J Takala

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Highs and lows in high-risk surgery: the controversy of goal-directed haemodynamic management
    Jukka Takala
    Clinic of Intensive Care Medicine, University Hospital Bern Inselspital, Bern, Switzerland
    Crit Care 9:642-4. 2005
  2. doi request reprint Better conduct of clinical trials: the control group in critical care trials
    Jukka Takala
    Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland
    Crit Care Med 37:S80-90. 2009
  3. ncbi request reprint Pulmonary capillary pressure
    Jukka Takala
    Department of Intensive Care Medicine, University Hospital Inselspital, 3010, Berne, Switzerland
    Intensive Care Med 29:890-3. 2003
  4. pmc The pulmonary artery catheter: the tool versus treatments based on the tool
    Jukka Takala
    Clinic of Intensive Care Medicine, University Hospital Bern, CH 3010 Bern, Switzerland
    Crit Care 10:162. 2006
  5. ncbi request reprint Hypoxemia due to increased venous admixture: influence of cardiac output on oxygenation
    Jukka Takala
    Department of Intensive Care Medicine, University Hospital Bern Inselspital, University of Bern, 3010, Bern, Switzerland
    Intensive Care Med 33:908-11. 2007
  6. pmc Brain herniation in a patient with apparently normal intracranial pressure: a case report
    Mats B Dahlqvist
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    J Med Case Reports 4:297. 2010
  7. pmc Risk assessment in the first fifteen minutes: a prospective cohort study of a simple physiological scoring system in the emergency department
    Tobias M Merz
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Freiburgstrasse, 3010 Bern, Switzerland
    Crit Care 15:R25. 2011
  8. pmc Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study
    Christian Torgersen
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Crit Care 13:R157. 2009
  9. pmc Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study
    Moritz Wyler von Ballmoos
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Crit Care 14:R111. 2010
  10. pmc Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow
    Vladimir Krejci
    Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, St Louis, MO 63110, USA
    Crit Care 11:R129. 2007

Detail Information

Publications97

  1. pmc Highs and lows in high-risk surgery: the controversy of goal-directed haemodynamic management
    Jukka Takala
    Clinic of Intensive Care Medicine, University Hospital Bern Inselspital, Bern, Switzerland
    Crit Care 9:642-4. 2005
    ..An understanding of the organisational and case-mix aspects of pre-, peri-and post-operative management is vital for planning multicentre trials of goal-directed management...
  2. doi request reprint Better conduct of clinical trials: the control group in critical care trials
    Jukka Takala
    Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland
    Crit Care Med 37:S80-90. 2009
    ..To review trial design issues related to control groups...
  3. ncbi request reprint Pulmonary capillary pressure
    Jukka Takala
    Department of Intensive Care Medicine, University Hospital Inselspital, 3010, Berne, Switzerland
    Intensive Care Med 29:890-3. 2003
  4. pmc The pulmonary artery catheter: the tool versus treatments based on the tool
    Jukka Takala
    Clinic of Intensive Care Medicine, University Hospital Bern, CH 3010 Bern, Switzerland
    Crit Care 10:162. 2006
    ..The information obtained with the PAC should be used to find better treatment strategies, and these strategies, instead of the tool itself, should be tested in clinical trials...
  5. ncbi request reprint Hypoxemia due to increased venous admixture: influence of cardiac output on oxygenation
    Jukka Takala
    Department of Intensive Care Medicine, University Hospital Bern Inselspital, University of Bern, 3010, Bern, Switzerland
    Intensive Care Med 33:908-11. 2007
  6. pmc Brain herniation in a patient with apparently normal intracranial pressure: a case report
    Mats B Dahlqvist
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    J Med Case Reports 4:297. 2010
    ..This enables early and potentially life-saving treatment of intracranial hypertension...
  7. pmc Risk assessment in the first fifteen minutes: a prospective cohort study of a simple physiological scoring system in the emergency department
    Tobias M Merz
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Freiburgstrasse, 3010 Bern, Switzerland
    Crit Care 15:R25. 2011
    ..The aim of this study is to evaluate a scoring system based on readily available physiological parameters immediately after admission to an emergency department (ED) for the purpose of identification of at-risk patients...
  8. pmc Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study
    Christian Torgersen
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Crit Care 13:R157. 2009
    ..The aim of this study was to investigate the association between hemodynamic variables and cardiogenic shock mortality...
  9. pmc Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study
    Moritz Wyler von Ballmoos
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Crit Care 14:R111. 2010
    ..We aimed to assess prediction of volume responsiveness with PPV in patients with increased pulmonary artery pressure...
  10. pmc Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow
    Vladimir Krejci
    Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, St Louis, MO 63110, USA
    Crit Care 11:R129. 2007
    ..The aim of this study was to measure the effects of low-dose vasopressin on regional (hepato-splanchnic and renal) and microcirculatory (liver, pancreas, and kidney) blood flow in septic shock...
  11. pmc Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study
    Hendrik Bracht
    Department of Intensive Care Medicine, University Hospital Bern, University of Bern, Freiburgstrasse, CH 3010 Bern, Switzerland
    Crit Care 11:R2. 2007
    ..The early ScvO2 profile of other patient groups is unknown. The aim of this study was to characterize unplanned admissions in a multidisciplinary intensive care unit (ICU) with respect to ScvO2 and outcome...
  12. pmc Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function
    Francesca Porta
    Department of Intensive Care Medicine, University Hospital Bern, CH 3010 Bern, Switzerland
    Crit Care 10:R118. 2006
    ..We studied the effect of prolonged endotoxin infusion on liver, muscle and kidney mitochondrial respiration and on hepatosplanchnic oxygen transport and microcirculation in pigs...
  13. pmc Causes of death and determinants of outcome in critically ill patients
    Viktoria D Mayr
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Crit Care 10:R154. 2006
    ..Whereas most studies focus on laboratory and clinical research, little is known about the causes of death and risk factors for death in critically ill patients...
  14. pmc Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study
    Fritz Daudel
    Department of Intensive Care Medicine, University Hospital Inselspital and University of Bern, Freiburgstrasse, CH 3010 Bern, Switzerland
    Crit Care 14:R122. 2010
    ..This study tests the hypothesis that PPV does not predict fluid responsiveness during an endotoxin-induced acute increase in pulmonary artery pressure and right ventricular loading...
  15. pmc Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study
    Matthias Haenggi
    Department of Intensive Care Medicine, Bern University Hospital, Inselspital, and University of Bern, Freiburgstrasse, Bern, Switzerland
    Crit Care 13:R20. 2009
    ..We studied intra-individual and inter-individual variability of two online sedation monitors, BIS and Entropy, in volunteers under sedation...
  16. pmc Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study
    Fritz Daudel
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse, 3010 Bern, Switzerland
    Crit Care 13:R42. 2009
    ..Using thromboelastometry (ROTEM(R)), we assessed the course of hemostatic alterations in patients with sepsis and related these alterations to the severity of organ dysfunction...
  17. pmc Does fluid loading influence measurements of intestinal permeability?
    Ilkka Parviainen
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Crit Care 9:R234-7. 2005
    ..The aim of this study was to assess the effect of fluid loading on the urinary recovery of sugar probes in healthy volunteers...
  18. pmc Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial
    Martin W Dunser
    Department of Intensive Care Medicine, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland
    Crit Care 13:R181. 2009
    ..In this study we investigated the association between MAP values of 70 mmHg or higher, vasopressor load, 28-day mortality and disease-related events in septic shock...
  19. pmc Effect of fluid resuscitation on mortality and organ function in experimental sepsis models
    Sebastian Brandt
    Department of Anaesthesia and Pain Therapy, Inselspital, Bern University Hospital and University of Bern, CH 3010 Bern, Switzerland
    Crit Care 13:R186. 2009
    ..We tested the effects of moderate vs. high-volume resuscitation strategies on mortality, systemic and regional blood flows, mitochondrial respiration, and organ function in two experimental sepsis models...
  20. pmc Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration
    Tomas Regueira
    Experimental Surgical Unit, Department of Clinical Research, University of Bern, Bern, Switzerland
    Crit Care 12:R88. 2008
    ..This study evaluated the effect on liver mitochondrial function of using norepinephrine to increase blood pressure in experimental sepsis...
  21. pmc Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study
    Matthias Haenggi
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Freiburgstrasse, CH 3010 Bern, Switzerland
    Crit Care 12:R119. 2008
    ..We evaluated processed electroencephalography (response and state entropy and bispectral index) as an adjunct to monitoring effects of commonly used sedative and analgesic drugs and intratracheal suctioning...
  22. pmc Resource use and outcome in critically ill patients with hematological malignancy: a retrospective cohort study
    Tobias M Merz
    Department of Intensive Care Medicine, Royal North Shore Hospital of Sydney, University of Sydney, St Leonards, 2065 NSW, Australia
    Crit Care 12:R75. 2008
    ....
  23. pmc Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital Inselspital and University of Bern, Bern, Switzerland
    BMC Gastroenterol 10:70. 2010
    ..The aim of this prospective, interventional study was to assess the effect of PEEP on the accuracy of pressure estimation at different measurement sites in a model of increased abdominal pressure...
  24. doi request reprint Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study
    Jukka Takala
    Department of Intensive Care Medicine, Bern University Hospital, 3010, Bern, Switzerland
    Intensive Care Med 34:1401-10. 2008
    ..To test the feasibility of and interactions among three software-driven critical care protocols...
  25. doi request reprint Should we target blood pressure in sepsis?
    Jukka Takala
    Department of Intensive Care Medicine, Bern University Hospital Inselspital and University of Bern, Bern, Switzerland
    Crit Care Med 38:S613-9. 2010
    ..To review blood pressure targets and their implementation in sepsis...
  26. pmc Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial
    Jukka Takala
    Department of Intensive Care Medicine, Bern University Hospital Inselspital, and University of Bern, Freiburgstrasse, CH 3010 Bern, Switzerland
    Crit Care 15:R148. 2011
    ..Acute hemodynamic instability increases morbidity and mortality. We investigated whether early non-invasive cardiac output monitoring enhances hemodynamic stabilization and improves outcome...
  27. ncbi request reprint Effect of dopexamine on outcome after major abdominal surgery: a prospective, randomized, controlled multicenter study. European Multicenter Study Group on Dopexamine in Major Abdominal Surgery
    J Takala
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital
    Crit Care Med 28:3417-23. 2000
    ....
  28. doi request reprint Forced fluid removal in critically ill patients with acute kidney injury
    C C Ganter
    Department of Intensive Care Medicine, Bern University Hospital, Switzerland
    Acta Anaesthesiol Scand 56:1183-90. 2012
    ..The aim was to test the feasibility of protocol-driven fluid removal with continuous renal replacement therapy (CRRT) in patients in whom standard fluid balance prescription did not result in substantial negative fluid balances...
  29. ncbi request reprint Measuring depth of sedation with auditory evoked potentials during controlled infusion of propofol and remifentanil in healthy volunteers
    Matthias Haenggi
    Department of Intensive Care Medicine, University Hospital Bern Inselspital CH 3010 Bern, Switzerland
    Anesth Analg 99:1728-36, table of contents. 2004
    ..47 versus 1.86 +/- 0.34, P < 0.01). Our results suggest that long latency auditory evoked potentials provide an objective electrophysiological analog to the clinical assessment of sedation independent of the sedation regime used...
  30. ncbi request reprint The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects
    Matthias Haenggi
    Department of Intensive Care Medicine, University Hospital of Bern, Bern, Switzerland
    Anesth Analg 103:1163-9. 2006
    ..Consequently, ERP can monitor sedation with midazolam but not with dexmedetomidine. The reverse is true for BIS...
  31. ncbi request reprint Effects of dopamine on systemic and regional blood flow and metabolism in septic and cardiac surgery patients
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital, Bern, Switzerland
    Shock 18:8-13. 2002
    ..The safety and indications of dopamine use in sepsis should be re-evaluated...
  32. ncbi request reprint Changes in splanchnic circulation during an alveolar recruitment maneuver in healthy porcine lungs
    Silvia Nunes
    Department of Intensive Care Medicine, University Hospital, Bern, Switzerland
    Anesth Analg 98:1432-8, table of contents. 2004
    ..This residual decrease may present a risk in conditions with markedly compromised circulatory reserves...
  33. doi request reprint Oxygen transport and mitochondrial function in porcine septic shock, cardiogenic shock, and hypoxaemia
    T Regueira
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
    Acta Anaesthesiol Scand 56:846-59. 2012
    ..We compared oxygen transport, lactate metabolism, and mitochondrial function in pigs with septic shock, cardiogenic shock, or hypoxic hypoxia...
  34. ncbi request reprint Pulmonary capillary pressure. A review
    C C Ganter
    Department of Intensive Care Medicine, University Hospital Inselspital, Bern, Switzerland
    Minerva Anestesiol 72:21-36. 2006
    ..At the bedside, measurement of Pcap can easily be determined by analyzing a pressure transient after an acute pulmonary artery occlusion with the balloon of a Swan-Ganz catheter...
  35. ncbi request reprint Splanchnic vasoregulation during mesenteric ischemia and reperfusion in pigs
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital, Bern, Switzerland
    Shock 18:142-7. 2002
    ....
  36. doi request reprint Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure
    Anna Giulia Brunello
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
    Intensive Care Med 36:66-74. 2010
    ..Neuromuscular abnormalities are common in ICU patients. We aimed to assess the incidence of clinically diagnosed ICU-acquired paresis (ICUAP) and its impact on outcome...
  37. ncbi request reprint Does ICU length of stay influence quality of life?
    K H Stricker
    Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland
    Acta Anaesthesiol Scand 49:975-83. 2005
    ..However, it is not known if such treatment results in impaired quality of life (QOL) as compared to patients with a short length of stay (LOS) when taking into account the initial severity of illness...
  38. doi request reprint Effect of site of lactate infusion on regional lactate exchange in pigs
    D Barthelmes
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, 3010 Bern, Switzerland
    Br J Anaesth 105:627-34. 2010
    ..We assessed the dose-response of hepatic and extra-hepatic lactate exchange during portal and central venous lactate infusion...
  39. ncbi request reprint Detection of artifacts in monitored trends in intensive care
    S Jakob
    Critical Care Research Program, Division of Intensive Care, Department of Anesthesiology and Intensive Care, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    Comput Methods Programs Biomed 63:203-9. 2000
    ..This makes large databases for tuning artifact algorithms mandatory. Despite these limitations, the performance of running median and slope detection were good in selected physiological variables...
  40. ncbi request reprint Effects of systemic arterial hypoperfusion on splanchnic hemodynamics and hepatic arterial buffer response in pigs
    S M Jakob
    Critical Care Research Program, Department of Anesthesiology and Intensive Care, Kuopio University Hospital, FIN 70210 Kuopio, Finland
    Am J Physiol Gastrointest Liver Physiol 280:G819-27. 2001
    ..In conclusion, during low systemic perfusion, the HABR is exhausted and hepatic function is impaired without signs of cellular damage...
  41. ncbi request reprint Splanchnic perfusion during hemodialysis: evidence for marginal tissue perfusion
    S M Jakob
    Critical Care Research Program, Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Crit Care Med 29:1393-8. 2001
    ..The aim of this study was to assess the response of splanchnic blood flow and oxygen transport to hemodialysis...
  42. ncbi request reprint Tonometry revisited: perfusion-related, metabolic, and respiratory components of gastric mucosal acidosis in acute cardiorespiratory failure
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital Bern, University of Bern, Bern, Switzerland
    Shock 29:543-8. 2008
    ..Hyperventilation partly masks mucosal acidosis. Inadequate tissue perfusion may persist despite stable hemodynamics and contributes to poor outcome...
  43. ncbi request reprint Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital Bern Inselspital, CH 3010 Bern, Switzerland
    J Crit Care 22:219-28. 2007
    ....
  44. doi request reprint Outcome after acute traumatic subdural and epidural haematoma in Switzerland: a single-centre experience
    Philipp Taussky
    Department of Neurosurgery, University Hospital, Bern, Switzerland
    Swiss Med Wkly 138:281-5. 2008
    ..The purpose of this study was to evaluate the impact of these strategies on outcome in patients treated in a single institution in Switzerland...
  45. ncbi request reprint Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction
    Rafael Knuesel
    Department of Intensive Care Medicine, Inselspital, University Hospital Berne, 3010, Berne, Switzerland
    Intensive Care Med 29:2255-65. 2003
    ..pCO(2) gradients may not parallel blood flow changes because of concomitant changes in metabolism, hemoglobin, temperature, and the Haldane effect...
  46. doi request reprint Can outcome prediction data change patient outcomes and organizational outcomes?
    Hans Ulrich Rothen
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    Curr Opin Crit Care 14:513-9. 2008
    ..Accordingly, organizational issues and quality management have become an important focus of interest in recent years. Here, we will review current concepts of how outcome data can be used to identify areas requiring action...
  47. doi request reprint Inverse thermodilution with conventional pulmonary artery catheters for the assessment of cerebral, hepatic, renal, and femoral blood flow
    Christoph C Ganter
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Inselspital, Bern, Switzerland
    Shock 32:194-200. 2009
    ..Inverse thermodilution using conventional PAC compared moderately well with USD for renal but not for other flows despite good in vitro correlation in various conditions. In addition, this method has significant technical limitations...
  48. doi request reprint Increased splanchnic oxygen extraction because of routine nursing procedures
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    Crit Care Med 37:483-9. 2009
    ..We hypothesized that therapeutic interventions used routinely in intensive care can interfere with the perfusion of the gut and the liver, and thereby increase the risk of mismatch between oxygen supply and demand...
  49. doi request reprint Effects of lung recruitment maneuvers on splanchnic organ perfusion during endotoxin-induced pulmonary arterial hypertension
    Fritz Daudel
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital, Bern, Switzerland
    Shock 34:488-94. 2010
    ..In conclusion, lipopolysaccharide-induced pulmonary arterial hypertension does not aggravate the RM-induced significant but short-lasting decreases in systemic, regional, and organ blood flows...
  50. ncbi request reprint Variability in outcome and resource use in intensive care units
    Hans U Rothen
    Department of Intensive Care Medicine, University Hospital, Murtenstrasse 35, 3010 Berne, Switzerland
    Intensive Care Med 33:1329-36. 2007
    ..To examine variability in outcome and resource use between ICUs. Secondary aims: to assess whether outcome and resource use are related to ICU structure and process, to explore factors associated with efficient resource use...
  51. ncbi request reprint Severe hypercapnia due to pulmonary embolism of polymethylmethacrylate during vertebroplasty
    Kay Stricker
    Department of Anesthesiology, University Hospital of Bern, Switzerland
    Anesth Analg 98:1184-6, table of contents. 2004
    ..Several pieces of polymethylmethacrylate were found in the pulmonary vasculature at autopsy...
  52. ncbi request reprint Severe transfusion-related acute lung injury
    Lukas Brander
    Department of Intensive Care Medicine, University Hospital, Inselspital, 3010 Bern, Switzerland
    Anesth Analg 101:499-501, table of contents. 2005
    ..Conservative transfusion strategies and preclusion of the implicated blood donors with granulocyte-reactive antibodies from future blood donation may prevent TRALI and potentially save lives...
  53. doi request reprint Arterial blood pressure during early sepsis and outcome
    Martin W Dunser
    Department of Intensive Care Medicine, Inselspital, 3010, Bern, Switzerland
    Intensive Care Med 35:1225-33. 2009
    ..To evaluate the association between arterial blood pressure (ABP) during the first 24 h and mortality in sepsis...
  54. ncbi request reprint Hepatosplanchnic blood flow control and oxygen extraction are modified by the underlying mechanism of impaired perfusion
    Hendrik Bracht
    Department of Intensive Care Medicine, University Hospital Bern, Switzerland
    Crit Care Med 33:645-53. 2005
    ..To assess the effects of low hepatosplanchnic blood flow on regional blood flow control and oxygenation...
  55. ncbi request reprint Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock
    Luzius B Hiltebrand
    Department of Anesthesia, University of Bern, Inselspital, Bern, Switzerland, and Department of Anesthesia and Intensive Care Medicine, Landspitali University Hospital, Reykjavik, Iceland
    Anesthesiology 106:1156-67. 2007
    ..The authors studied the effects of vasopressin on microcirculatory blood flow in the entire gastrointestinal tract in anesthetized pigs during early septic shock...
  56. ncbi request reprint ARDS. Monitoring tissue perfusion
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital Inselspital, Bern, Switzerland
    Crit Care Clin 18:143-63. 2002
    ..Combining the available methods in different parts of the gastrointestinal tract may help assess splanchnic perfusion more accurately in the near future...
  57. ncbi request reprint Effects of cerebral perfusion pressure and increased fraction of inspired oxygen on brain tissue oxygen, lactate and glucose in patients with severe head injury
    M Reinert
    Department of Neurosurgery, Inselspital Bern, University of Bern, Switzerland
    Acta Neurochir (Wien) 145:341-9; discussion 349-50. 2003
    ....
  58. ncbi request reprint Outcome and resource utilization in gastroenterological surgery
    M Lang
    Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Br J Surg 88:1006-14. 2001
    ..The nature and frequency of, and predictive factors for, postoperative complications were studied and the impact of complications on resource utilization was assessed...
  59. doi request reprint Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients
    Matthias Haenggi
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    Anesth Analg 109:807-16. 2009
    ..We hypothesized that auditory event-related potentials (ERPs), Bispectral Index (BIS), and Entropy can discriminate among clinically relevant sedation levels...
  60. ncbi request reprint Decreasing gut wall glucose as an early marker of impaired intestinal perfusion
    Vladimir Krejci
    Department of Anesthesiology, Inselspital, Bern, Switzerland
    Crit Care Med 34:2406-14. 2006
    ..The aim of this study was to assess the microcirculatory and metabolic consequences of reduced mesenteric blood flow...
  61. ncbi request reprint Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism
    Rafael Knuesel
    Clinic for Intensive Care Medicine, University Hospital of Bern Inselspital, Bern, Switzerland
    Crit Care Med 34:2638-45. 2006
    ..The aims of this study were to evaluate the properties of a new membrane-based microdialyzer in vitro and to assess the ability of the dialyzer to detect a clinically relevant decrease in splanchnic blood flow in vivo...
  62. ncbi request reprint Lack of effect of ranitidine on gastric luminal pH and mucosal PCO2 during the first day in the ICU
    S M Jakob
    Department of of Anaesthesiology and Intensive Care Medicine, Kuopio University Hospital, Kuopio, Switzerland
    Acta Anaesthesiol Scand 49:390-6. 2005
    ..However, gastric acid production may be impaired in acute circulatory failure due to poor mucosal perfusion, and H(2)-blockade could further impair mucosal perfusion...
  63. ncbi request reprint Metabolic changes after cardiac surgery
    S M Jakob
    Department of Intensive Care Medicine, University Hospital Bern, Freiburgstrasse, CH 3010 Bern, Switzerland
    Curr Opin Clin Nutr Metab Care 4:149-55. 2001
    ..There is evidence that better control of metabolic abnormalities improves the patients' outcome...
  64. ncbi request reprint Resource use in the ICU: short- vs. long-term patients
    K Stricker
    Department of Intensive Care Medicine, University Hospital, Bern, Switzerland
    Acta Anaesthesiol Scand 47:508-15. 2003
    ..Intensive care medicine uses a disproportionate share of medical resources, and little is known about the distribution of resources between different patient groups...
  65. doi request reprint The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest
    C Torgersen
    Department of Intensive Care Medicine, Inselspital, Medical University of Bern, Bern, Switzerland
    Acta Anaesthesiol Scand 54:1027-35. 2010
    ....
  66. doi request reprint Effects of endotoxin and catecholamines on hepatic mitochondrial respiration
    Francesca Porta
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
    Inflammation 32:315-21. 2009
    ..Endotoxin incubation alone induced a decrease in glutamate-dependent RCR compared to control samples (p = 0.002). We conclude that catecholamines and endotoxin impair the efficiency of mitochondrial complex I respiration in vitro...
  67. ncbi request reprint Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients
    Stephan M Jakob
    Department of Intensive Care Medicine, University Hospital, Bern, Switzerland
    Shock 18:1-7. 2002
    ..MEGX production cannot be used as an estimate of changes in splanchnic blood flow...
  68. doi request reprint Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery
    Lukas Brander
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital, Bern, Switzerland
    Surgery 146:88-99. 2009
    ..To test the hypothesis that reduced responsiveness to adrenocorticotropin (ACTH) stimulation before elective major abdominal surgery is associated with an increased incidence of postoperative complications...
  69. doi request reprint When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration
    Kay H Stricker
    Departments of Intensive Care Medicine, Bern University Hospital and University of Bern, Inselspital, Bern, Switzerland
    Anesth Analg 109:1640-3. 2009
    ..When the effects of IV drugs are inadequate in patients receiving CVVHDF, interference with adjacent catheters resulting in elimination of the drug by CVVHDF should be suspected...
  70. ncbi request reprint Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs
    Lukas Brander
    Department of Intensive Care Medicine, University Hospital Inselspital, Bern, Switzerland
    Shock 25:402-13. 2006
    ..Low-but not high-dose dobutamine redistributes blood flow toward the gut and celiac trunk. The jejunal microcirculatory flow, once impaired, is difficult to restore...
  71. doi request reprint Early prognostic value of the medical emergency team calling criteria in patients admitted to intensive care from the emergency department
    Reto Etter
    Department of Intensive Care Medicine, University Hospital Bern, University of Bern, Bern, Switzerland
    Crit Care Med 36:775-81. 2008
    ..To evaluate the early prognostic value of the medical emergency team (MET) calling criteria in patients admitted to intensive care from the emergency department...
  72. doi request reprint The immediate and sustained effects of volume challenge on regional blood flows in pigs
    Syed Z Ali
    Department of Anesthesiology, University Hospital Bern, Inselspital, CH 3010 Bern, Switzerland
    Anesth Analg 106:595-600, table of contents. 2008
    ..Hypovolemia and blood flow redistribution may compromise the perfusion of the intraabdominal organs. We investigated the effects of a volume challenge in different intra- and extraabdominal vascular beds...
  73. doi request reprint Thermodilution and esophageal Doppler ultrasound in the assessment of blood flow changes induced by endotoxin and dobutamine
    Yoshie Taniguchi
    Departments of Anesthesiology, Bern University Hospital, University of Bern, Bern, Switzerland
    J Trauma 65:175-82. 2008
    ..Intermittent (IT) and continuous (CT) thermodilution and esophageal Doppler (ED), are all used for hemodynamic monitoring. The aim of this study was to test the agreement between these methods during endotoxin (ET) and dobutamine infusion...
  74. ncbi request reprint Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler
    Margareta Roeck
    Department of Intensive Care Medicine, University Hospital Bern, 3010 Bern, Switzerland
    Intensive Care Med 29:1729-35. 2003
    ..To compare two methods of assessing a change in stroke volume in response to fluid challenge: esophageal Doppler and thermodilution with the pulmonary artery catheter...
  75. ncbi request reprint Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro
    Francesca Porta
    Department of Intensive Care Medicine, University Hospital Bern, 3010 Bern, Switzerland
    J Endotoxin Res 12:358-66. 2006
    ..While catecholamines are frequently used in sepsis, their effects on mitochondrial function are controversial. We assessed effects of dobutamine and dopamine endotoxin on isolated muscle mitochondria...
  76. doi request reprint Physiologic response to changing positive end-expiratory pressure during neurally adjusted ventilatory assist in sedated, critically ill adults
    Christina Passath
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
    Chest 138:578-87. 2010
    ..Changing positive end-expiratory pressure (PEEP) impacts respiratory muscle load and function and, hence, EAdi. We aimed to evaluate how PEEP affects the breathing pattern and neuroventilatory efficiency during NAVA...
  77. doi request reprint Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits
    Volker Neuschmelting
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    Acta Neurochir (Wien) 151:487-93. 2009
    ..The aim of this study was to evaluate angiographic effects of normovolaemic Norepinephrine (NE)-induced hypertension therapy on the rabbit basilar artery (BA) after SAH...
  78. doi request reprint Different patterns of Siglec-9-mediated neutrophil death responses in septic shock
    Stephan von Gunten
    Institute of Pharmacology, University of Bern, Switzerland
    Shock 32:386-92. 2009
    ..Further studies are required to understand the role of Siglec-9-mediated neutrophil death in septic shock...
  79. doi request reprint Assessment of splanchnic blood flow using magnetic resonance imaging
    Daniel Barthelmes
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    Eur J Gastroenterol Hepatol 21:693-700. 2009
    ..The aim of this study was to evaluate MRI as a tool for assessing intra-abdominal blood flows of the aorta, portal vein (VPO) and the major intestinal and hepatic vessels...
  80. pmc Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions
    Rolf Spirig
    Laboratory of Cardiovascular Research, Department of Clinical Research, University of Bern, Bern, Switzerland
    PLoS ONE 5:e0010983. 2010
    ..Current evidence suggests that different target genes may be affected by HIF-1alpha under normoxic conditions with physiological roles that differ from those induced by hypoxia...
  81. ncbi request reprint Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment
    Stephan von Gunten
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Blood 106:1423-31. 2005
    ..The new insights have important implications for the pathogenesis, diagnosis, and treatment of inflammatory diseases such as sepsis and rheumatoid arthritis...
  82. doi request reprint Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion
    Hendrik Bracht
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Intensive Care Med 34:1883-90. 2008
    ..Orthogonal polarization spectral (OPS) imaging is used to assess mucosal microcirculation. We tested sensitivity and variability of OPS in the assessment of mesenteric blood flow (Qsma) reduction...
  83. doi request reprint Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes
    Tomas Regueira
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    Liver Int 29:1582-92. 2009
    ....
  84. ncbi request reprint Safe long-distance interhospital ground transfer of critically ill patients with acute severe unstable respiratory and circulatory failure
    Ari Uusaro
    Kuopio University Hospital, Critical Care Research Program, Department of Anesthesiology and Intensive Care, Division of Critical Care, PO Box 1777, 70211, Kuopio, Finland
    Intensive Care Med 28:1122-5. 2002
    ..To assess the safety of long-distance ground interhospital transport of critically ill patients with the most severe unstable respiratory failure after establishment of a dedicated transport system...
  85. ncbi request reprint A european, multicenter, observational study to assess the value of gastric-to-end tidal PCO2 difference in predicting postoperative complications
    Gilles Lebuffe
    Department of Anesthesiology 2, CHU de Lille, Lille, France
    Anesth Analg 99:166-72. 2004
    ..8kPa) (sensitivity 0.27, specificity 0.92, positive predictive value 64%, negative predictive value 70%). We conclude that intraoperative Pr-etCO2 measurement may be a useful prognostic index of postoperative morbidity...
  86. ncbi request reprint Pulmonary capillary pressures during the acute respiratory distress syndrome
    Silvia Nunes
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Intensive Care Med 29:2174-9. 2003
    ..to assess Pcap under different levels of positive end-expiratory pressure (PEEP) and (3). to compare the visual method and a mathematical model to determine Pcap...
  87. ncbi request reprint High-frequency ventilation versus conventional ventilation for the treatment of acute lung injury and acute respiratory distress syndrome: a systematic review and cochrane analysis
    Hannah Wunsch
    Department of Anesthesiology, Columbia Presbyterian Medical Center, 630 W 168th St, New York, NY 10032, USA
    Anesth Analg 100:1765-72. 2005
    ..Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and The Cochrane Library should be consulted for the most recent version of the Review.)...
  88. ncbi request reprint Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock
    Angel Lopez
    Hospital Infanta Cristinam, Badajoz, Spain
    Crit Care Med 32:21-30. 2004
    ..To assess the safety and efficacy of the nitric oxide synthase inhibitor 546C88 in patients with septic shock. The predefined primary efficacy objective was survival at day 28...
  89. ncbi request reprint Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo
    Jan Bakker
    Department of Intensive Care, Gelre Lukas Hospital, Apeldoorn, The Netherlands
    Crit Care Med 32:1-12. 2004
    ..The predefined primary efficacy objective was resolution of shock, defined as a mean arterial pressure > or =70 mm Hg in the absence of both conventional vasopressors and study drug, determined at the end of the 72-hr treatment period...
  90. ncbi request reprint Dangers of growth hormone therapy in critically ill patients
    Esko Ruokonen
    Critical Care Research Program, Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Curr Opin Clin Nutr Metab Care 5:199-209. 2002
    ..This review reinforces that conclusion...
  91. ncbi request reprint Moving knowledge of global burden into preventive action
    Gerry J M Eijkemans
    Am J Ind Med 48:395-9. 2005
    ..The World Health Organization (WHO) has implemented a Comparative Risk Assessment (CRA) to estimate risk to exposed populations...
  92. ncbi request reprint Review of estimates of the global burden of injury and illness due to occupational exposures
    Timothy Driscoll
    School of Public Health, University of Sydney, New South Wales, Australia
    Am J Ind Med 48:491-502. 2005
    ..Over the last decade, there have been several attempts to estimate the global burden of ill health due to work activity. The most recent of these is the Comparative Risk Assessment (CRA) project of the World Health Organization...
  93. ncbi request reprint Comparison of continuous and intermittent renal replacement therapy for acute renal failure
    Dominik E Uehlinger
    Division of Nephrology Hypertension, University of Berne, Freiburgstrasse 10, 3010 Bern Inselspital, Switzerland
    Nephrol Dial Transplant 20:1630-7. 2005
    ..Intermittent and continuous RRT are available for these patients on the intensive care units (ICUs). It is unknown which technique is superior with respect to patient outcome...
  94. ncbi request reprint Jejunal luminal microdialysate lactate in cardiac tamponade--effect of low systemic blood flow on gut mucosa
    Jyrki Juhani Tenhunen
    Division of Intensive Care, Department of Anesthesiology and Intensive Care, University Hospital of Kuopio, P O B 1777, 70211 Kuopio, Finland
    Intensive Care Med 28:953-62. 2002
    ..To assess gut mucosal metabolic response and susceptibility to dysoxia during low systemic blood flow induced by cardiac tamponade...
  95. doi request reprint The pulmonary artery catheter: in medio virtus
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 36:3093-6. 2008
    ..To clarify the role of the pulmonary artery catheter in the intensive care unit...
  96. ncbi request reprint Intraperitoneal microdialysis: critique of an editorial
    Rafael Knuesel
    Crit Care Med 35:1802; discussion 1802. 2007
  97. ncbi request reprint Hemodynamic management of the critically ill patient: craft meets science
    Jukka Takala
    Curr Opin Crit Care 13:519-20. 2007