Affiliation: University of Basel
- Anniversary of the discovery of sec mutants by Novick and SchekmanAnne Spang
Growth and Development, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Mol Biol Cell 26:1783-5. 2015....
- N-glycosylation is required for secretion and mitosis in C. elegansJulia Stevens
Growth and Development, Biozentrum, University of Basel, Basel, Switzerland
PLoS ONE 8:e63687. 2013..Unexpectedly, we detected a chromosome segregation defect in ribo-1(RNAi) embryos suggesting an essential role of at least one N-glycosylated protein in metaphase-anaphase transition...
- The DSL1 complex: the smallest but not the least CATCHRAnne Spang
Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Traffic 13:908-13. 2012..In this review, different functions of the DSL1 complex are discussed, some open questions with the seemingly straightforward picture are pointed out and alternative functions of the DSL1 complex members are mentioned...
- Arf GAPs: gatekeepers of vesicle generationAnne Spang
University of Basel, Growth and Development, Biozentrum, Switzerland
FEBS Lett 584:2646-51. 2010..We discuss the roles of Arf GAPs as regulators and effectors for Arf GTP-binding proteins...
- On vesicle formation and tethering in the ER-Golgi shuttleAnne Spang
Biozentrum, Growth and Development, University of Basel, Basel, Switzerland
Curr Opin Cell Biol 21:531-6. 2009..Most likely, organized exit and arrival sites exist at each vesicular transport step along the exocytic and endocytic routes...
- On the fate of early endosomesAnne Spang
University of Basel, Biozentrum, Growth and Development, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Biol Chem 390:753-9. 2009..This brief review aims to discuss different molecular mechanisms whereby early-to-late endosome transition could be achieved...
- The life cycle of a transport vesicleA Spang
Biozentrum, Growth and Development, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Cell Mol Life Sci 65:2781-9. 2008..Recent findings imply, however, that tethers at the receiving compartment specifically detect the coat on vesicle...
- Reconstitution of retrograde transport from the Golgi to the ER in vitroA Spang
Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA
J Cell Biol 143:589-99. 1998..Putative retrograde carriers (COPI vesicles) generated from Golgi-enriched membranes contain v-SNAREs as well as Emp47p as cargo...
- Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomesA Spang
Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 95:11199-204. 1998..We conclude that Arf1p-GTP and coatomer comprise the minimum apparatus necessary to create a COPI-coated vesicle...
- The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulumA Spang
Friedrich Miescher Laboratorium, Max Planck Gesellschaft, D 72076 Tubingen, Germany
Mol Biol Cell 12:1035-45. 2001..In contrast, Sec7p, which is required for protein transport within the Golgi, is not required for retrograde protein trafficking...
- Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping functionP P Poon
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
EMBO J 18:555-64. 1999..An in vitro assay indicates that efficient retrieval from the Golgi to the ER requires these two proteins. These findings suggest that Glo3 and Gcs1 ARF GAPs mediate retrograde vesicular transport from the Golgi to the ER...