Hans Uwe Simon

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. pmc Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation
    Sebastien Conus
    Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland
    J Exp Med 205:685-98. 2008
  2. pmc Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils
    Frank Altznauer
    Dept of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    J Exp Med 199:1343-54. 2004
  3. pmc A novel link between p53 and ROS
    Zhaoyue He
    Institute of Pharmacology University of Bern Bern, Switzerland
    Cell Cycle 12:201. 2013
  4. doi request reprint DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants
    Barbara Geering
    2 University of Bern, Friedbuehlstrasse 49, CH 3010 Bern, Switzerland
    J Leukoc Biol 95:293-303. 2014
  5. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
  6. ncbi request reprint [Pathophysiological and pharmacotherapeutic aspects of IgE-mediated allergic reactions]
    H U Simon
    Pharmakologisches Institut, Universitat Bern
    Ther Umsch 58:266-73. 2001
  7. ncbi request reprint The neutralization of interleukin-5 as a therapeutic concept in allergic inflammation
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Switzerland
    Sarcoidosis Vasc Diffuse Lung Dis 19:25-8. 2002
  8. ncbi request reprint Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Eur J Immunol 33:834-9. 2003
  9. ncbi request reprint Neutrophil apoptosis pathways and their modifications in inflammation
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Immunol Rev 193:101-10. 2003
  10. pmc Refining the definition of hypereosinophilic syndrome
    Hans Uwe Simon
    Institute of Pharmacology, University of Bern, Switzerland
    J Allergy Clin Immunol 126:45-9. 2010

Detail Information

Publications97

  1. pmc Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation
    Sebastien Conus
    Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland
    J Exp Med 205:685-98. 2008
    ....
  2. pmc Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils
    Frank Altznauer
    Dept of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    J Exp Med 199:1343-54. 2004
    ..These data provide new insights into the regulation and function of survivin and have important implications for the pathogenesis, diagnosis, and treatment of inflammatory diseases and cancer...
  3. pmc A novel link between p53 and ROS
    Zhaoyue He
    Institute of Pharmacology University of Bern Bern, Switzerland
    Cell Cycle 12:201. 2013
    ..Comment on: Italiano D, et al. Cell Cycle 2012; 11:4589-96...
  4. doi request reprint DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants
    Barbara Geering
    2 University of Bern, Friedbuehlstrasse 49, CH 3010 Bern, Switzerland
    J Leukoc Biol 95:293-303. 2014
    ..As neutrophils treated with DAPKi also showed reduced recruitment to the site of inflammation in a mouse peritonitis model, DAPK2 may be a novel target for anti-inflammatory therapies. ..
  5. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  6. ncbi request reprint [Pathophysiological and pharmacotherapeutic aspects of IgE-mediated allergic reactions]
    H U Simon
    Pharmakologisches Institut, Universitat Bern
    Ther Umsch 58:266-73. 2001
    ..This review focuses on mechanisms of IgE-mediated allergic diseases and describes where current and new potential drugs interfere within these pathogenic processes...
  7. ncbi request reprint The neutralization of interleukin-5 as a therapeutic concept in allergic inflammation
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Switzerland
    Sarcoidosis Vasc Diffuse Lung Dis 19:25-8. 2002
    ..In this article, I summarize our current knowledge regarding anti-IL-5 therapy and speculate on the potential use of these drugs in the future...
  8. ncbi request reprint Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Eur J Immunol 33:834-9. 2003
    ..These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites...
  9. ncbi request reprint Neutrophil apoptosis pathways and their modifications in inflammation
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Immunol Rev 193:101-10. 2003
    ..This review focuses on recently published work regarding signaling pathways that regulate neutrophil apoptosis...
  10. pmc Refining the definition of hypereosinophilic syndrome
    Hans Uwe Simon
    Institute of Pharmacology, University of Bern, Switzerland
    J Allergy Clin Immunol 126:45-9. 2010
    ..Nevertheless, we suggest a new working definition that overcomes some of the most obvious limitations with the original definition...
  11. ncbi request reprint Targeting apoptosis in the control of inflammation
    H U Simon
    Dept of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Eur Respir J Suppl 44:20s-21s. 2003
  12. ncbi request reprint Cytokine and anti-cytokine therapy for asthma
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Curr Allergy Asthma Rep 6:117-21. 2006
    ..In this article, the results of these studies are discussed, and the obtained insights regarding asthma pathogenesis and new treatment options are summarized...
  13. ncbi request reprint Evidence for a pro-apoptotic function of CD137 in granulocytes
    H U Simon
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Swiss Med Wkly 131:455-8. 2001
    ..This review summarizes our current knowledge on the potential role of CD137 in the regulation of both neutrophil and eosinophil apoptosis...
  14. doi request reprint General laboratory diagnostics of eosinophilic GI diseases
    Sebastien Conus
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Best Pract Res Clin Gastroenterol 22:441-53. 2008
    ..Here, we review the pathogenesis and common laboratory approaches applied for their diagnosis, in particular eosinophil and mast cell markers...
  15. ncbi request reprint Novel approaches to therapy of hypereosinophilic syndromes
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Friedbuehlstrasse 49, CH 3010 Bern, Switzerland
    Immunol Allergy Clin North Am 27:519-27. 2007
    ..Consequently, new treatment options became available, such as imatinib and mepolizumab, which proved to be promising. This article summarizes these new pharmacologic approaches to the therapy of HES...
  16. doi request reprint Cell death in allergic diseases
    Hans Uwe Simon
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Apoptosis 14:439-46. 2009
    ..Whether the apoptosis is too little or too much depends on the cell type. In this review, we discuss the regulation of the lifespan of the participating leukocytes in allergic inflammatory responses...
  17. ncbi request reprint Regulation of eosinophil and neutrophil apoptosis--similarities and differences
    H U Simon
    Department of Pharmacology, University of Bern, Switzerland
    Immunol Rev 179:156-62. 2001
    ..The identification of differences in the apoptosis regulation may help to define new molecular targets that allow specific induction of either eosinophil or neutrophil apoptosis by pharmacological means...
  18. ncbi request reprint Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophilia
    H U Simon
    Department of Pharmacology, University of Bern, Switzerland
    Int Arch Allergy Immunol 124:242-5. 2001
    ..The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients...
  19. doi request reprint The pharmacokinetic profile of fesoterodine: similarities and differences to tolterodine
    Hans Uwe Simon
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Swiss Med Wkly 139:146-51. 2009
    ..The objective of this study was to establish the pharmacokinetic profile of fesoterodine and to highlight ist potential pharmacokinetic advantages over tolterodine...
  20. ncbi request reprint Molecules involved in the regulation of eosinophil apoptosis
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Switzerland
    Chem Immunol Allergy 91:49-58. 2006
    ..Drugs that specifically induce eosinophil apoptosis might be useful for triggering the resolution of unwanted eosinophilic inflammatory responses...
  21. ncbi request reprint Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
    Shida Yousefi
    Department of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    Nat Cell Biol 8:1124-32. 2006
    ..Taken together, calpain-mediated Atg5 cleavage provokes apoptotic cell death, therefore, represents a molecular link between autophagy and apoptosis--a finding with potential importance for clinical anticancer therapies...
  22. ncbi request reprint Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis
    Frank Altznauer
    Department of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    J Biol Chem 279:5947-57. 2004
    ....
  23. ncbi request reprint Macrophage migration inhibitory factor delays apoptosis in neutrophils by inhibiting the mitochondria-dependent death pathway
    Ralf Baumann
    Department of Pharmacology, University of Bern, Switzerland
    FASEB J 17:2221-30. 2003
    ..In conclusion, MIF is a survival cytokine for human neutrophils, a finding with potential pathologic relevance in infectious diseases...
  24. ncbi request reprint Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations
    Stephan von Gunten
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Blood 108:4255-9. 2006
    ....
  25. doi request reprint Different patterns of Siglec-9-mediated neutrophil death responses in septic shock
    Stephan von Gunten
    Institute of Pharmacology, University of Bern, Switzerland
    Shock 32:386-92. 2009
    ..Further studies are required to understand the role of Siglec-9-mediated neutrophil death in septic shock...
  26. ncbi request reprint Apoptotic pathways are inhibited by leptin receptor activation in neutrophils
    Andreina Bruno
    Department of Pharmacology, University of Bern, Bern, Switzerland
    J Immunol 174:8090-6. 2005
    ..Taken together, leptin is a survival cytokine for human neutrophils, a finding with potential pathologic relevance in inflammatory diseases...
  27. doi request reprint Lysosomal degradation of RhoH protein upon antigen receptor activation in T but not B cells
    Jan Schmidt-Mende
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Eur J Immunol 40:525-9. 2010
    ..This newly discovered regulatory pathway of RhoH expression might limit TCR signaling and subsequent T-cell activation upon Ag contact...
  28. ncbi request reprint cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis
    Ekatherina M Vassina
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Eur J Immunol 36:1975-84. 2006
    ..The cytokine-dependent mechanism of delayed eosinophil apoptosis described here may also apply to other eosinophilic diseases...
  29. doi request reprint Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
    Shida Yousefi
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Nat Med 14:949-53. 2008
    ....
  30. doi request reprint Protein overexpression following lentiviral infection of primary mature neutrophils is due to pseudotransduction
    Barbara Geering
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    J Immunol Methods 373:209-18. 2011
    ..Based on our data and previous reports of unspecific viral effects on immune cells following lentiviral transduction, we discourage scientists to use lentiviral transduction methods to manipulate primary mature neutrophils...
  31. ncbi request reprint Functional expression of CD134 by neutrophils
    Ralf Baumann
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Eur J Immunol 34:2268-75. 2004
    ..In conclusion, CD134 regulates neutrophil survival, suggesting that this molecule does not only contribute to adaptive but also to innate immune responses...
  32. ncbi request reprint Increased expression and a potential anti-inflammatory role of TRAIL in atopic dermatitis
    Ekatherina Vassina
    Department of Pharmacology, University of Bern, Bern, Switzerland
    J Invest Dermatol 125:746-52. 2005
    ..Moreover, increased expression of IL-1Ra was observed in keratinocytes of AD lesional skin. These data suggest that TRAIL-expressing inflammatory skin cells may contribute to the epidermal activation of the IL-1Ra gene in AD...
  33. ncbi request reprint Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment
    Stephan von Gunten
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Blood 106:1423-31. 2005
    ..The new insights have important implications for the pathogenesis, diagnosis, and treatment of inflammatory diseases such as sepsis and rheumatoid arthritis...
  34. ncbi request reprint Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alpha
    Arezoo Daryadel
    Department of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    J Biol Chem 281:27653-61. 2006
    ..Taken together, apoptotic mature neutrophils release MIF upon short term TNF-alpha stimulation. Therefore, apoptosis may not always occur without the induction of pro-inflammatory mechanisms...
  35. ncbi request reprint Leptin is an eosinophil survival factor
    Sebastien Conus
    Department of Pharmacology, University of Bern, Switzerland
    J Allergy Clin Immunol 116:1228-34. 2005
    ..It exerts proliferative and antiapoptotic activities in a variety of cell types, including T cells. Leptin also stimulates macrophages and neutrophils, and its production is increased during inflammation...
  36. ncbi request reprint Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatment
    Dagmar Simon
    Department of Dermatology, University of Bern, Switzerland
    J Allergy Clin Immunol 114:887-95. 2004
    ..In several clinical studies, topical calcineurin inhibitors have been shown to be effective in the treatment of atopic dermatitis (AD). They target signaling pathways that control gene expression, particularly the expression of cytokines...
  37. ncbi request reprint Induction of genes mediating interferon-dependent extracellular trap formation during neutrophil differentiation
    Sibylla Martinelli
    Department of Pharmacology, University of Bern, CH 3010, Switzerland
    J Biol Chem 279:44123-32. 2004
    ..These data contribute to our understanding regarding changes of gene expression during neutrophil differentiation and IFN-mediated anti-bacterial defense mechanisms...
  38. ncbi request reprint Cell death modulation by intravenous immunoglobulin
    Stephan von Gunten
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, Bern, Switzerland
    J Clin Immunol 30:S24-30. 2010
    ..These involve activation status of the target cell, cytokine microenvironment, pathogenesis and stage of disease, individual genetic determinants, species characteristics, and batch-to-batch variations of IVIG preparations...
  39. doi request reprint Inflammation-associated autophagy-related programmed necrotic death of human neutrophils characterized by organelle fusion events
    Cristina C Mihalache
    Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    J Immunol 186:6532-42. 2011
    ....
  40. ncbi request reprint Epidermal caspase-3 cleavage associated with interferon-gamma-expressing lymphocytes in acute atopic dermatitis lesions
    Dagmar Simon
    Department of Dermatology, University of Bern, Bern, Switzerland
    Exp Dermatol 15:441-6. 2006
    ....
  41. ncbi request reprint Anti-interleukin-5 antibody therapy in eosinophilic diseases
    Dagmar Simon
    Department of Dermatology, Inselspital, Bern, Switzerland
    Pathobiology 72:287-92. 2005
    ..The decrease of tissue eosinophils was, however, less dramatic. Investigating the effects of anti-IL-5 therapy will improve our understanding of the pathogenic roles of both IL-5 and eosinophils in eosinophilic inflammatory responses...
  42. ncbi request reprint Cathepsins and their involvement in immune responses
    Sebastien Conus
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Swiss Med Wkly 140:w13042. 2010
    ..Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases...
  43. doi request reprint Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils
    Nicola Andina
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 123:603-11. 2009
    ..IL-5-mediated transmembrane signal transduction involves both Lyn-mitogen-activated protein kinases and Janus kinase 2-signal transducer and activator of transcription pathways...
  44. pmc The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL
    Magali Humbert
    1 Division of Experimental Pathology, TP2, University of Bern, Murtenstrasse 31, P O Box 62, CH 3010 Bern, Switzerland
    J Leukoc Biol 95:83-93. 2014
    ....
  45. doi request reprint Living and dying for inflammation: neutrophils, eosinophils, basophils
    Barbara Geering
    Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, CH 3010 Bern, Switzerland
    Trends Immunol 34:398-409. 2013
    ..Because dysregulation of death pathways in granulocytes can contribute to inflammation-associated immunopathology, targeting granulocyte lifespan could be therapeutically promising. ..
  46. ncbi request reprint The interleukin-13 production by peripheral blood T cells from atopic dermatitis patients does not require CD2 costimulation
    Dagmar Simon
    Department of Dermatology, University of Bern, Bern, Switzerland
    Int Arch Allergy Immunol 132:148-55. 2003
    ..Although allergic mechanisms appear to be important, the pathogenesis of both extrinsic and intrinsic forms of atopic dermatitis (AD) is unknown...
  47. ncbi request reprint Sialic acid binding immunoglobulin-like lectins may regulate innate immune responses by modulating the life span of granulocytes
    Stephan von Gunten
    Department of Pharmacology, University of Bern, Bern, Switzerland
    FASEB J 20:601-5. 2006
    ..Based on these recent insights, we hypothesize that at least some members of the Siglec family regulate immune responses via the activation of caspase-dependent and caspase-independent cell death pathways...
  48. ncbi request reprint Autophagic-like cell death in neutrophils induced by autoantibodies
    Stephan von Gunten
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Autophagy 3:67-8. 2007
    ..Here, we discuss the pathophysiological and therapeutic implications of these recent findings...
  49. doi request reprint A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils
    Barbara Geering
    Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, Switzerland
    Blood 117:5953-62. 2011
    ..We conclude that in neutrophils, proapoptotic pathways after TNFR1 stimulation are initiated by p38 and PI3K, but not by caspase-8, a finding that should be considered in anti-inflammatory drug-development strategies...
  50. ncbi request reprint The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells
    Mattia Rizzi
    Experimental Oncology Hematology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
    J Leukoc Biol 81:1599-608. 2007
    ..In summary, our findings implicate a role for DAPK2 in granulocyte maturation...
  51. doi request reprint Expression of CD95 on mature leukocytes of MRL/lpr mice after transplantation of genetically modified bone marrow stem cells
    Elena Federzoni
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Immunol Lett 117:45-9. 2008
    ..This suggests that correction of CD95 deficiency can be achieved by gene therapy...
  52. ncbi request reprint Concurrent presence of agonistic and antagonistic anti-CD95 autoantibodies in intravenous Ig preparations
    Frank Altznauer
    Department of Pharmacology, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 112:1185-90. 2003
    ....
  53. ncbi request reprint Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies
    Stephan von Gunten
    Department of Pharmacology, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 119:1005-11. 2007
    ..Human intravenous immunoglobulin (IVIg) preparations are used for the treatment of autoimmune and allergic diseases. Natural autoantibodies are believed to contribute to IVIg-mediated anti-inflammatory effects...
  54. doi request reprint Anti-CD20 (rituximab) treatment improves atopic eczema
    Dagmar Simon
    Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 121:122-8. 2008
    ..Atopic eczema (AE) is a chronic inflammatory skin disorder characterized by eczematous skin lesions, pruritus, and typical histopathologic features...
  55. ncbi request reprint Mathematical modeling of the regulation of caspase-3 activation and degradation
    Jörg W Stucki
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    J Theor Biol 234:123-31. 2005
    ..In addition, we predict a novel mechanism of caspase-3 degradation that might be particularly relevant in long-living cells...
  56. doi request reprint Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease
    Shida Yousefi
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Curr Opin Immunol 24:736-9. 2012
    ....
  57. doi request reprint RhoH/TTF negatively regulates leukotriene production in neutrophils
    Arezoo Daryadel
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    J Immunol 182:6527-32. 2009
    ..Taken together, these data suggest that RhoH/TTF represents an inducible feedback inhibitor in neutrophils that is involved in the limitation of innate immune responses...
  58. pmc ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy
    Dipak Maskey
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Nat Commun 4:2130. 2013
    ..Our data suggest a dual role for ATG5 in response to drug-induced DNA damage, where it acts in two signalling pathways in two distinct cellular compartments, the cytosol and the nucleus. ..
  59. ncbi request reprint NADPH oxidase-independent formation of extracellular DNA traps by basophils
    Mahbubul Morshed
    Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    J Immunol 192:5314-23. 2014
    ..Taken together, these findings suggest that basophils exert direct innate immune effector functions in the extracellular space. ..
  60. doi request reprint Granulocyte death regulation by naturally occurring autoantibodies
    Stephan von Gunten
    Institute of Pharmacology, University of Bern, Switzerland
    Adv Exp Med Biol 750:157-72. 2012
    ....
  61. pmc Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis
    Sebastien Conus
    Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    J Biol Chem 287:21142-51. 2012
    ..As cathepsin D is ubiquitously expressed, this may represent a general mechanism to induce apoptosis in a variety of immune and nonimmune cells...
  62. doi request reprint Eosinophil extracellular DNA traps in skin diseases
    Dagmar Simon
    Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland
    J Allergy Clin Immunol 127:194-9. 2011
    ..In the skin, eosinophils are found in a broad spectrum of diseases, including infectious diseases...
  63. ncbi request reprint SHP-1: a regulator of neutrophil apoptosis
    Shida Yousefi
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Semin Immunol 15:195-9. 2003
    ..In summary, the current available data point to an important role of SHP-1 in the regulation of neutrophil apoptosis...
  64. ncbi request reprint Efalizumab-associated papular psoriasis
    Akmal S Hassan
    Department of Dermatology, University of Bern, Inselspital, 3010 Bern, Switzerland
    Arch Dermatol 143:900-6. 2007
    ..Some of the patients develop new papular lesions during treatment, which are predominantly located in the flexural regions...
  65. doi request reprint New drug targets in atopic dermatitis
    Dagmar Simon
    Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland
    Chem Immunol Allergy 96:126-31. 2012
    ..According to recent studies, neutralizing B and T cells products such as IgE or IL-5 might be effective in subgroups of patients with AD...
  66. doi request reprint Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapy
    Camilla Jandus
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Biochem Pharmacol 82:323-32. 2011
    ....
  67. doi request reprint Cathepsins: key modulators of cell death and inflammatory responses
    Sebastien Conus
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Biochem Pharmacol 76:1374-82. 2008
    ..In this review, the players and the molecular mechanisms involved in the lysosomal apoptotic pathways will be discussed as well as the importance of these pathways in the immune system and the pathogenesis of diseases...
  68. ncbi request reprint Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
    S Yousefi
    Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    Cell Death Differ 16:1438-44. 2009
    ..In conclusion, mitochondrial DNA release by neutrophils and NET formation do not require neutrophil death and do also not limit the lifespan of these cells...
  69. ncbi request reprint Eosinophilic disorders
    Dagmar Simon
    Department of Dermatology, University of Bern, Bern, Switzerland
    J Allergy Clin Immunol 119:1291-300; quiz 1301-2. 2007
    ..Interestingly, many subgroups of patients originally thought to have the idiopathic hypereosinophilic syndrome can be integrated in this classification...
  70. doi request reprint Autophagy regulation in macrophages and neutrophils
    Cristina C Mihalache
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Exp Cell Res 318:1187-92. 2012
    ..Specifically, it appears that autophagy protects against infections and inflammation. Here, we review recent work performed in macrophages and neutrophils, which both represent critical phagocytes in mammalians...
  71. ncbi request reprint Isolated autosomal dominant growth hormone deficiency: stimulating mutant GH-1 gene expression drives GH-1 splice-site selection, cell proliferation, and apoptosis
    Souzan Salemi
    Paediatric Endocrinology, University Children s Hospital, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Endocrinology 148:45-53. 2007
    ..Our findings that the proportion of 17.5-kDa produced from mutant GH-1 alleles increases with increased drive for gene expression may help to explain the variable onset progression, and severity observed in IGHD II...
  72. ncbi request reprint Apoptosis regulation by autophagy gene 5
    Shida Yousefi
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Crit Rev Oncol Hematol 63:241-4. 2007
    ..In particular, we would like to draw the attention of the readers to Atg5, which exhibits, like Bcl-2, a dual function by modulating both autophagy and apoptosis...
  73. doi request reprint Autophagy in cancer and chemotherapy
    Shida Yousefi
    Institute of Pharmacology, University of Bern, Friedb0ihlstrasse 49, CH 3010 Bern, Switzerland
    Results Probl Cell Differ 49:183-90. 2009
    ..This chapter summarizes our current understanding regarding the regulation of autophagy in tumors and discusses potential new anticancer drug treatment strategies...
  74. doi request reprint Induction of Bim limits cytokine-mediated prolonged survival of neutrophils
    N Andina
    Institute of Pharmacology, University of Bern, Bern CH 3010, Switzerland
    Cell Death Differ 16:1248-55. 2009
    ....
  75. doi request reprint Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells
    D Kassahn
    Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland
    Cell Death Differ 16:115-24. 2009
    ..We conclude that activation-induced degranulation of Fas ligand in cytotoxic lymphocytes is differently regulated than other classical cytotoxic granule proteins...
  76. ncbi request reprint Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A)
    G Kostylina
    Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, Bern, Switzerland
    Cell Death Differ 15:134-42. 2008
    ..Moreover, this study identified a new cellular target of NA and future drugs activating GPR109A receptors, the mature neutrophil...
  77. doi request reprint Glucocorticoids in autoimmune bullous diseases: are neutrophils the key cellular target?
    Dagmar Simon
    Department of Dermatology, University Hospital Bern, Inselspital, Bern, Switzerland
    J Invest Dermatol 133:2314-5. 2013
    ..The newly observed nongenomic effects of glucocorticoids on signaling pathways operating in neutrophils in vitro will stimulate further investigations on pathogenic mechanisms and drug actions in bullous skin diseases. ..
  78. doi request reprint Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma
    He Liu
    Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    Sci Transl Med 5:202ra123. 2013
    ..Hence, it appears that down-regulation of ATG5 contributes to tumorigenesis in early-stage cutaneous melanoma, and the expression of ATG5 and LC3 correlates with melanoma diagnosis and prognosis. ..
  79. ncbi request reprint Cell death in immune thrombocytopenia: novel insights and perspectives
    Stephan von Gunten
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Semin Hematol 50:S109-15. 2013
    ..In this article, we discuss novel and controversial findings on the role of PCD in the megakaryocyte lineage and their potential implications in terms of pathogenesis, diagnosis, and treatment of ITP...
  80. pmc Therapeutic approaches to patients with hypereosinophilic syndromes
    Hans Uwe Simon
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Semin Hematol 49:160-70. 2012
    ..More recently, the availability of novel targeted therapies and a better understanding of the etiologies of some subtypes of HES have necessitated a more structured approach...
  81. doi request reprint Autophagy in cells of the blood
    Shida Yousefi
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Biochim Biophys Acta 1793:1461-4. 2009
    ..Here, we review these findings, which point to an important role of autophagy in several cellular functions related to host defense...
  82. doi request reprint A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome
    S Salemi
    Institute of Pharmacology, University of Bern, Bern, Switzerland
    Allergy 64:913-8. 2009
    ..However, some patients may develop imatinib resistance because of an acquired T674I mutation, which is believed to prevent drug binding through steric hindrance...
  83. ncbi request reprint Increased lipopolysaccharide-induced tumour necrosis factor-alpha, interferon-gamma and interleukin-10 production in atopic dermatitis
    D Simon
    Department of Dermatology, Inselspital, University of Bern, CH 3010 Bern, Switzerland
    Br J Dermatol 157:583-6. 2007
    ..According to the hygiene hypothesis, decreased exposure to microbial products in early childhood does not allow sufficient maturation of the immune system that is associated with an increased risk of atopic sensitization...
  84. ncbi request reprint Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist
    H U Simon
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Immunol 165:4069-75. 2000
    ..The cellular content of ECP appears to be a no limiting factor in the case of repetitive stimulation, implying that mature eosinophils may not require a significant ECP resynthesis...
  85. ncbi request reprint Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus
    O A Thomet
    Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
    Biochem Pharmacol 61:1041-7. 2001
    ....
  86. ncbi request reprint Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disorders
    I V Heinisch
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 108:21-8. 2001
    ..The T cell-derived factor that induces CD137 expression in eosinophils remains to be identified...
  87. pmc Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils
    S Yousefi
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland
    J Exp Med 183:1407-14. 1996
    ..Compatible with this model, both Lyn and Syk are essential for the activation of the antiapoptotic pathway(s) induced through the IL-3/IL-5/GM-CSF receptor beta subunit in human eosinophils...
  88. pmc The T348M mutated form of cryopyrin is associated with defective lipopolysaccharide-induced interleukin 10 production in CINCA syndrome
    T Bihl
    Ann Rheum Dis 64:1380-1. 2005
  89. ncbi request reprint Critical role for caspases 3 and 8 in neutrophil but not eosinophil apoptosis
    I Daigle
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Int Arch Allergy Immunol 126:147-56. 2001
    ..CONCLUSION: The data of this study indicate differences in the usage of caspases between neutrophils and eosinophils...
  90. ncbi request reprint Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils
    O A Thomet
    Swiss Institute of Allergy and Asthma Research (SIAF, University of Zurich, Davos, Switzerland
    Clin Exp Allergy 31:1310-20. 2001
    ....
  91. ncbi request reprint Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response
    A Straumann
    Department of Gastroenterology, Kantonsspital, Olten, Switzerland
    J Allergy Clin Immunol 108:954-61. 2001
    ..T cells, IL-5, eosinophils, and IgE-mediated mechanisms appear to be involved, giving rise to the possibility that allergic reactions might play a role in the pathogenesis of the disease...
  92. ncbi request reprint Alternative functions for TRAIL receptors in eosinophils and neutrophils
    I Daigle
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Swiss Med Wkly 131:231-7. 2001
    ..The receptors of TRAIL belong to the superfamily of tumour necrosis factor (TNF)/nerve growth factor (NGF) receptors. Here we investigate TRAIL receptor expression and function in eosinophils and neutrophils...
  93. pmc Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation
    H U Simon
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Biochem J 297:389-97. 1994
    ....
  94. ncbi request reprint [Difficult to manage asthma: clinical phenotypes and principles of therapy]
    G Menz
    Hochgebirgsklinik Davos Wolfgang, CH
    Pneumologie 56:132-7. 2002
  95. pmc Therapeutic interleukin (IL) 1 blockade normalises increased IL1 beta and decreased tumour necrosis factor alpha and IL10 production in blood mononuclear cells of a patient with CINCA syndrome
    M Seitz
    Ann Rheum Dis 64:1802-3. 2005
  96. ncbi request reprint Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitis
    A G Schapowal
    Hochgebirgsklinik Davos Wolfgang, Switzerland
    Acta Otorhinolaryngol Belg 49:235-50. 1995
    ..Unfortunately there is so far no curative treatment. New drugs like cytokine or leukotriene receptor antagonists give hope for better results in treatment of aspirin intolerance in the future...
  97. ncbi request reprint IVIG--mechanisms of action
    H U Simon
    Department of Pharmacology, University of Bern, Switzerland ZLB Bioplasma AG, Bern, Switzerland
    Allergy 58:543-52. 2003
    ..These mechanisms are effective concomitantly and synergistically at every occasion of use of IVIG in inflammatory and autoimmune disorders...