Margot Thome

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. doi request reprint Multifunctional roles for MALT1 in T-cell activation
    Margot Thome
    Margot Thome is at the Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Rev Immunol 8:495-500. 2008
  2. ncbi request reprint The immunological synapse and actin assembly: a regulatory role for PKC theta
    Margot Thome
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066, Epalinges, Switzerland
    Dev Cell 4:3-5. 2003
  3. pmc Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1
    Margot Thome
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cold Spring Harb Perspect Biol 2:a003004. 2010
  4. ncbi request reprint Post-translational modifications regulate distinct functions of CARMA1 and BCL10
    Margot Thome
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Trends Immunol 28:281-8. 2007
  5. ncbi request reprint CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
    Margot Thome
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Rev Immunol 4:348-59. 2004
  6. ncbi request reprint The proteolytic activity of the paracaspase MALT1 is key in T cell activation
    Fabien Rebeaud
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Nat Immunol 9:272-81. 2008
  7. pmc Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface
    Katrin Cabalzar
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 8:e72051. 2013
  8. doi request reprint The protease activity of the paracaspase MALT1 is controlled by monoubiquitination
    Christiane Pelzer
    Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Epalinges, Switzerland
    Nat Immunol 14:337-45. 2013
  9. ncbi request reprint Bcl10 controls TCR- and FcgammaR-induced actin polymerization
    Daniel Rueda
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, Epalinges, Switzerland
    J Immunol 178:4373-84. 2007
  10. pmc Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
    Stephan Hailfinger
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 106:19946-51. 2009

Collaborators

Detail Information

Publications26

  1. doi request reprint Multifunctional roles for MALT1 in T-cell activation
    Margot Thome
    Margot Thome is at the Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Rev Immunol 8:495-500. 2008
    ....
  2. ncbi request reprint The immunological synapse and actin assembly: a regulatory role for PKC theta
    Margot Thome
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066, Epalinges, Switzerland
    Dev Cell 4:3-5. 2003
    ..In the December issue of Molecular Cell, Sasahara et al. provide new insights into the link between the T cell receptor and actin assembly in the immunological synapse, and reveal a critical regulatory role for PKC theta in this process...
  3. pmc Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1
    Margot Thome
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cold Spring Harb Perspect Biol 2:a003004. 2010
    ..Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future...
  4. ncbi request reprint Post-translational modifications regulate distinct functions of CARMA1 and BCL10
    Margot Thome
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Trends Immunol 28:281-8. 2007
    ..Moreover, the study of BCL10 phosphorylation isoforms has revealed a new mechanism controlling BCL10 nuclear translocation and an unexpected role for BCL10 in the regulation of the actin cytoskeleton...
  5. ncbi request reprint CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
    Margot Thome
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Rev Immunol 4:348-59. 2004
  6. ncbi request reprint The proteolytic activity of the paracaspase MALT1 is key in T cell activation
    Fabien Rebeaud
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Nat Immunol 9:272-81. 2008
    ..Thus, the proteolytic activity of MALT1 is central to T cell activation, which suggests a possible target for the development of immunomodulatory or anticancer drugs...
  7. pmc Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface
    Katrin Cabalzar
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 8:e72051. 2013
    ..Collectively, these findings suggest a model in which E549 at the dimerization interface is required for the formation of the enzymatically active, monoubiquitinated form of MALT1. ..
  8. doi request reprint The protease activity of the paracaspase MALT1 is controlled by monoubiquitination
    Christiane Pelzer
    Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Epalinges, Switzerland
    Nat Immunol 14:337-45. 2013
    ..Thus, monoubiquitination of MALT1 is essential for its catalytic activation and is therefore a potential target for the treatment of ABC-DLBCL and for immunomodulation...
  9. ncbi request reprint Bcl10 controls TCR- and FcgammaR-induced actin polymerization
    Daniel Rueda
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, Epalinges, Switzerland
    J Immunol 178:4373-84. 2007
    ..Remarkably, Bcl10 silencing also impairs FcgammaR-induced actin polymerization and phagocytosis in human monocytes. These results point to a key role of Bcl10 in F-actin-dependent immune responses of T cells and monocytes/macrophages...
  10. pmc Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
    Stephan Hailfinger
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 106:19946-51. 2009
    ..These results demonstrate a key role for the proteolytic activity of MALT1 in DLBCL of the ABC subtype, and provide a rationale for the development of pharmacological inhibitors of MALT1 in DLBCL therapy...
  11. doi request reprint Adapter and enzymatic functions of proteases in T-cell activation
    Stephan Hailfinger
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunol Rev 232:334-47. 2009
    ..Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation...
  12. pmc Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
    Stephan Hailfinger
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 108:14596-601. 2011
    ..These findings identify a central role for Malt1-dependent RelB cleavage in canonical NF-κB activation and thereby provide a rationale for the targeting of Malt1 in immunomodulation and cancer treatment...
  13. ncbi request reprint CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation
    Olivier Gaide
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 3:836-43. 2002
    ..Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation...
  14. ncbi request reprint TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1
    Margot Thome
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 153, CH 1066 Epalinges, Switzerland
    Trends Immunol 24:419-24. 2003
  15. ncbi request reprint Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation
    Fabien Rebeaud
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Trends Immunol 28:196-200. 2007
    ....
  16. ncbi request reprint Phosphorylation of CARMA1: the link(er) to NF-kappaB activation
    Daniel Rueda
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 23:551-3. 2005
    ..Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB...
  17. pmc RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis
    Etienne Meylan
    Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
    EMBO Rep 3:1201-8. 2002
    ..These data suggest that RIP4 is involved in NF-kappa B and JNK signaling and that caspase-dependent processing of RIP4 may negatively regulate NF-kappa B-dependent pro-survival or pro-inflammatory signals...
  18. ncbi request reprint The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
    J Biol Chem 277:45162-71. 2002
    ....
  19. doi request reprint Detection and measurement of paracaspase MALT1 activity
    Stephan Hailfinger
    Department of Biochemistry, University of Lausanne, Lausanne, Switzerland
    Methods Mol Biol 1133:177-88. 2014
    ..Here, we describe both in vitro and in vivo assays that have been developed to assess MALT1 activity. ..
  20. ncbi request reprint Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression
    Ralph Torgler
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 180:3990-9. 2008
    ..Indeed, lack of MyD88 significantly increased infection in vitro and in vivo. Thus, host cell wounding due to parasite migration induces inflammation which limits the extent of parasite infection...
  21. ncbi request reprint Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation
    Ravi S Misra
    Immunobiology Program, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    J Biol Chem 282:19365-74. 2007
    ..The current findings define a link among TCR, caspases, and the NF-kappaB pathway that occurs in a sequestered lipid raft environment in T cells...
  22. ncbi request reprint T cell division and death are segregated by mutation of TCRbeta chain constant domains
    Emma Teixeiro
    Laboratory of Transplantation Immunology, Department of Research, University Hospital Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Immunity 21:515-26. 2004
    ..This signaling defect leads to a reduced expression of Fas ligand (FasL) and to a reduction in AICD. These beta chain domains are involved in discriminating cell division and apoptosis...
  23. ncbi request reprint Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Curr Biol 13:1252-8. 2003
    ..Together, these results show that CARMA1 has a central role in antigen receptor signaling that results in activation and proliferation of both B and T lymphocytes...
  24. ncbi request reprint Mycobacterium tuberculosis subverts innate immunity to evade specific effectors
    Corinne Loeuillet
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    J Immunol 177:6245-55. 2006
    ..The apoptosis resistance of infected macrophages might be considered as an immune escape mechanism, whereby M. tuberculosis subverts innate immunity signaling to protect its host cell against FasL(+)-specific cytotoxic lymphocytes...
  25. ncbi request reprint Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis
    Ebun Aganna
    Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Arthritis Rheum 46:2445-52. 2002
    ..This study was undertaken to characterize the genetic basis of FCU, MWS, and an overlapping disorder in French Canadian, British, and Indian families, respectively...
  26. ncbi request reprint Bcl10
    Margot Thome
    Curr Biol 12:R45. 2002