Research Topics
Genomes and Genes
| Francois VerreySummaryAffiliation: University of Zurich Country: Switzerland Publications
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Detail Information
Publications
Novel renal amino acid transportersFrancois Verrey
University of Zurich, Institute of Physiology, CH 8057 Zurich, Switzerland
Annu Rev Physiol 67:557-72. 2005..Additionally, cationic amino acids and some other neutral amino acids leave the cell basolaterally via heterodimeric obligatory exchangers...- CATs and HATs: the SLC7 family of amino acid transportersFrancois Verrey
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
Pflugers Arch 447:532-42. 2004..Mutations in b(0,+)-like and y(+)L transporters lead to the hereditary diseases cystinuria and lysinuric protein intolerance (LPI), respectively... - Short-term aldosterone action on Na,K-ATPase surface expression: role of aldosterone-induced SGK1?Francois Verrey
Institute of Physiology, University of Zurich, Switzerland
Ann N Y Acad Sci 986:554-61. 2003..Results obtained in the Xenopus oocyte expression system suggest the possibility that this effect could be mediated in part by the aldosterone-induced kinase SGK1... - SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cellsFrancois Verrey
Institute of Physiology, University of Zurich, Switzerland
Cell Physiol Biochem 13:21-8. 2003.... - System L: heteromeric exchangers of large, neutral amino acids involved in directional transportFrancois Verrey
University of Zurich, Institute of Physiology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Pflugers Arch 445:529-33. 2003..By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L... - WNK4, as thiazides, shuts off NaCl reabsorption to stimulate Na/K exchangeFrancois Verrey
Institute of Physiology, , Winterthurerstrasse 190, , Switzerland
Nephrol Dial Transplant 22:1305-8. 2007 - Early transcriptional control of ENaC (de)ubiquitylation by aldosteroneF Verrey
Institute of Physiology and Centre for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
Kidney Int 73:691-6. 2008.... 
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutationsSimone M R Camargo
Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Gastroenterology 136:872-82. 2009..The expression of B(0)AT1 in kidney was recently shown to depend on its association with collectrin (Tmem27), a protein homologous to the membrane-anchoring domain of angiotensin-converting enzyme (ACE) 2...- The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistanceMarkus A Seeger
Institute of Physiology, Zurich Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Curr Drug Targets 9:729-49. 2008..The novel transport model merges Jardetzky's alternate access pump mechanism with the rotating site catalysis of F(1)F(0) ATPase and suggests a working hypothesis for the transport mechanism of RND transporters in general... 
Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3Dustin Singer
Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
J Biol Chem 284:19953-60. 2009..Taken together, our data indicate that the formerly orphan transporter XT2 functions as a sodium and chloride-de pend ent neutral amino acid transporter that we propose to rename B(0)AT3...- Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchangerTamara Ramadan
Zurich Centre for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
Pflugers Arch 454:507-16. 2007..Taken together, the results suggest that the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates... - Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrBMarkus A Seeger
Institute of Physiology and Zurich Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Nat Struct Mol Biol 15:199-205. 2008..Regain of function for impaired mutants was obtained upon exposure to the reducing agent DTT. The results support the presence of the asymmetric AcrB trimer in E. coli membranes and the functional rotation mechanism... - Steady-state kinetic characterization of the mouse B(0)AT1 sodium-dependent neutral amino acid transporterSimone M R Camargo
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Pflugers Arch 451:338-48. 2005.... - Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculusElisa Romeo
Institute of Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 290:F376-83. 2006..It also shows that the structurally highly similar orphan transporters XT2 and XT3 have the same luminal but a slightly differing axial localization along the kidney proximal tubule... - Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathwayTamara Ramadan
Institute of Physiology and Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse, Zurich, Switzerland
J Cell Physiol 206:771-9. 2006..We propose that it, thereby, may supply parallel exchangers with recycling uptake substrates that could drive the efflux of other amino acids... - Aromatic amino acid transporter AAT-9 of Caenorhabditis elegans localizes to neurons and muscle cellsEmilija Veljkovic
Institutes of Physiology and Zoology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Biol Chem 279:49268-73. 2004..Taken together, the results show that AAT-9 is expressed in excitable cells of the nematode head and pharynx in which it may provide a pathway for aromatic amino acid transport... - SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytesMarija Zecevic
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Pflugers Arch 448:29-35. 2004.... - Defective intestinal amino acid absorption in Ace2 null miceDustin Singer
Institute of Physiology, University of Zurich, Switzerland
Am J Physiol Gastrointest Liver Physiol 303:G686-95. 2012..In summary, mice lacking Ace2-dependent intestinal amino acid transport display no total niacin deficiency nor clear pellagra symptoms, even under a low-protein and low-niacin diet, despite gross amino acid homeostasis alterations... - Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labelingMarkus A Seeger
Institute of Physiology and Zurich Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Biochemistry 48:5801-12. 2009..This study provides evidence for a substantial role of membrane-located carboxylates as a central element of the proton translocation pathway in AcrB and other members of the RND superfamily... - Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2Benjamin Oberfeld
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 301:F189-96. 2011..Taken together, the data support the conclusion that Usp2-45 action on ENaC is promoted by various interactions, including through binding to Nedd4-2 that is suggested to position Usp2-45 favorably for ENaC deubiquitylation... - Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteinsCarsten A Wagner
Institute of Physiology, Center for Integrative Human Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 294:F1373-80. 2008..These adaptive changes in Romk(-/-) mice may help to limit renal Na(+) loss, and thereby, contribute to survival of these mice... - Kidney amino acid transportFrancois Verrey
Institute of Physiology, University of Zurich, Switzerland
Pflugers Arch 458:53-60. 2009..Thus, other transporters within the same membrane need to mediate the net efflux of exchange substrates, controlling thereby the net basolateral amino transport and thus the intracellular amino acid concentration... - Functional characterization of Caenorhabditis elegans heteromeric amino acid transportersEmilija Veljkovic
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Biol Chem 279:7655-62. 2004..Taken together, this study demonstrates that the heteromeric structure and the amino acid exchange function of HATs have been conserved throughout the evolution of nematodes to mammals... - Regulation of renal amino acid transporters during metabolic acidosisCaroline Moret
Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 292:F555-66. 2007..Our results suggest that the selective regulation of SNAT3 and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance... - Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease familyL Mastroberardino
Institute of Physiology, University of Zurich, Switzerland
Nature 395:288-91. 1998..The coexpression of h4F2hc is required for surface expression of these permease-related light chains, which belong to a new family of amino-acid transporters that form heterodimers with cell-surface glycoproteins... - T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis controlLuca Mariotta
F Verrey Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Physiol 590:6413-24. 2012..Additionally, it facilitates the release of AAAs across the basolateral membrane of small intestine and proximal kidney tubule epithelial cells, thereby allowing the efflux of other neutral AAs presumably via Lat2-4F2hc... - Does kidney amino acid transport have something to do with blood pressure?Francois Verrey
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Nephrol Dial Transplant 22:2449-51. 2007 - An amino acid transporter involved in gastric acid secretionPhilipp Kirchhoff
Institute of Physiology and Center for Integrative Human Physiology CIHP, University of Zurich, Winterthurerstr 190, 8057 Zurich, Switzerland
Pflugers Arch 451:738-48. 2006..These data suggest a novel role for heterodimeric amino acid transporters and may elucidate a pathway by which protein-rich diets stimulate gastric acid secretion... - Expression of heteromeric amino acid transporters along the murine intestineMital H Dave
Institute of Physiology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
J Physiol 558:597-610. 2004..Furthermore, strong expression of rBAT, b degrees (,+)AT and y(+)-LAT1 in the small intestine explains the reduced intestinal absorption of some amino acid in patients with cystinuria or lysinuric protein intolerance... - Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGKJ Loffing
Institute of Anatomy, , , Switzerland
Am J Physiol Renal Physiol 280:F675-82. 2001..Results from oocyte experiments suggest the hypothesis that a localized activation of SGK may play a role in the mediation of ENaC translocation... - Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanismMarkus A Seeger
Institute of Physiology and Zurich Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
Science 313:1295-8. 2006..The structural data imply an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter... - Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylationPanagiotis Fakitsas
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Am Soc Nephrol 18:1084-92. 2007..A deubiquitylating enzyme that targets ENaC in vitro and thus may play a role in sodium transport regulation was identified within a series of new in vivo early aldosterone-regulated gene products... - Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter familyR Pfeiffer
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
EMBO J 18:49-57. 1999.... - Functional characterization of a NapA Na(+)/H(+) antiporter from Thermus thermophilusEsther M Furrer
Institute of Physiology and Zurich Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
FEBS Lett 581:572-8. 2007..thermophilus resembles that of NhaA from E. coli, whereas in contrast to NhaA the T. thermophilus NapA antiporter is characterized by high Li(+)/H(+) antiport activity at acidic pH... - Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanismsF Verrey
Institute of Physiology, University of Zurich, Switzerland
Kidney Int 57:1277-82. 2000..This suggests mechanisms for the escape from aldosterone action... - Early aldosterone action: toward filling the gap between transcription and transportF Verrey
Institute of Physiology, University of Zurich, CH 8057 Zurich, Switzerland
Am J Physiol 277:F319-27. 1999.... - Early aldosterone effectsF Verrey
Institute of Physiology, University of Zurich, Switzerland
Exp Nephrol 6:294-301. 1998..The aim of this minireview is to describe briefly both the classical early and rapid nongenomic effects of aldosterone and to address the question whether nongenomic effects might play a role for the Na+ transport response... - Glycoprotein-associated amino acid exchangers: broadening the range of transport specificityF Verrey
Institute of Physiology, University of Zurich, Switzerland
Pflugers Arch 440:503-12. 2000.... - New glycoprotein-associated amino acid transportersF Verrey
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Membr Biol 172:181-92. 1999..In this review, we focus on the animal members of the LAT cluster that form, together with some of the nematode members, the family of glycoprotein-associated amino acid transporters (gpaAT family)... - Short term effect of aldosterone on Na,K-ATPase cell surface expression in kidney collecting duct cellsV Summa
Institute of Physiology, , Winterthurerstrasse 190, , Switzerland
J Biol Chem 276:47087-93. 2001..Feraille, E., Kaissling, B., Asher, C., Rossier, B. C., Firestone, G. L., Pearce, D., and Verrey, F. (2001) Am. J. Physiol. 280, F675-F682) but also by coordinately acting on the basolateral cell surface expression of the Na,K-ATPase... - Sodium reabsorption in aldosterone-sensitive distal nephron: news and contributions from genetically engineered animalsF Verrey
Institute of Physiology, University of Zurich, Switzerland
Curr Opin Nephrol Hypertens 10:39-47. 2001.... - Luminal heterodimeric amino acid transporter defective in cystinuriaR Pfeiffer
Institute of Physiology, University of Zurich, CH 8057 Zurich, Switzerland
Mol Biol Cell 10:4135-47. 1999..These biochemical, transport, and localization characteristics as well as the chromosomal localization on 19q support the notion that the b(0,+)AT protein is the product of the gene defective in non-type I cystinuria... - Characterization of early aldosterone-induced RNAs identified in A6 kidney epitheliaB Spindler
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Pflugers Arch 434:323-31. 1997..These characteristics of RNA accumulation and their time courses suggest a possible role of one of these induced RNAs in the mediation of the early effect of aldosterone on Na transport... - Identification of a new gene product (diphor-1) regulated by dietary phosphateM Custer
Institute of Physiology, University of Zurich, Switzerland
Am J Physiol 273:F801-6. 1997..Further characterizations of diphor-1 will show whether diphor-1 is primarily or secondarily involved in the response to dietary Pi... - Mediators of aldosterone action in the renal tubuleJ Loffing
Institute of Anatomy, , , Switzerland
Curr Opin Nephrol Hypertens 10:667-75. 2001..In view of the ongoing research, the question of how, and formally also whether, SGK1 acts on the epithelial sodium channel should be resolved in the near future... - Preferred transport of O-(2-[18F]fluoroethyl)-D-tyrosine (D-FET) into the porcine brainVictoria Makrides
Institute of Physiology, University of Zurich, Switzerland
Brain Res 1147:25-33. 2007..Therefore, the results from animal experiments concerning BBB amino acid transport may not be transferable to humans... - Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3Nadine Ruderisch
Institute of Physiology and Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
J Cereb Blood Flow Metab 31:1637-47. 2011..This differential expression of system A (Snat1) versus system N (Snat3) transporters suggests distinct roles for Snats in the cerebral vasculature and is consistent with Snat3 involvement in net transendothelial BBB AA transport... - Aldosterone modulates sodium kinetics of Na,K-ATPase containing an alpha 1 subunit in A6 kidney cell epitheliaJ Beron
Institute of Physiology, University of Zurich, Switzerland
Mol Biol Cell 6:261-71. 1995..In the long term it produces an increase in the maximal transport capacity, which corresponds to the known increase in the number of Na pumps... - Apical heterodimeric cystine and cationic amino acid transporter expressed in MDCK cellsChristian Bauch
Institute of Physiology, University of Zurich, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 283:F181-9. 2002.... - Regulation of Na+ pump function by aldosterone is alpha-subunit isoform specificR Pfeiffer
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Physiol 516:647-55. 1999..6. The fact that this early transcriptionally mediated activation of Na+ pumps by aldosterone is specific for pumps containing an alpha1 subunit should permit the identification in this subunit of structures involved in its regulation... - Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytesF Norbis
Institute of Physiology, University of Zurich, Switzerland
J Membr Biol 156:19-24. 1997..In conclusion, we have cloned from a rabbit small intestinal cDNA library a novel cDNA encoding a protein stimulating P(i)-uptake into Xenopus laevis oocytes, but which is not a P(i)-transporter itself...