M Tolnay

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms
    Markus Tolnay
    Institute of Pathology, Division of Neuropathology, Basel University, Schonbeinstrasse 40, 4003 Basel, Switzerland
    Acta Neuropathol 104:425-34. 2002
  2. pmc Transmission and spreading of tauopathy in transgenic mouse brain
    Florence Clavaguera
    Department of Neuropathology, Institute of Pathology, University of Basel, Switzerland
    Nat Cell Biol 11:909-13. 2009
  3. ncbi request reprint Pathology and genetics of frontotemporal lobar degeneration: an update
    M Tolnay
    Department of Neuropathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland
    Clin Neuropathol 26:143-56. 2007
  4. ncbi request reprint The neuropathological spectrum of neurodegenerative tauopathies
    Markus Tolnay
    Institute of Pathology, Division of Neuropathology, Basel University, Basel, Switzerland
    IUBMB Life 55:299-305. 2003
  5. ncbi request reprint A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: clinical and pathological features
    M Tolnay
    Institute of Pathology, Division of Neuropathology, Basel, Switzerland
    Neuropathol Appl Neurobiol 26:368-78. 2000
  6. ncbi request reprint Frontotemporal lobar degeneration--tau as a pied piper?
    Markus Tolnay
    Institute of Pathology, Division of Neuropathology, University of Basel, Basel, Switzerland
    Neurogenetics 4:63-75. 2002
  7. ncbi request reprint Frontotemporal lobar degeneration. An update on clinical, pathological and genetic findings
    M Tolnay
    Institute of Pathology, Division of Neuropathology, Basel University, Basel, Switzerland
    Gerontology 47:1-8. 2001
  8. ncbi request reprint Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies
    Markus Tolnay
    Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel, Switzerland
    Neuropathology 24:269-83. 2004
  9. ncbi request reprint Perisomatic granules (non-plaque dystrophic dendrites) of hippocampal CA1 neurons in Alzheimer's disease and Pick's disease: a lesion distinct from granulovacuolar degeneration
    A Probst
    Institute of Pathology, Division of Neuropathology, University of Basel, Schonbeinstrasse 40, CH 4003 Basel, Switzerland
    Acta Neuropathol 102:636-44. 2001
  10. doi request reprint Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation
    M Osinde
    Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland
    Neuropathol Appl Neurobiol 34:523-31. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms
    Markus Tolnay
    Institute of Pathology, Division of Neuropathology, Basel University, Schonbeinstrasse 40, 4003 Basel, Switzerland
    Acta Neuropathol 104:425-34. 2002
    ..AgD, however, shares the pathological tau doublet (64 and 69 kDa) as well as the predominance of 4R tau isoforms with CBD and PSP...
  2. pmc Transmission and spreading of tauopathy in transgenic mouse brain
    Florence Clavaguera
    Department of Neuropathology, Institute of Pathology, University of Basel, Switzerland
    Nat Cell Biol 11:909-13. 2009
    ....
  3. ncbi request reprint Pathology and genetics of frontotemporal lobar degeneration: an update
    M Tolnay
    Department of Neuropathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland
    Clin Neuropathol 26:143-56. 2007
    ..Presently, mutations in 4 genes (MAPT, PGRN, VCP, CHMP2B) are known to cause diverse types of FTLD pathology. Here, we summarize the recent neuropathological and genetic advances in FTLD research...
  4. ncbi request reprint The neuropathological spectrum of neurodegenerative tauopathies
    Markus Tolnay
    Institute of Pathology, Division of Neuropathology, Basel University, Basel, Switzerland
    IUBMB Life 55:299-305. 2003
    ..Finally, we will discuss the very recent finding of 'tau-deficient' tauopathy in a subset of frontotemporal dementia cases...
  5. ncbi request reprint A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: clinical and pathological features
    M Tolnay
    Institute of Pathology, Division of Neuropathology, Basel, Switzerland
    Neuropathol Appl Neurobiol 26:368-78. 2000
    ..These results are compared with those reported for other FTDP-17 families, i.e. for MSTD...
  6. ncbi request reprint Frontotemporal lobar degeneration--tau as a pied piper?
    Markus Tolnay
    Institute of Pathology, Division of Neuropathology, University of Basel, Basel, Switzerland
    Neurogenetics 4:63-75. 2002
    ....
  7. ncbi request reprint Frontotemporal lobar degeneration. An update on clinical, pathological and genetic findings
    M Tolnay
    Institute of Pathology, Division of Neuropathology, Basel University, Basel, Switzerland
    Gerontology 47:1-8. 2001
    ..Recent neuropathological and genetic data strongly suggest that there is more than one genetic background for frontotemporal lobar degeneration...
  8. ncbi request reprint Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies
    Markus Tolnay
    Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel, Switzerland
    Neuropathology 24:269-83. 2004
    ....
  9. ncbi request reprint Perisomatic granules (non-plaque dystrophic dendrites) of hippocampal CA1 neurons in Alzheimer's disease and Pick's disease: a lesion distinct from granulovacuolar degeneration
    A Probst
    Institute of Pathology, Division of Neuropathology, University of Basel, Schonbeinstrasse 40, CH 4003 Basel, Switzerland
    Acta Neuropathol 102:636-44. 2001
    ..In addition PSG should be acknowledged among main histological changes associated with hippocampal neurons in AD and Pick's disease...
  10. doi request reprint Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation
    M Osinde
    Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland
    Neuropathol Appl Neurobiol 34:523-31. 2008
    ..We examined the formation of neurofibrillary tangles (NFT) in adult mouse brain without the prior overexpression of Tau at embryonic or early post-natal stages to dissociate any developmental mechanisms...
  11. ncbi request reprint Ballooned neurons expressing alphaB-crystallin as a constant feature of the amygdala in argyrophilic grain disease
    M Tolnay
    Institute of Pathology, Division of Neuropathology, Basel University, Switzerland
    Neurosci Lett 246:165-8. 1998
    ....
  12. doi request reprint New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central?
    A Probst
    Department of Neuropathology, Institute of Pathology, University of Basel, Basel, Switzerland
    Eur J Neurol 15:1-4. 2008
    ....
  13. ncbi request reprint Focal myositis of the iliopsoas muscle--a benign pseudotumour: ultrasound appearance in correlation with CT and MRI
    A Hoffmann
    Department of Radiology, University Hospital Basel, Switzerland
    Ultraschall Med 27:180-4. 2006
    ..Focal myositis of the iliopsoas muscle is a rare condition. A case is presented, emphasizing the value of ultrasound for detection, localisation, image-guided biopsy and follow-up in correlation with CT and MRI findings...
  14. ncbi request reprint [Meningothelial meningioma in a mature cystic teratoma of the ovary]
    H Adams
    Institut fur Pathologie, Universitatsspital, Schonbeinstrasse 40, 4003, Basel, Schweiz
    Pathologe 28:278-80. 2007
    ..The characteristic histomorphology and immunohistochemical expression for epithelial membrane antigen (EMA) and desmoplakin are diagnostic...
  15. ncbi request reprint [Argyrophilic grain disease (AgD), a frequent and largely underestimated cause of dementia in old patients]
    A Probst
    Institut de Pathologie de l Université de Bâle, Département de Neuropathologie, Université de Bâle, Suisse, France
    Rev Neurol (Paris) 158:155-65. 2002
    ..In conclusion it seems very likely that AgD is a distinct dementing disorder of old age that has to be distinguished from other tauopathies, e.g. AD, by both morphological and genetic criteria...
  16. doi request reprint Assessment of nerve damage using a novel ultrasonic device for bone cutting
    Stefan Schaeren
    Orthopedic Surgery, University Hospital, Basel, Switzerland
    J Oral Maxillofac Surg 66:593-6. 2008
  17. doi request reprint Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice
    David T Winkler
    Department of Neurology, University Hospital Basel, Basel, Switzerland
    Biol Psychiatry 68:971-4. 2010
    ..Passive immunization for the treatment of Alzheimer's disease (AD) was rapidly translated into clinical trials. However, basic mechanisms of AD immunotherapy remain only partially understood...
  18. doi request reprint Hereditary systemic angiopathy (HSA) with cerebral calcifications, retinopathy, progressive nephropathy, and hepatopathy
    D T Winkler
    Department of Neurology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    J Neurol 255:77-88. 2008
    ..Early diagnosis of hereditary systemic angiopathies is important in order to prevent patients from repetitive invasive diagnostic measures and to avoid the use of inappropriate and potentially harmful drugs...
  19. ncbi request reprint Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy
    D T Winkler
    Department of Neuropathology, Institute of Pathology, University of Basel, CH 4003 Basel, Switzerland
    J Neurosci 21:1619-27. 2001
    ..This first mouse model of CAA-associated hemorrhagic stroke will now allow development of diagnostic and therapeutic strategies...
  20. ncbi request reprint The validity of clinical diagnoses of dementia in a group of consecutively autopsied memory clinic patients
    B E Gay
    Geriatric University Clinic, University Hospital Basel, Switzerland
    J Nutr Health Aging 12:132-7. 2008
    ..Clinicopathological studies are critical to our understanding of this disease and improving the accuracy of clinical diagnoses...
  21. ncbi request reprint Mouse models of alpha-synucleinopathy and Lewy pathology
    B Sommer
    Nervous System Research, Novartis Pharma Inc, CH 4002, Basel, Switzerland
    Exp Gerontol 35:1389-403. 2000
    ..The mouse models provide means to address fundamental aspects of alpha-synucleinopathy and to test therapeutic strategies...
  22. ncbi request reprint Subependymoma of the third ventricle after partial resection of a craniopharyngioma and repeated postoperative irradiation
    M Tolnay
    Division of Neuropathology, University of Basel, Switzerland
    Clin Neuropathol 15:63-6. 1996
    ..However, in view of the repeated post-operative irradiation in our case the possibility of radiation-induced glioma has also to be considered...
  23. ncbi request reprint Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
    A Bloch
    Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel, Switzerland
    Neuropathol Appl Neurobiol 32:284-95. 2006
    ..A larger cohort of ILBD cases will be needed to pinpoint the precise induction site of alphaSN pathology among these structures...
  24. pmc Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
    M E Calhoun
    Department of Neuropathology, Institute for Pathology, University of Basel, CH 4003 Basel, Switzerland
    Proc Natl Acad Sci U S A 96:14088-93. 1999
    ..APP23 mice on an App-null background developed a similar degree of both plaques and CAA, providing further evidence that a neuronal source of APP/Abeta is sufficient to induce cerebrovascular amyloid and associated neurodegeneration...
  25. ncbi request reprint Argyrophilic grain disease: molecular genetic difference to other four-repeat tauopathies
    Andre R Miserez
    Cardiovascular Genetics, Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Basel, Switzerland
    Acta Neuropathol 106:363-6. 2003
    ..These data suggest that a dysfunction of the tau protein in AgD-in contrast to other four-repeat tauopathies-may arise irrespective of the genetic background regarding the tau H1 or H2 haplotypes...
  26. ncbi request reprint Clinical characteristics of dementia associated with argyrophilic grain disease
    Gertrud M Steuerwald
    Memory Clinic Neuropsychology Center, University Hospital Basel, Basel, Switzerland
    Dement Geriatr Cogn Disord 24:229-34. 2007
    ..We aimed at characterizing the clinical features of dementia associated with argyrophilic grain disease (AgD)...
  27. ncbi request reprint Hippocampal sclerosis dementia: a reappraisal
    Alphonse Probst
    Department of Neuropathology, Institute of Pathology, University Hospital Basel, Schonbeinstrasse 40, Basel 4031, Switzerland
    Acta Neuropathol 114:335-45. 2007
    ..e. FTLD-U). Each of these disease processes could either independently or concertedly account for the dementia syndrome in HpSclD...
  28. ncbi request reprint Tauopathy models and human neuropathology: similarities and differences
    Stephan Frank
    Institute of Pathology, Department of Neuropathology, University Hospital Basel, Schonbeinstrasse 40, 4031, Basel, Switzerland
    Acta Neuropathol 115:39-53. 2008
    ..Here, we will review in vivo models of human tauopathies with particular preference to transgenic mouse models. Strengths and limitations of these models in recapitulating the complex pathogenesis of tauopathies will be discussed...
  29. ncbi request reprint Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22
    Armand Savioz
    Department of Psychiatry, University of Geneva School of Medicine, 1225 Geneva, Switzerland
    Neurobiol Dis 12:46-55. 2003
    ..Altogether, these data indicate principally that the Swiss kindred is unlinked to locus 17q21-22, and that tau is not at the origin of FTD in this family...
  30. pmc Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice
    Tristan Bolmont
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Otfried Müller Str 27, D 72076 Tubingen, Germany
    Am J Pathol 171:2012-20. 2007
    ....
  31. ncbi request reprint MAPT S305I mutation: implications for argyrophilic grain disease
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Acta Neuropathol 116:103-18. 2008
    ....
  32. pmc Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
    Nigel J Cairns
    Department of Neurology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Acta Neuropathol 114:5-22. 2007
    ..These criteria will be of value to the practicing neuropathologist and provide a foundation for clinical, clinico-pathologic, mechanistic studies and in vivo models of pathogenesis of FTLD...
  33. doi request reprint Clinical course of neuropathologically confirmed frontal-variant Alzheimer's disease
    Kirsten I Taylor
    Marie Curie Fellow at the University of Cambridge, Cambridge, UK
    Nat Clin Pract Neurol 4:226-32. 2008
    ..Management The patient and his spouse were referred for counseling, and the patient was referred for follow-up examinations...
  34. ncbi request reprint Inflammatory myofibroblastic tumour of the sella turcica
    Wolfram Jochum
    Neuropathol Appl Neurobiol 30:692-5. 2004
  35. ncbi request reprint Staging of sporadic Parkinson disease-related alpha-synuclein pathology: inter- and intra-rater reliability
    Christian M Müller
    Institute for Clinical Neuroanatomy, J W Goethe University Clinic, Frankfurt M, Germany
    J Neuropathol Exp Neurol 64:623-8. 2005
    ..Clearly defined stages of alpha-synpathology might aid the comparability between studies and also help to distinguish sPD from other synucleinopathies...
  36. pmc Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease
    Gaby Schoch
    Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    PLoS Med 3:e14. 2006
    ..Comparability of classifications is hampered by disparity of applied methods and inter-observer variability...