Stephane V Sizonenko
Affiliation: University of Geneva
- Selective cortical alteration after hypoxic-ischemic injury in the very immature rat brainStephane V Sizonenko
Unité de développement, Departement de Pediatrie, Hopital des Enfants, 6 Rue Willy Donze, 1211 Geneva 14 Switzerland
Pediatr Res 54:263-9. 2003..These alterations induced at P3 by unilateral HI share neuropathological similarities with the diffuse white matter lesions found in VLBW infants...
- Distinctive neuropathologic alterations in the deep layers of the parietal cortex after moderate ischemic-hypoxic injury in the P3 immature rat brainStephane V Sizonenko
Unité de Dévelopment, Department of Pediatrics, University of Geneva, 1211 Geneva, Switzerland
Pediatr Res 57:865-72. 2005..This model offers new possibilities for investigating the cellular and molecular mechanisms of damage and repair after neonatal HI injury...
- Impact of intrauterine growth restriction and glucocorticoids on brain development: insights using advanced magnetic resonance imagingStephane V Sizonenko
Department of Pediatrics, Geneva University Hospital, Switzerland
Mol Cell Endocrinol 254:163-71. 2006..In this review, we will focus on the modifications of CNS development that occur after exposition to adverse environment such as undernutrition or corticosteroid treatment that can now be studied in vivo with advanced MRI technology...
- Developmental changes and injury induced disruption of the radial organization of the cortex in the immature rat brain revealed by in vivo diffusion tensor MRIStephane V Sizonenko
Child Development Unit, Department of Paediatrics, School of Medicine, University of Geneva, Switzerland
Cereb Cortex 17:2609-17. 2007..Thus, the combined use of in vivo DTI and histopathology can assist in delineating normal developmental changes and postinjury modifications in the immature rodent brain...
- Glial responses to neonatal hypoxic-ischemic injury in the rat cerebral cortexStephane V Sizonenko
Department of Pediatrics, School of Medicine, University of Geneva, Switzerland
Int J Dev Neurosci 26:37-45. 2008..These findings imply that glial responses are central to cortical tissue remodelling following neonatal ischemia and represent a potential target for therapeutic approaches...
- [Intrauterine growth restriction: impact on brain development and function]S V Sizonenko
Service du développement et de la croissance, Département de l enfant et de l adolescent, HUG, Geneve
Rev Med Suisse 4:509-10, 512-4. 2008..In this review, we will delineate some modifications of CNS development and functions that occur after exposition to adverse environment and that can now be studied in vivo with advanced imaging technology...
- Multi-modal assessment of long-term erythropoietin treatment after neonatal hypoxic-ischemic injury in rat brainYohan Van de Looij
Division of Child Development and Growth, Department of Paediatrics, School of Medicine, University of Geneva and Geneva University Hospital, Geneva, Switzerland Laboratory for Functional and Metabolic Imaging LIFMET, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
PLoS ONE 9:e95643. 2014..This indicates that long-term high-dose EPO induces recovery of structural and functional connectivity despite persisting gross anatomical cortical alteration resulting from HI. ..
- Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fieldsNicolas Kunz
Division of Child Growth and Development, University of Geneva, Geneva, Switzerland Laboratory for functional and metabolic imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
NMR Biomed 26:1251-7. 2013..This study suggests that the observed differences in diffusion tensor imaging parameters between the two magnetic field strengths at short diffusion time may be related to differences in the apparent T2 values between the pools...
- High-field diffusion tensor imaging characterization of cerebral white matter injury in lipopolysaccharide-exposed fetal sheepYohan Van de Looij
Department of Pediatrics, University of Geneva, Geneva, Switzerland
Pediatr Res 72:285-92. 2012..The goal of this study was to characterize changes in white matter (WM) structure using advanced magnetic resonance imaging (MRI) following lipopolysaccharide (LPS) exposure in the preterm-equivalent fetal sheep...
- In vivo assessment of myelination by phase imaging at high magnetic fieldGregory A Lodygensky
Pediatrics, Pediatric and Neonatal ICU, Department of Radiology, University of Geneva, Geneva 14, Switzerland
Neuroimage 59:1979-87. 2012..We conclude that high-resolution phase images, acquired at high field, allow assessment of myelination and dysmyelination...
- MRI of animal models of developmental disorders and translation to human imagingYohan Van de Looij
aDivision of Child Development and Growth, Department of Pediatrics, University of Geneva, Geneva bLaboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Curr Opin Neurol 27:157-67. 2014..The aim of this review is to give an overview of the recent findings in MRI of animal models of developmental disorders and emphasize what we can learn from MRI on these models...
- Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolismEmmanuel Somm
Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland
Pediatr Res 75:51-61. 2014..Conclusion:Our data suggest that maternal bLf supplementation is a beneficial nutritional intervention able to revert some of the IUGR-induced sequelae, including brain hippocampal changes. ..
- Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in lifeEmmanuel Somm
Department of Pediatrics, Geneva University Hospitals, 1211 Geneva 14, Switzerland
Endocrinology 149:6289-99. 2008..These results prove a direct association between fetal nicotine exposure and offspring metabolic syndrome with early signs of dysregulations of adipose tissue and pancreatic development...
- Neuroimaging of cortical development and brain connectivity in human newborns and animal modelsGregory A Lodygensky
NICU, Department of Pediatrics, University of Geneva, Geneva, Switzerland
J Anat 217:418-28. 2010..Understanding the histological substrate of brain injury seen on MRI provides new insights into the immature brain, mechanisms of injury and their imaging phenotype...
- Longitudinal MR assessment of hypoxic ischemic injury in the immature rat brainYohan Van de Looij
Department of Pediatrics, Division of Child Development and Growth, University of Geneva, Geneva, Switzerland
Magn Reson Med 65:305-12. 2011....
- Growth factors and plasticityStephane V Sizonenko
Service du développement et de la croissance, Departement de Pediatrie, Faculte de Medecine, Geneva, Switzerland
Semin Fetal Neonatal Med 12:241-9. 2007..g. melatonin or erythropoietin, might reach clinical trials in the near future...
- Functional deficit and recovery of developing sensorimotor networks following neonatal hypoxic-ischemic injury in the ratCharles Quairiaux
Faculty of Medicine, Department of Fundamental Neurosciences, University of Geneva, 1211 Geneva, Switzerland
Cereb Cortex 20:2080-91. 2010..The model provides new perspectives for investigating the temporal and spatial characteristics of the recovery process following HI and eventually developing therapeutic interventions...