Research Topics
Genomes and Genes
| Hans Uwe SimonSummaryAffiliation: University of Bern Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Systems medicine and integrated care to combat chronic noncommunicable diseasesJean Bousquet
Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
Genome Med 3:43. 2011..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
[Pathophysiological and pharmacotherapeutic aspects of IgE-mediated allergic reactions]H U Simon
Pharmakologisches Institut, Universitat Bern
Ther Umsch 58:266-73. 2001..This review focuses on mechanisms of IgE-mediated allergic diseases and describes where current and new potential drugs interfere within these pathogenic processes...- Cytokine and anti-cytokine therapy for asthmaHans Uwe Simon
Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Curr Allergy Asthma Rep 6:117-21. 2006..In this article, the results of these studies are discussed, and the obtained insights regarding asthma pathogenesis and new treatment options are summarized... - Molecules involved in the regulation of eosinophil apoptosisHans Uwe Simon
Department of Pharmacology, University of Bern, Switzerland
Chem Immunol Allergy 91:49-58. 2006..Drugs that specifically induce eosinophil apoptosis might be useful for triggering the resolution of unwanted eosinophilic inflammatory responses... - The neutralization of interleukin-5 as a therapeutic concept in allergic inflammationHans Uwe Simon
Department of Pharmacology, University of Bern, Switzerland
Sarcoidosis Vasc Diffuse Lung Dis 19:25-8. 2002..In this article, I summarize our current knowledge regarding anti-IL-5 therapy and speculate on the potential use of these drugs in the future... - Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndromeHans Uwe Simon
Department of Pharmacology, University of Bern, Bern, Switzerland
Eur J Immunol 33:834-9. 2003..These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites... - Neutrophil apoptosis pathways and their modifications in inflammationHans Uwe Simon
Department of Pharmacology, University of Bern, Bern, Switzerland
Immunol Rev 193:101-10. 2003..This review focuses on recently published work regarding signaling pathways that regulate neutrophil apoptosis... - Refining the definition of hypereosinophilic syndromeHans Uwe Simon
Institute of Pharmacology, University of Bern, Switzerland
J Allergy Clin Immunol 126:45-9. 2010..Nevertheless, we suggest a new working definition that overcomes some of the most obvious limitations with the original definition... - Targeting apoptosis in the control of inflammationH U Simon
Dept of Pharmacology, University of Bern, , CH-3010 Bern, Switzerland
Eur Respir J Suppl 44:20s-21s. 2003 - Evidence for a pro-apoptotic function of CD137 in granulocytesH U Simon
Department of Pharmacology, University of Bern, Bern, Switzerland
Swiss Med Wkly 131:455-8. 2001..This review summarizes our current knowledge on the potential role of CD137 in the regulation of both neutrophil and eosinophil apoptosis... 
General laboratory diagnostics of eosinophilic GI diseasesSebastien Conus
Department of Pharmacology, University of Bern, Bern, Switzerland
Best Pract Res Clin Gastroenterol 22:441-53. 2008..Here, we review the pathogenesis and common laboratory approaches applied for their diagnosis, in particular eosinophil and mast cell markers...- Novel approaches to therapy of hypereosinophilic syndromesHans Uwe Simon
Department of Pharmacology, University of Bern, Friedbuehlstrasse 49, CH 3010 Bern, Switzerland
Immunol Allergy Clin North Am 27:519-27. 2007..Consequently, new treatment options became available, such as imatinib and mepolizumab, which proved to be promising. This article summarizes these new pharmacologic approaches to the therapy of HES... - Regulation of eosinophil and neutrophil apoptosis--similarities and differencesH U Simon
Department of Pharmacology, University of Bern, Switzerland
Immunol Rev 179:156-62. 2001..The identification of differences in the apoptosis regulation may help to define new molecular targets that allow specific induction of either eosinophil or neutrophil apoptosis by pharmacological means... - Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophiliaH U Simon
Department of Pharmacology, University of Bern, Switzerland
Int Arch Allergy Immunol 124:242-5. 2001..The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients... - The pharmacokinetic profile of fesoterodine: similarities and differences to tolterodineHans Uwe Simon
Institute of Pharmacology, University of Bern, Bern, Switzerland
Swiss Med Wkly 139:146-51. 2009..The objective of this study was to establish the pharmacokinetic profile of fesoterodine and to highlight ist potential pharmacokinetic advantages over tolterodine... - Cell death in allergic diseasesHans Uwe Simon
Institute of Pharmacology, University of Bern, Bern, Switzerland
Apoptosis 14:439-46. 2009..Whether the apoptosis is too little or too much depends on the cell type. In this review, we discuss the regulation of the lifespan of the participating leukocytes in allergic inflammatory responses... - Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosisFrank Altznauer
Department of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
J Biol Chem 279:5947-57. 2004.... - Different patterns of Siglec-9-mediated neutrophil death responses in septic shockStephan von Gunten
Institute of Pharmacology, University of Bern, Switzerland
Shock 32:386-92. 2009..Further studies are required to understand the role of Siglec-9-mediated neutrophil death in septic shock... - Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophilsFrank Altznauer
Dept of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
J Exp Med 199:1343-54. 2004..These data provide new insights into the regulation and function of survivin and have important implications for the pathogenesis, diagnosis, and treatment of inflammatory diseases and cancer... - Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environmentStephan von Gunten
Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Blood 106:1423-31. 2005..The new insights have important implications for the pathogenesis, diagnosis, and treatment of inflammatory diseases such as sepsis and rheumatoid arthritis... - Apoptotic pathways are inhibited by leptin receptor activation in neutrophilsAndreina Bruno
Department of Pharmacology, University of Bern, Bern, Switzerland
J Immunol 174:8090-6. 2005..Taken together, leptin is a survival cytokine for human neutrophils, a finding with potential pathologic relevance in inflammatory diseases... - Leptin is an eosinophil survival factorSebastien Conus
Department of Pharmacology, University of Bern, Switzerland
J Allergy Clin Immunol 116:1228-34. 2005..It exerts proliferative and antiapoptotic activities in a variety of cell types, including T cells. Leptin also stimulates macrophages and neutrophils, and its production is increased during inflammation... - Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatmentDagmar Simon
Department of Dermatology, University of Bern, Switzerland
J Allergy Clin Immunol 114:887-95. 2004..In several clinical studies, topical calcineurin inhibitors have been shown to be effective in the treatment of atopic dermatitis (AD). They target signaling pathways that control gene expression, particularly the expression of cytokines... - Anti-interleukin-5 antibody therapy in eosinophilic diseasesDagmar Simon
Department of Dermatology, Inselspital, Bern, Switzerland
Pathobiology 72:287-92. 2005..The decrease of tissue eosinophils was, however, less dramatic. Investigating the effects of anti-IL-5 therapy will improve our understanding of the pathogenic roles of both IL-5 and eosinophils in eosinophilic inflammatory responses... - Lysosomal degradation of RhoH protein upon antigen receptor activation in T but not B cellsJan Schmidt-Mende
Institute of Pharmacology, University of Bern, Bern, Switzerland
Eur J Immunol 40:525-9. 2010..This newly discovered regulatory pathway of RhoH expression might limit TCR signaling and subsequent T-cell activation upon Ag contact... - cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosisEkatherina M Vassina
Department of Pharmacology, University of Bern, Bern, Switzerland
Eur J Immunol 36:1975-84. 2006..The cytokine-dependent mechanism of delayed eosinophil apoptosis described here may also apply to other eosinophilic diseases... - Epidermal caspase-3 cleavage associated with interferon-gamma-expressing lymphocytes in acute atopic dermatitis lesionsDagmar Simon
Department of Dermatology, University of Bern, Bern, Switzerland
Exp Dermatol 15:441-6. 2006.... - Cell death modulation by intravenous immunoglobulinStephan von Gunten
Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, Bern, Switzerland
J Clin Immunol 30:S24-30. 2010..These involve activation status of the target cell, cytokine microenvironment, pathogenesis and stage of disease, individual genetic determinants, species characteristics, and batch-to-batch variations of IVIG preparations... - Inflammation-associated autophagy-related programmed necrotic death of human neutrophils characterized by organelle fusion eventsCristina C Mihalache
Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
J Immunol 186:6532-42. 2011.... - Protein overexpression following lentiviral infection of primary mature neutrophils is due to pseudotransductionBarbara Geering
Institute of Pharmacology, University of Bern, Bern, Switzerland
J Immunol Methods 373:209-18. 2011..Based on our data and previous reports of unspecific viral effects on immune cells following lentiviral transduction, we discourage scientists to use lentiviral transduction methods to manipulate primary mature neutrophils... - Cathepsins and their involvement in immune responsesSebastien Conus
Institute of Pharmacology, University of Bern, Bern, Switzerland
Swiss Med Wkly 140:w13042. 2010..Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases... - Autophagic-like cell death in neutrophils induced by autoantibodiesStephan von Gunten
Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Autophagy 3:67-8. 2007..Here, we discuss the pathophysiological and therapeutic implications of these recent findings... - Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defenseShida Yousefi
Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Nat Med 14:949-53. 2008.... - Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alphaArezoo Daryadel
Department of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
J Biol Chem 281:27653-61. 2006..Taken together, apoptotic mature neutrophils release MIF upon short term TNF-alpha stimulation. Therefore, apoptosis may not always occur without the induction of pro-inflammatory mechanisms... - Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammationSebastien Conus
Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland
J Exp Med 205:685-98. 2008.... - Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophilsNicola Andina
Institute of Pharmacology, University of Bern, Bern, Switzerland
J Allergy Clin Immunol 123:603-11. 2009..IL-5-mediated transmembrane signal transduction involves both Lyn-mitogen-activated protein kinases and Janus kinase 2-signal transducer and activator of transcription pathways... - The interleukin-13 production by peripheral blood T cells from atopic dermatitis patients does not require CD2 costimulationDagmar Simon
Department of Dermatology, University of Bern, Bern, Switzerland
Int Arch Allergy Immunol 132:148-55. 2003..Although allergic mechanisms appear to be important, the pathogenesis of both extrinsic and intrinsic forms of atopic dermatitis (AD) is unknown... - A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophilsBarbara Geering
Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, Switzerland
Blood 117:5953-62. 2011..We conclude that in neutrophils, proapoptotic pathways after TNFR1 stimulation are initiated by p38 and PI3K, but not by caspase-8, a finding that should be considered in anti-inflammatory drug-development strategies... - Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodiesStephan von Gunten
Department of Pharmacology, University of Bern, Bern, Switzerland
J Allergy Clin Immunol 119:1005-11. 2007..Human intravenous immunoglobulin (IVIg) preparations are used for the treatment of autoimmune and allergic diseases. Natural autoantibodies are believed to contribute to IVIg-mediated anti-inflammatory effects... - Anti-CD20 (rituximab) treatment improves atopic eczemaDagmar Simon
Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland
J Allergy Clin Immunol 121:122-8. 2008..Atopic eczema (AE) is a chronic inflammatory skin disorder characterized by eczematous skin lesions, pruritus, and typical histopathologic features... - Mathematical modeling of the regulation of caspase-3 activation and degradationJörg W Stucki
Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
J Theor Biol 234:123-31. 2005..In addition, we predict a novel mechanism of caspase-3 degradation that might be particularly relevant in long-living cells... - Expression of CD95 on mature leukocytes of MRL/lpr mice after transplantation of genetically modified bone marrow stem cellsElena Federzoni
Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Immunol Lett 117:45-9. 2008..This suggests that correction of CD95 deficiency can be achieved by gene therapy... - Granulocyte death regulation by naturally occurring autoantibodiesStephan von Gunten
Institute of Pharmacology, University of Bern, Switzerland
Adv Exp Med Biol 750:157-72. 2012.... - Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysisSebastien Conus
Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
J Biol Chem 287:21142-51. 2012..As cathepsin D is ubiquitously expressed, this may represent a general mechanism to induce apoptosis in a variety of immune and nonimmune cells... - The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cellsMattia Rizzi
Experimental Oncology Hematology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
J Leukoc Biol 81:1599-608. 2007..In summary, our findings implicate a role for DAPK2 in granulocyte maturation... - Eosinophil extracellular DNA traps in skin diseasesDagmar Simon
Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland
J Allergy Clin Immunol 127:194-9. 2011..In the skin, eosinophils are found in a broad spectrum of diseases, including infectious diseases... - Efalizumab-associated papular psoriasisAkmal S Hassan
Department of Dermatology, University of Bern, Inselspital, 3010 Bern, Switzerland
Arch Dermatol 143:900-6. 2007..Some of the patients develop new papular lesions during treatment, which are predominantly located in the flexural regions... - New drug targets in atopic dermatitisDagmar Simon
Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland
Chem Immunol Allergy 96:126-31. 2012..According to recent studies, neutralizing B and T cells products such as IgE or IL-5 might be effective in subgroups of patients with AD... - Eosinophilic disordersDagmar Simon
Department of Dermatology, University of Bern, Bern, Switzerland
J Allergy Clin Immunol 119:1291-300; quiz 1301-2. 2007..Interestingly, many subgroups of patients originally thought to have the idiopathic hypereosinophilic syndrome can be integrated in this classification... - Cathepsins: key modulators of cell death and inflammatory responsesSebastien Conus
Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Biochem Pharmacol 76:1374-82. 2008..In this review, the players and the molecular mechanisms involved in the lysosomal apoptotic pathways will be discussed as well as the importance of these pathways in the immune system and the pathogenesis of diseases... - Targeting siglecs--a novel pharmacological strategy for immuno- and glycotherapyCamilla Jandus
Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Biochem Pharmacol 82:323-32. 2011.... - Viable neutrophils release mitochondrial DNA to form neutrophil extracellular trapsS Yousefi
Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
Cell Death Differ 16:1438-44. 2009..In conclusion, mitochondrial DNA release by neutrophils and NET formation do not require neutrophil death and do also not limit the lifespan of these cells... - Autophagy regulation in macrophages and neutrophilsCristina C Mihalache
Institute of Pharmacology, University of Bern, Bern, Switzerland
Exp Cell Res 318:1187-92. 2012..Specifically, it appears that autophagy protects against infections and inflammation. Here, we review recent work performed in macrophages and neutrophils, which both represent critical phagocytes in mammalians... - Autophagy in cancer and chemotherapyShida Yousefi
Institute of Pharmacology, University of Bern, Friedb0ihlstrasse 49, CH 3010 Bern, Switzerland
Results Probl Cell Differ 49:183-90. 2009..This chapter summarizes our current understanding regarding the regulation of autophagy in tumors and discusses potential new anticancer drug treatment strategies... - Isolated autosomal dominant growth hormone deficiency: stimulating mutant GH-1 gene expression drives GH-1 splice-site selection, cell proliferation, and apoptosisSouzan Salemi
Paediatric Endocrinology, University Children s Hospital, Inselspital, University of Bern, CH 3010 Bern, Switzerland
Endocrinology 148:45-53. 2007..Our findings that the proportion of 17.5-kDa produced from mutant GH-1 alleles increases with increased drive for gene expression may help to explain the variable onset progression, and severity observed in IGHD II... - Apoptosis regulation by autophagy gene 5Shida Yousefi
Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Crit Rev Oncol Hematol 63:241-4. 2007..In particular, we would like to draw the attention of the readers to Atg5, which exhibits, like Bcl-2, a dual function by modulating both autophagy and apoptosis... - Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in diseaseShida Yousefi
Institute of Pharmacology, University of Bern, Bern, Switzerland Electronic address
Curr Opin Immunol 24:736-9. 2012.... - RhoH/TTF negatively regulates leukotriene production in neutrophilsArezoo Daryadel
Institute of Pharmacology, University of Bern, Bern, Switzerland
J Immunol 182:6527-32. 2009..Taken together, these data suggest that RhoH/TTF represents an inducible feedback inhibitor in neutrophils that is involved in the limitation of innate immune responses... - Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cellsD Kassahn
Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland
Cell Death Differ 16:115-24. 2009..We conclude that activation-induced degranulation of Fas ligand in cytotoxic lymphocytes is differently regulated than other classical cytotoxic granule proteins... - Induction of Bim limits cytokine-mediated prolonged survival of neutrophilsN Andina
Institute of Pharmacology, University of Bern, Bern CH 3010, Switzerland
Cell Death Differ 16:1248-55. 2009.... - Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A)G Kostylina
Department of Pharmacology, University of Bern, Friedbuhlstrasse 49, Bern, Switzerland
Cell Death Differ 15:134-42. 2008..Moreover, this study identified a new cellular target of NA and future drugs activating GPR109A receptors, the mature neutrophil... - Therapeutic approaches to patients with hypereosinophilic syndromesHans Uwe Simon
Institute of Pharmacology, University of Bern, Bern, Switzerland
Semin Hematol 49:160-70. 2012..More recently, the availability of novel targeted therapies and a better understanding of the etiologies of some subtypes of HES have necessitated a more structured approach... - Autophagy in cells of the bloodShida Yousefi
Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Biochim Biophys Acta 1793:1461-4. 2009..Here, we review these findings, which point to an important role of autophagy in several cellular functions related to host defense... - Increased lipopolysaccharide-induced tumour necrosis factor-alpha, interferon-gamma and interleukin-10 production in atopic dermatitisD Simon
Department of Dermatology, Inselspital, University of Bern, CH 3010 Bern, Switzerland
Br J Dermatol 157:583-6. 2007..According to the hygiene hypothesis, decreased exposure to microbial products in early childhood does not allow sufficient maturation of the immune system that is associated with an increased risk of atopic sensitization... - A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndromeS Salemi
Institute of Pharmacology, University of Bern, Bern, Switzerland
Allergy 64:913-8. 2009..However, some patients may develop imatinib resistance because of an acquired T674I mutation, which is believed to prevent drug binding through steric hindrance... - Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridusO A Thomet
Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
Biochem Pharmacol 61:1041-7. 2001.... - Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonistH U Simon
Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
J Immunol 165:4069-75. 2000..The cellular content of ECP appears to be a no limiting factor in the case of repetitive stimulation, implying that mature eosinophils may not require a significant ECP resynthesis... 
Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophilsS Yousefi
Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland
J Exp Med 183:1407-14. 1996..Compatible with this model, both Lyn and Syk are essential for the activation of the antiapoptotic pathway(s) induced through the IL-3/IL-5/GM-CSF receptor beta subunit in human eosinophils...- Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disordersI V Heinisch
Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 108:21-8. 2001..The T cell-derived factor that induces CD137 expression in eosinophils remains to be identified... - Alternative functions for TRAIL receptors in eosinophils and neutrophilsI Daigle
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Swiss Med Wkly 131:231-7. 2001..The receptors of TRAIL belong to the superfamily of tumour necrosis factor (TNF)/nerve growth factor (NGF) receptors. Here we investigate TRAIL receptor expression and function in eosinophils and neutrophils... - Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophilsO A Thomet
Swiss Institute of Allergy and Asthma Research (SIAF, University of Zurich, Davos, Switzerland
Clin Exp Allergy 31:1310-20. 2001.... - Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory responseA Straumann
Department of Gastroenterology, Kantonsspital, Olten, Switzerland
J Allergy Clin Immunol 108:954-61. 2001..T cells, IL-5, eosinophils, and IgE-mediated mechanisms appear to be involved, giving rise to the possibility that allergic reactions might play a role in the pathogenesis of the disease... - Critical role for caspases 3 and 8 in neutrophil but not eosinophil apoptosisI Daigle
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
Int Arch Allergy Immunol 126:147-56. 2001..CONCLUSION: The data of this study indicate differences in the usage of caspases between neutrophils and eosinophils... - The T348M mutated form of cryopyrin is associated with defective lipopolysaccharide-induced interleukin 10 production in CINCA syndromeT Bihl
Ann Rheum Dis 64:1380-1. 2005 - [Difficult to manage asthma: clinical phenotypes and principles of therapy]G Menz
Hochgebirgsklinik Davos-Wolfgang, CH
Pneumologie 56:132-7. 2002 - IVIG--mechanisms of actionH U Simon
Department of Pharmacology, University of Bern, Switzerland; ZLB Bioplasma AG, Bern, Switzerland
Allergy 58:543-52. 2003..These mechanisms are effective concomitantly and synergistically at every occasion of use of IVIG in inflammatory and autoimmune disorders... - Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferationH U Simon
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Biochem J 297:389-97. 1994.... - Therapeutic interleukin (IL) 1 blockade normalises increased IL1 beta and decreased tumour necrosis factor alpha and IL10 production in blood mononuclear cells of a patient with CINCA syndromeM Seitz
Ann Rheum Dis 64:1802-3. 2005 - Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitisA G Schapowal
Hochgebirgsklinik Davos Wolfgang, Switzerland
Acta Otorhinolaryngol Belg 49:235-50. 1995..Unfortunately there is so far no curative treatment. New drugs like cytokine or leukotriene receptor antagonists give hope for better results in treatment of aspirin intolerance in the future...