Claire Anne Siegrist

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
    Claire Anne Siegrist
    Departments of Pathology and Pediatrics, Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 21:3406-12. 2003
  2. ncbi request reprint Can successful vaccines teach us how to induce efficient protective immune responses?
    Paul Henri Lambert
    Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Nat Med 11:S54-62. 2005
  3. ncbi request reprint [Swiss vaccinology update: new glycoconjugate vaccines against pneumococcal and meningococcal infections]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Faculté de médecine et Hôpitaux universitaires de Genève CMU, I rue Michel Servet, 1211 Geneve 4
    Rev Med Suisse 7:154-8. 2011
  4. pmc A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology and Pediatrics, Medical Faculty of the University of Geneva, Geneva, Switzerland
    PLoS ONE 4:e5771. 2009
  5. pmc Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    PLoS ONE 3:e3683. 2008
  6. pmc Determinants of hepatitis A vaccine immunity in a cohort of human immunodeficiency virus-infected children living in Switzerland
    Pierre Alex Crisinel
    Department of Pediatrics, Geneva Medical School and University Hospitals of Geneva, Geneva, Switzerland
    Clin Vaccine Immunol 19:1751-7. 2012
  7. ncbi request reprint [New Swiss recommendations for adult boosters against pertussis, tetanus and diphtheria]
    C A Siegrist
    centre de vaccinologie, Faculté de médecine et HUG, CMU, 1211 Geneve 4
    Rev Med Suisse 8:125-8. 2012
  8. ncbi request reprint B-cell responses to vaccination at the extremes of age
    Claire Anne Siegrist
    Departments of Pathology Immunology and Pediatrics, WHO Collaborative Center for Neonatal Vaccinology, Medical Faculty of University of Geneva, Centre Medical Universitaire, Geneva 4, Switzerland
    Nat Rev Immunol 9:185-94. 2009
  9. ncbi request reprint [Vaccine update 2009: questions around the safety of the influenza A (H1N1) vaccine]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, HUG et Faculté de médecine, 1211 Geneve 14
    Rev Med Suisse 6:67-70. 2010
  10. ncbi request reprint [Vaccinology: which catch-up plans for patients with unknown or incomplete immunizations?]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Faculté de médecine et Hôpitaux universitaires de Genève CMU, I rue Michel Servet, 1211 Geneve 4
    Rev Med Suisse 5:63-8. 2009

Detail Information

Publications57

  1. ncbi request reprint Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
    Claire Anne Siegrist
    Departments of Pathology and Pediatrics, Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 21:3406-12. 2003
    ..This allows the definition of the main determinants of the influence of MatAb on infant immunity...
  2. ncbi request reprint Can successful vaccines teach us how to induce efficient protective immune responses?
    Paul Henri Lambert
    Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Nat Med 11:S54-62. 2005
    ....
  3. ncbi request reprint [Swiss vaccinology update: new glycoconjugate vaccines against pneumococcal and meningococcal infections]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Faculté de médecine et Hôpitaux universitaires de Genève CMU, I rue Michel Servet, 1211 Geneve 4
    Rev Med Suisse 7:154-8. 2011
    ..The additional information (and the answers to numerous expected questions) will be distributed to the 4300 subscribers of InfoVac (www.infovac. ch), which just celebrated its 10th birthday...
  4. pmc A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology and Pediatrics, Medical Faculty of the University of Geneva, Geneva, Switzerland
    PLoS ONE 4:e5771. 2009
    ..Here, we assessed whether these properties extend to early life and how CAF01 mediates its adjuvant properties in vivo...
  5. pmc Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    PLoS ONE 3:e3683. 2008
    ..In this study, we assessed the immunogenicity of a novel candidate vaccine comprising a mycobacterial fusion protein, Ag85B-ESAT-6, in a neonatal murine immunization model...
  6. pmc Determinants of hepatitis A vaccine immunity in a cohort of human immunodeficiency virus-infected children living in Switzerland
    Pierre Alex Crisinel
    Department of Pediatrics, Geneva Medical School and University Hospitals of Geneva, Geneva, Switzerland
    Clin Vaccine Immunol 19:1751-7. 2012
    ..This may translate into a shorter protection time. Hence, monitoring humoral immunity may be necessary to provide supplementary doses as needed...
  7. ncbi request reprint [New Swiss recommendations for adult boosters against pertussis, tetanus and diphtheria]
    C A Siegrist
    centre de vaccinologie, Faculté de médecine et HUG, CMU, 1211 Geneve 4
    Rev Med Suisse 8:125-8. 2012
    ..myvaccines.ch) is now available for free to both the public and the professio-..
  8. ncbi request reprint B-cell responses to vaccination at the extremes of age
    Claire Anne Siegrist
    Departments of Pathology Immunology and Pediatrics, WHO Collaborative Center for Neonatal Vaccinology, Medical Faculty of University of Geneva, Centre Medical Universitaire, Geneva 4, Switzerland
    Nat Rev Immunol 9:185-94. 2009
    ..This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups...
  9. ncbi request reprint [Vaccine update 2009: questions around the safety of the influenza A (H1N1) vaccine]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, HUG et Faculté de médecine, 1211 Geneve 14
    Rev Med Suisse 6:67-70. 2010
    ..The huge number of questions sent by professionals to InfoVac experts (www.infovac.ch), and the expressed gratitude, allows for some hope...
  10. ncbi request reprint [Vaccinology: which catch-up plans for patients with unknown or incomplete immunizations?]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Faculté de médecine et Hôpitaux universitaires de Genève CMU, I rue Michel Servet, 1211 Geneve 4
    Rev Med Suisse 5:63-8. 2009
    ..infovac.ch) for the most complex cases, or rely on viavac (www.viavac.ch), a new medical software that instantly establishes ready-to-use individualized catch-up plans including the most appropriate vaccine formulations...
  11. doi request reprint Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    Eur J Immunol 38:1247-56. 2008
    ..Thus, potent protective IFN-gamma-producing responses may be elicited by the exquisite activation of a minute number of in vivo targeted DC...
  12. ncbi request reprint Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines
    Nadine Schallert
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 32:752-60. 2002
    ....
  13. ncbi request reprint Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 176:165-72. 2006
    ..Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells...
  14. ncbi request reprint CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice
    Maria Pihlgren
    Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 21:2492-9. 2003
    ..In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool...
  15. doi request reprint Synchronization of dendritic cell activation and antigen exposure is required for the induction of Th1/Th17 responses
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, Medical Faculty of the University of Geneva, Geneva 1211, Switzerland
    J Immunol 188:4828-37. 2012
    ..Thus, the synchronization of DC targeting and activation is a critical determinant for Th1/Th17 adjuvanticity...
  16. doi request reprint Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants
    Beatris Mastelic
    Department of Pathology Immunology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Immunol 189:5764-72. 2012
    ..To our knowledge, this is the first demonstration that the T(FH) cell development limits early life GC responses and that adjuvants/delivery systems supporting T(FH) differentiation may restore adultlike early life GC B cell responses...
  17. doi request reprint Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland
    Catherine Myers
    Department of Pediatrics, Geneva Medical School and University Hospitals of Geneva, Switzerland
    Pediatr Infect Dis J 28:996-1001. 2009
    ..Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued...
  18. pmc Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity
    Lukas Flatz
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Nat Med 16:339-45. 2010
    ..These features, together with low seroprevalence in humans, suggest that rLCMV may show utility as a vaccine platform against infectious diseases and cancer...
  19. ncbi request reprint Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens
    Maria Pihlgren
    Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 170:2824-32. 2003
    ..Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life...
  20. ncbi request reprint Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres
    Matthias Regner
    World Health Organization Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    J Immunol 173:2669-74. 2004
    ....
  21. doi request reprint Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche
    Elodie Belnoue
    Department of Pathology Immunology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Immunol 188:1283-91. 2012
    ..Thereby, PCs are directed to associate in a functional BM niche with hematopoietic CXCR4(+)VLA-4(+)LFA-1(+) nursery cells, which provide PC survival factors...
  22. ncbi request reprint Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection
    Matthias Regner
    WHO Collaborating Center for Vaccinology, Department of Pathology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Microbes Infect 6:666-75. 2004
    ..Thus, the identification of hRSV antigen delivery systems with an age-appropriate adjuvanticity/reactogenicity balance may be feasible even in the vulnerable early-life period...
  23. ncbi request reprint Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 23:329-35. 2004
    ..Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation...
  24. doi request reprint Impact of synthetic and biologic disease-modifying antirheumatic drugs on antibody responses to the AS03-adjuvanted pandemic influenza vaccine: a prospective, open-label, parallel-cohort, single-center study
    Cem Gabay
    University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
    Arthritis Rheum 63:1486-96. 2011
    ..To identify the determinants of antibody responses to adjuvanted split influenza A (H1N1) vaccines in patients with inflammatory rheumatic diseases...
  25. doi request reprint Responses of solid organ transplant recipients to the AS03-adjuvanted pandemic influenza vaccine
    Claire Anne Siegrist
    Center for Vaccinology, Geneva University Hospitals, Geneva, Switzerland
    Antivir Ther 17:893-903. 2012
    ..Solid organ transplant (SOT) recipients are a priority group for influenza vaccination and strategies enhancing immunogenicity are needed...
  26. pmc Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients
    Bilal Mohty
    University Hospitals of Geneva, Centre for Vaccinology and Neonatal Immunology, Department of Pathology Immunology and Pediatrics, Medical Faculty, Geneva, Switzerland
    Haematologica 96:896-904. 2011
    ..The goal of this study was to assess the efficacy of the AS03-adjuvanted influenza H1N1/A/09 vaccine in allogeneic hematopoietic stem cell transplant recipients...
  27. pmc Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells
    Elodie Belnoue
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Centre Medical Universitaire, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    J Virol 81:7338-50. 2007
    ..Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection...
  28. pmc Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life
    Elodie Belnoue
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    PLoS ONE 8:e85302. 2013
    ....
  29. ncbi request reprint How do physicians immunize their own children? Differences among pediatricians and nonpediatricians
    Klara M Posfay-Barbe
    Centre for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Switzerland
    Pediatrics 116:e623-33. 2005
    ..Physicians are known to exert a direct influence on immunization rates by answering questions and clarifying misconceptions. Yet, it is unknown how they immunize their own children...
  30. ncbi request reprint Safety of DTaP-based combined immunization in very-low-birth-weight premature infants: frequent but mostly benign cardiorespiratory events
    Riccardo E Pfister
    Division of Neonatology and Pediatric Intensive Care and WHO Collaborating Centre for Neonatal Vaccinology, Department of Pediatrics, University Hospital of Geneva, Switzerland
    J Pediatr 145:58-66. 2004
    ..To evaluate the safety of diphtheria-tetanus-acellular pertussis-inactivated polio-Haemophilus influenzae type B (DTaP-IPV-HIB) immunization in premature infants...
  31. doi request reprint Comparison of clinical presentation of respiratory tract infections in H1N1/09-positive and H1N1/09-negative patients
    Pierre Alex Crisinel
    Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Geneva 14, Switzerland
    Eur J Pediatr 171:159-66. 2012
    ..24%) and myalgias (41% vs. 20%). H1N1/09-negative patients had more wheezing episodes (29% vs. 9%), higher rates of dyspnea (28% vs. 20%) and of hospital admissions (35% vs. 16%)...
  32. ncbi request reprint Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?
    Klara M Posfay-Barbe
    Department of Pediatrics, University Hospitals of Geneva, Switzerland
    Vaccine 28:4356-61. 2010
    ..Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection...
  33. pmc Higher memory responses in HIV-infected and kidney transplanted patients than in healthy subjects following priming with the pandemic vaccine
    Claire Anne Siegrist
    Department of Pathology Immunology and Paediatrics, Centre for Vaccinology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland
    PLoS ONE 7:e40428. 2012
    ..Memory responses require immune competence. We assessed the influence of priming with AS03-adjuvanted pandemic vaccine (Pandemrix®) on memory responses of HIV patients, kidney recipients (SOT) and healthy controls (HC)...
  34. doi request reprint Antibody responses to natural influenza A/H1N1/09 disease or following immunization with adjuvanted vaccines, in immunocompetent and immunocompromised children
    Sara Meier
    Center for Vaccinology and Neonatal Immunology, Department of Pediatrics and Pathology Immunology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland
    Vaccine 29:3548-57. 2011
    ..To compare antibody responses elicited by influenza A/H1N1/09 disease and immunization with adjuvanted vaccines, in immunocompetent or immunocompromised children...
  35. ncbi request reprint Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
    Claire Anne Siegrist
    Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 23:615-22. 2004
    ..This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity...
  36. doi request reprint Protective antibody responses to influenza A/H1N1/09 vaccination in children with celiac disease
    Michela G Schäppi
    Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland
    J Pediatr Gastroenterol Nutr 54:817-9. 2012
    ..All of the children with celiac disease reached protective antibody titers (≥40) and showed a geometric mean titer comparable with the control group (530 vs 573)...
  37. doi request reprint Memory B cell compartment constitution and susceptibility to recurrent lower respiratory tract infections in young children
    Johan N Siebert
    Department of Pediatrics, University Hospitals of Geneva and Medical School, University of Geneva, Geneva, Switzerland
    J Leukoc Biol 93:951-62. 2013
    ..However, the waning of antibodies might predispose children to recurrent infections in the absence of revaccination...
  38. doi request reprint Acceptability of maternal immunization against influenza: the critical role of obstetricians
    Geraldine Blanchard-Rohner
    Department of Paediatrics, Children s Hospital of Geneva, Geneva, Switzerland
    J Matern Fetal Neonatal Med 25:1800-9. 2012
    ..In Switzerland, immunization was first recommended to all pregnant women in 2009. We assessed the acceptability of this recommendation and its determinants two seasons later...
  39. ncbi request reprint Bordetella holmesii: an under-recognised Bordetella species
    Laure F Pittet
    Department of Paediatrics, Division of General Paediatrics, Children s Hospital, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland
    Lancet Infect Dis 14:510-9. 2014
    ..B holmesii's adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance. ..
  40. pmc Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussis
    Caroline Roduit
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology and Pediatrics, University of Geneva, Geneva, Switzerland
    Infect Immun 70:3521-8. 2002
    ..pertussis challenge. Thus, neonatal priming with antipertussis vaccines should be considered to reduce the window of vulnerability to pertussis at the time of its greatest severity...
  41. doi request reprint Influenza vaccination given at least 2 weeks before delivery to pregnant women facilitates transmission of seroprotective influenza-specific antibodies to the newborn
    Geraldine Blanchard-Rohner
    From the Department of Pediatrics, Children s Hospital of Geneva Department of Pediatrics and Pathology Immunology, Center for Vaccinology and Neonatal Immunology, Laboratory of Virology, Department of Genetics and Laboratory Medicine Clinical Research Center and Department of Gynecology and Obstetrics, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    Pediatr Infect Dis J 32:1374-80. 2013
    ..Pregnant women and infants are at higher risk of complications secondary to influenza infection. Immunization during pregnancy facilitates protection of the neonates through passive transfer of maternal antibodies...
  42. ncbi request reprint Vaccine-induced immunity in children after orthotopic liver transplantation: a 12-yr review of the Swiss national reference center
    Alessandro Diana
    Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
    Pediatr Transplant 11:31-7. 2007
    ....
  43. doi request reprint Mode of action of adjuvants: implications for vaccine safety and design
    Beatris Mastelic
    WHO Center for Vaccinology and Neonatal Immunology, CMU, 1 rue Michel Servet, 1211 Geneva, 4, Switzerland
    Biologicals 38:594-601. 2010
    ..More information on the conference output can be found on the IABS website, http://www.iabs.org/...
  44. doi request reprint Tetanus immunity as a surrogate for past diphtheria-tetanus-pertussis immunization in migrant children
    Isabel Garcia de la Fuente
    Division of General Pediatrics, Department of Pediatrics, University Hospitals of Geneva and University of Geneva Medical School, Geneva, Switzerland
    Pediatr Infect Dis J 32:274-7. 2013
    ..Overimmunizing" is costly and associated with risks of hyperimmunization, whereas assuming up-to-date immunizations may be misleading...
  45. ncbi request reprint Human papilloma virus immunization in adolescent and young adults: a cohort study to illustrate what events might be mistaken for adverse reactions
    Claire Anne Siegrist
    Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    Pediatr Infect Dis J 26:979-84. 2007
    ..To anticipate events that might be mistakenly assumed to be caused by immunization, their prevalence was monitored before vaccine introduction...
  46. ncbi request reprint Response to treatment and disease progression linked to CD4+ T cell surface CC chemokine receptor 5 density in human immunodeficiency virus type 1 vertical infection
    Alain Gervaix
    Departement de Pediatrie, Hopitaux Universitaires de Geneve, Geneva, Switzerland
    J Infect Dis 185:1055-61. 2002
    ..Moreover, they suggest that therapies aimed at reducing CCR5 accessibility should slow down HIV disease evolution in children...
  47. pmc Impaired antibody response causes persistence of prototypic T cell-contained virus
    Andreas Bergthaler
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    PLoS Biol 7:e1000080. 2009
    ....
  48. ncbi request reprint Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infants
    Aline Flatz-Jequier
    Department of Pediatrics, Children s Hospital, University Hospitals of Geneva and Medical Faculty of the University of Geneva, Geneva, Switzerland
    J Pediatr 153:429-31. 2008
    ..A cardiorespiratory event associated with the first vaccination was the sole risk factor for recurrence identified...
  49. doi request reprint Efficient orthogonal bioconjugation of dendrimers for synthesis of bioactive nanoparticles
    Hubert F Gaertner
    Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, Switzerland
    Bioconjug Chem 22:1103-14. 2011
    ..These PAMAM dendrimer-based approaches represent a robust and versatile platform for the development of bioactive nanoparticles...
  50. doi request reprint APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells
    Elodie Belnoue
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    Blood 111:2755-64. 2008
    ..Altogether, this identifies APRIL as a critical signal for PB survival that is poorly expressed in the early-life BM compartment...
  51. doi request reprint Vaccination during pregnancy to protect infants against influenza: why and why not?
    Geraldine Blanchard-Rohner
    Department of Pediatrics, University Hospitals of Geneva, Switzerland
    Vaccine 29:7542-50. 2011
    ..Therefore, educational interventions for the public and health care workers are necessary to increase protection of pregnant women and young infants from influenza related complications...
  52. doi request reprint ABCB1 polymorphisms and neuropsychiatric adverse events in oseltamivir-treated children during influenza H1N1/09 pandemia
    Arnaud G L'huillier
    Geneva Medical Faculty and University Hospitals of Geneva, Department of Pediatrics, Geneva, Switzerland
    Pharmacogenomics 12:1493-501. 2011
    ..To examine the safety profile of oseltamivir in children and evaluate the impact of P-glycoprotein polymorphisms on the incidence of neuropsychiatric adverse events (NPAE) in oseltamivir-treated children...
  53. doi request reprint Use of pneumococcal polysaccharide vaccine in children: what is the evidence?
    Ray Borrow
    Vaccine Evaluation Unit, Health Protection Agency, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, UK
    Curr Opin Infect Dis 25:292-303. 2012
    ..The use of pneumococcal polysaccharide vaccines (PPVs) has in recent years become a topic of much debate, especially for use in children...
  54. pmc Diagnosis of whooping cough in Switzerland: differentiating Bordetella pertussis from Bordetella holmesii by polymerase chain reaction
    Laure F Pittet
    Department of Paediatrics, Division of General Paediatrics, Children s Hospital, University Hospitals of Geneva, Geneva, Switzerland
    PLoS ONE 9:e88936. 2014
    ..holmesii seems to be circulating less than in neighboring countries and that specific diagnostic procedures are not necessary routinely. However, as the epidemiological situation may change rapidly, periodic reevaluation is suggested. ..
  55. ncbi request reprint [Why are boosters no longer necessary for protection against hepatitis B?]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Universite de Geneve, C M U, 1211 Geneve 4, Suisse
    Rev Prat 54:509-11. 2004
    ..This resulted into a change of initial recommendations, which now highlight that booster doses are unnecessary in immunocompetent persons after a complete course of vaccination...
  56. pmc Autoimmune diseases after adolescent or adult immunization: what should we expect?
    Claire Anne Siegrist
    Center for Vaccinology and Neonatal Immunology, Department of Pediatrics, University of Geneva, Geneva, Switzerland
    CMAJ 177:1352-4. 2007
  57. doi request reprint Chickenpox in a Swiss prison: susceptibility, post-exposure vaccination and control measures
    Laurent Getaz
    Department of Community Medicine and Primary Care, Geneva University Hospitals, Geneva, Switzerland
    Scand J Infect Dis 42:936-40. 2010
    ..Since the attack rate among susceptible household contacts is usually high, preventive measures such as vaccination and quarantine probably allowed containment of the spread of infection...