Zsuzsanna Varga

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Assessment of HER2 status in breast cancer: overall positivity rate and accuracy by fluorescence in situ hybridization and immunohistochemistry in a single institution over 12 years: a quality control study
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    BMC Cancer 13:615. 2013
  2. pmc The potential prognostic value of connexin 26 and 46 expression in neoadjuvant-treated breast cancer
    Ivett Teleki
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    BMC Cancer 13:50. 2013
  3. pmc Comparison of EndoPredict and Oncotype DX test results in hormone receptor positive invasive breast cancer
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 8:e58483. 2013
  4. doi request reprint Histology and immunophenotype of invasive lobular breast cancer. daily practice and pitfalls
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Breast Dis 30:15-9. 2008
  5. doi request reprint Topoisomerase 2A gene amplification in breast cancer. Critical evaluation of different FISH probes
    Zsuzsanna Varga
    Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Breast Cancer Res Treat 133:929-35. 2012
  6. doi request reprint Tubular and endothelial chimerism in renal allografts using fluorescence and chromogenic in situ hybridization (FISH, CISH) technology
    Zsuzsanna Varga
    Institute of Surgical Pathology, Department Pathology, University Hospital Zurich, Zurich, Switzerland
    Pathol Int 62:254-63. 2012
  7. doi request reprint Co-amplification of the HER2 gene and chromosome 17 centromere: a potential diagnostic pitfall in HER2 testing in breast cancer
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Breast Cancer Res Treat 132:925-35. 2012
  8. pmc Post-infection immunocomplex glomerulonephritis and Legionnaires' disease in a patient with adult Still's disease during treatment with interleukin 1 receptor antagonist anakinra: a case report
    Dieter Scholtze
    Department of Internal Medicine, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Med Case Reports 5:299. 2011
  9. ncbi request reprint Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer
    Z Varga
    Department of Pathology, University Hospital Zurich, Zurich
    Histopathology 44:332-8. 2004
  10. doi request reprint Use of intraoperative stereomicroscopy for preventing loss of metastases during frozen sectioning of sentinel lymph nodes in breast cancer
    Z Varga
    Department of Pathology, Institute of Surgical Pathology, University of Zurich, Zurich, Switzerland
    Histopathology 52:597-604. 2008

Collaborators

Detail Information

Publications44

  1. pmc Assessment of HER2 status in breast cancer: overall positivity rate and accuracy by fluorescence in situ hybridization and immunohistochemistry in a single institution over 12 years: a quality control study
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    BMC Cancer 13:615. 2013
    ..We addressed the question how stable and concordant IHC and FISH methods are and whether HER2 positivity rate has changed over this period...
  2. pmc The potential prognostic value of connexin 26 and 46 expression in neoadjuvant-treated breast cancer
    Ivett Teleki
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    BMC Cancer 13:50. 2013
    ..In this study we correlated Cx expression and cell proliferation with disease survival and pathological response to neoadjuvant chemotherapy in breast cancers using existing classification systems...
  3. pmc Comparison of EndoPredict and Oncotype DX test results in hormone receptor positive invasive breast cancer
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 8:e58483. 2013
    ....
  4. doi request reprint Histology and immunophenotype of invasive lobular breast cancer. daily practice and pitfalls
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Breast Dis 30:15-9. 2008
    ..Intra-operative evaluation of resection margins in ILC is often unsatisfactory due to the diffuse nature of the tumor. Size estimation of the invasive component poses a similar challenge in daily practice...
  5. doi request reprint Topoisomerase 2A gene amplification in breast cancer. Critical evaluation of different FISH probes
    Zsuzsanna Varga
    Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Breast Cancer Res Treat 133:929-35. 2012
    ..Because TOP2A, not HER2, is a target of anthracyclines, non-overlapping DNA probes should be used to evaluate any associations between such alterations and response to anthracycline-based chemotherapy...
  6. doi request reprint Tubular and endothelial chimerism in renal allografts using fluorescence and chromogenic in situ hybridization (FISH, CISH) technology
    Zsuzsanna Varga
    Institute of Surgical Pathology, Department Pathology, University Hospital Zurich, Zurich, Switzerland
    Pathol Int 62:254-63. 2012
    ..Tubular and/or endothelial chimerism occur frequently in gender mismatched renal allografts and, when combined, this is associated with T-cell mediated rejection...
  7. doi request reprint Co-amplification of the HER2 gene and chromosome 17 centromere: a potential diagnostic pitfall in HER2 testing in breast cancer
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Breast Cancer Res Treat 132:925-35. 2012
    ..It is recommended to report separate CEP17 and HER2 signals in complex HER2/CEP17 patterns...
  8. pmc Post-infection immunocomplex glomerulonephritis and Legionnaires' disease in a patient with adult Still's disease during treatment with interleukin 1 receptor antagonist anakinra: a case report
    Dieter Scholtze
    Department of Internal Medicine, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Med Case Reports 5:299. 2011
    ..abstract:..
  9. ncbi request reprint Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer
    Z Varga
    Department of Pathology, University Hospital Zurich, Zurich
    Histopathology 44:332-8. 2004
    ..To investigate whether alterations of the HER2 gene occur more frequently in histologically unfavourable subtypes of invasive breast cancer...
  10. doi request reprint Use of intraoperative stereomicroscopy for preventing loss of metastases during frozen sectioning of sentinel lymph nodes in breast cancer
    Z Varga
    Department of Pathology, Institute of Surgical Pathology, University of Zurich, Zurich, Switzerland
    Histopathology 52:597-604. 2008
    ..To determine the reliability of intraoperative frozen sections, SLN protocol with one frozen section was compared with macroscopic SLN evaluation with consecutive complete SLN embedding...
  11. ncbi request reprint Preferential nuclear and cytoplasmic NY-BR-1 protein expression in primary breast cancer and lymph node metastases
    Zsuzsanna Varga
    Institute of Surgical Pathology, Department Pathology, University Hospital of Zurich, Zurich, Switzerland
    Clin Cancer Res 12:2745-51. 2006
    ..However, current data are based on RT-PCR analysis and nothing is known about the presence of NY-BR-1 on a protein level. We previously generated a monoclonal antibody to NY-BR-1 to study the protein expression of NY-BR-1...
  12. ncbi request reprint Stability of the HER2 gene after primary chemotherapy in advanced breast cancer
    Zsuzsanna Varga
    Institute of Clinical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Virchows Arch 446:136-41. 2005
    ..Intratumoral heterogeneity as well as sampling variations can contribute to modification of the Her2 status after primary chemotherapy...
  13. ncbi request reprint Determination of the Her-2/neu gene amplification status in cytologic breast cancer specimens using automated silver-enhanced in-situ hybridization (SISH)
    Florian Rudolf Fritzsche
    Division of Cytology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Am J Surg Pathol 34:1180-5. 2010
    ..The advantages of signal permanency and bright-field microscopic result interpretation make this technique an attractive alternative to the current FISH-based gold standard...
  14. ncbi request reprint Distinct expression patterns of the immunogenic differentiation antigen NY-BR-1 in normal breast, testis and their malignant counterparts
    Jean Philippe Theurillat
    Institute of Surgical Pathology, Department Pathology, University Hospital of Zurich, Switzerland
    Int J Cancer 122:1585-91. 2008
    ..Accordingly, analysis of matching pairs of primary tumors with their recurrences showed a marked decrease of NY-BR-1 expression in recurrences after tamoxifen treatment (p < 0.0001)...
  15. doi request reprint Pathological processing techniques and final diagnosis of breast cancer sentinel lymph nodes
    Florian Rudolf Fritzsche
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Ann Surg Oncol 17:2892-8. 2010
    ..Micrometastases and isolated tumor cells (ITC) have recently been proposed as prognostically and therapeutically relevant. We compared 3 SLN protocols with regard to intraoperative and postoperative diagnosis...
  16. ncbi request reprint NY-ESO-1 protein expression in primary breast carcinoma and metastases: correlation with CD8+ T-cell and CD79a+ plasmacytic/B-cell infiltration
    Jean Philippe Theurillat
    Department Pathology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Int J Cancer 120:2411-7. 2007
    ..These findings suggest that NY-ESO-1-positive breast cancers represent a small subset of poorly differentiated tumors with evidence of cellular and humoral immune response...
  17. ncbi request reprint NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy
    Jean Philippe Theurillat
    Institute for Surgical Pathology, Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Cancer Immunol Immunother 56:1723-31. 2007
    ....
  18. doi request reprint IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity
    Nicole M Probst-Hensch
    Institute of Social and Preventive Medicine, University of Zurich, Zurich
    Clin Cancer Res 16:1025-32. 2010
    ..The prognostic relevance of tumor expression patterns of IGFI-related proteins remains poorly understood. This study associates the expression of selected IGF proteins with breast tumor and patient characteristics...
  19. doi request reprint Alpha-methylacyl-CoA racemase (AMACR) expression in epithelial ovarian cancer
    Aurelia Noske
    Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstr 12, CH 8091 Zurich, Switzerland
    Virchows Arch 459:91-7. 2011
    ..The prevalence may limit the value of AMACR for the differential diagnosis between metastatic colorectal carcinomas and primary ovarian carcinomas, whereas the association with estrogen receptor expression deserves further studies...
  20. ncbi request reprint Curative treatment of a pelvic side wall recurrence after conization for microinvasive cervical cancer stage IA1: a case report and review of the literature
    Konstantin J Dedes
    Division of Gynecology, Department of Obstetrics and Gynecology, University Hospital of Zurich, Zurich, Switzerland
    J Low Genit Tract Dis 11:177-81. 2007
    ..Reviewing case series with IA1 cervical cancers without LVSI, lymph node metastasis (LNM) is present in 0.5%...
  21. doi request reprint Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease
    Olivier Giger
    Institute of Surgical Pathology, Department Pathology, University Hospital Zurich, Zurich, Switzerland
    Pathol Int 60:726-34. 2010
    ..Furthermore NY-BR-1 positivity in apoeccrine glands of the axilla and anogenital region suggests a potential histogenetic link between these structures and Paget's disease...
  22. doi request reprint Silver-enhanced in situ hybridization for detection of polyomavirus DNA in patients with BK virus nephropathy
    Florian R Fritzsche
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Diagn Mol Pathol 20:105-10. 2011
    ..However, its diagnostic value in comparison with standard immunohistochemistry seems to be limited...
  23. ncbi request reprint Immunohistochemical differentiation and localization analysis of sweat glands in the adult human axilla
    Gertrude M Beer
    Division for Plastic, Hand, and Reconstructive Surgery, Department of Surgery, Institute of Clinical Pathology, University Hospital Zurich, Zurich, Switzerland
    Plast Reconstr Surg 117:2043-9. 2006
    ..To define the different types of sweat glands and their location and number, the authors carried out a prospective histologic study on adult human axillary skin, including various immunohistochemical markers...
  24. pmc How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of Breast- and Gynecopathologists
    Zsuzsanna Varga
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e37379. 2012
    ..The Swiss Working Group of Gyneco- and Breast Pathologists has surveyed inter- and intraobserver consistency of Ki-67-based proliferative fraction in breast carcinomas...
  25. ncbi request reprint Axillary staging using positron emission tomography in breast cancer patients qualifying for sentinel lymph node biopsy
    Mathias K Fehr
    Department of Obstetrics and Gynecology, University Hospital, Zurich, Switzerland
    Breast J 10:89-93. 2004
    ..5 mm (range 1-15 mm). Lymph node staging using FDG-PET is not accurate enough in clinically node-negative patients with breast cancer qualifying for SLNB and should not be used for this purpose...
  26. pmc Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype
    G Kristiansen
    Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Br J Cancer 102:1736-45. 2010
    ..We aimed to clarify the incidence and the clinicopathological value of non-muscle myoglobin (Mb) in a large cohort of non-invasive and invasive breast cancer cases...
  27. ncbi request reprint Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma
    D Lardinois
    Division of Thoracic Surgery, University Hospital, Zurich, Switzerland
    J Thorac Cardiovasc Surg 131:697-703. 2006
    ..We sought to investigate whether intrapleural topical application of cisplatin with a surgical carrier has a prolonged local tissue level in comparison with cisplatin solution while reducing systemic toxicity...
  28. doi request reprint Neuroradiology of cholesteatomas
    K Barath
    Institute of Neuroradiology, University Hospital Zurich, Switzerland
    AJNR Am J Neuroradiol 32:221-9. 2011
    ....
  29. ncbi request reprint Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva
    Olivier T Giger
    Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland
    Virchows Arch 450:471-4. 2007
    ..These findings provide further evidence that phyllodes tumors of the vulva might derive from mammary-like glands in the labium majus or from ectopic breast tissue...
  30. doi request reprint Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and glomerular hypertrophy in rat polycystic kidney disease
    Ming Wu
    Zurich Center for Integrative Human Physiology ZIHP, Zurich, Switzerland
    Am J Physiol Renal Physiol 297:F1597-605. 2009
    ..Our data might have an impact when long-term treatment using mTOR inhibitors in patients with autosomal dominant polycystic kidney disease is being considered...
  31. ncbi request reprint G2/M cell cycle checkpoint is functional in cervical cancer patients after initiation of external beam radiotherapy
    Ferdinando Cerciello
    Department of Radiation Oncology, Zurich University Hospital, University of Zurich, Zurich, Switzerland
    Int J Radiat Oncol Biol Phys 62:1390-8. 2005
    ..To investigate changes in cancer of the uterine cervix during radiotherapy (RT) with respect to G2/M transition in relation to tumor cell apoptosis and changes in the tumor vasculature in cervical carcinoma...
  32. doi request reprint The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer
    Eleftherios P Samartzis
    Department of Gynecology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 9:e83296. 2014
    ....
  33. ncbi request reprint Glycogen-rich carcinomas of the breast display unique characteristics with respect to proliferation and the frequency of oligonucleosomal fragments
    Z Varga
    Institute of Clinical Pathology, Department of Pathology, University Hospital Zurich, Switzerland
    Breast Cancer Res Treat 57:215-9. 1999
    ..The aggressive clinical behavior of these neoplasms may possibly be accounted for by an ineffective apoptotic elimination of otherwise slowly proliferating tumor cells...
  34. ncbi request reprint Pleomorphic lobular carcinoma of the breast: its cell kinetics, expression of oncogenes and tumour suppressor genes compared with invasive ductal carcinomas and classical infiltrating lobular carcinomas
    D Frolik
    Institute of Clinical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Histopathology 39:503-13. 2001
    ..CONCLUSION: Our data suggest that more frequent over-expression of Her2 among PLCs (G3) as well as the generally low apoptosis can contribute to their aggressive behaviour...
  35. ncbi request reprint Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies
    Simone Schmid
    Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Virchows Arch 450:665-70. 2007
    ..We conclude that acute interstitial nephritis and consecutive acute renal failure is a relevant side effect of atazanavir and tenofovir therapy in HIV-positive patients...
  36. ncbi request reprint Incidence of the superficial fascia and its relevance in skin-sparing mastectomy
    Gertrude M Beer
    Clinic for Hand, Plastic, and Reconstructive Surgery, University Hospital, Zurich, Switzerland
    Cancer 94:1619-25. 2002
    ..The feasibility of meeting these two goals simultaneously and the possible role and relevance of the SL as a guide to dissection in SSM was examined in this study...
  37. ncbi request reprint Sebaceous carcinoma of the breast
    Z Varga
    Institute of Clinical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Pathol Int 50:63-6. 2000
    ..The MIB-1 labeling index averaged 16%. At variance with sebaceous breast carcinomas on record, the present case is notable for its prolonged clinical course...
  38. ncbi request reprint CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis
    R D Fritz
    Institute of Medical Virology, University of Zurich, Zurich, Switzerland
    Oncogene 29:3575-82. 2010
    ..Analysis of multiple breast cancer samples reveals that CNK1-negative tumours show less Akt activity. Thus, CNK1 promotes oncogenic signalling through Akt in breast cancer cell lines and tumours...
  39. ncbi request reprint Metaplastic lipid-rich carcinoma of the breast
    Z Varga
    Institute of Clinical Pathology, University Hospital Zurich, Switzerland
    Pathol Int 48:912-6. 1998
    ..As an additional feature, part of the lesion exhibited chondroid metaplasia. Lipid-rich carcinoma of the breast is exceedingly rare and, to our knowledge, no such example harboring metaplastic elements has been described previously...
  40. ncbi request reprint NY-BR-1 is a differentiation antigen of the mammary gland
    Dirk Jager
    Medizinische Onkologie NCT, University Hospital Heidelberg, 69120 Heidelberg, Germany
    Appl Immunohistochem Mol Morphol 15:77-83. 2007
    ..These data indicate that NY-BR-1 is a differentiation antigen of the mammary gland that could be useful for diagnosis and/or immunotherapy of breast carcinomas...
  41. doi request reprint Phenotypic and genotypic characterisation of Pasteurella multocida strains isolated from pigs in Hungary
    Zsuzsanna Varga
    Veterinary Medical Research Institute of the Hungarian Academy of Sciences, H 1581 Budapest, P O Box 18, Hungary
    Acta Vet Hung 55:425-34. 2007
    ..A remarkable regional distribution of toxA gene positive strains was observed. All but two isolates were found in swine herds located in the Transdanubian region, separated from other parts of Hungary by the river Danube...
  42. ncbi request reprint Synchronous bilateral ductal carcinoma in situ of the male breast associated with gynecomastia in a 30-year-old patient following repeated injections of stanozolol
    Ralph F Staerkle
    Department of Surgery, Spital Uster, Uster, Switzerland
    Breast Cancer Res Treat 97:173-6. 2006
    ..The role of synthetic androgens in the development of male breast neoplasia warrants further scrutiny...
  43. ncbi request reprint Effects of isoflurane exposure on oncogene and tumour suppressor gene expressions in vital organs of CBA/CA mice
    Balázs Kádár
    Department of Anesthesiology and Intensive Therapy, Borsod County Hospital, 3501, Miskolc, Hungary
    In Vivo 21:861-5. 2007
    ..Whether isoflurane exposure results in any alteration in oncogene and tumour suppressor gene expression was investigated here...
  44. ncbi request reprint The effect of aspartame administration on oncogene and suppressor gene expressions
    Katalin Gombos
    Faculty of Medicine, Institute of Public Health University of Pécs, Pecs, Hungary
    In Vivo 21:89-92. 2007
    ..The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene...