L Tappy

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi request reprint Metabolic effects of parenteral nutrition enriched with n-3 polyunsaturated fatty acids in critically ill patients
    Luc Tappy
    Department of Physiology, University of Lausanne, Switzerland
    Clin Nutr 25:588-95. 2006
  2. doi request reprint Effects of a short-term overfeeding with fructose or glucose in healthy young males
    Emilienne Tudor Ngo Sock
    Faculty of Biology and Medicine, Department of Physiology, University of Lausanne, Rue du Bugnon 7, CH 1005 Lausanne, Switzerland
    Br J Nutr 103:939-43. 2010
  3. ncbi request reprint Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men
    David Faeh
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Diabetes 54:1907-13. 2005
  4. pmc Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets
    Bertrand Cariou
    INSERM, UMR 1087, F 44000, Nantes, France
    Nutr Metab (Lond) 10:4. 2013
  5. doi request reprint Does fructose consumption contribute to non-alcoholic fatty liver disease?
    Luc Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Clin Res Hepatol Gastroenterol 36:554-60. 2012
  6. pmc Fructose toxicity: is the science ready for public health actions?
    Luc Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 15:357-61. 2012
  7. pmc Divergent fifteen-year trends in traditional and cardiometabolic risk factors of cardiovascular diseases in the Seychelles
    Pascal Bovet
    University Institute for Social and Preventive Medicine and University Hospital Center, Lausanne, Switzerland
    Cardiovasc Diabetol 8:34. 2009
  8. pmc Prevalence, awareness and control of diabetes in the Seychelles and relationship with excess body weight
    David Faeh
    University Institute for Social and Preventive Medicine IUMSP, Lausanne, Switzerland
    BMC Public Health 7:163. 2007
  9. ncbi request reprint Substrate utilization in sepsis and multiple organ failure
    Luc Tappy
    Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne, Switzerland
    Crit Care Med 35:S531-4. 2007
  10. doi request reprint Metabolic effects of fructose and the worldwide increase in obesity
    Luc Tappy
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, CH 1005 Lausanne, Switzerland
    Physiol Rev 90:23-46. 2010

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Metabolic effects of parenteral nutrition enriched with n-3 polyunsaturated fatty acids in critically ill patients
    Luc Tappy
    Department of Physiology, University of Lausanne, Switzerland
    Clin Nutr 25:588-95. 2006
    ..We therefore assessed the effect of n-3 fatty acids delivered with parenteral nutrition on glucose metabolism in surgical intensive care patients...
  2. doi request reprint Effects of a short-term overfeeding with fructose or glucose in healthy young males
    Emilienne Tudor Ngo Sock
    Faculty of Biology and Medicine, Department of Physiology, University of Lausanne, Rue du Bugnon 7, CH 1005 Lausanne, Switzerland
    Br J Nutr 103:939-43. 2010
    ..05). IHCL and VLDL-TAG were not different between hypercaloric HFrD and HGlcD, but were increased compared to values observed with a weight maintenance diet. However, glucose led to a higher increase in IMCL than fructose...
  3. ncbi request reprint Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men
    David Faeh
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Diabetes 54:1907-13. 2005
    ..In conclusion, high-fructose diet induced dyslipidemia and hepatic and adipose tissue insulin resistance. Fish oil reversed dyslipidemia but not insulin resistance...
  4. pmc Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets
    Bertrand Cariou
    INSERM, UMR 1087, F 44000, Nantes, France
    Nutr Metab (Lond) 10:4. 2013
    ..abstract:..
  5. doi request reprint Does fructose consumption contribute to non-alcoholic fatty liver disease?
    Luc Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Clin Res Hepatol Gastroenterol 36:554-60. 2012
    ..Whether consumption of lower amounts of fructose over prolonged periods may contribute to the pathogenesis of NAFLD has not been convincingly documented in epidemiological studies and remains to be further assessed...
  6. pmc Fructose toxicity: is the science ready for public health actions?
    Luc Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 15:357-61. 2012
    ..This review evaluates the scientific basis for such action...
  7. pmc Divergent fifteen-year trends in traditional and cardiometabolic risk factors of cardiovascular diseases in the Seychelles
    Pascal Bovet
    University Institute for Social and Preventive Medicine and University Hospital Center, Lausanne, Switzerland
    Cardiovasc Diabetol 8:34. 2009
    ....
  8. pmc Prevalence, awareness and control of diabetes in the Seychelles and relationship with excess body weight
    David Faeh
    University Institute for Social and Preventive Medicine IUMSP, Lausanne, Switzerland
    BMC Public Health 7:163. 2007
    ..We assessed the prevalence, awareness and control of diabetes (DM) in the Seychelles, a rapidly developing country in the African region. We also examined the relationship between body mass index, fasting serum insulin and DM...
  9. ncbi request reprint Substrate utilization in sepsis and multiple organ failure
    Luc Tappy
    Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne, Switzerland
    Crit Care Med 35:S531-4. 2007
    ..Their use in patients with sepsis does not lead to adverse metabolic effects...
  10. doi request reprint Metabolic effects of fructose and the worldwide increase in obesity
    Luc Tappy
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, CH 1005 Lausanne, Switzerland
    Physiol Rev 90:23-46. 2010
    ..There is, however, no direct evidence for more serious metabolic consequences of high fructose corn syrup versus sucrose consumption...
  11. ncbi request reprint Adiposity in children born small for gestational age
    L Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
    Int J Obes (Lond) 30:S36-40. 2006
    ..It is also possible that events occurring during foetal/neonatal development lead to long-lasting alterations of the hypothalamo-pituitary-adrenal axis or the hypothalamo-pituitary-insulin-like growth factor-1 axis...
  12. doi request reprint Fructose and metabolic diseases: new findings, new questions
    Luc Tappy
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Nutrition 26:1044-9. 2010
    ..This has led to the recommendation to limit the daily intake of sugar calories...
  13. ncbi request reprint Hepatic de novo lipogenesis after liver transplantation
    K Minehira
    Institute of Physiology, Lausanne University School of Medicine, Switzerland
    JPEN J Parenter Enteral Nutr 25:229-35; discussion 235-6. 2001
    ..The disposal of orally administered carbohydrate is also essentially unchanged. This strongly argues against a role of hepatic DNL in the pathogenesis of obesity and dyslipidemia after liver transplantation...
  14. ncbi request reprint Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans
    K Minehira
    Department of Physiology, University of Lausanne, 1005 Lausanne, Switzerland
    Int J Obes Relat Metab Disord 28:1291-8. 2004
    ..The present study was undertaken to assess the effect of carbohydrate overfeeding on glucose-induced whole body DNL and adipose tissue lipogenic gene expression in lean and overweight humans...
  15. doi request reprint Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans
    V Lecoultre
    Department of Physiology, Faculty of Biology and Medicine, Lausanne University, Lausanne Switzerland
    Obesity (Silver Spring) 21:782-5. 2013
    ..To assess how intrahepatic fat and insulin resistance relate to daily fructose and energy intake during short-term overfeeding in healthy subjects...
  16. ncbi request reprint Mechanisms of action of beta-glucan in postprandial glucose metabolism in healthy men
    P Battilana
    Institute of Physiology, School of Medicine, University of Lausanne, Switzerland
    Eur J Clin Nutr 55:327-33. 2001
    ....
  17. ncbi request reprint Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men
    H Sobrecases
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 7, Rue du Bugnon, 1005 Lausanne, Switzerland
    Diabetes Metab 36:244-6. 2010
    ..The present study aimed to assess the effects of excess fat, fructose and fat-plus-fructose intakes on intrahepatocellular lipid (IHCL)...
  18. ncbi request reprint In normal men, free fatty acids reduce peripheral but not splanchnic glucose uptake
    V Rigalleau
    Institut de Physiologie, Lausanne, Switzerland
    Diabetes 50:727-32. 2001
    ..Total glucose output is increased by FFAs, by a mechanism that does not seem to involve stimulation of glucose-6-phosphatase...
  19. ncbi request reprint Fish oil after abdominal aorta aneurysm surgery
    M M Berger
    Department of Intensive Care Medicine, CHUV, Lausanne, Switzerland
    Eur J Clin Nutr 62:1116-22. 2008
    ..We aimed at evaluating the clinical impact and safety aspects of a FO containing parenteral nutrition (PN) after AAA surgery...
  20. ncbi request reprint Interaction of lipid and carbohydrate metabolism after infusions of lipids or of lipid lowering agents: lack of a direct relationship between free fatty acid concentrations and glucose disposal
    H Kleiber
    Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Diabete Metab 18:84-90. 1992
    ..kg-1.min-1) and in glucose storage (4.29 +/- 0.31 mg.kg-1.min-1) (p less than 0.5 vs Intralipid). These changes occurred even though FFA plasma concentrations were similar in the 3 experimental conditions.(ABSTRACT TRUNCATED AT 250 WORDS)..
  21. ncbi request reprint Effects of a glucose meal on energy metabolism in patients with cirrhosis before and after liver transplantation
    L Tappy
    Institut de Physiologie, 7 rue du Bugnon, CH 1005 Lausanne, Switzerland
    Arch Surg 136:80-4. 2001
    ..Liver transplantation results in hepatic denervation. This may produce alterations of liver energy and substrate metabolism, which may contribute to weight gain after liver transplantation...
  22. ncbi request reprint Intestinal absorption in patients after cardiac surgery
    M M Berger
    Anesthesiology and Surgical Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
    Crit Care Med 28:2217-23. 2000
    ..We designed this study to assess intestinal absorption in patients with adequate or altered hemodynamic status after cardiac surgery and to test clinical tolerance to early enteral nutrition...
  23. ncbi request reprint Dietary and lifestyle interventions in the management of the metabolic syndrome: present status and future perspective
    K Minehira
    Institut de Physiologie, Universite de Lausanne, Lausanne, Switzerland
    Eur J Clin Nutr 56:7 p following 1262. 2002
    ..To review the mechanisms underlying the metabolic syndrome, or syndrome X, in humans, and to delineate dietary and environmental strategies for its prevention...
  24. ncbi request reprint Measurement of substrate oxidation in man
    L Tappy
    Institut de Physiologie, Lausanne, Switzerland
    Diabetes Metab 23:435-42. 1997
    ..However, there are major pitfalls relating to the recovery of labelled CO2 in breath during oxidation of the substrate as well as during non-steady state conditions...
  25. ncbi request reprint New data and new concepts on the role of the liver in glucose homeostasis
    L Tappy
    Institute of Physiology, University of Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 4:273-7. 2001
    ..How this may be involved in the control of glycaemia and lipid concentrations will be reviewed. Finally, molecular mechanisms by which the alteration of liver metabolism may affect systemic glucose homeostasis will be outlined...
  26. ncbi request reprint Metabolic effects of fructose
    Kim Anne Le
    Department of Physiology, Faculty of Medicine, University of Lausanne, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 9:469-75. 2006
    ..Fructose/sucrose produces deleterious metabolic effects in animal models. This raises concern regarding the short-term and long-term effects of fructose and its risk in humans...
  27. ncbi request reprint A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans
    Kim Anne Le
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 84:1374-9. 2006
    ..In rodents, fructose leads to insulin resistance and ectopic lipid deposition. In humans, the effects of fructose on insulin sensitivity remain debated, whereas its effect on ectopic lipids has never been investigated...
  28. ncbi request reprint Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients
    E Henchoz
    Institute of Physiology, Faculty of Medicine, University of Lausanne, Lausanne, Switzerland
    Transplantation 76:923-9. 2003
    ..The prevalence of diabetes is high after transplantation. We hypothesized that liver transplantation induces additional alterations of glucose homeostasis because of liver denervation...
  29. ncbi request reprint Role of Na+-K+-ATPase in insulin-induced lactate release by skeletal muscle
    V Novel-Chate
    Institute of Physiology, Medical School, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Am J Physiol Endocrinol Metab 280:E296-300. 2001
    ..These data indicate that insulin stimulates muscle lactate release by activating Na+-K+-ATPase in healthy humans...
  30. ncbi request reprint Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men
    K A Lê
    Department of Physiology, University of Lausanne, 7, Rue du Bugnon, 1005 Lausanne, Switzerland
    Diabetes Metab 34:82-5. 2008
    ..The aim of this study was to investigate whether fructose may induce early molecular changes in skeletal muscle prior to the development of whole-body insulin resistance...
  31. doi request reprint Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes
    Kim Anne Le
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 89:1760-5. 2009
    ..Both nutritional and genetic factors are involved in the pathogenesis of nonalcoholic fatty liver disease and insulin resistance...
  32. ncbi request reprint Autoregulation of glucose production in health and disease
    L Tappy
    Institute of Physiology, University of Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 2:161-4. 1999
    ..Hyperglycemia in type 2 diabetic patients and in critically ill patients may result from a blunted effect of hyperglycemia on glucose production...
  33. ncbi request reprint Fractional hepatic de novo lipogenesis in healthy subjects during near-continuous oral nutrition and bed rest: a comparison with published data in artificially fed, critically ill patients
    K Minehira
    Institute of Physiology, University of Lausanne, School of Medicine, Switzerland
    Clin Nutr 21:345-50. 2002
    ..3%) (range 5.3-15.8%) was markedly higher than in healthy subjects (P<0.001). These data from healthy subjects indicate that fractional hepatic de novo lipogenesis is increased in critically ill patients...
  34. ncbi request reprint Assessment of adipose tissue metabolism by means of subcutaneous microdialysis in patients with sepsis or circulatory failure
    Alexandre Martinez
    Surgical Intensive Care Unit, University Hospital, Lausanne, Switzerland
    Clin Physiol Funct Imaging 23:286-92. 2003
    ..This speaks against a role of adipose tissue in the development of hyperlactataemia in critically ill patients...
  35. ncbi request reprint Effects of fatty acids on exercise plus insulin-induced glucose utilization in trained and sedentary subjects
    Oscar Matzinger
    Institute of Physiology, School of Medicine, University of Lausanne, Switzerland
    Am J Physiol Endocrinol Metab 282:E125-31. 2002
    ..These results suggest that endurance training enhances the inhibitory effect of lipids on whole body glucose metabolism during exercise...
  36. ncbi request reprint Major reduction in plasma Lp(a) levels during sepsis and burns
    V Mooser
    Department of Medicine, CHUV University Hospital, Lausanne, Switzerland
    Arterioscler Thromb Vasc Biol 20:1137-42. 2000
    ..Nongenetic factors have a major, acute, and unexpected impact on Lp(a) metabolism in burns and sepsis. Identification of these factors may provide new tools to lower elevated plasma Lp(a) levels...
  37. ncbi request reprint Effect of metformin on insulin sensitivity and insulin secretion in female obese patients with normal glucose tolerance
    C Binnert
    Institute of Physiology, School of Medicine, University of Lausanne, Lausanne, Switzerland
    Diabetes Metab 29:125-32. 2003
    ..Metformin is recognized as the treatment of chronic obese, insulin-resistant type 2 diabetic patients. Whether it improves insulin sensitivity in obese patients with normal glucose tolerance remains unknown...
  38. ncbi request reprint Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene
    L Tappy
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Diabetes 46:204-8. 1997
    ..Thus endogenous glucose production is inadequately inhibited by hyperglycemia in MODY patients, possibly as a result of impaired hepatic glucokinase activity. These alterations contribute to the pathogenesis of hyperglycemia...
  39. ncbi request reprint [Glucagon and glucose metabolism]
    L Tappy
    Departement de Physiologie, Universite de Lausanne
    Ann Endocrinol (Paris) 65:77-9. 2004
  40. ncbi request reprint Metabolic consequences of overfeeding in humans
    Luc Tappy
    Department of Physiology and Division of Endocrinology, Diabetes and Metabolism, Lausanne University Faculty of Biology and Medicine, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 7:623-8. 2004
    ..The present review is mainly focused on the recent developments regarding the effects of overfeeding on energy expenditure...
  41. ncbi request reprint Measurement of the whole body clearance of infused glycerol as a test of liver function after major hepatectomy
    Luc Tappy
    Institute of Physiology, School of Medicine, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Clin Physiol Funct Imaging 22:266-70. 2002
    ..It is significantly reduced in patients after major hepatectomy, suggesting that it constitutes a sensitive test of hepatic function. Its use as a preoperative testing procedure remains to be evaluated...
  42. doi request reprint Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects
    Caroline Couchepin
    Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne, Switzerland
    Diabetes Care 31:1254-6. 2008
    ..To compare the metabolic effects of fructose in healthy male and female subjects...
  43. doi request reprint Training in hypoxia fails to further enhance endurance performance and lactate clearance in well-trained men and impairs glucose metabolism during prolonged exercise
    Virgile Lecoultre
    Department of Physiology, University of Lausanne, Bugnon 7, CH 1005 Lausanne, Switzerland
    Exp Physiol 95:315-30. 2010
    ..Additionally, these findings suggest that training in hypoxia impairs blood glucose regulation in endurance-trained subjects during exercise...
  44. ncbi request reprint Effect of carbohydrate overfeeding on whole body and adipose tissue metabolism in humans
    Kaori Minehira
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    Obes Res 11:1096-103. 2003
    ..To evaluate the effect of a 4-day carbohydrate overfeeding on whole body net de novo lipogenesis and on markers of de novo lipogenesis in subcutaneous adipose tissue of healthy lean humans...
  45. doi request reprint Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose
    Virgile Lecoultre
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 92:1071-9. 2010
    ..When fructose is ingested together with glucose (GLUFRU) during exercise, plasma lactate and exogenous carbohydrate oxidation rates are higher than with glucose alone...
  46. ncbi request reprint Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers
    Nathalie Nicod
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    Obes Res 11:625-31. 2003
    ..The objective of this study was to evaluate a procedure aimed at assessing the compensatory mechanisms to insulin resistance...
  47. pmc Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
    Kaori Minehira
    Gladstone Institute of Cardiovascular Disease, University of California San Francisco, CA 94158, USA
    J Lipid Res 49:2038-44. 2008
    ..Thus, blocking VLDL secretion causes hepatic steatosis without insulin resistance, and there is little effect on muscle triglyceride stores or adiposity...
  48. doi request reprint Hypertriglyceridemia: a potential side effect of propofol sedation in critical illness
    J C Devaud
    Service of Pharmacy, Lausanne University Hospital, Lausanne, Switzerland
    Intensive Care Med 38:1990-8. 2012
    ..The present study aims to identify risk factors favoring its development in patients requiring prolonged ICU treatment...
  49. ncbi request reprint Environmental influences on diseases in later life
    L Tappy
    Institute of Physiology, Faculty of Medicine, University of Lausanne, Lausanne, Switzerland
    Nestle Nutr Workshop Ser Clin Perform Programme 9:19-30; discussion 30-5. 2004
  50. ncbi request reprint Timing of nutritional support
    R L Chiolero
    Surgical Intensive Care Unit, Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
    Nestle Nutr Workshop Ser Clin Perform Programme 7:151-64; discussion 164-8. 2002
  51. ncbi request reprint Similarity of cutaneous reactive hyperemia in the forearm of women with and without hyperinsulinemia
    A J Seywert
    Institute of Physiology, University of Lausanne, 1005 Lausanne, Switzerland
    Int J Obes Relat Metab Disord 28:611-5. 2004
    ..The present study was undertaken to assess in pre- and postmenopausal women whether obesity influences cutaneous reactive hyperemia in the forearm...
  52. ncbi request reprint Energy expenditure, physical activity and body-weight control
    L Tappy
    Institute of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Proc Nutr Soc 62:663-6. 2003
    ..If this were the case, physical activity would represent a major adaptative mechanism for body-weight control...
  53. ncbi request reprint Glucose-induced insulin secretion in dyslipidemic and normolipidemic patients with normal glucose tolerance
    Christophe Binnert
    Department of Physiology, Medical School, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Diabetes Care 28:1225-7. 2005
  54. ncbi request reprint Effect of nutritional support on glucose control
    Gerald Seematter
    Service of Anaesthesiology, University Hospital of Canton de Vaud CHUV, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 10:210-4. 2007
    ..There is evidence that maintaining a normal glycemia level in critically ill patients has beneficial effects on outcome. Strategies aimed at lowering glycemia are based on the understanding of mechanisms regulating glucose metabolism...
  55. ncbi request reprint Dairy calcium supplementation in overweight or obese persons: its effect on markers of fat metabolism
    Murielle Bortolotti
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 88:877-85. 2008
    ..Dairy calcium supplementation has been proposed to increase fat oxidation and to inhibit lipogenesis...
  56. ncbi request reprint Changes in insulin secretion and glucose metabolism induced by dexamethasone in lean and obese females
    Christine Besse
    Department of Physiology, University of Lausanne, Switzerland
    Obes Res 13:306-11. 2005
    ..This study evaluated the changes in glucose metabolism and insulin secretion induced by short-term dexamethasone administration in obese women...
  57. doi request reprint A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects
    Andrew Abdel-Sayed
    Department of Physiology, School of Biology and Medicine, University of Lausanne, 7 rue du Bugnon, Lausanne CH 1005, Switzerland
    Br J Nutr 100:393-9. 2008
    ..These results indicate that a 7 d HFrD markedly inhibits lipolysis and lipid oxidation. The HFrD also increases lactate production, and the ensuing increased lactate utilisation may contribute to suppress lipid oxidation...
  58. ncbi request reprint Metabolism of oral glucose in children born small for gestational age: evidence for an impaired whole body glucose oxidation
    Francois R Jornayvaz
    Endocrinology and Diabetology Unit, Department of Pediatrics, Lausanne University Hospital, Switzerland
    Metabolism 53:847-51. 2004
    ..These results indicate that metabolic alterations are present early in children born small for gestational age, and are possibly related to alterations of body composition...
  59. ncbi request reprint Mitochondrial dysfunction and insulin resistance: a matter of lifestyle?
    Kim Anne Le
    Department of Physiology, Lausanne University School of Biology and Medicine, Lausanne Switzerland
    Curr Opin Clin Nutr Metab Care 10:494-7. 2007
  60. doi request reprint High protein intake reduces intrahepatocellular lipid deposition in humans
    Murielle Bortolotti
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Clin Nutr 90:1002-10. 2009
    ..High protein intake may facilitate weight loss and improve glucose homeostasis in insulin-resistant patients, but its effects on IHCLs remain unknown...
  61. ncbi request reprint Nutritional support of obese critically ill patients
    René L Chioléro
    Surgical Intensive Care Unit, Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
    Nestle Nutr Workshop Ser Clin Perform Programme 8:187-200; discussion 200-5. 2003
  62. ncbi request reprint Relationship between stress, inflammation and metabolism
    Gerald Seematter
    Service of Anesthesiology, Lausanne University Hospital, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 7:169-73. 2004
    ..Given the possible role of low-grade inflammation in chronic metabolic disorders, this suggests that stress may be a factor in the development of insulin resistance and the metabolic syndrome...
  63. ncbi request reprint Metabolic effects of mental stress during over- and underfeeding in healthy women
    Gerald Seematter
    Institute of Physiology, University of Lausanne, Switzerland
    Obes Res 10:49-55. 2002
    ..To assess the short-term consequences of carbohydrate or fat overfeeding or of food restriction on the metabolic effects of mental stress in healthy lean women...
  64. ncbi request reprint Lactate and glucose metabolism in severe sepsis and cardiogenic shock
    Jean Pierre Revelly
    Surgical Intensive Care Unit, University Hospital, Lausanne, Switzerland
    Crit Care Med 33:2235-40. 2005
    ..To evaluate the relative importance of increased lactate production as opposed to decreased utilization in hyperlactatemic patients, as well as their relation to glucose metabolism...
  65. ncbi request reprint Assessment of hepatic glucose metabolism by indirect calorimetry in combination with a non-invasive technique using naturally enriched 13C glucose in healthy children and adolescents
    Roxane Selz
    Endocrinology and Diabetology Unit, Department of Pediatrics, University Hospital Center, Lausanne, Switzerland
    Horm Res 62:142-8. 2004
    ..This non-invasive method appears to be a promising tool to study the fate of hepatic glucose and therefore glycogen turnover in children at risk of developing glucose intolerance and/or type 2 diabetes...
  66. ncbi request reprint Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects
    Thomas Thi Pluess
    Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
    Intensive Care Med 33:789-97. 2007
    ..To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers...
  67. ncbi request reprint Fish oil supplementation does not alter energy efficiency in healthy males
    Murielle Bortolotti
    Department of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Clin Nutr 26:225-30. 2007
    ..The aim of this study was to evaluate whether such effects can be observed in humans. The metabolic effects of FO were assessed during exercise in order to obtain a direct measurement of energy efficiency...
  68. ncbi request reprint Effects of dexamethasone on the metabolic responses to mental stress in humans
    G Seematter
    Institute of Physiology, University of Lausanne, Switzerland
    Clin Physiol Funct Imaging 22:139-44. 2002
    ..0%. This indicates that mental stress elicits a stimulation of SNS through dexamethasone-insensitive pathway, distinct of those activated by insulin, alcohol, or hyperglycaemia...
  69. doi request reprint Combined effects of endurance training and dietary unsaturated fatty acids on physical performance, fat oxidation and insulin sensitivity
    Andreas Boss
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Br J Nutr 103:1151-9. 2010
    ..This difference was, however, not significant. It is concluded that a diet enriched with fish- and olive oil does not substantially enhance the effects of a short-term endurance training protocol in healthy young subjects...
  70. ncbi request reprint Microdialysis in the intensive care unit: a novel tool for clinical investigation or monitoring?
    Christophe Binnert
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 5:185-8. 2002
    ..Recent technical developments are reviewed. At present, this method is rarely used in metabolic monitoring of critically ill patients, but its potential applications are highlighted...
  71. doi request reprint Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load
    Christel Tran
    Faculty of Biology and Medicine, Department of Physiology, University of Lausanne, Rue du Bugnon 7, Lausanne CH 1005, Switzerland
    Br J Nutr 104:1139-47. 2010
    ..3 (sd 4.7)%). These results support the hypothesis that females may be protected against fructose-induced hypertriglyceridaemia because of a lower stimulation of DNL and a lower suppression of lipid oxidation...
  72. doi request reprint Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release
    Frederique Rodieux
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Obesity (Silver Spring) 16:298-305. 2008
    ..Procedures that involve bypassing the proximal small bowel, such as Roux-en-Y gastric bypass (RYGBP), are more efficient than gastric restriction procedures such as gastric banding (GB)...
  73. ncbi request reprint Effect of a thermogenic beverage on 24-hour energy metabolism in humans
    Servane Rudelle
    Department of Physiology, Lausanne University, Lausanne, Switzerland
    Obesity (Silver Spring) 15:349-55. 2007
    ..On the 3rd day, 23-hour energy metabolism, extrapolated to 24-hour, was measured in a calorimeter chamber. Blood pressure and heart rate were measured, and total day and night urines were analyzed for urea and catecholamine excretion...
  74. ncbi request reprint Labeled acetate to assess intestinal absorption in critically ill patients
    René L Chioléro
    Surgical Intensive Care Unit Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
    Crit Care Med 31:853-7. 2003
    ..To compare the absorption of carbon-13(13C) acetate-enriched nutrients with D-xylose absorption...
  75. ncbi request reprint Serum paracetamol concentration: an alternative to X-rays to determine feeding tube location in the critically ill
    Mette M Berger
    Soins Intensifs Chirurgicaux, Lausanne, Switzerland
    JPEN J Parenter Enteral Nutr 27:151-5. 2003
    ..Previous studies suggest that paracetamol absorption is very fast after jejunal administration. The aim was to determine whether paracetamol serum concentration measured by immunoassay can determine the tip position of the feeding tube...
  76. ncbi request reprint Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?
    Kevin J Acheson
    Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 79:40-6. 2004
    ..Caffeine ingestion stimulates both lipolysis and energy expenditure...
  77. ncbi request reprint Short-term administration of isotretinoin elevates plasma triglyceride concentrations without affecting insulin sensitivity in healthy humans
    Delphine Stoll
    Institute of Physiology, University of Lausanne School of Medicine, Switzerland
    Metabolism 53:4-10. 2004
    ..The data support the concept that hypertriglyceridemia-associated insulin resistance develops primarily when triglyceride production is increased...
  78. ncbi request reprint Low resting energy expenditure in constitutionally lean children: may a high energy efficiency be a factor maintenance of a low body weight?
    Luc Tappy
    Clin Nutr 22:341-2. 2003
  79. ncbi request reprint Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers
    Burkhard Michaeli
    Department of Intensive Care Medicine, CHUV, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
    Clin Nutr 26:70-7. 2007
    ..Endotoxin (LPS) has been shown to mimic several aspects of sepsis. The study aimed at testing the effects of oral FO supplements in healthy subjects submitted to intravenous LPS on systemic and endocrine response...
  80. ncbi request reprint How are we going to understand (dys)regulation of glucose metabolism?
    Luc Tappy
    Curr Opin Clin Nutr Metab Care 7:467-9. 2004
  81. ncbi request reprint Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure
    Marc Daniel Bollmann
    Surgical Intensive Care Unit, University Hospital CHUV, 1011 Lausanne, Switzerland
    Intensive Care Med 30:1103-10. 2004
    ..To compare the effects of sodium bicarbonate and lactate for continuous veno-venous hemodiafiltration (CVVHDF) in critically ill patients...
  82. ncbi request reprint Effects of hyperglycemia on glucose metabolism before and after oral glucose ingestion in normal men
    Vincent Rigalleau
    Service de nutrition diabétologie, Hopital Haut Leveque, Ave de Magellan, 33600 Pessac, France
    Am J Physiol Endocrinol Metab 290:E1198-204. 2006
    ..005) tests. A moderate hyperglycemia inhibits endogenous glucose production and contributes to glucose tolerance by enhancing nonoxidative glucose disposal. Hyperglycemia and oral glucose ingestion both stimulate glucose cycling...
  83. ncbi request reprint Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors?
    Luc Tappy
    Curr Opin Clin Nutr Metab Care 9:455-7. 2006
  84. ncbi request reprint Hepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients
    Nicolas Paquot
    Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, Liege, Belgium
    Obes Res 10:129-34. 2002
    ..Obese non-diabetic patients are characterized by an extra-hepatic insulin resistance. Whether obese patients also have decreased hepatic insulin sensitivity remains controversial...
  85. ncbi request reprint Effect of somatostatin on duodenal glucose absorption in man
    Francoise Féry
    Laboratory of Experimental Medicine and Department of Endocrinology, Hopital Erasme, University of Brussels, Brussels, Belgium
    J Clin Endocrinol Metab 90:4163-9. 2005
    ..Because it requires the use of somatostatin (SST), we examined, in this study, the effect of SST on intestinal glucose absorption...
  86. ncbi request reprint The prediction of insulin resistance with serum triglyceride and high-density lipoprotein cholesterol levels in an East African population
    Pascal Bovet
    Arch Intern Med 166:1236-7. 2006
  87. ncbi request reprint Type 2 diabetes and insulin resistance: an hepatocentric phenomenon?
    DAVID A D'ALESSIO
    Curr Opin Clin Nutr Metab Care 8:428-30. 2005
  88. ncbi request reprint Interaction between dietary lipids and physical inactivity on insulin sensitivity and on intramyocellular lipids in healthy men
    Rodrigue Stettler
    Departement de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Diabetes Care 28:1404-9. 2005
    ..To assess the effect of a possible interaction between dietary fat and physical inactivity on whole-body insulin sensitivity and intramyocellular lipids (IMCLs)...