A Spang


Affiliation: University of Basel
Country: Switzerland


  1. Ståhl T, Hümmer S, Ehrenfeuchter N, Mittal N, Fucile G, Spang A. Asymmetric distribution of glucose transporter mRNA provides a growth advantage in yeast. EMBO J. 2019;: pubmed publisher
    ..Our data provide evidence that asymmetric mRNA localization is an important factor in determining cellular fitness. ..
  2. Podinovskaia M, Spang A. The Endosomal Network: Mediators and Regulators of Endosome Maturation. Prog Mol Subcell Biol. 2018;57:1-38 pubmed publisher
    ..A greater understanding of coordination and fine-tuning of endosome maturation will help us address various pathologies more effectively. ..
  3. Spang A. The Road not Taken: Less Traveled Roads from the TGN to the Plasma Membrane. Membranes (Basel). 2015;5:84-98 pubmed publisher
    ..In this review different transport pathways, with a special emphasis on exomer-dependent transport, and concepts of regulation and sorting at the TGN are discussed. ..
  4. Estrada A, Muruganandam G, Prescianotto Baschong C, Spang A. The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes. Biol Open. 2015;4:792-802 pubmed publisher
    ..Our study supports a role for ArfGAP2/3 in recycling from endosomes and in transport to the vacuole/lysosome. ..
  5. Spang A. Anniversary of the discovery of sec mutants by Novick and Schekman. Mol Biol Cell. 2015;26:1783-5 pubmed publisher
  6. Spang A. The life cycle of a transport vesicle. Cell Mol Life Sci. 2008;65:2781-9 pubmed publisher
    ..Recent findings imply, however, that tethers at the receiving compartment specifically detect the coat on vesicle. ..
  7. Spang A. On the fate of early endosomes. Biol Chem. 2009;390:753-9 pubmed publisher
    ..This brief review aims to discuss different molecular mechanisms whereby early-to-late endosome transition could be achieved. ..
  8. Spang A, Shiba Y, Randazzo P. Arf GAPs: gatekeepers of vesicle generation. FEBS Lett. 2010;584:2646-51 pubmed publisher
    ..We discuss the roles of Arf GAPs as regulators and effectors for Arf GTP-binding proteins. ..
  9. Spang A. The DSL1 complex: the smallest but not the least CATCHR. Traffic. 2012;13:908-13 pubmed publisher
    ..In this review, different functions of the DSL1 complex are discussed, some open questions with the seemingly straightforward picture are pointed out and alternative functions of the DSL1 complex members are mentioned. ..

More Information


  1. Huranová M, Muruganandam G, Weiss M, Spang A. Dynamic assembly of the exomer secretory vesicle cargo adaptor subunits. EMBO Rep. 2016;17:202-19 pubmed publisher
    ..The multifactorial assembly pathway results in an exquisitely fine-tuned adaptor complex, enabling the cell to quickly respond and adapt to changes such as stress. ..
  2. Ritz A, Trautwein M, Grassinger F, Spang A. The prion-like domain in the exomer-dependent cargo Pin2 serves as a trans-Golgi retention motif. Cell Rep. 2014;7:249-60 pubmed publisher
    ..The aggregation of Pin2 is reversible upon stress removal and Pin2 is rapidly re-exported to the plasma membrane. Altogether, these data uncover a role for PLDs as protein localization elements. ..
  3. Ackema K, Hench J, Böckler S, Wang S, Sauder U, Mergentaler H, et al. The small GTPase Arf1 modulates mitochondrial morphology and function. EMBO J. 2014;33:2659-75 pubmed publisher
    ..Thus, Arf1 is involved in mitochondrial homeostasis and dynamics, independent of its role in vesicular traffic. ..
  4. Solinger J, Spang A. Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans. Mol Biol Cell. 2014;25:3909-25 pubmed publisher
    ..We propose a model in which the SM proteins in tethering complexes are required for coordinated flux of material through the endosomal system. ..
  5. Stevens J, Spang A. Attenuation of N-glycosylation causes polarity and adhesion defects in the C. elegans embryo. J Cell Sci. 2017;130:1224-1231 pubmed publisher
    ..Our data suggest a general role for N-glycosylation in plasma membrane compartmentalization and cell polarity. ..