Felix Stickel

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. doi request reprint Alcoholic steatohepatitis
    Felix Stickel
    Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Best Pract Res Clin Gastroenterol 24:683-93. 2010
  2. ncbi request reprint Update on the management of alcoholic steatohepatitis
    Felix Stickel
    Hepatology Unit, Klinik Beau Site, Department of Visceral Surgery and Medicine Inselspital, University of Bern, Bern, Switzerland
    J Gastrointestin Liver Dis 22:189-97. 2013
  3. doi request reprint Critical review of the use of erythropoietin in the treatment of anaemia during therapy for chronic hepatitis C
    F Stickel
    Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland
    J Viral Hepat 19:77-87. 2012
  4. doi request reprint Genetic determinants of alcoholic liver disease
    Felix Stickel
    Department of Visceral Surgery and Medicine, Inselspital, University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland
    Gut 61:150-9. 2012
  5. doi request reprint Review of liver injury associated with dietary supplements
    Felix Stickel
    Department of Visceral Surgery and Medicine, Institute of Clinical Pharmacology and Visceral Research, Inselspital, University of Berne, Berne, Switzerland
    Liver Int 31:595-605. 2011
  6. doi request reprint Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilis
    Felix Stickel
    Institute of Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, CH, Switzerland
    J Hepatol 50:111-7. 2009
  7. doi request reprint No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Switzerland
    Alcohol Clin Exp Res 32:959-65. 2008
  8. doi request reprint Role of nutrition in liver transplantation for end-stage chronic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, Inselspital, University of Berne, Berne, Switzerland
    Nutr Rev 66:47-54. 2008
  9. ncbi request reprint The role of genetic polymorphisms in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH 3010 Berne, Switzerland
    Alcohol Alcohol 41:209-24. 2006
  10. doi request reprint Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis
    Eleonora Patsenker
    Institute of Clinical Pharmacology and Visceral Research, University of Bern, Switzerland
    J Hepatol 55:388-98. 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint Alcoholic steatohepatitis
    Felix Stickel
    Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Best Pract Res Clin Gastroenterol 24:683-93. 2010
    ..Treatment includes abstinence, enteral nutrition, corticosteroids, and possibly pentoxifylline. A debate is ongoing whether certain patients with severe alcoholic steatohepatitis could be eligible for liver transplantation...
  2. ncbi request reprint Update on the management of alcoholic steatohepatitis
    Felix Stickel
    Hepatology Unit, Klinik Beau Site, Department of Visceral Surgery and Medicine Inselspital, University of Bern, Bern, Switzerland
    J Gastrointestin Liver Dis 22:189-97. 2013
    ..Although considered a contraindication in most transplant centers, recent evidence indicates that carefully selected patients with AH could be good candidates for liver transplantation with a prognosis comparable to other indications. ..
  3. doi request reprint Critical review of the use of erythropoietin in the treatment of anaemia during therapy for chronic hepatitis C
    F Stickel
    Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland
    J Viral Hepat 19:77-87. 2012
    ..However, the evidence supporting its use in patients with pre-existing anaemia, non-1 viral genotypes, a former relapse or nonresponse, liver transplant recipients and cardiovascular or pulmonary disease is considered insufficient...
  4. doi request reprint Genetic determinants of alcoholic liver disease
    Felix Stickel
    Department of Visceral Surgery and Medicine, Inselspital, University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland
    Gut 61:150-9. 2012
    ..Subsequently, the same variant was repeatedly confirmed as the first robust genetic risk factor for progressive ALD...
  5. doi request reprint Review of liver injury associated with dietary supplements
    Felix Stickel
    Department of Visceral Surgery and Medicine, Institute of Clinical Pharmacology and Visceral Research, Inselspital, University of Berne, Berne, Switzerland
    Liver Int 31:595-605. 2011
    ..Measures to reduce risk include tighter regulation of their production and distribution and increased awareness of users and professionals of the potential risks...
  6. doi request reprint Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilis
    Felix Stickel
    Institute of Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, CH, Switzerland
    J Hepatol 50:111-7. 2009
    ..Nutritional supplements are widely used. Recently, liver injury after consumption of Herbalife preparations was reported but the underlying pathogenesis remained cryptic...
  7. doi request reprint No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Switzerland
    Alcohol Clin Exp Res 32:959-65. 2008
    ..We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics...
  8. doi request reprint Role of nutrition in liver transplantation for end-stage chronic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, Inselspital, University of Berne, Berne, Switzerland
    Nutr Rev 66:47-54. 2008
    ..Specific problems such as micronutrient deficiency, fluid balance, cholestasis, encephalopathy, and comorbid conditions need attention in order to optimize patient outcome...
  9. ncbi request reprint The role of genetic polymorphisms in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH 3010 Berne, Switzerland
    Alcohol Alcohol 41:209-24. 2006
    ....
  10. doi request reprint Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis
    Eleonora Patsenker
    Institute of Clinical Pharmacology and Visceral Research, University of Bern, Switzerland
    J Hepatol 55:388-98. 2011
    ..The aim of the present study was to compare the potential of the commonly used immunosuppressants to halt experimental liver fibrosis progression...
  11. pmc Cannabinoid receptor type I modulates alcohol-induced liver fibrosis
    Eleonora Patsenker
    Department of Clinical Pharmacology and Visceral Research, University of Bern, Switzerland
    Mol Med 17:1285-94. 2011
    ..Inhibition of CB1 by SR141716, or via genetic knock-out protects against alcoholic-induced fibrosis in vitro and in vivo...
  12. doi request reprint Role of integrins in fibrosing liver diseases
    Eleonora Patsenker
    Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Switzerland
    Am J Physiol Gastrointest Liver Physiol 301:G425-34. 2011
    ..However, accumulating evidence points to an instrumental role of integrin-mediated signaling in a variety of chronic and acute noncancerous diseases, particularly of the liver...
  13. doi request reprint Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
    Felix Stickel
    Institute of Clinical Pharmacology and Visceral Research, University of Bern, Bern, Switzerland
    Hepatology 53:86-95. 2011
    ..03). The population attributable risk of cirrhosis in alcoholic carriers of allele PNPLA3 rs738409(G) was estimated at 26.6%...
  14. doi request reprint Repeat-dose sirolimus pharmacokinetics and pharmacodynamics in patients with hepatic allografts
    Jurg Reichen
    University Clinic for Visceral Surgery and Medicine, University Hospital Inselspital, Berne, Switzerland
    Eur J Clin Pharmacol 68:589-97. 2012
    ....
  15. pmc Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
    Eleonora Patsenker
    Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland
    Gastroenterology 135:660-70. 2008
    ..Because its role in liver fibrosis is unknown, we studied alphavbeta6 function in vitro and explored the antifibrotic potential of the specific alphavbeta6 antagonist EMD527040...
  16. doi request reprint Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate
    Johann von Felden
    Department of Visceral Surgery and Medicine, University of Berne, Switzerland
    Int J Clin Pharmacol Ther 51:219-23. 2013
    ..Among the bestselling preparations are dietary supplement containing glucosamine and chondroitine sulfate taken to improve symptoms of osteoarthritis...
  17. pmc Significance of serum adiponectin levels in patients with chronic liver disease
    Maria Luisa Balmer
    Institute of Clinical Pharmacology and Visceral Research, University of Bern, Bern, Switzerland
    Clin Sci (Lond) 119:431-6. 2010
    ..In conclusion, adiponectin levels correlate positively with surrogate markers of hepatic fibrosis (transient elastography, fasting serum bile acids and hyaluronate) and are significantly elevated in cases of cirrhosis...
  18. doi request reprint Relationship between renal resistance index and renal function in liver transplant recipients after cessation of calcineurin inhibitor
    Ute Eisenberger
    Department of Nephrology and Hypertension, University of Berne, Berne, Switzerland
    Clin Transplant 23:499-504. 2009
    ..016). Individual changes of RI correlated significantly with individual changes of crea (r = 0.54, p < 0.001). Conversion from CNI to SRL can ameliorate renal function accompanied by a reduction of intrarenal RI after OLT...
  19. ncbi request reprint TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Medical University of Vienna, Austria
    Cytokine 31:142-8. 2005
    ..8 (95% CI 1.4-5.7, p = 0.004). In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg...
  20. ncbi request reprint Serum hyaluronate correlates with histological progression in alcoholic liver disease
    Felix Stickel
    Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Gastroenterol Hepatol 15:945-50. 2003
    ..In addition, serum hyaluronate was determined in 40 non-cirrhotic alcoholic patients with either a normal serum aspartate aminotransferase (AST) or an AST elevated at least two-fold...
  21. ncbi request reprint Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Hepatol 42:914-9. 2005
    ..This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC...
  22. ncbi request reprint Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers
    Nils Homann
    Department of Medicine I, University of Lubeck, Germany
    Int J Cancer 118:1998-2002. 2006
    ..11-4.36), respectively. The data identify genotype ADH1C*1/1 as an independent risk factor for the development of alcohol-associated tumors among heavy drinkers, indicating a genetic predisposition of individuals carrying this genotype...
  23. doi request reprint Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease
    Elmar Aigner
    General Hospital Oberndorf, Department of Internal Medicine, Oberndorf, Austria
    Gastroenterology 135:680-8. 2008
    ..Iron perturbations are frequently observed in nonalcoholic fatty liver disease (NAFLD). We aimed to investigate a potential association of copper status with disturbances of iron homeostasis in NAFLD...
  24. ncbi request reprint Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis
    Felix Stickel
    Department of Medicine I, University of Erlangen Nurnberg, Erlangen, Germany
    Arch Intern Med 165:1835-40. 2005
    ..Our objective was to establish the role of the functional polymorphisms of GSTP1 (codon 105 Ile-->Val) and MnSOD (codon 16 of precursor protein Ala-->Val) on the evolution of cirrhosis in patients with HHC and CHC...
  25. doi request reprint Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease
    Christoph H Osterreicher
    Department of Medicine, University of California, San Diego, Leichtag Building, Room 349 I, 9500 Gilman Drive, 0702, La Jolla, CA 92093 0702, USA
    Cytokine 42:18-23. 2008
    ..Its contribution to the progression of ALD has not been investigated sufficiently so far...
  26. ncbi request reprint Keratin variants associate with progression of fibrosis during chronic hepatitis C infection
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
    Hepatology 43:1354-63. 2006
    ..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other...
  27. ncbi request reprint Alcoholic liver disease: from pathophysiology to therapy
    Helmut K Seitz
    Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Alcohol Clin Exp Res 29:1276-81. 2005
  28. ncbi request reprint Genomics of liver fibrosis and cirrhosis
    Christoph H Osterreicher
    Department of Medicine, Division of Digestive and Liver Diseases, Columbia University, New York, New York 10032, USA
    Semin Liver Dis 27:28-43. 2007
    ....
  29. ncbi request reprint Slimming at all costs: Herbalife-induced liver injury
    Felix Stickel
    J Hepatol 47:444-6. 2007
  30. ncbi request reprint Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential
    Zili Dan
    Laboratory of Liver Research, Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
    FASEB J 19:845-7. 2005
    ..No toxicity was found with equivalent doses of the control extract from nonalcoholic rats. We demonstrate that polar retinol metabolites cause marked hepatocyte death through the induction of apoptosis...
  31. ncbi request reprint Alcoholic liver disease in the elderly
    Helmut K Seitz
    Department of Medicine and Center of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, D 69121 Heidelberg, Germany
    Clin Geriatr Med 23:905-21, viii. 2007
    ..In addition, chronic alcohol consumption may enhance drug associated liver disease and may also act as a cofactor in other liver diseases, such as viral hepatitis and nonalcoholic fatty liver disease...
  32. doi request reprint Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    Yury Popov
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Hepatol 48:453-64. 2008
    ..We studied alphavbeta6 expression in experimental and human liver fibrosis and the potential of its pharmacological inhibition for treatment of hepatic fibrosis...
  33. ncbi request reprint Herbal hepatotoxicity
    Felix Stickel
    Department of Medicine, Salem Medical Center, Heidelberg, Germany
    J Hepatol 43:901-10. 2005
  34. ncbi request reprint Hepatitis induced by Kava (Piper methysticum rhizoma)
    Felix Stickel
    Department of Medicine I, Friedrich Alexander University Erlangen Nuremberg, Ulmenweg 18, D 91054 Erlangen, Germany
    J Hepatol 39:62-7. 2003
    ..Kava root (Piper methysticum rhizoma), used frequently in Europe as a remedy against anxiety, contains kavapyrones with sedative effects. Seven case reports suggested the development of hepatitis after the intake of Kava...