Research Topics
| Luc TappySummaryAffiliation: University of Lausanne Country: Switzerland Publications
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Publications
Metabolic consequences of overfeeding in humansLuc Tappy
Department of Physiology and Division of Endocrinology, Diabetes and Metabolism, Lausanne University Faculty of Biology and Medicine, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 7:623-8. 2004..The present review is mainly focused on the recent developments regarding the effects of overfeeding on energy expenditure...- Dairy calcium supplementation in overweight or obese persons: its effect on markers of fat metabolismMurielle Bortolotti
Institute of Physiology, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 88:877-85. 2008..Dairy calcium supplementation has been proposed to increase fat oxidation and to inhibit lipogenesis... 
Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetesKim Anne Le
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 89:1760-5. 2009..Both nutritional and genetic factors are involved in the pathogenesis of nonalcoholic fatty liver disease and insulin resistance...- A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humansKim Anne Le
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 84:1374-9. 2006..In rodents, fructose leads to insulin resistance and ectopic lipid deposition. In humans, the effects of fructose on insulin sensitivity remain debated, whereas its effect on ectopic lipids has never been investigated... - Contributions of fat and protein to the incretin effect of a mixed mealGuillaume Carrel
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 94:997-1003. 2011..The relative contributions of fat and protein to the incretin effect are still largely unknown... - Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjectsCaroline Couchepin
Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne, Switzerland
Diabetes Care 31:1254-6. 2008..To compare the metabolic effects of fructose in healthy male and female subjects... - High protein intake reduces intrahepatocellular lipid deposition in humansMurielle Bortolotti
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 90:1002-10. 2009..High protein intake may facilitate weight loss and improve glucose homeostasis in insulin-resistant patients, but its effects on IHCLs remain unknown... - Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucoseVirgile Lecoultre
Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 92:1071-9. 2010..When fructose is ingested together with glucose (GLUFRU) during exercise, plasma lactate and exogenous carbohydrate oxidation rates are higher than with glucose alone... - Combined effects of endurance training and dietary unsaturated fatty acids on physical performance, fat oxidation and insulin sensitivityAndreas Boss
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Br J Nutr 103:1151-9. 2010..This difference was, however, not significant. It is concluded that a diet enriched with fish- and olive oil does not substantially enhance the effects of a short-term endurance training protocol in healthy young subjects... - Metabolic effects of fructoseKim Anne Le
Department of Physiology, Faculty of Medicine, University of Lausanne, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 9:469-75. 2006..Fructose/sucrose produces deleterious metabolic effects in animal models. This raises concern regarding the short-term and long-term effects of fructose and its risk in humans... - Metabolic and physiologic effects of an endotoxin challenge in healthy obese subjectsMarcel Rohrer
Service of Adult Intensive Care Medicine, CHUV, Lausanne, Switzerland
Clin Physiol Funct Imaging 31:371-5. 2011..The aim of this study was to test the physiologic response of healthy obese subjects to a standardized intravenous LPS challenge... - Effect of nutritional support on glucose controlGerald Seematter
Service of Anaesthesiology, University Hospital of Canton de Vaud CHUV, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 10:210-4. 2007..There is evidence that maintaining a normal glycemia level in critically ill patients has beneficial effects on outcome. Strategies aimed at lowering glycemia are based on the understanding of mechanisms regulating glucose metabolism... - Fructose and metabolic diseases: new findings, new questionsLuc Tappy
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Nutrition 26:1044-9. 2010..This has led to the recommendation to limit the daily intake of sugar calories... - Fructose toxicity: is the science ready for public health actions?Luc Tappy
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 15:357-61. 2012..This review evaluates the scientific basis for such action... - Substrate utilization in sepsis and multiple organ failureLuc Tappy
Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne, Switzerland
Crit Care Med 35:S531-4. 2007..Their use in patients with sepsis does not lead to adverse metabolic effects... - Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone releaseFrederique Rodieux
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Obesity (Silver Spring) 16:298-305. 2008..Procedures that involve bypassing the proximal small bowel, such as Roux-en-Y gastric bypass (RYGBP), are more efficient than gastric restriction procedures such as gastric banding (GB)... - Trace element supplementation after major burns increases burned skin trace element concentrations and modulates local protein metabolism but not whole-body substrate metabolismMette M Berger
Department of Adult Intensive Care Medicine and Burns Centre, Lausanne, Switzerland
Am J Clin Nutr 85:1301-6. 2007..After major burns, patients exhibit an intense catabolism, and the wounds require surgery and grafting for closure. Complications, such as weight loss and delayed wound healing, are worsened by trace element (TE) deficiencies... - Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy menDavid Faeh
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Diabetes 54:1907-13. 2005..In conclusion, high-fructose diet induced dyslipidemia and hepatic and adipose tissue insulin resistance. Fish oil reversed dyslipidemia but not insulin resistance... - Intravenous fish oil blunts the physiological response to endotoxin in healthy subjectsThomas Thi Pluess
Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
Intensive Care Med 33:789-97. 2007..To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers... - Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patientsMallory Moret
Service of Endocrinology, Diabetology and Metabolism, University Hospital, University of Lausanne, Lausanne, Switzerland
Neuroendocrinology 89:131-9. 2009..This study was undertaken to further evaluate the role of insulin to modulate LH secretion in lean PCOS patients with normal insulin sensitivity and normal volunteers... 
Divergent fifteen-year trends in traditional and cardiometabolic risk factors of cardiovascular diseases in the SeychellesPascal Bovet
University Institute for Social and Preventive Medicine and University Hospital Center, Lausanne, Switzerland
Cardiovasc Diabetol 8:34. 2009....- Assessment of adipose tissue metabolism by means of subcutaneous microdialysis in patients with sepsis or circulatory failureAlexandre Martinez
Surgical Intensive Care Unit, University Hospital, Lausanne, Switzerland
Clin Physiol Funct Imaging 23:286-92. 2003..This speaks against a role of adipose tissue in the development of hyperlactataemia in critically ill patients... 
Prevalence, awareness and control of diabetes in the Seychelles and relationship with excess body weightDavid Faeh
University Institute for Social and Preventive Medicine IUMSP, Lausanne, Switzerland
BMC Public Health 7:163. 2007..We assessed the prevalence, awareness and control of diabetes (DM) in the Seychelles, a rapidly developing country in the African region. We also examined the relationship between body mass index, fasting serum insulin and DM...- Effect of a thermogenic beverage on 24-hour energy metabolism in humansServane Rudelle
Department of Physiology, Lausanne University, Lausanne, Switzerland
Obesity (Silver Spring) 15:349-55. 2007..On the 3rd day, 23-hour energy metabolism, extrapolated to 24-hour, was measured in a calorimeter chamber. Blood pressure and heart rate were measured, and total day and night urines were analyzed for urea and catecholamine excretion... - Lactate and glucose metabolism in severe sepsis and cardiogenic shockJean-Pierre Revelly
Surgical Intensive Care Unit, University Hospital, Lausanne, Switzerland
Crit Care Med 33:2235-40. 2005..Increased lactate production was concomitant to hyperglycemia and increased glucose turnover, suggesting that the latter substantially influences lactate metabolism during critical illness... - Training in hypoxia fails to further enhance endurance performance and lactate clearance in well-trained men and impairs glucose metabolism during prolonged exerciseVirgile Lecoultre
Department of Physiology, University of Lausanne, Bugnon 7, CH 1005 Lausanne, Switzerland
Exp Physiol 95:315-30. 2010..Additionally, these findings suggest that training in hypoxia impairs blood glucose regulation in endurance-trained subjects during exercise... - Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in miceKaori Minehira
Gladstone Institute of Cardiovascular Disease, University of California San Francisco, CA 94158, USA
J Lipid Res 49:2038-44. 2008..Thus, blocking VLDL secretion causes hepatic steatosis without insulin resistance, and there is little effect on muscle triglyceride stores or adiposity... - Measurement of the whole body clearance of infused glycerol as a test of liver function after major hepatectomyLuc Tappy
Institute of Physiology, School of Medicine, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
Clin Physiol Funct Imaging 22:266-70. 2002..It is significantly reduced in patients after major hepatectomy, suggesting that it constitutes a sensitive test of hepatic function. Its use as a preoperative testing procedure remains to be evaluated... - Metabolic effects of fructose and the worldwide increase in obesityLuc Tappy
Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, CH 1005 Lausanne, Switzerland
Physiol Rev 90:23-46. 2010..There is, however, no direct evidence for more serious metabolic consequences of high fructose corn syrup versus sucrose consumption... - Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteersNathalie Nicod
Institute of Physiology, University of Lausanne, Lausanne, Switzerland
Obes Res 11:625-31. 2003..The compensatory insulin secretion in response to insulin resistance can be assessed by means of a hyperglycemic clamp after a dexamethasone challenge... - Metabolic effects of parenteral nutrition enriched with n-3 polyunsaturated fatty acids in critically ill patientsLuc Tappy
Department of Physiology, University of Lausanne, Switzerland
Clin Nutr 25:588-95. 2006..We therefore assessed the effect of n-3 fatty acids delivered with parenteral nutrition on glucose metabolism in surgical intensive care patients... - The lack of effect of insulin on luteinizing hormone pulsatility in healthy male volunteers provides evidence of a sexual dimorphism in the metabolic regulation of reproductive hormonesMarie Hélène Pesant
Service of Endocrinology, Diabetology and Metabolism, Department of Medicine, Lausanne University Hospital, Switzerland
Am J Clin Nutr 96:283-8. 2012..This link is particularly important in healthy women, in whom insulin is a positive signal for the reproductive system. In contrast, very little is known regarding this relation in men... - Effect of carbohydrate overfeeding on whole body and adipose tissue metabolism in humansKaori Minehira
Institute of Physiology, University of Lausanne, Lausanne, Switzerland
Obes Res 11:1096-103. 2003..The pentose-phosphate pathway is active in adipose tissue of healthy humans, consistent with an active role of this tissue in de novo lipogenesis... - Assessment of hepatic glucose metabolism by indirect calorimetry in combination with a non-invasive technique using naturally enriched 13C glucose in healthy children and adolescentsRoxane Selz
Endocrinology and Diabetology Unit, Department of Pediatrics, University Hospital Center, Lausanne, Switzerland
Horm Res 62:142-8. 2004..This non-invasive method appears to be a promising tool to study the fate of hepatic glucose and therefore glycogen turnover in children at risk of developing glucose intolerance and/or type 2 diabetes... - Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesityDimitri Favre
Service of Internal Medicine, Centre Hospitalier Universitaire Vaudoisand University of Lausanne, Lausanne, Switzerland
Diabetes 60:3169-74. 2011..In this study, we investigated whether impaired expression of the inducible cAMP early repressor (ICER), a transcriptional antagonist of CREB, is responsible for the increased CREB activity in adipocytes of obese mice and humans... - Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humansFanny Theytaz
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Am J Clin Nutr 96:1008-16. 2012..A high dietary protein intake has been shown to blunt the deposition of intrahepatic lipids in high-fat- and high-carbohydrate-fed rodents and humans... - Does fructose consumption contribute to non-alcoholic fatty liver disease?Luc Tappy
Department of Physiology, University of Lausanne, Lausanne, Switzerland Service of Endocrinology, Diabetes and Metabolism, Centre Hospitalier Universitaire Vaudois, Lausanne University School of Medicine, Lausanne, Switzerland Electronic address
Clin Res Hepatol Gastroenterol 36:554-60. 2012..Whether consumption of lower amounts of fructose over prolonged periods may contribute to the pathogenesis of NAFLD has not been convincingly documented in epidemiological studies and remains to be further assessed... - Relationship between stress, inflammation and metabolismGerald Seematter
Service of Anesthesiology, Lausanne University Hospital, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 7:169-73. 2004..Given the possible role of low-grade inflammation in chronic metabolic disorders, this suggests that stress may be a factor in the development of insulin resistance and the metabolic syndrome... - Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?Kevin J Acheson
Nestle Research Center, Lausanne, Switzerland
Am J Clin Nutr 79:40-6. 2004..Caffeine ingestion stimulates both lipolysis and energy expenditure... - Nutritional support of obese critically ill patientsRené L Chioléro
Surgical Intensive Care Unit, Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
Nestle Nutr Workshop Ser Clin Perform Programme 8:187-200; discussion 200-5. 2003 - Labeled acetate to assess intestinal absorption in critically ill patientsRené L Chioléro
Surgical Intensive Care Unit Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
Crit Care Med 31:853-7. 2003..To compare the absorption of carbon-13(13C) acetate-enriched nutrients with D-xylose absorption... - Microdialysis in the intensive care unit: a novel tool for clinical investigation or monitoring?Christophe Binnert
Institute of Physiology, University of Lausanne, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 5:185-8. 2002..Recent technical developments are reviewed. At present, this method is rarely used in metabolic monitoring of critically ill patients, but its potential applications are highlighted... - Serum paracetamol concentration: an alternative to X-rays to determine feeding tube location in the critically illMette M Berger
Soins Intensifs Chirurgicaux, Lausanne, Switzerland
JPEN J Parenter Enteral Nutr 27:151-5. 2003..Previous studies suggest that paracetamol absorption is very fast after jejunal administration. The aim was to determine whether paracetamol serum concentration measured by immunoassay can determine the tip position of the feeding tube... - Effects of fatty acids on exercise plus insulin-induced glucose utilization in trained and sedentary subjectsOscar Matzinger
Institute of Physiology, School of Medicine, University of Lausanne, Switzerland
Am J Physiol Endocrinol Metab 282:E125-31. 2002..These results suggest that endurance training enhances the inhibitory effect of lipids on whole body glucose metabolism during exercise... - Changes in insulin secretion and glucose metabolism induced by dexamethasone in lean and obese femalesChristine Besse
Department of Physiology, University of Lausanne, Switzerland
Obes Res 13:306-11. 2005..This indicates that obese women are unable to increase their insulin secretion appropriately... - Hepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patientsNicolas Paquot
Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart-Tilman, , Belgium
Obes Res 10:129-34. 2002..DISCUSSION: Our data indicate that both obese non-diabetic and obese type 2 diabetic patients have a blunted suppressive action of insulin on glucose production, indicating hepatic and renal insulin resistance... - Glucose-induced insulin secretion in dyslipidemic and normolipidemic patients with normal glucose toleranceChristophe Binnert
Department of Physiology, Medical School, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
Diabetes Care 28:1225-7. 2005 - How are we going to understand (dys)regulation of glucose metabolism?Luc Tappy
Curr Opin Clin Nutr Metab Care 7:467-9. 2004 - Metabolism of oral glucose in children born small for gestational age: evidence for an impaired whole body glucose oxidationFrancois R Jornayvaz
Endocrinology and Diabetology Unit, Department of Pediatrics, Lausanne University Hospital, Switzerland
Metabolism 53:847-51. 2004..These results indicate that metabolic alterations are present early in children born small for gestational age, and are possibly related to alterations of body composition... - Fish oil supplementation does not alter energy efficiency in healthy malesMurielle Bortolotti
Department of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
Clin Nutr 26:225-30. 2007..The aim of this study was to evaluate whether such effects can be observed in humans. The metabolic effects of FO were assessed during exercise in order to obtain a direct measurement of energy efficiency... - Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteersBurkhard Michaeli
Department of Intensive Care Medicine, CHUV, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
Clin Nutr 26:70-7. 2007..Endotoxin (LPS) has been shown to mimic several aspects of sepsis. The study aimed at testing the effects of oral FO supplements in healthy subjects submitted to intravenous LPS on systemic and endocrine response... - Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failureMarc-Daniel Bollmann
Surgical Intensive Care Unit, University Hospital CHUV, 1011 Lausanne, Switzerland
Intensive Care Med 30:1103-10. 2004..Lactate did not exert undesirable effects, except moderate hyperglycemia, and achieved comparable effects on acid-base balance to bicarbonate... - Mitochondrial dysfunction and insulin resistance: a matter of lifestyle?Kim Anne Le
Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne Switzerland
Curr Opin Clin Nutr Metab Care 10:494-7. 2007 - Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors?Luc Tappy
Curr Opin Clin Nutr Metab Care 9:455-7. 2006 - Metabolic effects of mental stress during over- and underfeeding in healthy womenGerald Seematter
Institute of Physiology, University of Lausanne, Switzerland
Obes Res 10:49-55. 2002..To assess the short-term consequences of carbohydrate or fat overfeeding or of food restriction on the metabolic effects of mental stress in healthy lean women... - A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjectsAndrew Abdel-Sayed
Department of Physiology, School of Biology and Medicine, University of Lausanne, 7 rue du Bugnon, Lausanne CH 1005, Switzerland
Br J Nutr 100:393-9. 2008..These results indicate that a 7 d HFrD markedly inhibits lipolysis and lipid oxidation. The HFrD also increases lactate production, and the ensuing increased lactate utilisation may contribute to suppress lipid oxidation... - Short-term administration of isotretinoin elevates plasma triglyceride concentrations without affecting insulin sensitivity in healthy humansDelphine Stoll
Institute of Physiology, University of Lausanne School of Medicine, Switzerland
Metabolism 53:4-10. 2004..The data support the concept that hypertriglyceridemia-associated insulin resistance develops primarily when triglyceride production is increased... - Effects of hyperglycemia on glucose metabolism before and after oral glucose ingestion in normal menVincent Rigalleau
Service de nutrition diabétologie, Hopital Haut Leveque, Ave de Magellan, 33600 Pessac, France
Am J Physiol Endocrinol Metab 290:E1198-204. 2006..005) tests. A moderate hyperglycemia inhibits endogenous glucose production and contributes to glucose tolerance by enhancing nonoxidative glucose disposal. Hyperglycemia and oral glucose ingestion both stimulate glucose cycling... - Low resting energy expenditure in constitutionally lean children: may a high energy efficiency be a factor maintenance of a low body weight?Luc Tappy
Clin Nutr 22:341-2. 2003 - Interaction between dietary lipids and physical inactivity on insulin sensitivity and on intramyocellular lipids in healthy menRodrigue Stettler
, 7 rue du Bugnon, 1005 Lausanne, Switzerland
Diabetes Care 28:1404-9. 2005..IMCL content was influenced by dietary lipid and physical inactivity but was not directly associated with insulin resistance... - Effect of somatostatin on duodenal glucose absorption in manFrancoise Féry
Laboratory of Experimental Medicine and Department of Endocrinology, Hopital Erasme, University of Brussels, Brussels, Belgium
J Clin Endocrinol Metab 90:4163-9. 2005..Because it requires the use of somatostatin (SST), we examined, in this study, the effect of SST on intestinal glucose absorption... - Type 2 diabetes and insulin resistance: an hepatocentric phenomenon?DAVID A D'ALESSIO
Curr Opin Clin Nutr Metab Care 8:428-30. 2005 - The prediction of insulin resistance with serum triglyceride and high-density lipoprotein cholesterol levels in an East African populationPascal Bovet
Arch Intern Med 166:1236-7. 2006