Beat Trueb

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. doi request reprint Role of FGFRL1 and other FGF signaling proteins in early kidney development
    Beat Trueb
    Department of Clinical Research, University of Bern, Murtenstrasse 35, Bern, Switzerland
    Cell Mol Life Sci 70:2505-18. 2013
  2. doi request reprint Biology of FGFRL1, the fifth fibroblast growth factor receptor
    Beat Trueb
    Department of Clinical Research, University of Bern, Switzerland
    Cell Mol Life Sci 68:951-64. 2011
  3. pmc The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryos
    Florian Steinberg
    Department of Clinical Research, University of Bern
    J Biol Chem 285:2193-202. 2010
  4. ncbi request reprint Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1
    Bo Li
    ITI Research Institute, University of Bern, P O Box 54, CH 3010 Bern, Switzerland
    J Biol Chem 279:20401-10. 2004
  5. doi request reprint The murine Fgfrl1 receptor is essential for the development of the metanephric kidney
    Simon D Gerber
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 335:106-19. 2009
  6. pmc Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor
    Florian Steinberg
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    J Biol Chem 285:37704-15. 2010
  7. ncbi request reprint Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor
    Beat Trueb
    ITI Research Institute, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Biochim Biophys Acta 1727:65-74. 2005
  8. doi request reprint Interaction of the receptor FGFRL1 with the negative regulator Spred1
    Lei Zhuang
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Cell Signal 23:1496-504. 2011
  9. pmc Comparison of the receptor FGFRL1 from sea urchins and humans illustrates evolution of a zinc binding motif in the intracellular domain
    Lei Zhuang
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    BMC Biochem 10:33. 2009
  10. doi request reprint Identification of a fibronectin interaction site in the extracellular matrix protein ameloblastin
    Michael Beyeler
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Exp Cell Res 316:1202-12. 2010

Collaborators

Detail Information

Publications24

  1. doi request reprint Role of FGFRL1 and other FGF signaling proteins in early kidney development
    Beat Trueb
    Department of Clinical Research, University of Bern, Murtenstrasse 35, Bern, Switzerland
    Cell Mol Life Sci 70:2505-18. 2013
    ..It might also promote tight adhesion of cells in the condensed metanephric mesenchyme as required for the mesenchymal-to-epithelial transition. ..
  2. doi request reprint Biology of FGFRL1, the fifth fibroblast growth factor receptor
    Beat Trueb
    Department of Clinical Research, University of Bern, Switzerland
    Cell Mol Life Sci 68:951-64. 2011
    ..A human patient with a frameshift mutation exhibits craniosynostosis, arguing for an additional role of FGFRL1 during bone formation. FGFRL1 contributes to the complexity of the FGF signaling system...
  3. pmc The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryos
    Florian Steinberg
    Department of Clinical Research, University of Bern
    J Biol Chem 285:2193-202. 2010
    ..We furthermore show that ectopic expression of FGFRL1 in Xenopus embryos antagonizes FGFR signaling during early development. Taken together, our data provide strong evidence that FGFRL1 is indeed a decoy receptor for FGFs...
  4. ncbi request reprint Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1
    Bo Li
    ITI Research Institute, University of Bern, P O Box 54, CH 3010 Bern, Switzerland
    J Biol Chem 279:20401-10. 2004
    ..LIM-nebulette reveals a subcellular distribution at focal adhesions similar to Lasp-1. Thus, LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions...
  5. doi request reprint The murine Fgfrl1 receptor is essential for the development of the metanephric kidney
    Simon D Gerber
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 335:106-19. 2009
    ..We also observed a loss of Pax2 positive nephron precursor cells and an increase of apoptosis in the cortical zone of the remnant kidney. Fgfrl1 is therefore essential for mesenchymal differentiation in the early steps of nephrogenesis...
  6. pmc Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor
    Florian Steinberg
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    J Biol Chem 285:37704-15. 2010
    ..Moreover, FGFRL1 also fused HEK293 and HeLa cells with untransfected CHO cells. Our data show that FGFRL1 is the first mammalian protein that is capable of inducing syncytium formation of heterologous cells in vitro...
  7. ncbi request reprint Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor
    Beat Trueb
    ITI Research Institute, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Biochim Biophys Acta 1727:65-74. 2005
    ..These genes are also found adjacent to the fgfrl1a gene of Fugu, suggesting that FGFRL1, SPON2, CTBP1 and MEAEA were preserved as a coherent block during the evolution of Fugu and man...
  8. doi request reprint Interaction of the receptor FGFRL1 with the negative regulator Spred1
    Lei Zhuang
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Cell Signal 23:1496-504. 2011
    ..It is conceivable that FGFRL1, Sef and some Sprouty/Spred proteins work in concert to control growth factor signaling during branching morphogenesis of the kidneys and other organs...
  9. pmc Comparison of the receptor FGFRL1 from sea urchins and humans illustrates evolution of a zinc binding motif in the intracellular domain
    Lei Zhuang
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    BMC Biochem 10:33. 2009
    ....
  10. doi request reprint Identification of a fibronectin interaction site in the extracellular matrix protein ameloblastin
    Michael Beyeler
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Exp Cell Res 316:1202-12. 2010
    ..The recruited fibronectin should then promote cell adhesion on the implant surface, thereby accelerating osseointegration of the implant...
  11. doi request reprint Characterization of the first FGFRL1 mutation identified in a craniosynostosis patient
    Thorsten Rieckmann
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Biochim Biophys Acta 1792:112-21. 2009
    ..Deletion of either one led to the preferential redistribution of FGFRL1 to the plasma membrane. It is therefore likely that mutant FGFRL1 contributes to the skeletal malformations of the patient...
  12. pmc Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling
    Simon D Gerber
    Department of Clinical Research, University of Bern, Bern, Switzerland
    PLoS ONE 7:e33457. 2012
    ..Some of these genes might play an important role during early nephron formation. Our study should help to define the minimal set of genes that is required to form a functional nephron...
  13. ncbi request reprint Cementum attachment protein/protein-tyrosine phosphotase-like member A is not expressed in teeth
    Christof Schild
    Department of Clinical Research, University of Bern, CH 3010 Bern, Switzerland
    Int J Mol Med 23:293-6. 2009
    ..These results were confirmed by real-time PCR. Thus, the sequence deposited in public databanks under the name 'cementum attachment protein' does not represent genuine CAP...
  14. ncbi request reprint Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm
    Stefan Baertschi
    ITI Research Institute, University of Bern, Switzerland
    FEBS J 274:6241-53. 2007
    ..Other skeletal muscles do not appear to be affected in the Fgfrl1 deficient mice. Thus, Fgfrl1 plays a critical role in the development of the diaphragm...
  15. ncbi request reprint Fgfrl1, a fibroblast growth factor receptor-like gene, is found in the cephalochordate Branchiostoma floridae but not in the urochordate Ciona intestinalis
    Michael Beyeler
    ITI Research Institute, University of Bern, Murtenstrasse 35, PO Box 54, CH 3010 Bern, Switzerland
    Comp Biochem Physiol B Biochem Mol Biol 145:43-9. 2006
    ..Thus, the FGFRL1 gene might have evolved just before branching of the vertebrate lineage from the other chordates...
  16. ncbi request reprint Expression of FGFRL1, a novel fibroblast growth factor receptor, during embryonic development
    Beat Trueb
    ITI Research Institute, University of Bern, CH 3010 Bern, Switzerland
    Int J Mol Med 17:617-20. 2006
    ..It is conceivable that Fgfrl1 interacts with other Fgfrs, which are expressed in cartilage and muscle, to modulate FGF signaling...
  17. ncbi request reprint Expression of phosphoproteins and amelotin in teeth
    Beat Trueb
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, CH 3010 Bern, Switzerland
    Int J Mol Med 19:49-54. 2007
    ..It was expressed considerably later than the other enamel proteins, suggesting that amelotin may serve a function different from those of amelogenin, ameloblastin and enamelin...
  18. ncbi request reprint The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion
    Thorsten Rieckmann
    ITI Research Institute, University of Bern, Switzerland
    Exp Cell Res 314:1071-81. 2008
    ..With its dimeric structure and its adhesion promoting properties, FGFRL1 resembles the nectins, a family of cell adhesion molecules found at cell-cell junctions...
  19. ncbi request reprint Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors
    Christof Schild
    ITI Research Institute, University of Bern, CH 3010 Bern, Switzerland
    Int J Mol Med 16:1169-73. 2005
    ..Since FGFRL1 appears to be involved in the control of cell proliferation and differentiation, its aberrant expression might contribute to the development and progression of ovarian tumors...
  20. pmc Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1
    Ruth Amann
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Int J Mol Med 32:983-8. 2013
    ..It is therefore conceivable that FgfrL1 signals indirectly via Fgfr1. The mechanisms by which FgfrL1 affects the activity of Fgfr1 remain to be elucidated...
  21. ncbi request reprint Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress
    Christof Schild
    ITI Research Institute, University of Bern, P O Box 54, Murteustr 35, CH 3010 Bern, Switzerland
    Biochim Biophys Acta 1691:33-40. 2004
    ..Thus, adenylate cyclase as well as one or several protein kinases might be involved in the mechanoregulation of these CCN genes...
  22. ncbi request reprint Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues
    Beat Trueb
    ITI Research Institute, University of Bern, P O Box 54, CH 3010 Bern, Switzerland
    J Biol Chem 278:33857-65. 2003
    ..When overexpressed in MG-63 osteosarcoma cells, the novel receptor had a negative effect on cell proliferation. Taken together our data are consistent with the view that FGFRL1 acts as a decoy receptor for FGF ligands...
  23. ncbi request reprint The lipoma preferred partner LPP interacts with alpha-actinin
    Bo Li
    ITI Research Institute, University of Bern, PO Box 54, CH 3010 Bern, Switzerland
    J Cell Sci 116:1359-66. 2003
    ..It is likely that this difference leads to slightly different roles played by LPP and zyxin during the assembly and disassembly of focal adhesions...
  24. ncbi request reprint Mechanical stress is required for high-level expression of connective tissue growth factor
    Christof Schild
    M E Müller Institute for Biomechanics, University of Bern, Bern, CH 3010, Switzerland
    Exp Cell Res 274:83-91. 2002
    ..Since CTGF controls the synthesis of several extracellular matrix proteins, it is likely that this growth factor is responsible for the increased synthesis of collagen I and other matrix proteins in stressed fibroblasts...