Donat R Spahn

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Management of bleeding following major trauma: a European guideline
    Donat R Spahn
    Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Crit Care 11:R17. 2007
  2. ncbi request reprint Allogeneic red blood cell transfusion: physiology of oxygen transport
    Caveh Madjdpour
    Department of Anoesthesiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Best Pract Res Clin Anaesthesiol 21:163-71. 2007
  3. doi request reprint Alternatives to blood transfusion
    Donat R Spahn
    Institute of Anaesthesiology, University and University Hospital Zurich, Zurich, Switzerland
    Lancet 381:1855-65. 2013
  4. doi request reprint The chiasm: transfusion practice versus patient blood management
    Donat R Spahn
    Institute of Anesthesiology, Section Head Medical, Anesthesiology Intensive Care Medicine OR Management, University and University Hospital Zurich, CH 8091 Zurich, Switzerland
    Best Pract Res Clin Anaesthesiol 27:37-42. 2013
  5. doi request reprint Severe bleeding in surgical and trauma patients: the role of fibrinogen replacement therapy
    Donat R Spahn
    Institute of Anaesthesiology, University and University Hospital Zurich, CH 8091 Zurich, Switzerland
    Thromb Res 130:S15-9. 2012
  6. pmc Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review
    Sibylle Kozek-Langenecker
    Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Hans Sachs Gasse 10 12, 1180 Vienna, Austria
    Crit Care 15:R239. 2011
  7. pmc Clinical review: Prothrombin complex concentrates--evaluation of safety and thrombogenicity
    Benny Sørensen
    Haemostasis Research Unit, Centre for Haemostasis and Thrombosis, Department of Haematology and Oncology, Guy s and St Thomas Hospital and NHS Trust Foundation, King s College London School of Medicine, 1st Floor, North Wing, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Crit Care 15:201. 2011
  8. pmc Management of bleeding following major trauma: an updated European guideline
    Rolf Rossaint
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
    Crit Care 14:R52. 2010
  9. doi request reprint Anemia and patient blood management in hip and knee surgery: a systematic review of the literature
    Donat R Spahn
    Institute of Anesthesiology, University Hospital and University of Zurich, Zurich, Switzerland
    Anesthesiology 113:482-95. 2010
  10. ncbi request reprint Impact of the C2/C6 ratio of high-molecular-weight hydroxyethyl starch on pharmacokinetics and blood coagulation in pigs
    Sebastian Schramm
    Department of Anesthesiology, University Hospital Lausanne, Switzerland
    Anesthesiology 107:442-51. 2007

Detail Information

Publications72

  1. pmc Management of bleeding following major trauma: a European guideline
    Donat R Spahn
    Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Crit Care 11:R17. 2007
    ..Evidence-based recommendations can be made with respect to many aspects of the acute management of the bleeding trauma patient, which when implemented may lead to improved patient outcomes...
  2. ncbi request reprint Allogeneic red blood cell transfusion: physiology of oxygen transport
    Caveh Madjdpour
    Department of Anoesthesiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Best Pract Res Clin Anaesthesiol 21:163-71. 2007
    ..Therefore, the goal of this article is to review the basics of oxygen transport and normovolaemic anaemia...
  3. doi request reprint Alternatives to blood transfusion
    Donat R Spahn
    Institute of Anaesthesiology, University and University Hospital Zurich, Zurich, Switzerland
    Lancet 381:1855-65. 2013
    ..We summarise the current roles of alternatives to blood in the management of medical and surgical anaemias...
  4. doi request reprint The chiasm: transfusion practice versus patient blood management
    Donat R Spahn
    Institute of Anesthesiology, Section Head Medical, Anesthesiology Intensive Care Medicine OR Management, University and University Hospital Zurich, CH 8091 Zurich, Switzerland
    Best Pract Res Clin Anaesthesiol 27:37-42. 2013
    ..PBM has been adopted by the World Health Organization as the new standard of care and all member states are urged to implement this concept. Australia is leading the world in that PBM is indeed implemented at the current time...
  5. doi request reprint Severe bleeding in surgical and trauma patients: the role of fibrinogen replacement therapy
    Donat R Spahn
    Institute of Anaesthesiology, University and University Hospital Zurich, CH 8091 Zurich, Switzerland
    Thromb Res 130:S15-9. 2012
    ....
  6. pmc Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review
    Sibylle Kozek-Langenecker
    Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Hans Sachs Gasse 10 12, 1180 Vienna, Austria
    Crit Care 15:R239. 2011
    ..In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive trauma setting...
  7. pmc Clinical review: Prothrombin complex concentrates--evaluation of safety and thrombogenicity
    Benny Sørensen
    Haemostasis Research Unit, Centre for Haemostasis and Thrombosis, Department of Haematology and Oncology, Guy s and St Thomas Hospital and NHS Trust Foundation, King s College London School of Medicine, 1st Floor, North Wing, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Crit Care 15:201. 2011
    ..The risk of a thrombotic complication due to treatment with PCCs should be weighed against the need for rapid and effective correction of coagulopathy...
  8. pmc Management of bleeding following major trauma: an updated European guideline
    Rolf Rossaint
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
    Crit Care 14:R52. 2010
    ..Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes...
  9. doi request reprint Anemia and patient blood management in hip and knee surgery: a systematic review of the literature
    Donat R Spahn
    Institute of Anesthesiology, University Hospital and University of Zurich, Zurich, Switzerland
    Anesthesiology 113:482-95. 2010
    ..High-impact prospective studies are necessary to confirm these findings and establish firm clinical guidelines...
  10. ncbi request reprint Impact of the C2/C6 ratio of high-molecular-weight hydroxyethyl starch on pharmacokinetics and blood coagulation in pigs
    Sebastian Schramm
    Department of Anesthesiology, University Hospital Lausanne, Switzerland
    Anesthesiology 107:442-51. 2007
    ..The authors assessed in vivo the effect of a lowered C2/C6 ratio on pharmacokinetic characteristics and the impact on blood coagulation of high-molecular-weight, low-substituted HES...
  11. doi request reprint The influence of laboratory coagulation tests and clotting factor levels on Rotation Thromboelastometry (ROTEM(R)) during major surgery with hemorrhage
    Oliver M Theusinger
    Institute of Anesthesiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Anesth Analg 117:314-21. 2013
    ....
  12. doi request reprint Is dilutional coagulopathy induced by different colloids reversible by replacement of fibrinogen and factor XIII concentrates?
    Stephanie L Kind
    From the Institute of Anesthesiology and Clinic of Cardiac and Vascular Surgery, University and University Hospital Zurich, Switzerland Department of Anesthesiology, Metro Health Medical Center, Cleveland, Ohio and Division of Biostatistics, Institute of Social and Preventive Medicine, University of Zurich, Switzerland
    Anesth Analg 117:1063-71. 2013
    ..In this in vitro trial, we assessed the effect on blood coagulation of 60% dilution with different colloids and investigated reversibility by replacement of factor XIII (F XIII), fibrinogen, and the combination of fibrinogen and F XIII...
  13. ncbi request reprint Novel starches: single-dose pharmacokinetics and effects on blood coagulation
    Caveh Madjdpour
    Department of Anesthesiology, Division of Clinical Pharmacology and Toxicology, University Hospital Lausanne, Switzerland
    Anesthesiology 106:132-43. 2007
    ..The goal of the current study was to determine the pharmacokinetics of CMS and CM-HES and to investigate their influence on blood coagulation in comparison with the standard low-molecular, low-substituted HES (130/0.42) used in Europe...
  14. doi request reprint Mismatch of arterial and central venous blood gas analysis during haemorrhage
    Oliver M Theusinger
    Institute of Anaesthesiology, University Hospital Zurich, Zurich
    Eur J Anaesthesiol 27:890-6. 2010
    ..Arterial base excess and lactate levels are key parameters in the assessment of critically ill patients. The use of venous blood gas analysis may be of clinical interest when no arterial blood is available initially...
  15. ncbi request reprint Haemoglobin, oxygen carriers and perioperative organ perfusion
    Roman Kocian
    Institute of Anaesthesiology, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland
    Best Pract Res Clin Anaesthesiol 22:63-80. 2008
    ..Research into some of these compounds has been discontinued, while others have advanced into clinical phase III trials, but none has achieved market approval for Europe, US or Canada so far...
  16. doi request reprint Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma
    Oliver M Theusinger
    Institute of Anesthesiology, Clinic of Cardiac and Vascular Surgery, University Hospital Zurich, and Institute of Sockal and Preventive Medicine, University of Zurich, CH 8091 Zurich, Switzerland
    Anesth Analg 113:1003-12. 2011
    ..We investigated whether hyperfibrinolysis and its severity was associated with outcome of traumatized and nontraumatized patients...
  17. doi request reprint Continuous low-dose aspirin therapy in robotic-assisted laparoscopic radical prostatectomy does not increase risk of surgical hemorrhage
    Ashkan Mortezavi
    Department of Urology, University Hospital Zurich, Zurich, Switzerland
    J Laparoendosc Adv Surg Tech A 23:500-5. 2013
    ..In this retrospective study we analyzed the risk for perioperative bleeding and surgical outcome after RARP with OAT...
  18. ncbi request reprint Artificial O2 carriers: status in 2005
    Donat R Spahn
    Department of Anesthesiology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
    Curr Pharm Des 11:4099-114. 2005
    ..The most advanced products are in clinical phase III trials but no product has achieved market approval yet in the US, Europe or Canada...
  19. doi request reprint Transfusion in trauma: why and how should we change our current practice?
    Oliver M Theusinger
    Institute of Anesthesiology, University Hospital and University of Zurich, Zurich, Switzerland
    Curr Opin Anaesthesiol 22:305-12. 2009
    ..The aim of this review is to emphasize why bleeding and coagulation has to be monitored closely in trauma patients and to discuss the rationale behind modern and future transfusion strategies...
  20. doi request reprint Strategies to reduce the use of blood products: a European perspective
    Oliver M Theusinger
    Institute of Anesthesiology, University Hospital and University of Zurich, Switzerland
    Curr Opin Anaesthesiol 25:59-65. 2012
    ..The aim of this review is to discuss the rationale for patient blood management, explain patient blood management in detail including modern and future transfusion strategies...
  21. ncbi request reprint Effect of high- and low-molecular-weight low-substituted hydroxyethyl starch on blood coagulation during acute normovolemic hemodilution in pigs
    Caroline Thyes
    Department of Anesthesiology, Division of Clinical Pharmacology and Toxicology, University Hospital Lausanne, Switzerland
    Anesthesiology 105:1228-37. 2006
    ..The current study aimed to investigate in vivo the isolated effect of molecular weight on blood coagulation during progressive acute normovolemic hemodilution...
  22. doi request reprint In vitro factor XIII supplementation increases clot firmness in Rotation Thromboelastometry (ROTEM)
    Oliver M Theusinger
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Thromb Haemost 104:385-91. 2010
    ....
  23. doi request reprint The effect of hydroxyethyl starches (HES 130/0.42 and HES 200/0.5) on activated renal tubular epithelial cells
    Moritz Wittlinger
    Institute of Anesthesiology, University of Zurich, Zurich, Switzerland
    Anesth Analg 110:531-40. 2010
    ..We established an in vitro model of tumor necrosis factor-alpha (TNF-alpha)-stimulated human proximal tubular epithelial (HK-2) cells to assess the possible effects of HES 130/0.42 and HES 200/0.5 on these activated cells...
  24. doi request reprint Impact of preoperative right-ventricular function and platelet transfusion on outcome after lung transplantation
    Marco P Zalunardo
    Institute of Anaesthesiology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 39:538-42. 2011
    ..We investigated the impact of poor preoperative right-ventricular function and blood-product use on outcome after lung transplantation...
  25. doi request reprint Anesthetic-induced improvement of the inflammatory response to one-lung ventilation
    Elisena de Conno
    Institute of Anesthesiology, University of Zurich, Zurich, Switzerland
    Anesthesiology 110:1316-26. 2009
    ..The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess possible immunomodulatory effects of the anesthetics propofol and sevoflurane...
  26. doi request reprint Resuscitation and transfusion management in trauma patients: emerging concepts
    Oliver M Theusinger
    Institute for Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Curr Opin Crit Care 18:661-70. 2012
    ....
  27. pmc Effects of blood products on inflammatory response in endothelial cells in vitro
    Martin Urner
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e33403. 2012
    ..Experiments were designed to assess the inflammatory potential of different blood products in an endothelial cell-based in vitro model and to compare baseline levels of potentially activating substances in transfusion products...
  28. doi request reprint The revised digital transcutaneous PCO2/SpO2 ear sensor is a reliable noninvasive monitoring tool in patients after cardiac surgery
    Regine Roediger
    Institute of Anaesthesiology, University Hospital of Zurich, Zurich, Switzerland
    J Cardiothorac Vasc Anesth 25:243-9. 2011
    ....
  29. doi request reprint Sensitivities of rat primary sensory afferent nerves to magnesium: implications for differential nerve blocks
    Nisha Vastani
    Institute of Anaesthesiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Eur J Anaesthesiol 30:21-8. 2013
    ..Contrasting findings have been published regarding the role of magnesium sulphate used as an additive to local anaesthetics in peripheral nerve blocks...
  30. ncbi request reprint Anemia and perioperative red blood cell transfusion: a matter of tolerance
    Caveh Madjdpour
    Department of Anesthesiology, University Hospital CHUV, Lausanne, Switzerland
    Crit Care Med 34:S102-8. 2006
    ..Therefore, knowing the compensatory mechanisms during acute anemia is crucial. This review focuses on acute anemia tolerance, its limits, and physiologic transfusion triggers in the perioperative period...
  31. ncbi request reprint Current status of artificial O2 carriers
    Caroline Thyes
    Department of Anesthesiology, University Hospital Lausanne, CHUV CH 1011 Lausanne, Switzerland
    Anesthesiol Clin North America 23:373-89, viii. 2005
    ....
  32. ncbi request reprint Perioperative antiplatelet therapy
    Pierre Guy Chassot
    Institute of Anesthesiology, University Hospital of Lausanne, Lausanne, Switzerland
    Am Fam Physician 82:1484-9. 2010
    ..g., intracranial, posterior eye chamber) or surgeries associated with massive bleeding and difficult hemostasis...
  33. doi request reprint Urological surgery and antiplatelet drugs after cardiac and cerebrovascular accidents
    Daniel Eberli
    Urology Clinic, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Urol 183:2128-36. 2010
    ..We assess the current scientific evidence and propose strategies concerning treatment of these patients...
  34. doi request reprint A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic
    Beatrice Beck-Schimmer
    Swiss HPB Hepato Pancreatico Biliary Center, University of Zurich, Zurich, Switzerland
    Ann Surg 248:909-18. 2008
    ..To evaluate the effects of pharmacological preconditioning with a volatile anesthetic in patients undergoing liver resection with inflow occlusion...
  35. ncbi request reprint Strategies for transfusion therapy
    Donat R Spahn
    Department of Anesthesiology, University Hospital Lausanne Chuv, CH 1011 Lausanne, Switzerland
    Best Pract Res Clin Anaesthesiol 18:661-73. 2004
    ....
  36. ncbi request reprint Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-contro
    Michael Zaugg
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Anesthesiology 107:33-44. 2007
    ..Neuraxial blockade is used as primary anesthetic technique in one third of surgical procedures. The authors tested whether bisoprolol would protect patients at risk for cardiovascular complications undergoing surgery with spinal block...
  37. ncbi request reprint Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse
    Anne Frédérique Bourquin
    Anesthesiology Pain Research Group, Department of Anesthesiology, Lausanne University Hospital CHUV, CH 1011 Lausanne, Switzerland
    Pain 122:14.e1-14. 2006
    ..Use of this model in genetically altered mice should be very effective for determining the mechanisms involved in neuropathic pain...
  38. doi request reprint Preconditioning depolarizing ramp currents enhance the effect of sodium channel blockers in primary sensory afferents
    Nisha Vastani
    Institute of Anesthesiology, University Hospital of Zurich, Zurich, Switzerland
    Neuromodulation 16:336-44. 2013
    ..This study investigated the role of subthreshold preconditioning ramp currents on axonal nerve excitability parameters in the presence of sodium channel blockers in myelinated A and unmyelinated C fibers...
  39. pmc Cement-augmented dorsal instrumentation of the spine as a safe adjunct to the multimodal management of metastatic pheochromocytoma: a case report
    Daniel Rittirsch
    Division of Trauma Surgery, University Hospital Zurich, Switzerland
    Patient Saf Surg 6:1. 2012
    ..Nevertheless, direct manipulation of metastatic lesions should be avoided as far as possible in order to minimize the risk of hemodynamic complications...
  40. ncbi request reprint Transfusion in the cardiac patient
    Donat R Spahn
    Department of Anesthesiology, University Hospital Lausanne Chuv, CH 1011 Lausanne, Switzerland
    Crit Care Clin 20:269-79. 2004
    ....
  41. doi request reprint Validity of an arterial pressure waveform analysis device: does the puncture site play a role in the agreement with intermittent pulmonary artery catheter thermodilution measurements?
    Sebastian Schramm
    Department of Anesthesiology, University Hospital Lausanne, Lausanne, Switzerland
    J Cardiothorac Vasc Anesth 24:250-6. 2010
    ..This study was conducted to determine if there is an impact of the arterial catheter site and to investigate the accuracy of this system when compared with the pulmonary artery catheter using the bolus thermodilution technique (PAC)...
  42. ncbi request reprint Allogeneic blood transfusions: benefit, risks and clinical indications in countries with a low or high human development index
    Carlos Marcucci
    Department of Anesthesiology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
    Br Med Bull 70:15-28. 2004
    ..In countries with a low HDI, clinical signs of circulatory failure or myocardial ischaemia and an Hb level <5 g/dl can serve as transfusion guidelines...
  43. pmc Blood management in intensive care medicine: CRIT and ABC--what can we learn?
    Donat R Spahn
    Department of Anesthesiology, University Hospital Lausanne, Switzerland
    Crit Care 8:89-90. 2004
    ....
  44. pmc Prevalence of medication overuse headache in an interdisciplinary pain clinic
    Corinne Wanner Schmid
    Institute of Anesthesiology, University Hospital of Zurich, Ramistrasse 100, Zurich 8091, Switzerland
    J Headache Pain 14:4. 2013
    ..The aim was the evaluation of the diagnostic criteria of MOH in a mixed population of chronic pain patients to gain information about the prevalence and possible associations with MOH...
  45. doi request reprint Propofol decreases the axonal excitability in rat primary sensory afferents
    Lisa Neukom
    Institute of Anesthesiology, University Hospital of Zurich, Switzerland
    Life Sci 90:343-50. 2012
    ..The aim of this present study was to investigate the changes of peripheral sensory nerve excitability produced by propofol...
  46. ncbi request reprint Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study
    Oliver M Theusinger
    Department of Anesthesiology, University Hospital and University of Lausanne, Switzerland
    Anesthesiology 107:923-7. 2007
    ..Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron...
  47. ncbi request reprint Transfusion-transmissible infections and transfusion-related immunomodulation
    Felix Buddeberg
    Institute of Anaesthesiology, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Best Pract Res Clin Anaesthesiol 22:503-17. 2008
    ..Although transfusion-related immunomodulation is thought to be mediated mainly by donor white blood cells, the benefit of leukoreduction on overall mortality and on infectious complications is highly debatable...
  48. ncbi request reprint The effect of clonidine on perioperative blood coagulation
    Michael T Ganter
    Department of Anesthesiology, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Clin Anesth 17:456-62. 2005
    ..To evaluate the influence of perioperative stress protection by clonidine on blood coagulation...
  49. ncbi request reprint Molecular evidence of late preconditioning after sevoflurane inhalation in healthy volunteers
    Eliana Lucchinetti
    Institute of Anesthesiology, University Hospital Zurich, Switzerland
    Anesth Analg 105:629-40. 2007
    ..We hypothesized that sevoflurane inhalation would modify the transcriptome in human blood and modulate the expression of adhesion molecules in white blood cells consistent with the occurrence of a late preconditioning phase...
  50. ncbi request reprint Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons
    Marie Pertin
    Anesthesiology Pain Research Group, Department of Anesthesiology, Lausanne University Hospital, CH 1011 Lausanne, Switzerland
    J Neurosci 25:10970-80. 2005
    ....
  51. pmc Knowledge of Glasgow coma scale by air-rescue physicians
    Catherine Heim
    Department of Anesthesiology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Scand J Trauma Resusc Emerg Med 17:39. 2009
    ..To assess the theoretical and practical knowledge of the Glasgow Coma Scale (GCS) by trained Air-rescue physicians in Switzerland...
  52. ncbi request reprint Acute normovolemic hemodilution: physiology, limitations, and clinical use
    Marina Jamnicki
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    J Cardiothorac Vasc Anesth 17:747-54. 2003
  53. ncbi request reprint Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients
    Sylvain Gander
    Department of Anesthesiology, University Hospital, CHUV BH 10, CH 1011 Lausanne, Switzerland
    Anesth Analg 100:580-4. 2005
    ..002). Pao(2) was higher before apnea in the PEEP group (P = 0.038). Application of positive airway pressure during induction of general anesthesia in morbidly obese patients increases nonhypoxic apnea duration by 50%...
  54. ncbi request reprint The place of artificial oxygen carriers in reducing allogeneic blood transfusions and augmenting tissue oxygenation
    Donat R Spahn
    Department of Anesthesiology, University Hospital Lausanne Chuv, CH 1011 Lausanne, Switzerland
    Can J Anaesth 50:S41-7. 2003
  55. ncbi request reprint Prevention of atelectasis formation during the induction of general anesthesia in morbidly obese patients
    Marta Coussa
    Department of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 98:1491-5, table of contents. 2004
    ..Therefore, this technique should be considered for anesthesia induction in morbidly obese patients...
  56. ncbi request reprint Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study
    Karine Julier
    Department of Anesthesiology, University Hospital Lausanne, Switzerland
    Anesthesiology 98:1315-27. 2003
    ..In addition, several variables associated with the protective effects of preconditioning were evaluated...
  57. ncbi request reprint Artificial oxygen carriers: status 2002
    Donat R Spahn
    Department of Anesthesiology, University Hospital Lausanne Chuv, Lausanne, Switzerland
    Vox Sang 83:281-5. 2002
  58. ncbi request reprint Is the effect of inguinal field block with 0.5% bupivacaine on postoperative pain after hernia repair enhanced by addition of ketorolac or S(+) ketamine?
    Steve Clerc
    Department of Anesthesiology, University Hospital, Lausanne, Switzerland
    Clin J Pain 21:101-5. 2005
    ..The aim of the study was to assess whether coadministration of S(+) ketamine or ketorolac would enhance or prolong local analgesic effect of bupivacaine after inguinal hernia repair...
  59. ncbi request reprint Perflubron emulsion in prolonged hemorrhagic shock: influence on hepatocellular energy metabolism and oxygen-dependent gene expression
    Markus Paxian
    Klinik für Anaesthesiologie und Intensivmedizin, Universitat des Saarlandes, Hamburg, Germany
    Anesthesiology 98:1391-9. 2003
    ..Artificial oxygen carriers may improve oxygen supply to vital organs while avoiding the need for allogeneic transfusion...
  60. ncbi request reprint Nonsurgical treatment of major bleeding
    Rolf Rossaint
    Department of Anesthesiology, Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Anesthesiol Clin 25:35-48, viii. 2007
    ..If bleeding cannot be stopped by these measures, adjunctive use of fibrinogen or recombinant activated factor VII (rFVIIa) have the potential to correct systemic coagulopathy associated with massive blood loss and its management...
  61. ncbi request reprint Perioperative beta-adrenergic receptor blockade: physiologic foundations and clinical controversies
    Martin J London
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Anesthesiology 100:170-5. 2004
  62. ncbi request reprint Estimating the cost of blood: past, present, and future directions
    Aryeh Shander
    Department of Anesthesiology and Critical Care, New Jersey Institute for the Advancement of Bloodless Medicine and Surgery Englewood Hospital and Medical Center, 350 Engle Street, Englewood, NJ 07631, USA
    Best Pract Res Clin Anaesthesiol 21:271-89. 2007
    ..g., academic, private, multi- or single-center clinic). These initiatives, their rationale, importance, and future directions are described...
  63. ncbi request reprint The effect of increased FIO(2) before tracheal extubation on postoperative atelectasis
    Zilgia Benoît
    Department of Anesthesiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse
    Anesth Analg 95:1777-81, table of contents. 2002
    ..A safety margin in terms of oxygenation during tracheal extubation is essential, and further studies should therefore evaluate whether atelectasis formation could be prevented despite the use of 100% oxygen...
  64. ncbi request reprint Perioperative use of anti-platelet drugs
    Pierre Guy Chassot
    Department of Anoesthesiology, University Hospital Lausanne Chuv, Bugnon 46, CH 1011 Lausanne, Switzerland
    Best Pract Res Clin Anaesthesiol 21:241-56. 2007
    ..Clopidogrel is mandatory as long as the coronary stents are not fully endothelialized, which takes 6-24 weeks depending on the technique used, but might be required for a longer period...
  65. ncbi request reprint Hypocalcemia in trauma: frequent but frequently undetected and underestimated
    Donat R Spahn
    Crit Care Med 33:2124-5. 2005
  66. ncbi request reprint Esmolol improves left ventricular function via enhanced beta-adrenergic receptor signaling in a canine model of coronary revascularization
    John V Booth
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 97:162-9. 2002
    ..The authors also tested whether the mechanism includes preserved beta AR signaling...
  67. ncbi request reprint Fluid resuscitation in the intensive care unit
    Thomas A Neff
    N Engl J Med 351:1905-8; author reply 1905-8. 2004
  68. ncbi request reprint Physiologic transfusion triggers: do we have to use (our) brain?
    Donat R Spahn
    Anesthesiology 104:905-6. 2006
  69. pmc Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding--a European perspective
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, B 1070 Brussels, Belgium
    Crit Care 10:R120. 2006
    ..Our aim was to develop consensus guidelines for use of recombinant activated factor VII (rFVIIa) in massive hemorrhage...
  70. ncbi request reprint Key issues in advanced bleeding care in trauma
    Rolf Rossaint
    Department of Anaesthesiology, University Hospital Aachen, Aachen
    Shock 26:322-31. 2006
    ..This state-of-the-art review aims to address key issues in acute control of bleeding in the trauma patient...
  71. ncbi request reprint Pragmatic treatment versus elaborative but incomplete testing: a Hobson's choice?
    Donat R Spahn
    Anesthesiology 107:526-9. 2007
  72. ncbi request reprint Complications of different ventilation strategies in endoscopic laryngeal surgery: a 10-year review
    Yves Jaquet
    Department of Otolaryngology, Head and Neck Surgery, University Hospital of Lausanne, Switzerland
    Anesthesiology 104:52-9. 2006
    ..The aim of this study was to investigate specific complications of each technique, with special emphasis on transtracheal and transglottal jet ventilation...