I Tobler

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc Seasonal aspects of sleep in the Djungarian hamster
    Svitlana Palchykova
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    BMC Neurosci 4:9. 2003
  2. pmc Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype
    I Tobler
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:6464-9. 2001
  3. ncbi request reprint Sleep in the blind mole rat Spalax ehrenbergi
    I Tobler
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Sleep 24:147-54. 2001
  4. ncbi request reprint [Why do we sleep? Contributions from animal research]
    I Tobler
    Institut fur Pharmakologie und Toxikologie, Universitat Zurich
    Ther Umsch 57:417-20. 2000
  5. ncbi request reprint Rest-activity rhythm of the blind mole rat Spalax ehrenbergi under different lighting conditions
    I Tobler
    Institute of Pharmacology, University of Zurich, Switzerland
    Behav Brain Res 96:173-83. 1998
  6. pmc Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice
    R Winsky-Sommerer
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Neuroscience 154:595-605. 2008
  7. ncbi request reprint Sleep homeostasis in the rat in the light and dark period
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Brain Res Bull 74:37-44. 2007
  8. ncbi request reprint Sleep and sleep regulation in normal and prion protein-deficient mice
    I Tobler
    Graduate Program in Pharmacology, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 17:1869-79. 1997
  9. ncbi request reprint Sleep and rest regulation in young and old oestrogen-deficient female mice
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    J Neuroendocrinol 18:567-76. 2006
  10. ncbi request reprint The dynamics of spindles and EEG slow-wave activity in NREM sleep in mice
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Arch Ital Biol 142:511-23. 2004

Collaborators

Detail Information

Publications24

  1. pmc Seasonal aspects of sleep in the Djungarian hamster
    Svitlana Palchykova
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    BMC Neurosci 4:9. 2003
    ..The second recording was performed when they had returned to summer physiology, despite the maintenance of the 'winter' conditions...
  2. pmc Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype
    I Tobler
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:6464-9. 2001
    ..Because alpha1 GABA(A) receptors mediate the sedative action of Dz, our results provide evidence that the hypnotic effect of Dz and its EEG "fingerprint" can be dissociated from its sedative action...
  3. ncbi request reprint Sleep in the blind mole rat Spalax ehrenbergi
    I Tobler
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Sleep 24:147-54. 2001
    ..A prominent adaptation is their blindness, which is due to an atrophy of the eyes...
  4. ncbi request reprint [Why do we sleep? Contributions from animal research]
    I Tobler
    Institut fur Pharmakologie und Toxikologie, Universitat Zurich
    Ther Umsch 57:417-20. 2000
    ..These results allow to search for genes and gene products which change as a function of the vigilance states in these more simpler organisms. Thereafter, homologous genes can be investigated in mice...
  5. ncbi request reprint Rest-activity rhythm of the blind mole rat Spalax ehrenbergi under different lighting conditions
    I Tobler
    Institute of Pharmacology, University of Zurich, Switzerland
    Behav Brain Res 96:173-83. 1998
    ....
  6. pmc Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice
    R Winsky-Sommerer
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Neuroscience 154:595-605. 2008
    ..These findings show that the lack of alpha3-GABA(A) receptors is extensively compensated for to preserve the integrity of thalamo-cortical function in physiological and pathophysiological situations...
  7. ncbi request reprint Sleep homeostasis in the rat in the light and dark period
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Brain Res Bull 74:37-44. 2007
    ..The slower dynamics of low frequency delta power compared to fast delta frequencies point to heterogeneity within the traditionally defined SWA band...
  8. ncbi request reprint Sleep and sleep regulation in normal and prion protein-deficient mice
    I Tobler
    Graduate Program in Pharmacology, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 17:1869-79. 1997
    ..After the sleep deprivation, SWA was increased, but the changes in EEG power density and SWA were more prominent and lasted longer in the PrP-null mice. Our results suggest that PrP plays a role in promoting sleep continuity...
  9. ncbi request reprint Sleep and rest regulation in young and old oestrogen-deficient female mice
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    J Neuroendocrinol 18:567-76. 2006
    ..The results indicate that despite the pronounced redistribution of sleep and motor activity in oestrogen deficient mice, the basic homeostatic mechanisms of sleep regulation in ArKO mice remain intact...
  10. ncbi request reprint The dynamics of spindles and EEG slow-wave activity in NREM sleep in mice
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Arch Ital Biol 142:511-23. 2004
    ..The data suggest that spindles in NREM sleep may be involved in sleep maintenance, while spindles heralding the transition to REM sleep may be related to mechanisms of REM sleep initiation...
  11. pmc Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity
    C Kopp
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 101:3674-9. 2004
    ....
  12. ncbi request reprint Interhemispheric coherence of the sleep electroencephalogram in mice with congenital callosal dysgenesis
    V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuroscience 124:481-8. 2004
    ..This applies also to the functional changes induced by sleep deprivation in NREM sleep. In contrast, interhemispheric synchronisation of theta oscillations in waking and REM sleep may be mediated by direct interhippocampal connections...
  13. ncbi request reprint Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Neuroscience 147:833-41. 2007
    ..The data indicate that the GABAergic system is involved in the regulation of cortical synchronization of neuronal activity and suggest a link between regional EEG synchronization and behavioral states...
  14. ncbi request reprint Sleep and cortical temperature in the Djungarian hamster under baseline conditions and after sleep deprivation
    T Deboer
    , , Switzerland
    J Comp Physiol A 174:145-55. 1994
    ..Also in the Djungarian hamster the time course of SWA seems to reflect a homeostatically regulated process as was formulated in the two-process model of sleep regulation...
  15. ncbi request reprint Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease
    H P Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Neurology 66:1418-24. 2006
    ..The prevalence and characteristics of sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease (sCJD) are poorly understood...
  16. ncbi request reprint Diazepam-induced changes on sleep and the EEG spectrum in mice: role of the alpha3-GABA(A) receptor subtype
    C Kopp
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 17:2226-30. 2003
    ..Despite the exclusive expression of alpha3-containing GABAA receptors in the reticular thalamic nucleus, these receptors do not seem to be critical for the mediation of the effects of diazepam on the sleep EEG...
  17. ncbi request reprint Handedness leads to interhemispheric EEG asymmetry during sleep in the rat
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr 190 CH 8057, Zurich, Switzerland
    J Neurophysiol 99:969-75. 2008
    ..We conclude that inherent laterality is manifested when animals are exposed to complex behavioral tasks, and sleep plays a role in consolidating the hemispheric dominance of the brain...
  18. ncbi request reprint Shortening of the photoperiod affects sleep distribution, EEG and cortical temperature in the Djungarian hamster
    T Deboer
    Institute of Pharmacology, , Switzerland
    J Comp Physiol A 179:483-92. 1996
    ..The lower EEG power density in the short photoperiod may contribute to energy conservation...
  19. ncbi request reprint Sleep extension in humans: sleep stages, EEG power spectra and body temperature
    D J Dijk
    Institute of Pharmacology, , Switzerland
    Sleep 14:294-306. 1991
    ..Thus the time course of Tcore dissociated from the time course of SWA. This indicates that SWA in NREM sleep is not directly related to the variation in core body temperature...
  20. ncbi request reprint Sleep and EEG spectra in the Syrian hamster (Mesocricetus auratus) under baseline conditions and following sleep deprivation
    I Tobler
    Pharmakologisches Institut, , Switzerland
    J Comp Physiol A 161:449-59. 1987
    ..In contrast, 3 h SD induced a large and more prolonged effect. The similarities and differences of sleep and sleep regulation are summarized for the hamster, rat and man...
  21. ncbi request reprint Altered circadian activity rhythms and sleep in mice devoid of prion protein
    I Tobler
    Institute of Pharmacology, University of Zurich, Switzerland
    Nature 380:639-42. 1996
    ....
  22. pmc Cortical metabolic rates as measured by 2-deoxyglucose-uptake are increased after waking and decreased after sleep in mice
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Brain Res Bull 75:591-7. 2008
    ..The data are consistent with the prediction that sleep may reset cerebral metabolic rates to a lower level...
  23. ncbi request reprint Behavioral sleep in the Asian elephant in captivity
    I Tobler
    Institute of Pharmacology, , Switzerland
    Sleep 15:1-12. 1992
    ..TST in the infant decreased during the course of the 15-month recording period from 8.1 hours to 5.1 hours. SS occurred for the first time at the age of 9 months...
  24. ncbi request reprint Running wheel size influences circadian rhythm period and its phase shift in mice
    T Deboer
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    J Comp Physiol A 186:969-73. 2000
    ..It can be concluded that technical features of the running wheel can influence the circadian period of wheel running...