L A Steiner

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi request reprint Near-infrared spectroscopy can monitor dynamic cerebral autoregulation in adults
    Luzius A Steiner
    Department of Anaesthesia, University Hospital Basel, CH 4031, Basel, Switzerland
    Neurocrit Care 10:122-8. 2009
  2. pmc Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies?
    Luzius A Steiner
    Crit Care 12:107. 2008
  3. pmc Cerebral perfusion in sepsis-associated delirium
    David Pfister
    Department of Anaesthesia, Operative Intensive Care Unit, University Hospital Basel, Spitalstrasse 21, CH 4031 Basel, Switzerland
    Crit Care 12:R63. 2008
  4. ncbi request reprint Monitoring the injured brain: ICP and CBF
    L A Steiner
    Surgical Intensive Care Unit, Department of Anaesthesia, University Hospital Basel, CH 4031 Basel, Switzerland
    Br J Anaesth 97:26-38. 2006
  5. ncbi request reprint Effects of simulated hypovolaemia on haemodynamics, left ventricular function, mesenteric blood flow and gastric Pco2
    L A Steiner
    Department of Anaesthesia, University Hospital Basel, Basel, Switzerland
    Acta Anaesthesiol Scand 51:143-50. 2007
  6. ncbi request reprint Assessment of cerebrovascular autoregulation in head-injured patients: a validation study
    Luzius A Steiner
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2404-9. 2003
  7. ncbi request reprint Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure
    Luzius A Steiner
    Department of Anaesthesia, University Hospital Basel, 4031 Basel, Switzerland
    Intensive Care Med 30:2180-7. 2004
  8. ncbi request reprint Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure
    Luzius A Steiner
    Wolfson Brain Imaging Centre, University Department of Anesthesia, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 23:1371-7. 2003
  9. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
  10. ncbi request reprint Predicting the response of intracranial pressure to moderate hyperventilation
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Acta Neurochir (Wien) 147:477-83; discussion 483. 2005

Collaborators

Detail Information

Publications48

  1. doi request reprint Near-infrared spectroscopy can monitor dynamic cerebral autoregulation in adults
    Luzius A Steiner
    Department of Anaesthesia, University Hospital Basel, CH 4031, Basel, Switzerland
    Neurocrit Care 10:122-8. 2009
    ..To study the correlation between a dynamic index of cerebral autoregulation assessed with blood flow velocity (FV) using transcranial Doppler, and a tissue oxygenation index (TOI) recorded with near-infrared spectroscopy (NIRS)...
  2. pmc Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies?
    Luzius A Steiner
    Crit Care 12:107. 2008
    ....
  3. pmc Cerebral perfusion in sepsis-associated delirium
    David Pfister
    Department of Anaesthesia, Operative Intensive Care Unit, University Hospital Basel, Spitalstrasse 21, CH 4031 Basel, Switzerland
    Crit Care 12:R63. 2008
    ..We tested the hypothesis that cerebral perfusion and selected serum markers of inflammation and delirium differ in septic patients with and without sepsis-associated delirium...
  4. ncbi request reprint Monitoring the injured brain: ICP and CBF
    L A Steiner
    Surgical Intensive Care Unit, Department of Anaesthesia, University Hospital Basel, CH 4031 Basel, Switzerland
    Br J Anaesth 97:26-38. 2006
    ..However, there is no clear evidence that incorporating data from CBF monitors into our management strategies improves outcome in brain-injured patients...
  5. ncbi request reprint Effects of simulated hypovolaemia on haemodynamics, left ventricular function, mesenteric blood flow and gastric Pco2
    L A Steiner
    Department of Anaesthesia, University Hospital Basel, Basel, Switzerland
    Acta Anaesthesiol Scand 51:143-50. 2007
    ..We investigated the cardiovascular effects of simulated hypovolaemia to determine whether it caused mesenteric ischaemia detectable by gastric tonometry...
  6. ncbi request reprint Assessment of cerebrovascular autoregulation in head-injured patients: a validation study
    Luzius A Steiner
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2404-9. 2003
    ..Cerebrovascular autoregulation is frequently measured in head-injured patients. We attempted to validate 4 bedside methods used for assessment of autoregulation...
  7. ncbi request reprint Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure
    Luzius A Steiner
    Department of Anaesthesia, University Hospital Basel, 4031 Basel, Switzerland
    Intensive Care Med 30:2180-7. 2004
    ..We investigated the time-course of changes in middle cerebral artery mean flow velocity (FVm) and intracranial pressure (ICP) in head-injured patients during sustained moderate reductions in arterial partial pressure of CO(2) (PaCO(2))...
  8. ncbi request reprint Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure
    Luzius A Steiner
    Wolfson Brain Imaging Centre, University Department of Anesthesia, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 23:1371-7. 2003
    ..Pericontusional oedema on computed tomography was associated with lower absolute values of CBF and CBV but did not differ from nonoedematous tissue in the relative response to CPP elevation...
  9. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
    ..To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury...
  10. ncbi request reprint Predicting the response of intracranial pressure to moderate hyperventilation
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Acta Neurochir (Wien) 147:477-83; discussion 483. 2005
    ..We investigated the ability of pre-hyperventilation ICP and cerebrospinal compensatory reserve to predict the reduction in ICP achievable with moderate hyperventilation in head injured patients...
  11. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  12. ncbi request reprint Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury
    A S Cunningham
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK
    Brain 128:1931-42. 2005
    ..At a voxel-based level, however (and in common with ischaemic stroke), the extent of irreversible tissue damage cannot be accurately predicted by early abnormalities of any single physiological variable...
  13. ncbi request reprint Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:17-20. 2005
    ..Our data suggest that the response of pressure reactivity to hyperventilation is heterogeneous. This could be due to hyperventilation-induced changes in cerebral metabolism, or the change in CPP...
  14. ncbi request reprint Intracranial hypertension: what additional information can be derived from ICP waveform after head injury?
    M Balestreri
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 146:131-41. 2004
    ..We have studied whether the value of ICP monitoring can be augmented by indices describing cerebrovascular pressure-reactivity and pressure-volume compensatory reserve derived from ICP and arterial blood pressure (ABP) waveforms...
  15. ncbi request reprint Cerebral autoregulation following head injury
    M Czosnyka
    Department of Neurosurgery, Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
    J Neurosurg 95:756-63. 2001
    ....
  16. pmc Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury
    L A Steiner
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 74:765-70. 2003
    ..Investigation of these relations requires quantitative measures of cerebral blood flow and CMRO(2), to allow assessment of oxygen supply and demand relations...
  17. ncbi request reprint Association between outcome, cerebral pressure reactivity and slow ICP waves following head injury
    M Balestreri
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:25-8. 2005
    ..To investigate the relationships between slow vasogenic waves ('B waves') of intracranial pressure (ICP), pressure-reactivity and outcome after traumatic brain injury...
  18. doi request reprint Bupivacaine concentrations in the lumbar cerebrospinal fluid of patients during spinal anaesthesia
    W Ruppen
    Department of Anaesthesia, University Hospital Basel, Spitalstrasse 21, Basel CH 4031, Switzerland
    Br J Anaesth 102:832-8. 2009
    ..The purpose of this study was to determine the concentration of bupivacaine in the lumbar CSF of patients with an adequate level of spinal anaesthesia after injection of plain bupivacaine 0.5%...
  19. ncbi request reprint Should we measure cerebral blood flow in head-injured patients?
    L A Steiner
    Academic Neurosurgery Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 16:429-39. 2002
    ....
  20. ncbi request reprint Continuous assessment of cerebral autoregulation: clinical and laboratory experience
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 86:581-5. 2003
    ..00002). This method can be used in many clinical scenarios for continuous monitoring of cerebral autoregulation, predicting outcome and optimising treatment strategies...
  21. pmc Effect of age on intraoperative cerebrovascular autoregulation and near-infrared spectroscopy-derived cerebral oxygenation
    C S Burkhart
    Department of Anaesthesia and Intensive Care Medicine, University Hospital Basel, Switzerland
    Br J Anaesth 107:742-8. 2011
    ....
  22. pmc Predictive value of Glasgow Coma Scale after brain trauma: change in trend over the past ten years
    M Balestreri
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 75:161-2. 2004
    ..We investigated the predictive value of the GCS in a large group of patients whose computerised multimodal bedside monitoring data had been collected over the previous 10 years...
  23. doi request reprint Effects of catecholamines on cerebral blood vessels in patients with traumatic brain injury
    D Pfister
    University Hospital Basel, Department of Anaesthesia, Basel, Switzerland
    Eur J Anaesthesiol Suppl 42:98-103. 2008
    ..This suggests that norepinephrine may be the catecholamine that is the most suitable substance to maintain or restore adequate cerebral perfusion. The data, however, are insufficient to formulate a guideline...
  24. ncbi request reprint Hyperoxia and the cerebral hemodynamic responses to moderate hyperventilation
    A J Johnston
    Department of Anaesthetics, Addenbrooke s Hospital, University of Cambridge, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Anaesthesiol Scand 47:391-6. 2003
    ..Hyperoxia is thought to modulate the production of lactic acid. This study examined the kinetics of middle cerebral artery flow velocity (MCA FV) reduction during hyperventilation, and its modulation by hyperoxia...
  25. ncbi request reprint Intracranial pressure in patients with sepsis
    D Pfister
    Department of Anaesthesia, Operative Intensive Care Unit, University Hospital Basel, Spitalstrasse 21, CH 4031 Basel, Switzerland
    Acta Neurochir Suppl 102:71-5. 2008
    ..We hypothesized that aggressive fluid administration will increase intracranial pressure (ICP) and may cause critical reductions in cerebral perfusion pressure (CPP)...
  26. ncbi request reprint Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity
    A J Johnston
    University of Cambridge Department of Anaesthetics, Box 93 and Academic Neurosurgery, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Anaesth 90:774-86. 2003
    ..This overview summarizes the available information in this area and suggests some avenues for further research...
  27. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
    ..To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury...
  28. ncbi request reprint Validation of a tonometric noninvasive arterial blood pressure monitor in the intensive care setting
    L A Steiner
    University Department of Anaesthesia and Academic Neurosurgery, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Anaesthesia 58:448-54. 2003
    ..Furthermore, there was a tendency to underestimate low pressures and overestimate high pressures. In our opinion, the Colin CBM-7000 cannot be recommended for continuous blood pressure monitoring in the intensive care setting...
  29. ncbi request reprint Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?
    Jonathan P Coles
    Division of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Brain 127:2479-90. 2004
    ..It also remains unclear whether CPP values below 65 mmHg can be safely used in this population. Clarification of the significance of a reduction in CMRO2 and neuronal electrical function will require further study...
  30. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  31. ncbi request reprint The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesth Analg 97:572-6, table of contents. 2003
    ..We propose that large doses of propofol should be used cautiously in head-injured patients, because there is the potential to increase the injured brain's vulnerability to secondary insults...
  32. ncbi request reprint Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients
    Andrew J Johnston
    University of Cambridge Department of Anaesthetics, Addenbrooke s Hospital, Box 93, Cambridge, CB2 2QQ, United Kingdom
    Intensive Care Med 30:45-50. 2004
    ..To explore the pharmacokinetics and pharmacodynamics of dopamine and norepinephrine...
  33. ncbi request reprint Asymmetry of pressure autoregulation after traumatic brain injury
    Eric A Schmidt
    Academic Neurosurgery Unit, Department of Anaesthesiology, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 99:991-8. 2003
    ..The aim of this study was to assess the asymmetry of autoregulation between the left and right sides of the brain by using bilateral transcranial Doppler ultrasonography in a cohort of patients with head injuries...
  34. ncbi request reprint The accuracy of non-invasive carbon dioxide monitoring: a clinical evaluation of two transcutaneous systems
    D Bolliger
    Department of Anaesthesia and Intensive Care Unit, University of Basel Hospital, CH 4031 Basel, Switzerland
    Anaesthesia 62:394-9. 2007
    ..We conclude that these systems cannot replace conventional blood gas analysis in the clinical setting studied...
  35. ncbi request reprint Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury
    Marcella Balestreri
    Academic Neurosurgical Unit Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 4:8-13. 2006
    ..To investigate the relationships between intracranial pressure (ICP), cerebral perfusion pressure (CPP), and outcome after traumatic brain injury...
  36. doi request reprint Monitoring of cerebrovascular autoregulation: facts, myths, and missing links
    Marek Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 10:373-86. 2009
    ....
  37. ncbi request reprint Incidence and mechanisms of cerebral ischemia in early clinical head injury
    Jonathan P Coles
    The Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:202-11. 2004
    ..The ischemic burden represented by this "traumatic penumbra" is poorly detected by bedside clinical monitors and has significant associations with outcome...
  38. ncbi request reprint Postoperative management of adult central neurosurgical patients: systemic and neuro-monitoring
    David Pfister
    Department of Anaesthesia, University Hospital Basel, CH 4031 Basel, Switzerland
    Best Pract Res Clin Anaesthesiol 21:449-63. 2007
    ..Accordingly, in most patients the decision on which monitors are to be used must be based on the patient's presentation and clinical judgment...
  39. ncbi request reprint Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury
    Luzius A Steiner
    Academic Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Crit Care Med 30:733-8. 2002
    ..To test the hypothesis that patients with poor outcome were managed at a cerebral perfusion pressure (CPP) differing more from their CPPOPT than were patients with good outcome...
  40. doi request reprint Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Neurosurg Focus 25:E2. 2008
    ..A cerebrovascular pressure reactivity index (PRx) can be determined as the moving correlation coefficient between mean intracranial pressure (ICP) and mean arterial blood pressure...
  41. ncbi request reprint Assessment of the Caradyne WhisperFlow for administration of continuous positive airway pressure in a 3 Tesla magnetic resonance scanner
    L A Steiner
    University Department of Anaesthesia and Academic Neurosurgery, Box 167, Addenbrooke s Hospital, Cambridge CB 2QQ, UK
    Anaesthesia 57:470-4. 2002
    ..In addition, the airway pressure generated by the valves was not affected by the magnetic field. We conclude that the tested system can be safely used in a 3 Tesla magnetic resonance environment...
  42. doi request reprint Bupivacaine concentrations in lumbar cerebrospinal fluid in patients with failed spinal anaesthesia
    L A Steiner
    Department of Anaesthesia, University Hospital Basel, Spitalstrasse 21, Basel CH 4031, Switzerland
    Br J Anaesth 102:839-44. 2009
    ..We report lumbar CSF concentrations of bupivacaine in 20 patients in whom adequate block after subarachnoid injection failed to develop...
  43. doi request reprint Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery--a randomized controlled trial
    Melanie Gamberini
    Department of Anesthesia, University Hospital Basel, Basel, Switzerland
    Crit Care Med 37:1762-8. 2009
    ..We tested the hypothesis that prophylactic short-term administration of oral rivastigmine, a cholinesterase inhibitor, reduces the incidence of delirium in elderly patients during the first 6 days after elective cardiac surgery...
  44. ncbi request reprint Assessing drug effects on cerebral autoregulation using the static rate of autoregulation
    Luzius A Steiner
    Anesth Analg 95:1463; author reply 1463-4. 2002
  45. ncbi request reprint Sex-related differences and traumatic brain injury
    Marcella Balestreri
    J Neurosurg 99:616; author reply 616-7. 2003
  46. ncbi request reprint Nonlinear analysis of cerebral hemodynamic and intracranial pressure signals for characterization of autoregulation
    Xiao Hu
    Brain Monitoring and Modeling Laboratory, Division of Neurosurgery, University of California, Los Angeles 90034, USA
    IEEE Trans Biomed Eng 53:195-209. 2006
    ..On the other hand, complex patterns of C measure evolution were observed among 14 cases of propofol data indicating a nontrivial effect of propofol on the dependency of CBFV on ABP...
  47. ncbi request reprint Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury
    Arun K Gupta
    Neuroscience Critical Care Unit, University of Cambridge Department of Anaesthesia, UK
    J Neurotrauma 21:678-84. 2004
    ..pH(b) differentiated between survivors and non-survivors. Measurement of pH(b) may be a useful indicator of outcome in patients with TBI...
  48. ncbi request reprint Hyperglycemia and brain tissue pH after traumatic brain injury
    David A Zygun
    Neuroscience Critical Care Unit and Department of Anaesthesia, University of Cambridge, Cambridge, England
    Neurosurgery 55:877-81; discussion 882. 2004
    ..We tested the hypothesis that blood glucose levels are associated with brain tissue pH (pH(b)) and that the correction of hyperglycemia would result in an improvement in pH(b)...