom levels suggesting one mechanism by which PTSD could contribute to atherosclerotic disease...
  40. ncbi request reprint The effect of natural habituation on coagulation responses to acute mental stress and recovery in men
    Roland von Kanel
    Department of General Internal Medicine Division of Psychosomatic Medicine, University Hospital Inselspital, CH 3010 Berne, Switzerland
    Thromb Haemost 92:1327-35. 2004
    ..An incapacity of the coagulation system to adapt to stress repeats is perhaps a consequence of evolution, but might also contribute to increased coronary risk in some individuals, particularly in those with cardiovascular diseases...
  41. ncbi request reprint Responsiveness and habituation of soluble ICAM-1 to acute psychosocial stress in men: determinants and effect of stress-hemoconcentration
    R von Kanel
    Department of General Internal Medicine, University Hospital Inselspital, Bern, Switzerland
    Physiol Res 56:627-39. 2007
    ..001). Stress responsiveness of plasma sICAM-1 was predicted by stress perception and hemodynamic reactivity and affected by stress-hemoconcentration but unrelated to cortisol reactivity and not readily adapting to repeated stress...
  42. doi request reprint Non-fatal cardiovascular outcome in patients with posttraumatic stress symptoms caused by myocardial infarction
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
    J Cardiol 58:61-8. 2011
    ..Between 10% and 20% of patients develop PTSD related to the traumatic experience of myocardial infarction (MI). We investigated the hypothesis that PTSD symptoms caused by MI predict adverse cardiovascular outcome...
  43. ncbi request reprint Altered blood coagulation in patients with posttraumatic stress disorder
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Berne, Switzerland
    Psychosom Med 68:598-604. 2006
    ..A hypercoagulable state before occurrence of coronary thrombosis contributes to atherosclerosis development. We investigated whether PTSD would be associated with increased coagulation activity...
  44. doi request reprint [Multimodal therapy of functional gastrointestinal disorders]
    N Egloff
    Kompetenzbereich für Psychosomatische Medizin, Universitätsklinik für Allgemeine Innere Medizin, Inselspital, Universitatsspital Bern
    Praxis (Bern 1994) 99:487-93. 2010
    ..Our overview portrays the options for the therapy of FGD and proposes that these are best provided by an interdisciplinary team of primary care physicians, gastroenterologists, and psychosomatic medicine specialists...
  45. ncbi request reprint Independent relation of vital exhaustion and inflammation to fibrinolysis in apparently healthy subjects
    Roland von Kanel
    Institute for Behavioral Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Scand Cardiovasc J 38:28-32. 2004
    ..Candidate mechanisms by which VE predicts CAD events are impaired fibrinolysis and inflammatory changes, the latter also affecting hemostasis. We investigated whether VE and inflammation would independently relate to hemostasis...
  46. ncbi request reprint Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimer
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Switzerland
    J Gerontol A Biol Sci Med Sci 61:963-9. 2006
    ..We hypothesized that, compatible with premature frailty, chronic stress and age are related in predicting inflammation and coagulation activity in Alzheimer caregivers...
  47. ncbi request reprint Contribution of the type 1 plasminogen activator inhibitor 4G/5G gene polymorphism to impaired fibrinolysis in vital exhaustion
    Roland von Kanel
    Institute for Behavioral Sciences, Swiss Federal Institute of Technology, University Hospital, Zurich, Switzerland
    Ital Heart J 4:791-6. 2003
    ..Genetic and environmental factors both regulate the plasma PAI-1 levels. We investigated the contribution of the PAI-1 4G/5G gene polymorphism to the plasma levels of PAI-1 in exhaustion...
  48. ncbi request reprint Reduced glucocorticoid sensitivity of monocyte interleukin-6 production in male industrial employees who are vitally exhausted
    Petra H Wirtz
    Department of Behavioral Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Psychosom Med 65:672-8. 2003
    ..We hypothesized that vital exhaustion may alter the regulation of monocyte activity, as measured by lipopolysaccharide (LPS)-stimulated and glucocorticoid inhibited release of the proinflammatory cytokine interleukin-6 (IL-6)...
  49. ncbi request reprint Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise
    Roland von Kanel
    Division of General Internal Medicine and Cardiovascular Prevention and Rehabilitation, Swiss Cardiovascular Center Berne, Department of Cardiology, University Hospital Berne, Berne, Switzerland
    Am J Hypertens 20:670-5. 2007
    ..We investigated the association of screening blood pressure (BP) and cardiorespiratory fitness with baseline levels and exercise-induced changes in levels of soluble atherosclerotic risk markers...
  50. ncbi request reprint Elevated Plasma C-reactive protein in chronically distressed subjects who carry the A allele of the TNF-alpha -308 G/A polymorphism
    Pascal Jeanmonod
    Institute for Behavioral Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Psychosom Med 66:501-6. 2004
    ..We investigated the effect of exhaustion severity on plasma levels of C-reactive protein (CRP) and whether exhaustion might regulate CRP levels via the -308G/A polymorphism of the tumor necrosis factor (TNF)-alpha gene...
  51. doi request reprint Association between burnout and circulating levels of pro- and anti-inflammatory cytokines in schoolteachers
    Roland von Kanel
    Division of Psychosomatic Medicine, Inselspital, Bern University Hospital and University of Bern, Switzerland
    J Psychosom Res 65:51-9. 2008
    ..Knowing that a chronic low-grade systemic inflammatory state contributes to atherosclerosis, we investigated circulating cytokine levels in relation to burnout symptoms...
  52. doi request reprint Overcommitment but not effort-reward imbalance relates to stress-induced coagulation changes in teachers
    Roland von Kanel
    Division of Psychosomatic Medicine, Bern University Hospital Inselspital and University of Bern, Bern, Switzerland
    Ann Behav Med 37:20-8. 2009
    ..Stress-related hypercoagulability might link job stress with atherosclerosis...
  53. pmc Monocyte proinflammatory cytokine release is higher and glucocorticoid sensitivity is lower in middle aged men than in women independent of cardiovascular risk factors
    P H Wirtz
    Institute of Clinical Psychology II, University of Zurich, Zurich, Switzerland
    Heart 90:853-8. 2004
    ..To investigate whether stimulated monocyte cytokine release and its inhibition by glucocorticoids differs between men and women...
  54. doi request reprint Quality of life: a potentially useful measure to indicate subclinical flares in Crohn disease
    R J A Cámara
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, Bern, Switzerland
    Intern Med J 42:e145-51. 2012
    ..If QoL measures were to be associated with intestinal inflammatory activity, they might be useful for early detection of subclinical flares...
  55. pmc Relationship between heart rate variability, interleukin-6, and soluble tissue factor in healthy subjects
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    Brain Behav Immun 22:461-8. 2008
    ..Inflammation and related hypercoagulability might particularly contribute to atherothrombotic events in a setting of decreased HRV...
  56. ncbi request reprint Procoagulant stress reactivity and recovery in apparently healthy men with systolic and diastolic hypertension
    Petra H Wirtz
    Department of Clinical Psychology and Psychotherapy, University of Zurich, Zurich, and Department of General Internal Medicine, University Hospital Berne, Switzerland
    J Psychosom Res 63:51-8. 2007
    ....
  57. pmc Sleep and biomarkers of atherosclerosis in elderly Alzheimer caregivers and controls
    Roland von Kanel
    Department of General Internal Medicine, Inselspital, University Hospital and University of Bern, Bern, Switzerland
    Gerontology 56:41-50. 2010
    ..Perturbed sleep might contribute to cardiovascular disease by accelerating atherosclerosis. Sleep is poor in Alzheimer caregivers who are also a group at increased cardiovascular risk...
  58. doi request reprint [Nondermatomal somatosensory deficits in chronic pain patients]
    N Egloff
    Kompetenzbereich für Psychosomatische Medizin, Universitätsklinik für Allgemeine Innere Medizin, C L Lory Haus, Inselspital Bern, 3010, Bern, Schweiz
    Schmerz 25:632-42. 2011
    ..Most patients with chronic pain disorders as well as those with NDSD often report an antecedent period of high psychobiological stress. The data from functional imaging reveal a complex pattern of a central nervous dysregulation...
  59. ncbi request reprint Relationship between hemoconcentration and blood coagulation responses to acute mental stress
    Lilian Zgraggen
    Institute for Behavioral Sciences, Federal Institute of Technology, Zurich, Switzerland
    Thromb Res 115:175-83. 2005
    ..Acute mental stress elicits reliable changes in blood coagulation factors. We studied whether stress-related changes in coagulation measures are associated with concomitant hemoconcentration...
  60. doi request reprint Association between longitudinal changes in depressive symptoms and plasma fibrinogen levels in school teachers
    Roland von Kanel
    Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
    Psychophysiology 46:473-80. 2009
    ..This dynamic relationship between depression and the inflammatory biomarker fibrinogen might advance our knowledge about psychobiological mechanisms underlying both CAD and sickness behavior...
  61. ncbi request reprint Poor sleep is associated with higher plasma proinflammatory cytokine interleukin-6 and procoagulant marker fibrin D-dimer in older caregivers of people with Alzheimer's disease
    Roland von Kanel
    Department of General Internal Medicine, University Hospital, Berne, Switzerland
    J Am Geriatr Soc 54:431-7. 2006
    ..To determine whether objective measures of sleep correlate with plasma levels of the proinflammatory cytokine interleukin (IL)-6 and the procoagulant marker fibrin D-dimer in caregivers of patients with dementia...
  62. ncbi request reprint Association between sleep apnea severity and blood coagulability: Treatment effects of nasal continuous positive airway pressure
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Bern, Bern, Switzerland
    Sleep Breath 10:139-46. 2006
    ..Apnea severity may be associated with impairment in the fibrinolytic capacity. To the extent that our sample size was limited, the observation that CPAP treatment led to a decrease in PAI-1 in OSA must be regarded as tentative...
  63. doi request reprint Association of vital exhaustion and depressive symptoms with changes in fibrin D-dimer to acute psychosocial stress
    Roland von Kanel
    Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    J Psychosom Res 67:93-101. 2009
    ..We aimed to investigate the hypothesis that vital exhaustion and depression correlate with stress-induced changes in the hypercoagulability marker D-dimer...
  64. ncbi request reprint Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease?
    R von Kanel
    Division of Psychosocial Medicine, University Hospital, Zurich, Switzerland
    Psychosom Med 63:531-44. 2001
    ..This review explores whether changes in blood coagulation, anticoagulant, and fibrinolytic activity may constitute psychobiological pathways that link psychological factors with coronary syndromes...
  65. doi request reprint Physician speciality and pain reduction in patients with depressive symptoms under treatment with venlafaxine
    S Begré
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Inselspital, 3010 Bern, Switzerland
    Eur Psychiatry 25:455-60. 2010
    ..Naturalistic studies on patients with chronic pain and depressive symptoms investigating the impact of medical speciality on treatment outcome in a primary care setting are lacking...
  66. ncbi request reprint [Neither Descartes nor Freud? current pain models in psychosomatic medicine]
    N Egloff
    Kompetenzbereich für Psychosomatische Medizin Inselspital, Universitat Bern
    Praxis (Bern 1994) 97:549-57. 2008
    ..Current scientific knowledge calls for distinct pain concepts, which integrate neurobiological and neuropsychological aspects of pain processing...
  67. ncbi request reprint Avoidance and inhibition do not predict nonrespondent bias among patients with inflammatory bowel disease
    Rafael J A Cámara
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, Bern, Switzerland
    J Epidemiol 21:44-51. 2011
    ..However, this is only possible when withdrawers and nonwithdrawers differ in an important way. We tested the hypothesis that withdrawers are more likely than nonwithdrawers to be avoidant and negatively affected...
  68. ncbi request reprint [The effect of stress-relieving interventions on inflammatory bowel disease: quality assessment of 10 therapeutic studies]
    Rafael J A Cámara
    Klinik für Allgemeine Innere Medizin, Abteilung für Psychosomatische Medizin, Universitätsspital Bern Inselspital, Freiburgstrasse, CH 3010 Bern, Switzerland
    Z Psychosom Med Psychother 56:116-35. 2010
    ..We performed a quality assessment of previous studies on the effect of stress reduction on IBD in order to formulate recommendations for future studies and to evaluate their potential for improvement...
  69. doi request reprint [Characteristics of patients suffering from chronic pain with depressive symptoms in three different treatment settings]
    Stefan Begré
    Klinik für Allgemeine Innere Medizin, Kompetenzbereich für Psychosomatische Medizin, Inselspital, Universitatsspital Bern, Bern, Schweiz
    Med Klin (Munich) 105:393-8. 2010
    ..Only few studies considered demographic and medical characteristics of pain patients with depressive symptoms...
  70. ncbi request reprint Relation of autonomic activity to plasminogen activator inhibitor-1 plasma concentration and the role of body mass index
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    Blood Coagul Fibrinolysis 18:353-9. 2007
    ..More apparent, higher BMI explained a significant proportion of the variance in the relationship between depressed sympathetic and parasympathetic activity and elevated plasma PAI-1 concentration...
  71. doi request reprint Change in pain severity with open label venlafaxine use in patients with a depressive symptomatology: an observational study in primary care
    Stefan Begré
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Inselspital, CH 3010 Bern, Switzerland
    Eur Psychiatry 23:178-86. 2008
    ..This observational study aimed to elucidate the efficacy of venlafaxine and its prescription by Swiss primary care physicians and psychiatrists in patients with chronic pain and depressive symptomatology...
  72. doi request reprint The role of psychological stress in inflammatory bowel disease: quality assessment of methods of 18 prospective studies and suggestions for future research
    Rafael J A Cámara
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Bern University Hospital, University of Bern, Switzerland
    Digestion 80:129-39. 2009
    ..However, since this influence remains hypothetical, further research is essential. We aimed to devise recommendations for future investigations in IBD by means of scrutinizing previously applied methodology...
  73. ncbi request reprint Glucocorticoid sensitivity of circulating monocytes in essential hypertension
    Petra H Wirtz
    Institute for Behavioral Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Hypertens 17:489-94. 2004
    ..We investigated whether stimulated monocyte cytokine release and its inhibition by glucocorticoids would differ between hypertensive and normotensive subjects...
  74. doi request reprint Regional origin and decrease of pain in patients with depressive symptoms under treatment with venlafaxine
    Stefan Begré
    Division of Psychosomatic Medicine, Department of General Internal Medicine, University Hospital Inselspital, 3010, Bern, Switzerland
    Soc Psychiatry Psychiatr Epidemiol 45:17-24. 2010
    ..Language barrier and sociocultural disparity of Eastern and Southern European patients may hamper recovery from pain and depression compared to Middle European patients in Switzerland...
  75. doi request reprint Inflammation as a psychophysiological biomarker in chronic psychosocial stress
    Alexander Hänsel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
    Neurosci Biobehav Rev 35:115-21. 2010
    ..In summary, job stress, low socioeconomic status, childhood adversities as well as life events, caregiver stress, and loneliness were all shown to exert effects on immunologic activity...
  76. pmc Day/Night rhythm of hemostatic factors in obstructive sleep apnea
    Roland von Kanel
    Department of General Internal Medicine, Bern University Hospital, Inselspital, Switzerland
    Sleep 33:371-7. 2010
    ..To investigate the hypothesis that day/night patterns of prothrombotic activity differ between patients with obstructive sleep apnea (OSA) and individuals with no OSA...
  77. doi request reprint Prevalence and predictors of posttraumatic stress disorder in patients with acute myocardial infarction
    Lina Wiedemar
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    Heart Lung 37:113-21. 2008
    ..We estimated the prevalence of posttraumatic stress disorder (PTSD) and identified predictors of self-rated PTSD symptoms in patients post-myocardial infarction (MI)...
  78. ncbi request reprint Relation of white matter anisotropy to visual memory in 17 healthy subjects
    Stefan Begré
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital Berne, University of Berne, Freiburgstrasse, CH 3010 Berne, Switzerland
    Brain Res 1168:60-6. 2007
    ..61 to r< .81; df=15, p< .01 to p< .0001). The findings provide in vivo evidence for the contribution of white matter structure to visual memory in healthy people...
  79. doi request reprint [Chronic right-sided pain-associated nondermatomal somatosensory deficit following an accident]
    Niklaus Egloff
    Kompetenzbereich für Psychosomatische Medizin, Universitätsklinik für Allgemeine Innere Medizin, Inselspital, Universitatsspital Bern
    Praxis (Bern 1994) 99:797-801. 2010
    ..Psychological stress prior to or around the triggering event seems an important risk factor for NDSDs...
  80. ncbi request reprint The interrelationship of psychosocial risk factors for coronary artery disease in a working population: do we measure distinct or overlapping psychological concepts?
    Brigitte M Kudielka
    Institute for Behavioral Sciences, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Behav Med 30:35-43. 2004
    ..This strengthens the assumption that the psychometric scales used constitute distinct psychological concepts, in particular, depressive symptomatology and negative affectivity versus vital exhaustion...
  81. ncbi request reprint The effect of repeated acute mental stress on habituation and recovery responses in hemoconcentration and blood cells in healthy men
    Katharina Mischler
    Institute for Behavioral Sciences, Federal Institute of Technology, Zurich, Switzerland
    Life Sci 77:1166-79. 2005
    ..Plasma volume shift accompanying stress affects the time course of stress polycytosis...
  82. doi request reprint Depression and anxiety symptoms affect change in exercise capacity during cardiac rehabilitation
    Evelyne Egger
    Department of General Internal Medicine, Bern University Hospital, Inselspital, and University of Bern, Switzerland
    Eur J Cardiovasc Prev Rehabil 15:704-8. 2008
    ..To study whether symptoms of depression and anxiety would affect changes in exercise capacity and body mass index (BMI) during rehabilitation...
  83. ncbi request reprint Trajectory of posttraumatic stress disorder caused by myocardial infarction: a two-year follow-up study
    Chiara C Abbas
    Bern University Hospital, Switzerland
    Int J Psychiatry Med 39:359-76. 2009
    ..The aim of this study was to investigate the longitudinal course of an interviewer-rated diagnosis of PTSD and PTSD symptom severity following MI...
  84. doi request reprint Independent association of sleep quality, fatigue, and vital exhaustion with platelet count in patients with a previous venous thromboembolic event
    René Krummenacher
    Department of General Internal Medicine, Inselspital, CH 3010 Bern, Switzerland
    Platelets 20:566-74. 2009
    ..Given the emerging role of inflammatory processes in VTE, the findings suggest a mechanism through which behavioral and chronic psychological stressors might contribute to incident and recurrent venous thrombotic events...
  85. doi request reprint Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controls
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Berne, Switzerland
    Gerontology 54:131-7. 2008
    ..Elderly individuals who provide care to a spouse suffering from dementia bear an increased risk of coronary heart disease (CHD)...
  86. ncbi request reprint Overcommitment to work is associated with vital exhaustion
    Daniel Preckel
    Swiss Federal Institute of Technology ETH, Institute for Behavioral Sciences, Turnerstrasse 1, 8092 Zurich, Switzerland
    Int Arch Occup Environ Health 78:117-22. 2005
    ....
  87. doi request reprint Change over time in posttraumatic stress caused by myocardial infarction and predicting variables
    Roman Hari
    Department of General Internal Medicine, Division of Psychosomatic Medicine, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    J Psychosom Res 69:143-50. 2010
    ..While several predictors of posttraumatic stress in the first year after MI have been described, we particularly sought to identify longer-term predictors and predictors of change in posttraumatic stress over time...
  88. doi request reprint Clinical diagnosis of posttraumatic stress disorder after myocardial infarction
    Erika Guler
    Cardiovascular Prevention and Rehabilitation, Department of General Internal Medicine, Bern University Hospital, Inselspital, and University of Bern, Bern, Switzerland
    Clin Cardiol 32:125-9. 2009
    ..Clinician-rated large-scale studies estimating the prevalence of posttraumatic stress disorder (PTSD) related to myocardial infarction (MI) and identifying predictors of clinical PTSD are currently lacking...
  89. doi request reprint [Pathogenesis of functional gastrointestinal disorders - an interdisciplinary perspective]
    N Egloff
    Kompetenzbereich für Psychosomatische Medizin, Universitätsklinik für Allgemeine Innere Medizin, Inselspital, Universitatsspital Bern
    Praxis (Bern 1994) 99:419-27. 2010
    ..Our overview clearly shows that an interdisciplinary perspective of the pathogenesis of FGD may best serve clinicians and patients...
  90. doi request reprint [Therapy of disorders with central pain sensitization.]
    N Egloff
    Kompetenzbereich für Psychosomatische Medizin, Inselspital, Universitat Bern
    Praxis (Bern 1994) 98:271-83. 2009
    ..The lists of medications targeting neuropathic and somatoform pain disorder show considerable overlap. Psychotherapy helps patients with central pain sensitization to improve pain control, emotional regulation and pain behaviour...