Research Topics
Species | Donat R SpahnSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Management of bleeding following major trauma: a European guidelineDonat R Spahn
Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
Crit Care 11:R17. 2007..Evidence-based recommendations can be made with respect to many aspects of the acute management of the bleeding trauma patient, which when implemented may lead to improved patient outcomes...
The chiasm: Transfusion practice versus patient blood managementDonat R Spahn
Institute of Anesthesiology, Section Head Medical, Anesthesiology Intensive Care Medicine OR Management, University and University Hospital Zurich, CH 8091 Zurich, Switzerland Electronic address
Best Pract Res Clin Anaesthesiol 27:37-42. 2013..PBM has been adopted by the World Health Organization as the new standard of care and all member states are urged to implement this concept. Australia is leading the world in that PBM is indeed implemented at the current time...- Severe bleeding in surgical and trauma patients: the role of fibrinogen replacement therapyDonat R Spahn
Institute of Anaesthesiology, University and University Hospital Zurich, CH 8091 Zurich, Switzerland
Thromb Res 130:S15-9. 2012.... - Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic reviewSibylle Kozek-Langenecker
Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Hans Sachs Gasse 10 12, 1180 Vienna, Austria
Crit Care 15:R239. 2011..In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive trauma setting... - Knowledge of Glasgow coma scale by air-rescue physiciansCatherine Heim
Department of Anesthesiology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
Scand J Trauma Resusc Emerg Med 17:39. 2009..To assess the theoretical and practical knowledge of the Glasgow Coma Scale (GCS) by trained Air-rescue physicians in Switzerland... - Clinical review: Prothrombin complex concentrates--evaluation of safety and thrombogenicityBenny Sørensen
Haemostasis Research Unit, Centre for Haemostasis and Thrombosis, Department of Haematology and Oncology, Guy s and St Thomas Hospital and NHS Trust Foundation, King s College London School of Medicine, 1st Floor, North Wing, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
Crit Care 15:201. 2011..The risk of a thrombotic complication due to treatment with PCCs should be weighed against the need for rapid and effective correction of coagulopathy... - Management of bleeding following major trauma: an updated European guidelineRolf Rossaint
Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
Crit Care 14:R52. 2010..Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes... - Anemia and patient blood management in hip and knee surgery: a systematic review of the literatureDonat R Spahn
Institute of Anesthesiology, University Hospital and University of Zurich, Zurich, Switzerland
Anesthesiology 113:482-95. 2010..High-impact prospective studies are necessary to confirm these findings and establish firm clinical guidelines... 
Impact of the C2/C6 ratio of high-molecular-weight hydroxyethyl starch on pharmacokinetics and blood coagulation in pigsSebastian Schramm
Department of Anesthesiology, University Hospital Lausanne, Switzerland
Anesthesiology 107:442-51. 2007..The authors assessed in vivo the effect of a lowered C2/C6 ratio on pharmacokinetic characteristics and the impact on blood coagulation of high-molecular-weight, low-substituted HES...- Novel starches: single-dose pharmacokinetics and effects on blood coagulationCaveh Madjdpour
Department of Anesthesiology, Division of Clinical Pharmacology and Toxicology, University Hospital Lausanne, Switzerland
Anesthesiology 106:132-43. 2007..The goal of the current study was to determine the pharmacokinetics of CMS and CM-HES and to investigate their influence on blood coagulation in comparison with the standard low-molecular, low-substituted HES (130/0.42) used in Europe... - Mismatch of arterial and central venous blood gas analysis during haemorrhageOliver M Theusinger
Institute of Anaesthesiology, University Hospital Zurich, Zurich
Eur J Anaesthesiol 27:890-6. 2010..Arterial base excess and lactate levels are key parameters in the assessment of critically ill patients. The use of venous blood gas analysis may be of clinical interest when no arterial blood is available initially... - Haemoglobin, oxygen carriers and perioperative organ perfusionRoman Kocian
Institute of Anaesthesiology, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland
Best Pract Res Clin Anaesthesiol 22:63-80. 2008..Research into some of these compounds has been discontinued, while others have advanced into clinical phase III trials, but none has achieved market approval for Europe, US or Canada so far... - Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe traumaOliver M Theusinger
Institute of Anesthesiology, Clinic of Cardiac and Vascular Surgery, University Hospital Zurich, and Institute of Sockal and Preventive Medicine, University of Zurich, CH 8091 Zurich, Switzerland
Anesth Analg 113:1003-12. 2011..We investigated whether hyperfibrinolysis and its severity was associated with outcome of traumatized and nontraumatized patients... - Allogeneic red blood cell transfusion: physiology of oxygen transportCaveh Madjdpour
Department of Anoesthesiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
Best Pract Res Clin Anaesthesiol 21:163-71. 2007..Therefore, the goal of this article is to review the basics of oxygen transport and normovolaemic anaemia... - Artificial O2 carriers: status in 2005Donat R Spahn
Department of Anesthesiology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
Curr Pharm Des 11:4099-114. 2005..The most advanced products are in clinical phase III trials but no product has achieved market approval yet in the US, Europe or Canada... - Strategies to reduce the use of blood products: a European perspectiveOliver M Theusinger
Institute of Anesthesiology, University Hospital and University of Zurich, Switzerland
Curr Opin Anaesthesiol 25:59-65. 2012..The aim of this review is to discuss the rationale for patient blood management, explain patient blood management in detail including modern and future transfusion strategies... - In vitro factor XIII supplementation increases clot firmness in Rotation Thromboelastometry (ROTEM)Oliver M Theusinger
Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
Thromb Haemost 104:385-91. 2010.... - The effect of hydroxyethyl starches (HES 130/0.42 and HES 200/0.5) on activated renal tubular epithelial cellsMoritz Wittlinger
Institute of Anesthesiology, University of Zurich, Zurich, Switzerland
Anesth Analg 110:531-40. 2010..We established an in vitro model of tumor necrosis factor-alpha (TNF-alpha)-stimulated human proximal tubular epithelial (HK-2) cells to assess the possible effects of HES 130/0.42 and HES 200/0.5 on these activated cells... - Effect of high- and low-molecular-weight low-substituted hydroxyethyl starch on blood coagulation during acute normovolemic hemodilution in pigsCaroline Thyes
Department of Anesthesiology, Division of Clinical Pharmacology and Toxicology, University Hospital Lausanne, Switzerland
Anesthesiology 105:1228-37. 2006..In addition, HES 650/0.42 may have a lower efficacy in immediately restoring plasma volume... - Impact of preoperative right-ventricular function and platelet transfusion on outcome after lung transplantationMarco P Zalunardo
Institute of Anaesthesiology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Eur J Cardiothorac Surg 39:538-42. 2011..We investigated the impact of poor preoperative right-ventricular function and blood-product use on outcome after lung transplantation... - Effects of blood products on inflammatory response in endothelial cells in vitroMartin Urner
Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
PLoS ONE 7:e33403. 2012..Experiments were designed to assess the inflammatory potential of different blood products in an endothelial cell-based in vitro model and to compare baseline levels of potentially activating substances in transfusion products... - The revised digital transcutaneous PCO2/SpO2 ear sensor is a reliable noninvasive monitoring tool in patients after cardiac surgeryRegine Roediger
Institute of Anaesthesiology, University Hospital of Zurich, Zurich, Switzerland
J Cardiothorac Vasc Anesth 25:243-9. 2011.... - Transfusion in trauma: why and how should we change our current practice?Oliver M Theusinger
Institute of Anesthesiology, University Hospital and University of Zurich, Zurich, Switzerland
Curr Opin Anaesthesiol 22:305-12. 2009..The aim of this review is to emphasize why bleeding and coagulation has to be monitored closely in trauma patients and to discuss the rationale behind modern and future transfusion strategies... - Current status of artificial O2 carriersCaroline Thyes
Department of Anesthesiology, University Hospital Lausanne, CHUV) CH-1011 Lausanne, Switzerland
Anesthesiol Clin North America 23:373-89, viii. 2005.... - Anesthetic-induced improvement of the inflammatory response to one-lung ventilationElisena de Conno
Institute of Anesthesiology, University of Zurich, Zurich, Switzerland
Anesthesiology 110:1316-26. 2009..The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess possible immunomodulatory effects of the anesthetics propofol and sevoflurane... - Perioperative antiplatelet therapyPierre Guy Chassot
Institute of Anesthesiology, University Hospital of Lausanne, Lausanne, Switzerland
Am Fam Physician 82:1484-9. 2010..g., intracranial, posterior eye chamber) or surgeries associated with massive bleeding and difficult hemostasis... - Anemia and perioperative red blood cell transfusion: a matter of toleranceCaveh Madjdpour
Department of Anesthesiology, University Hospital (CHUV, Lausanne, Switzerland
Crit Care Med 34:S102-8. 2006..Therefore, knowing the compensatory mechanisms during acute anemia is crucial. This review focuses on acute anemia tolerance, its limits, and physiologic transfusion triggers in the perioperative period... - Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controMichael Zaugg
Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
Anesthesiology 107:33-44. 2007..Neuraxial blockade is used as primary anesthetic technique in one third of surgical procedures. The authors tested whether bisoprolol would protect patients at risk for cardiovascular complications undergoing surgery with spinal block... - A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anestheticBeatrice Beck-Schimmer
Swiss HPB Hepato Pancreatico Biliary Center, University of Zurich, Zurich, Switzerland
Ann Surg 248:909-18. 2008..To evaluate the effects of pharmacological preconditioning with a volatile anesthetic in patients undergoing liver resection with inflow occlusion... - Strategies for transfusion therapyDonat R Spahn
Department of Anesthesiology, University Hospital Lausanne Chuv, CH 1011 Lausanne, Switzerland
Best Pract Res Clin Anaesthesiol 18:661-73. 2004.... - Sensitivities of rat primary sensory afferent nerves to magnesium: implications for differential nerve blocksNisha Vastani
Institute of Anaesthesiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
Eur J Anaesthesiol 30:21-8. 2013..Contrasting findings have been published regarding the role of magnesium sulphate used as an additive to local anaesthetics in peripheral nerve blocks... - Cement-augmented dorsal instrumentation of the spine as a safe adjunct to the multimodal management of metastatic pheochromocytoma: a case reportDaniel Rittirsch
Division of Trauma Surgery, University Hospital Zurich, Switzerland
Patient Saf Surg 6:1. 2012..Nevertheless, direct manipulation of metastatic lesions should be avoided as far as possible in order to minimize the risk of hemodynamic complications... - Validity of an arterial pressure waveform analysis device: does the puncture site play a role in the agreement with intermittent pulmonary artery catheter thermodilution measurements?Sebastian Schramm
Department of Anesthesiology, University Hospital Lausanne, Lausanne, Switzerland
J Cardiothorac Vasc Anesth 24:250-6. 2010..This study was conducted to determine if there is an impact of the arterial catheter site and to investigate the accuracy of this system when compared with the pulmonary artery catheter using the bolus thermodilution technique (PAC)... - Transfusion in the cardiac patientDonat R Spahn
Department of Anesthesiology, University Hospital Lausanne Chuv, CH 1011 Lausanne, Switzerland
Crit Care Clin 20:269-79. 2004.... - Allogeneic blood transfusions: benefit, risks and clinical indications in countries with a low or high human development indexCarlos Marcucci
Department of Anesthesiology, University Hospital Lausanne, CH-1011 Lausanne, Switzerland
Br Med Bull 70:15-28. 2004..In countries with a low HDI, clinical signs of circulatory failure or myocardial ischaemia and an Hb level <5 g/dl can serve as transfusion guidelines... - Urological surgery and antiplatelet drugs after cardiac and cerebrovascular accidentsDaniel Eberli
Urology Clinic, University Hospital Zurich, CH 8091 Zurich, Switzerland
J Urol 183:2128-36. 2010..We assess the current scientific evidence and propose strategies concerning treatment of these patients... - Resuscitation and transfusion management in trauma patients: emerging conceptsOliver M Theusinger
aInstitute for Anesthesiology, University Hospital Zurich, Zurich, Switzerland bInstitute of Anesthesiology, Medical Section Anesthesiology, Intensive Care Medicine and OR Management University Hospital Zurich and University of Zurich, Zurich, Switzerland
Curr Opin Crit Care 18:661-70. 2012.... - The effect of clonidine on perioperative blood coagulationMichael T Ganter
Department of Anesthesiology, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland
J Clin Anesth 17:456-62. 2005..Until day of discharge, no thrombotic or thromboembolic events were reported in both groups. CONCLUSIONS: Preoperative administration of a single dose of clonidine has no effect on perioperative blood coagulation... - Transfusion-transmissible infections and transfusion-related immunomodulationFelix Buddeberg
Institute of Anaesthesiology, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
Best Pract Res Clin Anaesthesiol 22:503-17. 2008..Although transfusion-related immunomodulation is thought to be mediated mainly by donor white blood cells, the benefit of leukoreduction on overall mortality and on infectious complications is highly debatable... - Molecular evidence of late preconditioning after sevoflurane inhalation in healthy volunteersEliana Lucchinetti
Institute of Anesthesiology, University Hospital Zurich, Switzerland
Anesth Analg 105:629-40. 2007..We hypothesized that sevoflurane inhalation would modify the transcriptome in human blood and modulate the expression of adhesion molecules in white blood cells consistent with the occurrence of a late preconditioning phase... - Prevalence of medication overuse headache in an interdisciplinary pain clinicCorinne Wanner Schmid
Institute of Anesthesiology, University Hospital of Zurich, Ramistrasse 100, Zurich 8091, Switzerland
J Headache Pain 14:4. 2013..The aim was the evaluation of the diagnostic criteria of MOH in a mixed population of chronic pain patients to gain information about the prevalence and possible associations with MOH... - Propofol decreases the axonal excitability in rat primary sensory afferentsLisa Neukom
Institute of Anesthesiology, University Hospital of Zurich, Switzerland
Life Sci 90:343-50. 2012..The aim of this present study was to investigate the changes of peripheral sensory nerve excitability produced by propofol... - Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patientsSylvain Gander
Department of Anesthesiology, University Hospital, CHUV BH-10, CH-1011 Lausanne, Switzerland
Anesth Analg 100:580-4. 2005..002). Pao(2) was higher before apnea in the PEEP group (P = 0.038). Application of positive airway pressure during induction of general anesthesia in morbidly obese patients increases nonhypoxic apnea duration by 50%... - Acute normovolemic hemodilution: physiology, limitations, and clinical useMarina Jamnicki
Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
J Cardiothorac Vasc Anesth 17:747-54. 2003 - The place of artificial oxygen carriers in reducing allogeneic blood transfusions and augmenting tissue oxygenationDonat R Spahn
Department of Anesthesiology, University Hospital Lausanne (CHUV, CH-1011 Lausanne, Switzerland
Can J Anaesth 50:S41-7. 2003 - Blood management in intensive care medicine: CRIT and ABC--what can we learn?Donat R Spahn
Department of Anesthesiology, University Hospital Lausanne, Switzerland
Crit Care 8:89-90. 2004.... - Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective studyOliver M Theusinger
Department of Anesthesiology, University Hospital and University of Lausanne, Switzerland
Anesthesiology 107:923-7. 2007..Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron... - Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter studyKarine Julier
Department of Anesthesiology, University Hospital Lausanne, Switzerland
Anesthesiology 98:1315-27. 2003..This study demonstrated for the first time translocation of protein kinase C isoforms delta and epsilon in human myocardium in response to sevoflurane... - Prevention of atelectasis formation during the induction of general anesthesia in morbidly obese patientsMarta Coussa
Department of Anesthesiology, University Hospital, Lausanne, Switzerland
Anesth Analg 98:1491-5, table of contents. 2004..Therefore, this technique should be considered for anesthesia induction in morbidly obese patients... - Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neuronsMarie Pertin
Anesthesiology Pain Research Group, Department of Anesthesiology, Lausanne University Hospital, CH 1011 Lausanne, Switzerland
J Neurosci 25:10970-80. 2005.... - Artificial oxygen carriers: status 2002Donat R Spahn
Department of Anesthesiology, University Hospital Lausanne (CHUV, Lausanne, Switzerland
Vox Sang 83:281-5. 2002 - Is the effect of inguinal field block with 0.5% bupivacaine on postoperative pain after hernia repair enhanced by addition of ketorolac or S(+) ketamine?Steve Clerc
Department of Anesthesiology, University Hospital, Lausanne, Switzerland
Clin J Pain 21:101-5. 2005..The aim of the study was to assess whether coadministration of S(+) ketamine or ketorolac would enhance or prolong local analgesic effect of bupivacaine after inguinal hernia repair... - Perflubron emulsion in prolonged hemorrhagic shock: influence on hepatocellular energy metabolism and oxygen-dependent gene expressionMarkus Paxian
, , Hamburg, Germany
Anesthesiology 98:1391-9. 2003..The improved hepatocellular oxygen availability is reflected in normalization of oxygen-dependent gene expression. However, improved oxygen availability failed to affect early hepatocellular injury... - Nonsurgical treatment of major bleedingRolf Rossaint
Department of Anesthesiology, Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
Anesthesiol Clin 25:35-48, viii. 2007..If bleeding cannot be stopped by these measures, adjunctive use of fibrinogen or recombinant activated factor VII (rFVIIa) have the potential to correct systemic coagulopathy associated with massive blood loss and its management... - Perioperative beta-adrenergic receptor blockade: physiologic foundations and clinical controversiesMartin J London
Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
Anesthesiology 100:170-5. 2004 - Estimating the cost of blood: past, present, and future directionsAryeh Shander
Department of Anesthesiology and Critical Care, New Jersey Institute for the Advancement of Bloodless Medicine and Surgery Englewood Hospital and Medical Center, 350 Engle Street, Englewood, NJ 07631, USA
Best Pract Res Clin Anaesthesiol 21:271-89. 2007..g., academic, private, multi- or single-center clinic). These initiatives, their rationale, importance, and future directions are described... - Fluid resuscitation in the intensive care unitThomas A Neff
N Engl J Med 351:1905-8; author reply 1905-8. 2004 - Key issues in advanced bleeding care in traumaRolf Rossaint
Department of Anaesthesiology, University Hospital Aachen, Aachen
Shock 26:322-31. 2006..This state-of-the-art review aims to address key issues in acute control of bleeding in the trauma patient... - Esmolol improves left ventricular function via enhanced beta-adrenergic receptor signaling in a canine model of coronary revascularizationJohn V Booth
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesthesiology 97:162-9. 2002..0008). CONCLUSIONS: These data provide prospective evidence that esmolol administration results in improved myocardial function. Furthermore, the mechanism appears to involve enhanced myocardial beta AR signaling... - Hypocalcemia in trauma: frequent but frequently undetected and underestimatedDonat R Spahn
Crit Care Med 33:2124-5. 2005 - Complications of different ventilation strategies in endoscopic laryngeal surgery: a 10-year reviewYves Jaquet
Department of Otolaryngology, Head and Neck Surgery, University Hospital of Lausanne, Switzerland
Anesthesiology 104:52-9. 2006..The aim of this study was to investigate specific complications of each technique, with special emphasis on transtracheal and transglottal jet ventilation... - Physiologic transfusion triggers: do we have to use (our) brain?Donat R Spahn
Anesthesiology 104:905-6. 2006 - Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding--a European perspectiveJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Free University of Brussels, B 1070 Brussels, Belgium
Crit Care 10:R120. 2006..Our aim was to develop consensus guidelines for use of recombinant activated factor VII (rFVIIa) in massive hemorrhage... - Perioperative use of anti-platelet drugsPierre Guy Chassot
Department of Anoesthesiology, University Hospital Lausanne Chuv, Bugnon 46, CH 1011 Lausanne, Switzerland
Best Pract Res Clin Anaesthesiol 21:241-56. 2007..Clopidogrel is mandatory as long as the coronary stents are not fully endothelialized, which takes 6-24 weeks depending on the technique used, but might be required for a longer period... - Pragmatic treatment versus elaborative but incomplete testing: a Hobson's choice?Donat R Spahn
Anesthesiology 107:526-9. 2007 - The effect of increased FIO(2) before tracheal extubation on postoperative atelectasisZilgia Benoît
Department of Anesthesiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse
Anesth Analg 95:1777-81, table of contents. 2002..IMPLICATIONS: For safety reasons, it is common to ventilate patients with 100% oxygen before tracheal extubation. This study demonstrates that this practice favors postoperative atelectasis...