Research Topics
Genomes and Genes | Margot ThomeSummaryAffiliation: University of Lausanne Country: Switzerland Publications
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Publications
Multifunctional roles for MALT1 in T-cell activationMargot Thome
Margot Thome is at the Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nat Rev Immunol 8:495-500. 2008....
Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1Margot Thome
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Cold Spring Harb Perspect Biol 2:a003004. 2010..Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future...
Post-translational modifications regulate distinct functions of CARMA1 and BCL10Margot Thome
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Trends Immunol 28:281-8. 2007..Moreover, the study of BCL10 phosphorylation isoforms has revealed a new mechanism controlling BCL10 nuclear translocation and an unexpected role for BCL10 in the regulation of the actin cytoskeleton...- CARMA1, BCL-10 and MALT1 in lymphocyte development and activationMargot Thome
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Nat Rev Immunol 4:348-59. 2004 - The proteolytic activity of the paracaspase MALT1 is key in T cell activationFabien Rebeaud
Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
Nat Immunol 9:272-81. 2008..Thus, the proteolytic activity of MALT1 is central to T cell activation, which suggests a possible target for the development of immunomodulatory or anticancer drugs... - Bcl10 controls TCR- and FcgammaR-induced actin polymerizationDaniel Rueda
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, Epalinges, Switzerland
J Immunol 178:4373-84. 2007..Remarkably, Bcl10 silencing also impairs FcgammaR-induced actin polymerization and phagocytosis in human monocytes. These results point to a key role of Bcl10 in F-actin-dependent immune responses of T cells and monocytes/macrophages... - Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphomaStephan Hailfinger
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Proc Natl Acad Sci U S A 106:19946-51. 2009..These results demonstrate a key role for the proteolytic activity of MALT1 in DLBCL of the ABC subtype, and provide a rationale for the development of pharmacological inhibitors of MALT1 in DLBCL therapy... - Adapter and enzymatic functions of proteases in T-cell activationStephan Hailfinger
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunol Rev 232:334-47. 2009..Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation... - Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell linesStephan Hailfinger
Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
Proc Natl Acad Sci U S A 108:14596-601. 2011..These findings identify a central role for Malt1-dependent RelB cleavage in canonical NF-κB activation and thereby provide a rationale for the targeting of Malt1 in immunomodulation and cancer treatment... - The immunological synapse and actin assembly: a regulatory role for PKC thetaMargot Thome
Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066, Epalinges, Switzerland
Dev Cell 4:3-5. 2003..In the December issue of Molecular Cell, Sasahara et al. provide new insights into the link between the T cell receptor and actin assembly in the immunological synapse, and reveal a critical regulatory role for PKC theta in this process... - CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activationOlivier Gaide
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nat Immunol 3:836-43. 2002..Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation... - Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activationFabien Rebeaud
Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
Trends Immunol 28:196-200. 2007.... - TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1Margot Thome
Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 153, CH-1066 Epalinges, Switzerland
Trends Immunol 24:419-24. 2003 - Phosphorylation of CARMA1: the link(er) to NF-kappaB activationDaniel Rueda
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Immunity 23:551-3. 2005..Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB... - RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosisEtienne Meylan
Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
EMBO Rep 3:1201-8. 2002..These data suggest that RIP4 is involved in NF-kappa B and JNK signaling and that caspase-dependent processing of RIP4 may negatively regulate NF-kappa B-dependent pro-survival or pro-inflammatory signals... - Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expressionRalph Torgler
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
J Immunol 180:3990-9. 2008..Indeed, lack of MyD88 significantly increased infection in vitro and in vivo. Thus, host cell wounding due to parasite migration induces inflammation which limits the extent of parasite infection... - The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complexOlivier Micheau
Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
J Biol Chem 277:45162-71. 2002.... - Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activationRavi S Misra
Immunobiology Program, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
J Biol Chem 282:19365-74. 2007..The current findings define a link among TCR, caspases, and the NF-kappaB pathway that occurs in a sequestered lipid raft environment in T cells... - Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferationTakeshi Egawa
Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Curr Biol 13:1252-8. 2003..Together, these results show that CARMA1 has a central role in antigen receptor signaling that results in activation and proliferation of both B and T lymphocytes... - T cell division and death are segregated by mutation of TCRbeta chain constant domainsEmma Teixeiro
Laboratory of Transplantation Immunology, Department of Research, University Hospital-Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland
Immunity 21:515-26. 2004..This signaling defect leads to a reduced expression of Fas ligand (FasL) and to a reduction in AICD. These beta chain domains are involved in discriminating cell division and apoptosis... - Mycobacterium tuberculosis subverts innate immunity to evade specific effectorsCorinne Loeuillet
Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
J Immunol 177:6245-55. 2006..The apoptosis resistance of infected macrophages might be considered as an immune escape mechanism, whereby M. tuberculosis subverts innate immunity signaling to protect its host cell against FasL(+)-specific cytotoxic lymphocytes... - Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosisEbun Aganna
Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
Arthritis Rheum 46:2445-52. 2002..This study was undertaken to characterize the genetic basis of FCU, MWS, and an overlapping disorder in French Canadian, British, and Indian families, respectively... - Bcl10Margot Thome
Curr Biol 12:R45. 2002