Jurg Tschopp

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. pmc RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis
    Etienne Meylan
    Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
    EMBO Rep 3:1201-8. 2002
  2. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
  3. pmc Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
    P Menu
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Cell Death Dis 2:e137. 2011
  4. pmc A pilot study of IL-1 inhibition by anakinra in acute gout
    Alexander So
    Service of Rhumatologie, Department of Medicine, Centre Hospitalier Universtaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland
    Arthritis Res Ther 9:R28. 2007
  5. doi Mitochondria: Sovereign of inflammation?
    Jurg Tschopp
    Department of Biochemistry, University of Lausanne, Center for Immunity and Infection, Epalinges, Switzerland
    Eur J Immunol 41:1196-202. 2011
  6. doi NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
    Jurg Tschopp
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nat Rev Immunol 10:210-5. 2010
  7. ncbi PIDD mediates NF-kappaB activation in response to DNA damage
    Sophie Janssens
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 123:1079-92. 2005
  8. pmc DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
    Manuele Rebsamen
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    EMBO Rep 10:916-22. 2009
  9. pmc Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis
    Stefan K Drexler
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 109:18384-9. 2012
  10. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003

Detail Information

Publications67

  1. pmc RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis
    Etienne Meylan
    Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
    EMBO Rep 3:1201-8. 2002
    ..These data suggest that RIP4 is involved in NF-kappa B and JNK signaling and that caspase-dependent processing of RIP4 may negatively regulate NF-kappa B-dependent pro-survival or pro-inflammatory signals...
  2. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  3. pmc Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
    P Menu
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Cell Death Dis 2:e137. 2011
    ..Our results demonstrate that the NLRP3 inflammasome is not critically implicated in atherosclerosis progression in the ApoE mouse model...
  4. pmc A pilot study of IL-1 inhibition by anakinra in acute gout
    Alexander So
    Service of Rhumatologie, Department of Medicine, Centre Hospitalier Universtaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland
    Arthritis Res Ther 9:R28. 2007
    ..No adverse effects were observed. IL-1 blockade appears to be an effective therapy for acute gouty arthritis. The clinical findings need to be confirmed in a controlled study...
  5. doi Mitochondria: Sovereign of inflammation?
    Jurg Tschopp
    Department of Biochemistry, University of Lausanne, Center for Immunity and Infection, Epalinges, Switzerland
    Eur J Immunol 41:1196-202. 2011
    ..Mapping the connections between mitochondria, metabolism and inflammation is of great interest, as malfunctioning of this network is associated with many chronic inflammatory diseases...
  6. doi NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
    Jurg Tschopp
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nat Rev Immunol 10:210-5. 2010
    ....
  7. ncbi PIDD mediates NF-kappaB activation in response to DNA damage
    Sophie Janssens
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 123:1079-92. 2005
    ..Depletion of PIDD and RIP1, but not caspase-2, abrogates DNA-damage-induced NEMO modification and NF-kappaB activation. We propose that PIDD acts as a molecular switch, controlling the balance between life and death upon DNA damage...
  8. pmc DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
    Manuele Rebsamen
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    EMBO Rep 10:916-22. 2009
    ..These findings delineate the DAI signalling pathway to NF-kappaB and suggest a possible new immune modulation strategy of the MCMV...
  9. pmc Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis
    Stefan K Drexler
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 109:18384-9. 2012
    ....
  10. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  11. doi NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells
    Francesco Staehli
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    J Immunol 188:3820-8. 2012
    ..Our data show that NLRC5 acts as a key transcriptional regulator of MHC I in lymphocytes and support an essential role for NLRs in directing not only innate but also adaptive immune responses...
  12. pmc Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex
    Nils Holler
    Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Switzerland
    Mol Cell Biol 23:1428-40. 2003
    ..These results demonstrate that the limited oligomerization of FasL, and most likely of some other tumor necrosis factor family ligands such as CD40L, is required for triggering of the signaling pathways...
  13. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
    ..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
  14. doi T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 460:269-73. 2009
    ....
  15. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
    ..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
  16. doi Differential expression of NLRP3 among hematopoietic cells
    Greta Guarda
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    J Immunol 186:2529-34. 2011
    ..Thus, NLRP3 levels at the site of adaptive response initiation are controlled by recruitment of NLRP3-expressing cells and by NLRP3 induction...
  17. ncbi Intracellular trafficking of interleukin-1 receptor I requires Tollip
    Brian Brissoni
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Curr Biol 16:2265-70. 2006
    ..Our findings suggest that Tollip functions as an endosomal adaptor linking IL-1RI, via Tom1, to the endosomal degradation machinery...
  18. ncbi NALPs: a novel protein family involved in inflammation
    Jurg Tschopp
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Rev Mol Cell Biol 4:95-104. 2003
    ....
  19. doi A role for mitochondria in NLRP3 inflammasome activation
    Rongbin Zhou
    Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 469:221-5. 2011
    ..This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases...
  20. ncbi TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
    Claudia Bossen
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Blood 111:1004-12. 2008
    ..TACI supported survival of activated B cells and plasmablasts in vitro, providing a rational basis to explain the immunoglobulin deficiency reported in TACI-deficient persons...
  21. doi Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF
    Laeticia Kolly
    Service of Rheumatology, Departement de l appareil locomoteur, Centre Hospitalier Universitaire Vaudois and University of Lausanne, University of Lausanne, Lausanne, Switzerland
    J Immunol 183:4003-12. 2009
    ..In conclusion, these results strongly suggest that ASC modulates joint inflammation in AIA through its effects on cell-mediated immune responses but not via its implication in inflammasome formation...
  22. pmc Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway
    Antoine Tinel
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    EMBO J 26:197-208. 2007
    ..In this way, auto-proteolysis of PIDD might participate in the orchestration of the DNA damage-induced life and death signaling pathways...
  23. pmc The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes
    Susanne M A Lens
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Mol Cell Biol 22:5419-33. 2002
    ..Thus, a major role of c-FLIP(L) in vivo is the modulation of T-cell proliferation by decreasing the T-cell receptor signaling threshold...
  24. ncbi The inflammasome
    Virginie Petrilli
    Department of Biochemistry, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Curr Biol 15:R581. 2005
  25. ncbi Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Curr Biol 14:1929-34. 2004
    ..The activation of the NALP3-inflammasome by MDP may be the basis of the potent adjuvant activity of MDP...
  26. ncbi A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
    Annick Mayor
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Nat Immunol 8:497-503. 2007
    ..Our data demonstrate a similarity in one type of innate immunity in plants and mammals that is consistent with convergent evolution of a shared mechanism...
  27. doi Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
    James E Vince
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:215-27. 2012
    ....
  28. pmc Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
    Arnaud Didierlaurent
    Department of Biochemistry, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell Biol 26:735-42. 2006
    ..Tollip therefore controls the magnitude of inflammatory cytokine production in response to IL-1beta and LPS...
  29. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
    ..The current use of nano-TiO(2) may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure...
  30. doi TRADD protein is an essential component of the RIG-like helicase antiviral pathway
    Marie Cecile Michallet
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 28:651-61. 2008
    ..Thus, TRADD is not only an essential component of proinflammatory TNFRI signaling, but is also required for RLH-Cardif-dependent antiviral immune responses...
  31. doi Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    Rongbin Zhou
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nat Immunol 11:136-40. 2010
    ..The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1beta in the pathogenesis of type 2 diabetes...
  32. ncbi Structure of the PRYSPRY-domain: implications for autoinflammatory diseases
    Christian Grütter
    Department of Biochemistry, University of Zurich, CH 8057 Zurich, Switzerland
    FEBS Lett 580:99-106. 2006
    ..Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site...
  33. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
    ..These findings provide insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, and further support a pivotal role of the inflammasome in several autoinflammatory diseases...
  34. ncbi Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human
    Claudia Bossen
    Biochemistry Department, University of Lausanne, CH 1066 Epalinges, Switzerland
    J Biol Chem 281:13964-71. 2006
    ..Although human APRIL does not interact with BAFF-R, the shorter variant of mouse APRIL exhibits weak but detectable binding to mouse BAFF-R...
  35. doi Histones trigger sterile inflammation by activating the NLRP3 inflammasome
    Ramanjaneyulu Allam
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 43:3336-42. 2013
    ..These results identify cytosolic uptake of necrotic cell-derived histones as a triggering mechanism of sterile inflammation, which involves NLRP3 inflammasome activation and IL-1β secretion via oxidative stress. ..
  36. pmc Identification of proteoglycans as the APRIL-specific binding partners
    Karine Ingold
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    J Exp Med 201:1375-83. 2005
    ....
  37. ncbi The RIP kinases: crucial integrators of cellular stress
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Trends Biochem Sci 30:151-9. 2005
    ..Hence, RIP kinases are crucial regulators of cell survival and cell death...
  38. ncbi The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
    Antoine Tinel
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Science 304:843-6. 2004
    ..Because PIDD functions in p53-mediated apoptosis, the complex assembled by PIDD and caspase-2 is likely to regulate apoptosis induced by genotoxins...
  39. pmc Malarial hemozoin is a Nalp3 inflammasome activating danger signal
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 4:e6510. 2009
    ..Thus, we hypothesized that hemozoin could activate the Nalp3 inflammasome, due to its particulate nature reminiscent of other inflammasome-activating agents...
  40. doi Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome
    Kate Schroder
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Curr Biol 19:R262-5. 2009
    ..Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death...
  41. doi The NLRP3 inflammasome: a sensor for metabolic danger?
    Kate Schroder
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Science 327:296-300. 2010
    ..Thus, we propose that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress...
  42. ncbi BAFF and the regulation of B cell survival
    Pascal Schneider
    Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Ch des Boveresses 155, CH 1066, Epalinges, Switzerland
    Immunol Lett 88:57-62. 2003
    ..Elevated amounts of BAFF can be found in the serum of patients suffering from autoimmune diseases. The BAFF system is a promising target for the treatment of autoimmune diseases...
  43. ncbi The molecular architecture of the TNF superfamily
    Jean Luc Bodmer
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066, Epalinges, Switzerland
    Trends Biochem Sci 27:19-26. 2002
    ..Protein folds reminiscent of the THD and CRD are also found in other protein families, raising the possibility that the mode of interaction between TNF and TNF receptors might be conserved in other contexts...
  44. ncbi New insights into the mechanism of IL-1beta maturation
    Kimberly Burns
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Curr Opin Immunol 15:26-30. 2003
  45. ncbi Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 437:1167-72. 2005
    ..Cardif thus functions as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes...
  46. ncbi RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 5:503-7. 2004
    ..Therefore, in contrast to other TLRs, which use interleukin 1 receptor-associated kinase (IRAK) proteins to activate NF-kappa B, TLR 3-induced NF-kappa B activation is dependent on RIP kinases...
  47. pmc Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Science 320:674-7. 2008
    ..Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor...
  48. ncbi TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1
    Margot Thome
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 153, CH 1066 Epalinges, Switzerland
    Trends Immunol 24:419-24. 2003
  49. ncbi Intracellular pattern recognition receptors in the host response
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 442:39-44. 2006
    ..Nonetheless, it is apparent that these proteins are likely to have critical roles in health and disease...
  50. ncbi Ubiquitination of the Epstein-Barr virus-encoded latent membrane protein 1 depends on the integrity of the TRAF binding site
    Sylvia Rothenberger
    Institute of Biochemistry, University of Lausanne, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Oncogene 22:5614-8. 2003
    ..Taken together, our results suggest that TRAF proteins are involved in the ubiquitination of LMP1, and that their binding to LMP1 may facilitate their own ubiquitination...
  51. ncbi Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 22:561-9. 2006
    ..In this review, we discuss the mechanistic aspects of these important arms of the host innate response to dsRNA and a few viral strategies utilized to counteract them...
  52. ncbi Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 117:561-74. 2004
    ..Mutations in one of the scaffold proteins of the inflammasome, NALP3/Cryopyrin, are associated with autoinflammatory disorders underscoring the importance of regulating inflammatory caspase activation...
  53. doi The inflammasome: an integrated view
    Olaf Gross
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunol Rev 243:136-51. 2011
    ....
  54. ncbi Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    Immunity 18:655-64. 2003
    ..We suggest that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways...
  55. pmc Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
    Kimberly Burns
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH 1066 Epalinges, Switzerland
    J Exp Med 197:263-8. 2003
    ..Thus, MyD88s acts as a negative regulator of IL-1R/TLR/MyD88-triggered signals, leading to a transcriptionally controlled negative regulation of innate immune responses...
  56. doi Antiviral antibodies target adenovirus to phagolysosomes and amplify the innate immune response
    Anne K Zaiss
    Department of Biochemistry and Molecular Biology, University of Lausanne, Epalinges, Switzerland
    J Immunol 182:7058-68. 2009
    ..Furthermore, these results illustrate a cross-talk where the adaptive immune system positively regulates the innate immune system and the antiviral state...
  57. ncbi The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
    J Biol Chem 277:45162-71. 2002
    ....
  58. doi Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system
    Pantxika Bellecave
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Hepatology 51:1127-36. 2010
    ..We conclude that the pre-activation status of the endogenous IFN system in the liver of patients with CHC is in part regulated by cleavage of MAVS...
  59. ncbi The inflammasome: a danger sensing complex triggering innate immunity
    Virginie Petrilli
    Department of Biochemistry, University of Lausanne, Ch des Boveresses 155, CH 1066, Epalinges, Switzerland
    Curr Opin Immunol 19:615-22. 2007
    ..These and other issues related to the inflammasome are discussed in this review...
  60. ncbi NLRs join TLRs as innate sensors of pathogens
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Trends Immunol 26:447-54. 2005
    ....
  61. doi The inflammasomes
    Kate Schroder
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Cell 140:821-32. 2010
    ..Regulatory mechanisms that potentiate or limit inflammasome activation are examined, as well as emerging links between the inflammasome and pyroptosis and autophagy...
  62. ncbi The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF
    Aubry Tardivel
    Department of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 34:509-18. 2004
    ..These results suggest that BAFF is required not only to inhibit apoptosis of maturating B cells, but also to promote differentiation events, in particular those leading to the generation of marginal zone B cells...
  63. doi The role of the inflammasome in nonmyeloid cells
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    J Clin Immunol 30:623-7. 2010
    ..This review focuses on recent progress in our understanding of the processing and functional role of IL-1 in epithelial, mesenchymal, and neuronal cells and in conditions such as tissue repair...
  64. doi Intracellular pattern-recognition receptors
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Adv Drug Deliv Rev 60:830-40. 2008
    ..Here, we provide an overview of recent findings covering this area of innate and inflammatory responses that originate from the cytoplasm...
  65. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
    ..Thus, the inflammasome constitutes an important arm of the innate immunity...
  66. ncbi CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation
    Olivier Gaide
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 3:836-43. 2002
    ..Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation...
  67. ncbi Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation
    Magdalena Kovacsovics
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066, Epalinges, Switzerland
    Curr Biol 12:838-43. 2002
    ..Helicard accelerates Fas ligand-mediated DNA degradation, whereas a noncleavable or a helicase-dead Helicard mutant does not, implicating Helicard in the nuclear remodeling occurring during apoptosis...