B Stieger

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    B Noe
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 94:10346-50. 1997
  2. ncbi Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
    Johannes Noe
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Ramistrasse 100, E RAE 09, 8091 Zurich, Switzerland
    J Hepatol 43:536-43. 2005
  3. ncbi Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver
    Frank Dombrowski
    Department of Pathology, University of Magdeburg, Magdeburg, Germany
    Lab Invest 86:166-74. 2006
  4. ncbi Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 44:62-74. 2006
  5. ncbi The canalicular bile salt export pump BSEP (ABCB11) as a potential therapeutic target
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
    Curr Drug Targets 12:661-70. 2011
  6. doi Recent insights into the function and regulation of the bile salt export pump (ABCB11)
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Curr Opin Lipidol 20:176-81. 2009
  7. doi Role of the bile salt export pump, BSEP, in acquired forms of cholestasis
    Bruno Stieger
    Department of Medicine, University Hospital Zurich, Switzerland
    Drug Metab Rev 42:437-45. 2010
  8. ncbi The bile salt export pump
    Bruno Stieger
    Department of Medicine, Institute of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
    Pflugers Arch 453:611-20. 2007
  9. ncbi Hepatocyte transplantation: potential of hepatocyte progenitor cells and bone marrow derived stem cells
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Swiss Med Wkly 136:552-6. 2006
  10. ncbi Bile acid and xenobiotic transporters in liver
    B Stieger
    University Hospital, Department of Medicine, Zurich, Switzerland
    Curr Opin Cell Biol 10:462-7. 1998

Detail Information

Publications66

  1. pmc Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    B Noe
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 94:10346-50. 1997
    ..They indicate that oatp2 may play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides from the body...
  2. ncbi Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
    Johannes Noe
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Ramistrasse 100, E RAE 09, 8091 Zurich, Switzerland
    J Hepatol 43:536-43. 2005
    ..We functionally characterized novel ABCB11 mutations encountered in two patients with a PFIC2 and a BRIC2 phenotype, respectively...
  3. ncbi Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver
    Frank Dombrowski
    Department of Pathology, University of Magdeburg, Magdeburg, Germany
    Lab Invest 86:166-74. 2006
    ....
  4. ncbi Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 44:62-74. 2006
    ..Furthermore, data suggest a polymorphic transporter expression pattern, which might constitute a risk factor for the development of acquired forms of cholestatic liver diseases...
  5. ncbi The canalicular bile salt export pump BSEP (ABCB11) as a potential therapeutic target
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
    Curr Drug Targets 12:661-70. 2011
    ..Finally, it sets the current therapeutic approaches for cholestatic liver disease into perspective to the pathophysiologic mechanisms of impaired BSEP function...
  6. doi Recent insights into the function and regulation of the bile salt export pump (ABCB11)
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Curr Opin Lipidol 20:176-81. 2009
    ..Its impairment can be caused by inherited mutations or by acquired factors and leads to cholestasis. Bile salts are an important constituent of bile and are secreted by the bile salt export pump (BSEP) from hepatocytes...
  7. doi Role of the bile salt export pump, BSEP, in acquired forms of cholestasis
    Bruno Stieger
    Department of Medicine, University Hospital Zurich, Switzerland
    Drug Metab Rev 42:437-45. 2010
    ..Some drugs are now known to be competitive inhibitors of Bsep. In addition, a polymorphism in the gene coding for BSEP has been identified as a potential susceptibility factor for acquired cholestasis...
  8. ncbi The bile salt export pump
    Bruno Stieger
    Department of Medicine, Institute of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland
    Pflugers Arch 453:611-20. 2007
    ..Furthermore, many genetic variants of Bsep are known, some of which potentially render individuals susceptible to acquired forms of liver disease...
  9. ncbi Hepatocyte transplantation: potential of hepatocyte progenitor cells and bone marrow derived stem cells
    Bruno Stieger
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Swiss Med Wkly 136:552-6. 2006
    ..Such cells may be a source for hepatocyte transplantation and hence have the potential to offer a novel therapy for liver failure...
  10. ncbi Bile acid and xenobiotic transporters in liver
    B Stieger
    University Hospital, Department of Medicine, Zurich, Switzerland
    Curr Opin Cell Biol 10:462-7. 1998
    ..In addition, liver transporter genes responsible for hereditary forms of cholestatic liver disease have been identified and found to belong to the superfamily of ATP-binding cassette proteins...
  11. ncbi Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver
    N Hagenbuch
    Department of Medicine, University Hospital, Zurich, Switzerland
    J Hepatol 34:881-7. 2001
    ..The hepatic clearance of drugs and cholephilic organic anions is stimulated by phenobarbital (PB). Our aim was to analyze the effects of PB on the expression of hepatocellular bile salt and organic anion transporters...
  12. ncbi Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
    G A Kullak-Ublick
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 120:525-33. 2001
    ..We aimed to characterize the novel OATP-B with respect to tissue distribution and hepatocellular localization and to compare its substrate specificity with those of OATP-A, OATP-C, and OATP8...
  13. ncbi Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver
    V Cattori
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital Zurich, Switzerland
    FEBS Lett 474:242-5. 2000
    ..1 microM) and steroid conjugates. Based on nuclease protection analysis Oatp4 appears to be the predominant transcript in rat liver indicating that rlst-1 plays a minor role in overall hepatic organic anion uptake...
  14. ncbi The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
    T Gerloff
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Biol Chem 273:10046-50. 1998
    ..These results indicate that the sister of P-glycoprotein is the major canalicular bile salt export pump of mammalian liver...
  15. ncbi Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3
    V Cattori
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, 8091 Zurich, Switzerland
    Pflugers Arch 443:188-95. 2001
    ..Thus, while Oatp4 seems to work in concert with Oatp1 and Oatp2 in the basolateral membrane of rat hepatocytes, Oatp3 is a multispecific transport system in the small intestine...
  16. ncbi Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes
    S J Rippin
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 33:776-82. 2001
    ....
  17. ncbi Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
    P J Meier
    Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 26:1667-77. 1997
    ..Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities...
  18. ncbi Transport function and hepatocellular localization of mrp6 in rat liver
    J Madon
    Division of Clinical Pharmacology, Department of Medicine, University Hospital, Zurich, Switzerland
    Mol Pharmacol 57:634-41. 2000
    ....
  19. ncbi Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
    M G Ismair
    Division of Clinical Pharmacology Toxicology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 121:1185-90. 2001
    ..The smaller isoforms CCK-8 and CCK-4 are rapidly taken up into hepatocytes, metabolized, and excreted into bile. Our aim was to identify and characterize the hepatocellular CCK-8 uptake system...
  20. ncbi Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
    F Pizzagalli
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Mol Endocrinol 16:2283-96. 2002
    ..Thus, in contrast to most other family members, OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis...
  21. ncbi Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes
    M Bissig
    Department of Medicine, University Hospital, Zurich, Switzerland
    J Biol Chem 269:3017-21. 1994
    ..Bissig, M., Sorribas, V., Hagenbuch, B., Meier, P. J., and Murer, H. (1994) J. Biol. Chem. 269, 3022-3026)...
  22. pmc Expression cloning of a rat liver Na(+)-independent organic anion transporter
    E Jacquemin
    Department of Medicine, University Hospital, Zurich, Switzerland
    Proc Natl Acad Sci U S A 91:133-7. 1994
    ....
  23. ncbi The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions
    K Fattinger
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Clin Pharmacol Ther 69:223-31. 2001
    ..In this study we investigated whether inhibition of the hepatocanalicular bile salt export pump (rodents, Bsep; humans, BSEP ABCB11) could account for bosentan-induced liver injury...
  24. ncbi Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
    G A Kullak-Ublick
    Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 109:1274-82. 1995
    ..Based on a recently cloned rat liver organic anion transporter, we attempted to clone the corresponding human liver organic anion transporting polypeptide...
  25. ncbi Structure-effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination
    H R Ha
    Department of Internal Medicine, University Hospital Zurich, Switzerland
    Eur J Clin Pharmacol 55:807-14. 2000
    ..Amiodarone (AMI) has proven to be a potent anti-arrhythmic compound. Due to the structural similarity between AMI and thyroid hormone, it is possible that the drug could inhibit the activity of the 5'-thyroxine-deiodinase...
  26. ncbi Bile salt transporters
    Peter J Meier
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, 8091 Switzerland
    Annu Rev Physiol 64:635-61. 2002
    ..Furthermore, defective expression and function of bile salt transporters have been recognized as important causes for various cholestatic liver diseases...
  27. pmc Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells
    G A Kullak-Ublick
    Divisions of Clinical Pharmacology Toxicology, Department of Medicine, University Hospital, CH 8091, Zurich, Switzerland
    Cytotechnology 34:1-9. 2000
    ..We conclude that the Ntcp-EGFP fusion proteinfollows the sorting route of Ntcp, is functionallyidentical to Ntcp and could be used to monitor proteintrafficking in living HepG2 cells...
  28. doi The role of bile acid retention and a common polymorphism in the ABCB11 gene as host factors affecting antiviral treatment response in chronic hepatitis C
    R Iwata
    Clinic for Gastroenterology and Hepatology, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland
    J Viral Hepat 18:768-78. 2011
    ..Our data support a role for BA as host factor affecting therapy response in HCV-2/3 patients, whereas a weaker association was found for HCV-1...
  29. doi Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2
    L Todesco
    Division of Clinical Pharmacology and Toxicology and Department of Research, University Hospital, Basel, Switzerland
    Cell Mol Life Sci 65:1596-608. 2008
    ..Our cell system is suitable for studying in vitro interactions with OCTN2, which can subsequently be investigated in vivo...
  30. ncbi Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition
    C Simon
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Acta Neurol Scand 115:232-42. 2007
    ..We therefore correlated intestinal expression levels and genetics of CYP3A4, CYP2C9/19, MDR1 and MRP2 with dose requirement and plasma levels of carbamazepine and phenytoin...
  31. ncbi Functional expression of the canalicular bile salt export pump of human liver
    Johannes Noe
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 123:1659-66. 2002
    ..Therefore, the aim of this study was to functionally characterize human BSEP...
  32. ncbi Small hepatocytes in culture develop polarized transporter expression and differentiation
    Marguerite Anne Sidler Pfändler
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091 Zurich, Switzerland
    J Cell Sci 117:4077-87. 2004
    ....
  33. ncbi Enterohepatic transport of bile salts and genetics of cholestasis
    Christiane Pauli-Magnus
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Ramistrasse 100, E RAE 09, 8091 Zurich, Switzerland
    J Hepatol 43:342-57. 2005
  34. pmc Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system
    B Hagenbuch
    Department of Medicine, University Hospital, Zurich, Switzerland
    Proc Natl Acad Sci U S A 88:10629-33. 1991
    ..Northern blot analysis with the cloned probe revealed crossreactivity with mRNA species from rat kidney and intestine as well as from liver tissues of mouse, guinea pig, rabbit, and man...
  35. ncbi Hepatocyte performance on different crystallographic faces of rutile
    S Buchloh
    Nonmetallic Inorganic Materials, Department of Materials, ETH Zurich, Sonneggstr 5, 8092, Zurich, Switzerland
    Biomaterials 24:2605-10. 2003
    ..These findings suggest that hepatocytes do not recognize the specific differences of differently orientated rutile crystal surfaces...
  36. doi Dearterialization of the liver causes intrahepatic cholestasis due to reduced bile transporter expression
    Harm Hoekstra
    Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland
    Transplantation 85:1159-66. 2008
    ..We aimed to define the involvement of bile secretory dysfunction in the pathogenesis of liver injury after HAT...
  37. ncbi Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury
    Carmen Lang
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland
    Pharmacogenet Genomics 17:47-60. 2007
    ..The aim of this study was therefore to describe the extent of genetic variability in ABCB11 and ABCB4 in patients with drug-induced liver injury and to in vitro functionally characterize newly detected ABCB11 mutations and polymorphisms...
  38. doi ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes
    Manfred G Ismair
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland
    Hepatology 49:1673-82. 2009
    ..quot;Lubrol-microdomains" contain the machinery for canalicular bile formation and may be the starting place for canalicular lipid secretion...
  39. ncbi Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver
    Pascal Frei
    Division of Clinical Pharmacology and Toxicology, Dept of Medicine, Univ Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 288:G771-8. 2005
    ..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
  40. ncbi Enterohepatic bile salt transporters in normal physiology and liver disease
    Gerd A Kullak-Ublick
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Gastroenterology 126:322-42. 2004
    ..Finally, dysfunction of individual bile salt transporters such as BSEP, on account of genetic mutations, steric inhibition, suppression of gene expression, or disturbed signaling, is an important cause of cholestatic liver disease...
  41. ncbi Differential expression of bile salt and organic anion transporters in developing rat liver
    Bo Gao
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    J Hepatol 41:201-8. 2004
    ..Here, we investigated the ontogenesis of the polar expression of hepatocellular organic anion and bile salt transport systems in rat liver...
  42. pmc Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump
    Yvonne Meier
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    World J Gastroenterol 14:38-45. 2008
    ....
  43. doi Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney
    Zoulikha M Zaïr
    University Hospital Zurich, Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, CH 8091 Zurich, Switzerland
    Pharmacogenomics 9:597-624. 2008
    ....
  44. doi The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1α (HNF-1α)
    Kerstin Klein
    Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland
    Mol Pharmacol 78:1079-87. 2010
    ..134, P < 0.05) or OAT7 (r = 0.461, P < 0.001) mRNA expression levels in surgical liver biopsies from 75 patients further supported an important role of HNF-1α in the regulation of OAT gene expression...
  45. ncbi Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr2+/- mice
    Harm Hoekstra
    Swiss HPB Center, Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland
    Hepatology 43:1022-31. 2006
    ..In conclusion, toxic bile composition, due to a high biliary bile salt/phospholipid ratio, acted synergistically with cold ischemia in the pathogenesis of bile duct injury after transplantation...
  46. doi The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats
    Regula Schürch
    Division of Clinical Pharmacology and Toxicology, University Hospital and University of Basel, Switzerland
    Eur J Pharmacol 635:171-6. 2010
    ..Our study supports the hypothesis that a decrease in the carnitine plasma and/or glomerular filtrate concentration increases renal expression and activity of OCTN2...
  47. ncbi Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes
    Laura Fouassier
    INSERM U680, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Am J Physiol Gastrointest Liver Physiol 293:G25-35. 2007
    ..In conclusion, hypoxia triggers a downregulation of hepatocellular transporters, which may contribute to cholestasis, whereas Cftr, which drives secretion in cholangiocytes, is upregulated...
  48. ncbi Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice
    Henk Wolters
    Center for Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    J Hepatol 37:556-63. 2002
    ..We investigated the physiological relevance of this regulation by evaluating transporter expression in mice experiencing different transhepatic bile salt fluxes...
  49. ncbi Function of both sinusoidal and canalicular transporters controls the concentration of organic anions within hepatocytes
    Corinne Planchamp
    Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire, Hopitaux Universitaires de Geneve, Rue Micheli du Crest, 24, 1205 Geneva, Switzerland
    Mol Pharmacol 71:1089-97. 2007
    ..These results highlight that the function of both sinusoidal and canalicular transporters is important to determine the concentration of organic anions within hepatocytes...
  50. ncbi Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)
    Thomas Lang
    EPIDAUROS Biotechnologie AG, Bernried, Germany
    Drug Metab Dispos 34:1582-99. 2006
    ..Our results contribute to a better understanding of the molecular basis and of ethnic differences in drug response, and provide a valuable tool for future research on the heredity of cholestatic liver injury...
  51. ncbi Twenty years of ATP-binding cassette (ABC) transporters
    Bruno Stieger
    Pflugers Arch 453:543. 2007
  52. ncbi Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats
    Yasumasa Gotoh
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Am J Physiol Endocrinol Metab 282:E1245-54. 2002
    ..These results suggest that urinary E(2)-17betaG excretion is subject to hormonal regulation and that the large gender difference can be explained by regulation in Oatp1-mediated reabsorption...
  53. ncbi Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    Andreas Geier
    Department of Internal Medicine III, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 37:198-205. 2002
    ..Maintained binding activity of RXRalpha:RARalpha may explain differences in Mrp2 expression...
  54. ncbi Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy
    Jingsong Cao
    Graduate Center for Toxicology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0305, USA
    Am J Physiol Gastrointest Liver Physiol 283:G757-66. 2002
    ..These data also demonstrate that decreased Mrp2 expression is not necessarily accompanied by increased Mrp3 expression...
  55. ncbi Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump
    Sachiko Mita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G159-67. 2005
    ..This double-expressing system can be used as a model to clarify vectorial transport of bile salts across hepatocytes under physiological conditions...
  56. ncbi Physiological characteristics of allo-cholic acid
    Maria E Mendoza
    Department of Physiology and Pharmacology, University of Salamanca, Spain
    J Lipid Res 44:84-92. 2003
    ....
  57. ncbi Biliary cholesterol secretion: more lessons from plants?
    Bruno Stieger
    J Hepatol 38:843-6. 2003
  58. ncbi Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions
    Nita J Patel
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Pharmacol 64:154-9. 2003
    ....
  59. ncbi Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate
    Daniel Rost
    Department of Gastroenterology, University Hospital, Heidelberg, Germany
    Hepatology 38:187-95. 2003
    ..In conclusion, we show that CA feeding may cause cholestasis associated with a posttranscriptional down-regulation of Oatp4. UDCA may prevent impairment of hepatic function by restoring hepatic transporter expression...
  60. doi Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families
    Sandra S Strautnieks
    Institute of Liver Studies, King s College London School of Medicine at King s College Hospital, London, England
    Gastroenterology 134:1203-14. 2008
    ..We characterized mutations of ABCB11 (encoding BSEP) in such patients and correlated genotypes with residual protein detection and risk of malignancy...
  61. ncbi Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency
    A S Knisely
    Institute of Liver Studies, King s College Hospital, London, UK
    Hepatology 44:478-86. 2006
    ..In conclusion, PFIC associated with BSEP deficiency represents a previously unrecognized risk for HCC in young children. Immunohistochemical evidence of BSEP deficiency correlates well with demonstrable mutation in ABCB11...
  62. ncbi Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta
    Marc Le Vee
    Institut National de la Santé et de la Recherche Médicale U620, Faculty of Pharmacy, Rennes, France
    Drug Metab Dispos 36:217-22. 2008
    ..Such IL-1beta effects may likely participate in both cholestasis and alterations of hepatic detoxification pathways caused by inflammation in humans...
  63. ncbi Quantitative microscopy reveals 3D organization and kinetics of endocytosis in rat hepatocytes
    Permsin Marbet
    Structural Cell Biology, Centre for Biomedical Research, University of Basel, Switzerland
    Microsc Res Tech 69:693-707. 2006
    ..In addition, we show that quantitative microscopy using high resolution data sets can detect and characterize kinetics of various parameters thus adding a dynamic component to 3D information...
  64. ncbi Gd-BOPTA transport into rat hepatocytes: pharmacokinetic analysis of dynamic magnetic resonance images using a hollow-fiber bioreactor
    Corinne Planchamp
    Geneva University Hospitals, Radiology Department, Geneva, Switzerland
    Invest Radiol 39:506-15. 2004
    ..To investigate the transport of the hepatobiliary magnetic resonance (MR) imaging contrast agent Gd-BOPTA into rat hepatocytes...
  65. ncbi Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver
    Ying Wang
    Institute of Molecular Biology, University of Zurich, Switzerland
    FASEB J 18:1071-9. 2004
    ..Together, these findings point to a critical role of MTF-1 in embryonic liver formation, heavy metal toxicity, and hematopoiesis...
  66. ncbi Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers
    Corinne Planchamp
    Département de Radiologie and Division de Gastroentérologie, Hopitaux Universitaires de Geneve, Geneva, Switzerland
    Invest Radiol 40:187-94. 2005
    ..Consequently, the aim of our study was to measure the hepatic SI enhancement during Gd-BOPTA perfusion as well as the Oatp and Mrp2 expression in normal and cirrhotic livers...