Thomas A Smith

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Measures of clinical malaria in field trials of interventions against Plasmodium falciparum
    Thomas A Smith
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Malar J 6:53. 2007
  2. pmc Estimation of heterogeneity in malaria transmission by stochastic modelling of apparent deviations from mass action kinetics
    Thomas A Smith
    Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basel, Switzerland
    Malar J 7:12. 2008
  3. pmc The dynamics of natural Plasmodium falciparum infections
    Ingrid Felger
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e45542. 2012
  4. pmc A novel approach for measuring the burden of uncomplicated Plasmodium falciparum malaria: application to data from Zambia
    Valerie Crowell
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 8:e57297. 2013
  5. pmc What should vaccine developers ask? Simulation of the effectiveness of malaria vaccines
    Melissa A Penny
    Swiss Tropical Institute, Basel, Switzerland
    PLoS ONE 3:e3193. 2008
  6. pmc Spatial and temporal dynamics of malaria transmission in rural Western Kenya
    Nyaguara Amek
    Kenya Medical Research Institute Centers for Disease Control and Prevention CDC Research and Public Health Collaboration, P O Box 1578, Kisumu, Kenya
    Parasit Vectors 5:86. 2012
  7. pmc Spatio-temporal malaria transmission patterns in Navrongo demographic surveillance site, northern Ghana
    Simon Kasasa
    Swiss Tropical and Public Health Institute, Socinstrasse 57, P, O, Box 4002, Basel, Switzerland
    Malar J 12:63. 2013
  8. pmc Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission
    Bernadette J Huho
    Ifakara Health Institute, Dar es Salaam, Tanzania
    Malar J 11:118. 2012
  9. pmc Selection of mosquito life-histories: a hidden weapon against malaria?
    Heather M Ferguson
    Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, UK
    Malar J 11:106. 2012
  10. pmc Ensemble modeling of the likely public health impact of a pre-erythrocytic malaria vaccine
    Thomas Smith
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Med 9:e1001157. 2012

Detail Information

Publications89

  1. pmc Measures of clinical malaria in field trials of interventions against Plasmodium falciparum
    Thomas A Smith
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Malar J 6:53. 2007
    ....
  2. pmc Estimation of heterogeneity in malaria transmission by stochastic modelling of apparent deviations from mass action kinetics
    Thomas A Smith
    Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basel, Switzerland
    Malar J 7:12. 2008
    ..It is proposed that the level of micro-heterogeneity can be estimated from statistical models that estimate the amount of variation in transmission most compatible with a mass-action model for the relationship of infection to exposure...
  3. pmc The dynamics of natural Plasmodium falciparum infections
    Ingrid Felger
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e45542. 2012
    ..Consequently, information on effects of host immune status or age on infection dynamics is fragmentary...
  4. pmc A novel approach for measuring the burden of uncomplicated Plasmodium falciparum malaria: application to data from Zambia
    Valerie Crowell
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 8:e57297. 2013
    ..To obtain valid estimates of the overall malaria burden using these methods, there remains a need for surveys to include the whole range of ages of hosts in the population and for data on seasonality patterns in confirmed case series...
  5. pmc What should vaccine developers ask? Simulation of the effectiveness of malaria vaccines
    Melissa A Penny
    Swiss Tropical Institute, Basel, Switzerland
    PLoS ONE 3:e3193. 2008
    ....
  6. pmc Spatial and temporal dynamics of malaria transmission in rural Western Kenya
    Nyaguara Amek
    Kenya Medical Research Institute Centers for Disease Control and Prevention CDC Research and Public Health Collaboration, P O Box 1578, Kisumu, Kenya
    Parasit Vectors 5:86. 2012
    ..There are few studies examining the extent and drivers of local variation in malaria exposure in endemic areas...
  7. pmc Spatio-temporal malaria transmission patterns in Navrongo demographic surveillance site, northern Ghana
    Simon Kasasa
    Swiss Tropical and Public Health Institute, Socinstrasse 57, P, O, Box 4002, Basel, Switzerland
    Malar J 12:63. 2013
    ..This study analysed data from Kassena-Nankana districts in northern Ghana to obtain small area estimates of malaria transmission rates allowing for this uncertainty...
  8. pmc Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission
    Bernadette J Huho
    Ifakara Health Institute, Dar es Salaam, Tanzania
    Malar J 11:118. 2012
    ..However, this has never been verified at a population level in a setting with intense transmission, where chronically infectious asymptomatic carriers are common and cured patients are rapidly and repeatedly re-infected...
  9. pmc Selection of mosquito life-histories: a hidden weapon against malaria?
    Heather M Ferguson
    Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow, UK
    Malar J 11:106. 2012
    ....
  10. pmc Ensemble modeling of the likely public health impact of a pre-erythrocytic malaria vaccine
    Thomas Smith
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Med 9:e1001157. 2012
    ..Their applicability to low transmission settings is unclear. Evaluations of the efficiency of different deployment strategies in diverse settings should consider uncertainties in model structure...
  11. doi request reprint Reproduction numbers in malaria and their implications
    Thomas Smith
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Trends Parasitol 28:3-8. 2012
    ..This has importance for both formal modeling of malaria and for planning malaria intervention strategies in the field...
  12. pmc Impact of promoting longer-lasting insecticide treatment of bed nets upon malaria transmission in a rural Tanzanian setting with pre-existing high coverage of untreated nets
    Tanya L Russell
    Biomedical and Environmental Thematic Group, Ifakara Health Institute, P O Box 53, Ifakara, Tanzania
    Malar J 9:187. 2010
    ..Since 2006, a national-scale programme has promoted the use of longer-lasting insecticide treatment kits (consisting of an insecticide plus binder) co-packaged with all bed nets manufactured in the country...
  13. pmc Malaria and its possible control on the island of Príncipe
    Reto Hagmann
    Swiss Tropical Institute, Socinstrasse 57, P O Box, CH 4002 Basel, Switzerland
    Malar J 2:15. 2003
    ....
  14. pmc Rapid Urban Malaria Appraisal (RUMA) II: epidemiology of urban malaria in Dar es Salaam (Tanzania)
    Shr Jie Wang
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Malar J 5:28. 2006
    ..The thinking behind malaria research and control strategies stems largely from experience gained in rural areas and needs to be adapted to the urban environment...
  15. pmc Spatial distribution of the chromosomal forms of anopheles gambiae in Mali
    Nafomon Sogoba
    Malaria Research and Training Center, Faculte de Medecine, de Pharmacie et d Ondoto Stomatologie, Université de Bamako, BP, 1805, Bamako, Mali
    Malar J 7:205. 2008
    ..gambiae s.s. is not yet available at country level to support control efforts...
  16. pmc Detectability of Plasmodium falciparum clones
    Michael T Bretscher
    Swiss TPH, Basel, Switzerland
    Malar J 9:234. 2010
    ..Detectability can be estimated by typing repeated samples from the same host but it has been unclear what should be the time interval between the samples and how the data should be analysed...
  17. pmc Interpreting malaria age-prevalence and incidence curves: a simulation study of the effects of different types of heterogeneity
    Amanda Ross
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 9:132. 2010
    ..Little is known about their impact on the shape of age-prevalence and incidence curves. In this study, the effects of heterogeneity in transmission, treatment-seeking and risk of co-morbidity were simulated...
  18. pmc Comparative performance of the Mbita trap, CDC light trap and the human landing catch in the sampling of Anopheles arabiensis, An. funestus and culicine species in a rice irrigation in western Kenya
    Evan M Mathenge
    International Centre of Insect Physiology and Ecology, Mbita Point Research and Training Centre, Mbita Point, Kenya
    Malar J 4:7. 2005
    ..This study reports a field evaluation of the Mbita trap in a rice irrigation scheme in Kenya..
  19. pmc MalHaploFreq: a computer programme for estimating malaria haplotype frequencies from blood samples
    Ian M Hastings
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Malar J 7:130. 2008
    ..For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish the relative frequencies of the mutant and wildtypes i.e. 1:3, 2:2 or 3:1...
  20. pmc Spatio-temporal analysis of the role of climate in inter-annual variation of malaria incidence in Zimbabwe
    Musawenkoi L H Mabaso
    Malaria Research Lead Programme, Medical Research Council, P O Box 70380, Overport 4067, Durban, South Africa
    Int J Health Geogr 5:20. 2006
    ..We used Bayesian negative binomial models for spatio-temporal analysis of the relationship between annual malaria incidence and selected climatic covariates at a district level in Zimbabwe from 1988-1999...
  21. pmc Quantifying behavioural interactions between humans and mosquitoes: evaluating the protective efficacy of insecticidal nets against malaria transmission in rural Tanzania
    Gerry F Killeen
    Ifakara Health Research and Development Centre, Box 53, Ifakara, Morogoro, United Republic of Tanzania
    BMC Infect Dis 6:161. 2006
    ..Behavioural adaptation by mosquitoes to increasing ITN coverage could allow vector mosquitoes to bite outside of peak sleeping hours and undermine efficacy of this key malaria prevention measure...
  22. pmc Cost-sharing strategies combining targeted public subsidies with private-sector delivery achieve high bednet coverage and reduced malaria transmission in Kilombero Valley, southern Tanzania
    G F Killeen
    Ifakara Health Research and Development Centre, Box 53, Ifakara, Morogoro, United Republic of Tanzania
    BMC Infect Dis 7:121. 2007
    ..Here we evaluate resulting changes in bednet coverage and malaria transmission...
  23. doi request reprint Towards a comprehensive simulation model of malaria epidemiology and control
    T Smith
    Swiss Tropical Institute, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
    Parasitology 135:1507-16. 2008
    ..The project thus provides a general platform for comparing, fitting, and evaluating different model structures, and for quantitative prediction of effects of different interventions and integrated control programmes...
  24. ncbi request reprint Commentary: malaria death rates remain highly pertinent
    Tom Smith
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
    Int J Epidemiol 35:704-5. 2006
  25. ncbi request reprint Consequences of multiple infection with Plasmodium falciparum in an area of high endemicity
    T Smith
    Swiss Tropical Institute, Basel, Switzerland
    Parassitologia 41:247-50. 1999
    ..The normal situation for P. falciparum is one in which the host is partially immune, and competition between parasite genotypes in this situation is not expected to result in selection for virulence...
  26. ncbi request reprint Bayesian age-stage modelling of Plasmodium falciparum sequestered parasite loads in severe malaria patients
    T Smith
    Swiss Tropical Institute, Socinstrasse 57, Postfach, CH 4002, Basel, Switzerland
    Parasitology 129:289-99. 2004
    ..The resulting models should prove a useful tool for cross-validating biochemical approaches for estimating the sequestered load...
  27. ncbi request reprint Relationships between the outcome of Plasmodium falciparum infection and the intensity of transmission in Africa
    T Smith
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 71:80-6. 2004
    ..The effects of transmission reduction on mortality rates in older age groups are also uncertain. However, it is clear that reduction of exposure during infancy is not reflected in increased mortality at older ages...
  28. ncbi request reprint Child mortality and malaria transmission intensity in Africa
    T A Smith
    Swiss Tropical Institute, Socinstrasse 57, PO Box CH 4002, Basel, Switzerland
    Trends Parasitol 17:145-9. 2001
    ..falciparum...
  29. ncbi request reprint Estimation of infection and recovery rates for highly polymorphic parasites when detectability is imperfect, using hidden Markov models
    Tom Smith
    Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basel, Switzerland
    Stat Med 22:1709-24. 2003
    ..This analysis confirmed that the duration of infections with parasites belonging to the MSP-2 FC27 allelic family increased with age...
  30. ncbi request reprint Mosquito nets for the elderly?
    T Smith
    Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    Trans R Soc Trop Med Hyg 96:37-8. 2002
    ..There may be substantial benefits of malaria transmission reduction for older people, that have been overlooked in public health programmes and burden of disease calculations...
  31. doi request reprint Uses of mosquito-stage transmission-blocking vaccines against Plasmodium falciparum
    Thomas A Smith
    Swiss Tropical and Public Health Institute, Socinstrasse 57, P O Box, CH 4002 Basel, Switzerland
    Trends Parasitol 27:190-6. 2011
    ....
  32. pmc Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance
    Jutta Marfurt
    Swiss Tropical Institute, Department of Medical Parasitology and Infection Biology, and Department of Public Health and Epidemiology, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
    Malar J 9:8. 2010
    ....
  33. pmc Rapid Urban Malaria Appraisal (RUMA) IV: epidemiology of urban malaria in Cotonou (Benin)
    Shr Jie Wang
    Swiss Tropical Institute STI, P O Box, CH 4002 Basel, Switzerland
    Malar J 5:45. 2006
    ..An estimated 40 % of the population in Benin lives in urban areas. The purpose of the study was to estimate malaria endemicity and the fraction of malaria-attributable fevers in health facilities in Cotonou...
  34. pmc Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1424. 2011
    ..02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and monitoring the effects of interventions...
  35. doi request reprint Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua New Guinea
    Christian Nsanzabana
    Swiss Tropical Institute, Basel, and 2Institut de biologie, Universite de Neuchatel, Neuchatel, Switzerland
    J Infect Dis 201:435-43. 2010
    ..Our estimates of mutation and haplotype frequencies provide estimates of selection coefficients acting in this environment, which are key parameters for understanding the dynamics of resistance...
  36. pmc High sensitivity detection of Plasmodium species reveals positive correlations between infections of different species, shifts in age distribution and reduced local variation in Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Malar J 8:41. 2009
    ....
  37. pmc Rapid Urban Malaria Appraisal (RUMA) III: epidemiology of urban malaria in the municipality of Yopougon (Abidjan)
    Shr Jie Wang
    Swiss Tropical Institute STI, P O Box, CH 4002 Basel, Switzerland
    Malar J 5:29. 2006
    ..The prevalence of malaria, its distribution in the city and the fractions of fevers attributable to malaria in the health facilities have not been previously investigated...
  38. pmc Rapid urban malaria appraisal (RUMA) I: epidemiology of urban malaria in Ouagadougou
    Shr Jie Wang
    Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Malar J 4:43. 2005
    ..Rapid urbanization in sub-Saharan Africa has a major impact on malaria epidemiology. While much is known about malaria in rural areas in Burkina Faso, the urban situation is less well understood...
  39. pmc Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province 441, Papua New Guinea
    Proc Natl Acad Sci U S A 109:10030-5. 2012
    ....
  40. pmc Simulation of the cost-effectiveness of malaria vaccines
    Fabrizio Tediosi
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:127. 2009
    ..This analysis needs to consider a range of delivery modalities to ensure that clinical development plans can be aligned with the most appropriate deployment strategies...
  41. pmc Reporting diarrhoea through a vernacular term in Quechua-speaking settings of rural Bolivia
    Gonzalo Duran Pacheco
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    J Health Popul Nutr 29:552-9. 2011
    ..An average specificity of at least 97% and the sensitivity of at least 50% were obtained. The findings suggest that the use of k'echalera would identify fewer cases of diarrhoea than a symptom-based definition in rural Bolivia...
  42. pmc Three different Plasmodium species show similar patterns of clinical tolerance of malaria infection
    Ivo Muller
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:158. 2009
    ..There is little data on the age dependence of tolerance in other species of human malaria...
  43. pmc How much remains undetected? Probability of molecular detection of human Plasmodia in the field
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 6:e19010. 2011
    ..falciparum and P. vivax parasite clones in consecutive samples of the same patient and at investigating the impact of sampling strategies on basic epidemiological measures such as multiplicity of infection (MOI)...
  44. ncbi request reprint A prospective study of Plasmodium falciparum multiplicity of infection and morbidity in Tanzanian children
    L Henning
    Swiss Tropical Institute, Socinstrasse 57, P O Box, CH 4002, Basel, Switzerland
    Trans R Soc Trop Med Hyg 98:687-94. 2004
    ..These results provide further evidence that relationships between asymptomatic malaria infections and clinical malaria change with cumulative exposure...
  45. ncbi request reprint A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea
    Blaise Genton
    Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    J Infect Dis 185:820-7. 2002
    ..The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types...
  46. pmc Simulation of malaria epidemiology and control in the highlands of Western Kenya
    Erin M Stuckey
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, Postfach, Basel, CH 4002, Switzerland
    Malar J 11:357. 2012
    ..This work investigates the applicability of mathematical modelling of malaria transmission dynamics in Rachuonyo South, a district with low, unstable transmission in the highlands of western Kenya...
  47. ncbi request reprint Predicting the cost-effectiveness of introducing a pre-erythrocytic malaria vaccine into the expanded program on immunization in Tanzania
    Fabrizio Tediosi
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 75:131-43. 2006
    ..The cost-effectiveness ratio increases rapidly and approximately linearly with vaccine cost per dose. The approach can be adopted for comparative analyses of the cost effectiveness of different vaccines and other intervention strategies...
  48. doi request reprint Estimating malaria transmission through mathematical models
    Erin M Stuckey
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, Postfach, 4002 Basel, Switzerland University of Basel, Petersplatz 1, 4003 Basel, Switzerland Electronic address
    Trends Parasitol 29:477-82. 2013
    ..Results from such models can provide public health officials with accurate estimates of transmission, by seasonal pattern, that are necessary for assessing and tailoring malaria control and elimination programs to specific settings. ..
  49. pmc Simulated impact of RTS,S/AS01 vaccination programs in the context of changing malaria transmission
    Alan Brooks
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e32587. 2012
    ..It is critical to anticipate where and how it should be implemented if trials are successful. Such planning may be complicated by changing levels of malaria transmission...
  50. ncbi request reprint The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. II. Mortality and morbidity
    B Genton
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Ann Trop Med Parasitol 89:377-90. 1995
    ....
  51. pmc The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea
    Jutta Marfurt
    Swiss Tropical Institute, Socinstrasse 57, P, O, Box, CH 4002 Basel, Switzerland
    Malar J 7:61. 2008
    ..In Papua New Guinea (PNG), combination therapy with amodiaquine (AQ) or chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) was introduced as first-line treatment against uncomplicated malaria in 2000...
  52. pmc Modelling the cost-effectiveness of mass screening and treatment for reducing Plasmodium falciparum malaria burden
    Valerie Crowell
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel, Switzerland
    Malar J 12:4. 2013
    ..falciparum malaria disease-burden reduction in settings with varying receptivity (ability of the combined vector population in a setting to transmit disease) and access to case management...
  53. pmc Malaria--a major health problem within an oil palm plantation around Popondetta, Papua New Guinea
    Bianca Pluess
    Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:56. 2009
    ..This study provides an overview of the malaria epidemiology within an oil palm plantation in Popondetta, south-eastern Papua New Guinea, its implication for the company with its employees and their families and the potential for control...
  54. doi request reprint Cost-effectiveness of the introduction of a pre-erythrocytic malaria vaccine into the expanded program on immunization in sub-Saharan Africa: analysis of uncertainties using a stochastic individual-based simulation model of Plasmodium falciparum malaria
    Nicolas Maire
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Value Health 14:1028-38. 2011
    ....
  55. ncbi request reprint Prospective risk of morbidity in relation to multiplicity of infection with Plasmodium falciparum in São Tomé
    D A Muller
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basle, Switzerland
    Acta Trop 78:155-62. 2001
    ..This weak age-dependence in clinical immunity might be a consequence of a cohort effect resulting from resurgence of the disease after the breakdown of malaria control programs in the 1980s...
  56. ncbi request reprint The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity
    B Genton
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Ann Trop Med Parasitol 89:359-76. 1995
    ..Identification of significant temporal and local variations in malaria endemicity is important for the design and evaluation of intervention studies, including field trials of an antimalarial vaccine...
  57. pmc Measurement of overall insecticidal effects in experimental hut trials
    Olivier J T Briët
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland
    Parasit Vectors 5:256. 2012
    ..This paper critically examines the way the effect is defined, and discusses how it can be used to infer effectiveness of intervention programmes...
  58. pmc Implementing new health interventions in developing countries: why do we lose a decade or more?
    Alan Brooks
    Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel, CH 4002, Switzerland
    BMC Public Health 12:683. 2012
    ..We evaluated five milestones for each intervention, and assessed if the milestones were associated with beginning implementation...
  59. ncbi request reprint Malaria mapping using transmission models: application to survey data from Mali
    A Gemperli
    Biostatistics and Basic Epidemiology Group, Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Am J Epidemiol 163:289-97. 2006
    ..The approach makes more efficient use of the available data than do previous malaria mapping methods, and it produces highly plausible maps of malaria distribution...
  60. ncbi request reprint Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers
    L B Ochola
    Swiss Tropical Institute, Socinstrasse 57, Postfach, CH 4002, Basel, Switzerland
    Parasitology 131:449-58. 2005
    ..Longitudinal analyses are needed that allow for the clearance rates of the marker molecules and for variations between hosts in the history of parasitaemia...
  61. pmc Rapid urban malaria appraisal (RUMA) in sub-Saharan Africa
    Shr Jie Wang
    Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Malar J 4:40. 2005
    ..The rapid urban malaria appraisal (RUMA) methodology aims to provide a cost-effective tool to conduct rapid assessments of the malaria situation in urban sub-Saharan Africa and to improve the understanding of urban malaria epidemiology...
  62. pmc Importance of factors determining the effective lifetime of a mass, long-lasting, insecticidal net distribution: a sensitivity analysis
    Olivier J T Briët
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 11:20. 2012
    ..Because its effects on transmission are important (more so than the effects of individual protection), estimates of the lifetime of mass distribution rounds should be based on the effective length of epidemiological protection...
  63. pmc In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78
    Urs Duthaler
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Antimicrob Agents Chemother 54:4596-604. 2010
    ..When combined, synergistic but also antagonistic effects depending on the doses administered were observed, which should be elucidated in more detail in future studies...
  64. pmc A research agenda for malaria eradication: modeling
    Marcel Tanner
    PLoS Med 8:e1000403. 2011
    ....
  65. ncbi request reprint Urbanization in sub-saharan Africa and implication for malaria control
    Jennifer Keiser
    Office of Population Research, Princeton University, Princeton, New Jersey, 08544, USA
    Am J Trop Med Hyg 71:118-27. 2004
    ..Mitigation of the current burden of malaria in urban African settings, in turn, is a necessity for stimulating environmentally and socially sustainable development...
  66. ncbi request reprint Effect of strategic gastrointestinal nematode control on faecal egg count in traditional West African cattle
    J Zinsstag
    Swiss Tropical Institute, Basle
    Vet Res 31:259-66. 2000
    ..The financial evaluation of anthelmintic interventions cannot be predicted from FEC and must necessarily rely on the direct monitoring of livestock productivity parameters...
  67. ncbi request reprint Associations of peak shifts in age--prevalence for human malarias with bednet coverage
    T Smith
    Papua New Guinea Institute of Medical Research, P O Box 378, Madang, Papua New Guinea
    Trans R Soc Trop Med Hyg 95:1-6. 2001
    ..vivax. It is concluded that short-term variations in inoculation rate are not important determinants of parasite prevalence in this population...
  68. ncbi request reprint Heritability of gastrointestinal nematode faecal egg counts in West African village N'Dama cattle and its relation to age
    J Zinsstag
    Swiss Tropical Institute, PO Box, Socinstrasse 7, CH 4002, Basle, Switzerland
    Vet Parasitol 89:71-8. 2000
    ....
  69. ncbi request reprint Premunition in Plasmodium falciparum infection: insights from the epidemiology of multiple infections
    T Smith
    Swiss Tropical Institute, Basel, Switzerland
    Trans R Soc Trop Med Hyg 93:59-64. 1999
    ..This has important implications for our understanding of immunity against P. falciparum, its ecological niche, and the epidemiological impact of interventions against it...
  70. ncbi request reprint Effect of insecticide-treated bed nets on the dynamics of multiple Plasmodium falciparum infections
    T Smith
    Swiss Tropical Institute, Basel, Switzerland
    Trans R Soc Trop Med Hyg 93:53-7. 1999
    ..This suggests that, in areas of high P. falciparum endemicity, ITNs have little effect on the establishment of chronic malaria infection...
  71. ncbi request reprint Dynamics of multiple Plasmodium falciparum infections in infants in a highly endemic area of Tanzania
    T Smith
    Swiss Tropical Institute, Basel, Switzerland
    Trans R Soc Trop Med Hyg 93:35-9. 1999
    ....
  72. ncbi request reprint Spatial patterns of infant mortality in Mali: the effect of malaria endemicity
    A Gemperli
    Swiss Tropical Institute, Basel, Switzerland
    Am J Epidemiol 159:64-72. 2004
    ..However, at points very remote from those sampled, it is important to consider prediction error...
  73. ncbi request reprint Distribution of survival times of deliberate Plasmodium falciparum infections in tertiary syphilis patients
    W Sama
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basel, Switzerland
    Trans R Soc Trop Med Hyg 100:811-6. 2006
    ..It is desirable to know the correct distribution because its shape profoundly influences the length of monitoring needed in an intervention programme for eliminating or reducing malaria...
  74. ncbi request reprint Multiple Plasmodium falciparum infections in Tanzanian infants
    I Felger
    Swiss Tropical Institute, Basel, Switzerland
    Trans R Soc Trop Med Hyg 93:29-34. 1999
    ..The findings help in the understanding of infection dynamics, premunition, and development of semi-immunity in malaria...
  75. ncbi request reprint Age and seasonal variation in the transition rates and detectability of Plasmodium falciparum malaria
    W Sama
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basel, Switzerland
    Parasitology 132:13-21. 2006
    ..The best fitting models had no age dependence in infection or clearance rates, suggesting that acquired immunity mainly affects detectability...
  76. ncbi request reprint Bayesian modelling of geostatistical malaria risk data
    L Gosoniu
    Swiss Tropical Institute, Basel, Switzerland
    Geospat Health 1:127-39. 2006
    ..Results indicate that the stationarity assumption is important because it influences the significance of environmental factors and the corresponding malaria risk maps...
  77. ncbi request reprint Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity
    T Smith
    Swiss Tropical Institute, Basel, Switzerland
    Trans R Soc Trop Med Hyg 93:15-20. 1999
    ..There was a significant correlation between parasite density and multiplicity of infection in infants and young children (1-2 years of age) but not in older individuals...
  78. ncbi request reprint Malaria infection and morbidity in infants in relation to genetic polymorphisms in Tanzania
    H A Stirnadel
    Swiss Tropical Institute, Basel
    Trop Med Int Health 4:187-93. 1999
    ....
  79. ncbi request reprint Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial
    C Burri
    Swiss Tropical Institute, Basel
    Lancet 355:1419-25. 2000
    ..Despite these problems, melarsoprol is likely to remain the drug of choice for the next decade. We therefore did a randomised trial comparing the standard treatment schedule with a new, concise regimen...
  80. pmc Clustering of vector control interventions has important consequences for their effectiveness: a modelling study
    Angelina Mageni Lutambi
    Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland Ifakara Health Institute, Dar es Salaam, Tanzania
    PLoS ONE 9:e97065. 2014
    ..Vector control plans should consider the spatial arrangement of any intervention package to ensure effectiveness is maximized. ..
  81. ncbi request reprint Spatial patterns of child growth in Papua New Guinea and their relation to environment, diet, socio-economic status and subsistence activities
    I Mueller
    Swiss Tropical Institute, Basel
    Ann Hum Biol 28:263-80. 2001
    ..This indicates that nutritional interventions in PNG should aim at promoting the consumption of such high energy and high protein foods as well as strengthening the general economic base of rural populations...
  82. ncbi request reprint Assessing the public health importance of Schistosoma mansoni in different endemic areas: attributable fraction estimates as an approach
    H Guyatt
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 53:660-7. 1995
    ..japonicum. Attributable fraction estimates for these three schistosome species in different endemic areas would greatly aid in the assessment of the health burden of this parasite and the effectiveness of control programs...
  83. pmc Relationship between child survival and malaria transmission: an analysis of the malaria transmission intensity and mortality burden across Africa (MTIMBA) project data in Rufiji demographic surveillance system, Tanzania
    Susan F Rumisha
    Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland
    Malar J 13:124. 2014
    ..This work linked the MTIMBA entomology database with the routinely collected vital events within the Rufiji Demographic Surveillance System to analyse the transmission-mortality relation in the region...
  84. pmc Combination chemotherapy against Clonorchis sinensis: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in a rat model
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Antimicrob Agents Chemother 53:3770-6. 2009
    ..sinensis is confirmed, and combination chemotherapy with praziquantel produces synergistic and antagonistic effects depending on the doses administered. Further preclinical investigations are warranted...
  85. pmc Solar drinking water disinfection (SODIS) to reduce childhood diarrhoea in rural Bolivia: a cluster-randomized, controlled trial
    Daniel Mäusezahl
    Department of Public Health and Epidemiology, Swiss Tropical Institute STI, University of Basel, Switzerland
    PLoS Med 6:e1000125. 2009
    ..Laboratory studies suggest that SODIS is highly efficacious in inactivating waterborne pathogens. Previous field studies provided limited evidence for its effectiveness in reducing diarrhoea...
  86. ncbi request reprint Antimicrobial prophylaxis to prevent surgical site infections in a rural sub-Saharan hospital
    J Fehr
    Department of Medicine and Diagnostics, Swiss Tropical Institute, Basel, Switzerland
    Clin Microbiol Infect 12:1224-7. 2006
    ..Staphylococcus aureus (36%), Escherichia coli (5%) and enterococci (4%) were the pathogens isolated most commonly from SSIs...
  87. ncbi request reprint Prospective risk of morbidity in relation to malaria infection in an area of high endemicity of multiple species of Plasmodium
    T Smith
    Swiss Tropical Institute, Basel
    Am J Trop Med Hyg 64:262-7. 2001
    ..Covariate adjustment had considerable effects on estimated relationships between species, and confounding variables may account for many differences among reports of inter-species interactions in human malaria...
  88. ncbi request reprint Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against Plasmodium falciparum in Papua New Guinean children
    Blaise Genton
    PNG Institute of Medical Research, Maprik, Papua, New Guinea
    Vaccine 22:30-41. 2003
    ..Vaccine immunogenicity was neither impaired by circulating parasites nor increased after pre-treatment with SP and pre-treatment is not advisable in future trials of malaria vaccines, at least for those including blood-stage antigens...
  89. pmc Exploring the contributions of bed nets, cattle, insecticides and excitorepellency to malaria control: a deterministic model of mosquito host-seeking behaviour and mortality
    Gerry F Killeen
    Ifakara Health Research and Development Centre, Box 53, Ifakara, Kilombero, Morogoro, United Republic of Tanzania
    Trans R Soc Trop Med Hyg 101:867-80. 2007
    ..As financial support, technology and distribution systems for insecticide-treated nets improve, massive reductions in malaria transmission could be realised...