C Siegrist

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines
    Nadine Schallert
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 32:752-60. 2002
  2. ncbi request reprint Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice
    C A Siegrist
    W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Eur J Immunol 28:4138-48. 1998
  3. ncbi request reprint [Vaccinology update for 2008: what's new in Switzerland?]
    C A Siegrist
    Centre de vaccinologie et d immunologie néonatale, CMU, 1211 Geneve
    Rev Med Suisse 4:72-5. 2008
  4. ncbi request reprint Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
    Claire Anne Siegrist
    Departments of Pathology and Pediatrics, Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 21:3406-12. 2003
  5. ncbi request reprint The challenges of vaccine responses in early life: selected examples
    C A Siegrist
    Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland
    J Comp Pathol 137:S4-9. 2007
  6. ncbi request reprint Mechanisms underlying adverse reactions to vaccines
    C A Siegrist
    Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland
    J Comp Pathol 137:S46-50. 2007
  7. ncbi request reprint [Vaccine adjuvants and macrophagic myofasciitis]
    C A Siegrist
    Departement de Pathologie, centre de vaccinologie, Universite de Geneve, CMU, Suisse
    Arch Pediatr 12:96-101. 2005
  8. ncbi request reprint Human papilloma virus immunization in adolescent and young adults: a cohort study to illustrate what events might be mistaken for adverse reactions
    Claire Anne Siegrist
    Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    Pediatr Infect Dis J 26:979-84. 2007
  9. ncbi request reprint Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
    Claire Anne Siegrist
    Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 23:615-22. 2004
  10. ncbi request reprint [Why are boosters no longer necessary for protection against hepatitis B?]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Universite de Geneve, C M U, 1211 Geneve 4, Suisse
    Rev Prat 54:509-11. 2004

Detail Information

Publications63

  1. ncbi request reprint Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines
    Nadine Schallert
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 32:752-60. 2002
    ....
  2. ncbi request reprint Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice
    C A Siegrist
    W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Eur J Immunol 28:4138-48. 1998
    ..It suggests that effective vaccine responses may be obtained earlier in presence of maternal antibodies through the use of appropriate immunization strategies using conventional or novel vaccines for early priming...
  3. ncbi request reprint [Vaccinology update for 2008: what's new in Switzerland?]
    C A Siegrist
    Centre de vaccinologie et d immunologie néonatale, CMU, 1211 Geneve
    Rev Med Suisse 4:72-5. 2008
    ..A source of information to be recommended without hesitation!..
  4. ncbi request reprint Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
    Claire Anne Siegrist
    Departments of Pathology and Pediatrics, Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 21:3406-12. 2003
    ..This allows the definition of the main determinants of the influence of MatAb on infant immunity...
  5. ncbi request reprint The challenges of vaccine responses in early life: selected examples
    C A Siegrist
    Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland
    J Comp Pathol 137:S4-9. 2007
    ..Novel vaccination strategies including early priming and subsequent boosting are most likely to counteract these effects and provide protection from exposure to infectious disease in early life...
  6. ncbi request reprint Mechanisms underlying adverse reactions to vaccines
    C A Siegrist
    Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland
    J Comp Pathol 137:S46-50. 2007
    ..Finally, many reported adverse events are simply chance instances of infection or disease onset around the time of vaccination and are not causally associated with administration of vaccine...
  7. ncbi request reprint [Vaccine adjuvants and macrophagic myofasciitis]
    C A Siegrist
    Departement de Pathologie, centre de vaccinologie, Universite de Geneve, CMU, Suisse
    Arch Pediatr 12:96-101. 2005
    ..The existence of sampling bias inherent to the complexity of the clinical and pathological diagnoses remains the most likely hypothesis...
  8. ncbi request reprint Human papilloma virus immunization in adolescent and young adults: a cohort study to illustrate what events might be mistaken for adverse reactions
    Claire Anne Siegrist
    Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    Pediatr Infect Dis J 26:979-84. 2007
    ..To anticipate events that might be mistakenly assumed to be caused by immunization, their prevalence was monitored before vaccine introduction...
  9. ncbi request reprint Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
    Claire Anne Siegrist
    Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 23:615-22. 2004
    ..This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity...
  10. ncbi request reprint [Why are boosters no longer necessary for protection against hepatitis B?]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Universite de Geneve, C M U, 1211 Geneve 4, Suisse
    Rev Prat 54:509-11. 2004
    ..This resulted into a change of initial recommendations, which now highlight that booster doses are unnecessary in immunocompetent persons after a complete course of vaccination...
  11. ncbi request reprint [Vaccinology update 2005: a new category of recommendations for optimal vaccine protection]
    C A Siegrist
    Commission fédérale pour les vaccinations Centre de vaccinologie et d immunologie néonatale, Departement de pédiatrie Université de Genève CMU, 1211 Geneve 4
    Rev Med Suisse 2:67-70. 2006
    ..The challenge is now to inform parents about this new possibility of an optimal prevention, in addition to baseline immunizations...
  12. ncbi request reprint Influence of anesthesia on immune responses and its effect on vaccination in children: review of evidence
    J N Siebert
    World Health Organization Collaborating Center for Neonatal Vaccinology, Departments of Pathology and Pediatrics, University of Geneva Medical School, Geneva, Switzerland
    Paediatr Anaesth 17:410-20. 2007
    ....
  13. ncbi request reprint How to improve communication on vaccine issues at the national level? INFOVAC-PED: an example from Switzerland
    C Siegrist
    Department of Pediatrics and Pathology, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 4, Geneva, Switzerland
    Vaccine 20:S98-S100. 2001
    ..The rapid success of this novel initiative underlines the need to better support front line physicians...
  14. ncbi request reprint [First glance at the 2007 national immunization plan]
    C A Siegrist
    Centre de vaccinologie et d immunologie néonatale, Départment de pédiatrie, Universite de Geneve
    Rev Med Suisse 3:63-7. 2007
    ..Recommendations about new vaccines, such as against cervical cancer, will be communicated in real time to all the physicians registered at InfoVac...
  15. ncbi request reprint [Vaccinology update 2004]
    C A Siegrist
    Directrice du Département de pédiatrie, Centre de vaccinologie et d immunologie néonatale, Universite de Geneve, CMU, I, rue Michel Servet, 1211 Geneve 4
    Rev Med Suisse 1:79-82. 2005
    ..What did not change in 2004 ? The Internet address allowing physicians to send any question related to vaccination: www.infovac.ch..
  16. ncbi request reprint [The child with recurrent infections: which screening for immunoe deficiency?]
    C A Siegrist
    Centre de vaccinologie et d immunologie néonatale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Suisse
    Arch Pediatr 8:205-10. 2001
    ..This article indicates for which pediatric patients an immunodeficiency screening should be considered, and how to analyze its results...
  17. ncbi request reprint Vaccination in the neonatal period and early infancy
    C A Siegrist
    Department of Pediatrics, WHO Collaborating Centre for Neonatal Vaccinology, University of Geneva, CMU, Switzerland
    Int Rev Immunol 19:195-219. 2000
    ..The extent to which early life murine immunization models may be useful for preclinical evaluation of infant responses is outlined in this review...
  18. ncbi request reprint Neonatal and early life vaccinology
    C A Siegrist
    WHO Collaborating Centre for Neonatal Vaccinology, Departments of Pediatrics and Pathology, University of Geneva, 1 Michel Servet, 1211 4, Geneva, Switzerland
    Vaccine 19:3331-46. 2001
    ..Thus, neonatal priming and early boosting with vaccine formulations optimised for sufficient early life immunogenicity and maximal safety profiles, could allow better control of the huge infectious disease burden in early life...
  19. ncbi request reprint CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice
    Maria Pihlgren
    Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 21:2492-9. 2003
    ..In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool...
  20. ncbi request reprint A brief view of known landmarks reorientates path integration in hamsters
    A S Etienne
    Laboratory of Ethology, University of Geneva, 54 route des Acacias, 1227 Geneva, Switzerland
    Naturwissenschaften 87:494-8. 2000
    ..Taking episodic positional fixes may greatly enhance the functional value of path integration...
  21. ncbi request reprint Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 23:329-35. 2004
    ..Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation...
  22. ncbi request reprint Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens
    Maria Pihlgren
    Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 170:2824-32. 2003
    ..Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life...
  23. ncbi request reprint Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 176:165-72. 2006
    ..Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells...
  24. ncbi request reprint Can successful vaccines teach us how to induce efficient protective immune responses?
    Paul Henri Lambert
    Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Nat Med 11:S54-62. 2005
    ....
  25. ncbi request reprint Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection
    Matthias Regner
    WHO Collaborating Center for Vaccinology, Department of Pathology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Microbes Infect 6:666-75. 2004
    ..Thus, the identification of hRSV antigen delivery systems with an age-appropriate adjuvanticity/reactogenicity balance may be feasible even in the vulnerable early-life period...
  26. ncbi request reprint CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles
    Xavier Martinez
    W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Virology 305:428-35. 2003
    ....
  27. pmc Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussis
    Caroline Roduit
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology and Pediatrics, University of Geneva, Geneva, Switzerland
    Infect Immun 70:3521-8. 2002
    ..pertussis challenge. Thus, neonatal priming with antipertussis vaccines should be considered to reduce the window of vulnerability to pertussis at the time of its greatest severity...
  28. ncbi request reprint Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres
    Matthias Regner
    World Health Organization Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    J Immunol 173:2669-74. 2004
    ....
  29. pmc Autoimmune diseases after adolescent or adult immunization: what should we expect?
    Claire Anne Siegrist
    Center for Vaccinology and Neonatal Immunology, Department of Pediatrics, University of Geneva, Geneva, Switzerland
    CMAJ 177:1352-4. 2007
  30. ncbi request reprint How do physicians immunize their own children? Differences among pediatricians and nonpediatricians
    Klara M Posfay-Barbe
    Centre for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Switzerland
    Pediatrics 116:e623-33. 2005
    ..Physicians are known to exert a direct influence on immunization rates by answering questions and clarifying misconceptions. Yet, it is unknown how they immunize their own children...
  31. doi request reprint Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    Eur J Immunol 38:1247-56. 2008
    ..Thus, potent protective IFN-gamma-producing responses may be elicited by the exquisite activation of a minute number of in vivo targeted DC...
  32. pmc Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells
    Elodie Belnoue
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Centre Medical Universitaire, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    J Virol 81:7338-50. 2007
    ..Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection...
  33. doi request reprint Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infants
    Aline Flatz-Jequier
    Department of Pediatrics, Children s Hospital, University Hospitals of Geneva and Medical Faculty of the University of Geneva, Geneva, Switzerland
    J Pediatr 153:429-31. 2008
    ..A cardiorespiratory event associated with the first vaccination was the sole risk factor for recurrence identified...
  34. ncbi request reprint Vaccine-induced immunity in children after orthotopic liver transplantation: a 12-yr review of the Swiss national reference center
    Alessandro Diana
    Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
    Pediatr Transplant 11:31-7. 2007
    ....
  35. ncbi request reprint Effect of month of vaccine administration on antibody responses in The Gambia and Pakistan
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 11:1529-41. 2006
    ..To explore the relationship between calendar month of administration and antibody (Ab) response to vaccination in subjects from The Gambia and Pakistan, two countries with distinct patterns of seasonality...
  36. ncbi request reprint TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
    Claudia Bossen
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Blood 111:1004-12. 2008
    ..TACI supported survival of activated B cells and plasmablasts in vitro, providing a rational basis to explain the immunoglobulin deficiency reported in TACI-deficient persons...
  37. doi request reprint Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants
    Markus Knuf
    Paediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Pediatr 152:655-60, 660.e1. 2008
    ..Because young infants are at highest risk of pertussis complications, this study assessed whether neonatal acellular pertussis (aP) vaccination could provide earlier immunity...
  38. ncbi request reprint The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response
    Geraldine Blanchard Rohner
    Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    J Immunol 180:2165-73. 2008
    ..These findings suggest that these two parameters are good markers of B cell responses to priming and can be used as predictors of long term humoral immunity induced by glycoconjugate vaccines received in early infancy...
  39. doi request reprint Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high-quality antibody
    Yeh Chen Lee
    University Department of Paediatrics, University of Oxford, Oxford, UK
    Clin Infect Dis 46:186-92. 2008
    ....
  40. pmc Early appearance of bactericidal antibodies after polysaccharide challenge of toddlers primed with a group C meningococcal conjugate vaccine: what is its role in the maintenance of protection?
    Theodore F Tsai
    Wyeth Research, 500 Arcola Rd, Collegeville, Pennsylvania 19426, USA
    Clin Vaccine Immunol 13:854-61. 2006
    ..The majority of toddlers previously immunized with MCC and challenged 1 year later with PS antigen mounted protective levels of bactericidal antibody within 2 to 4 days...
  41. ncbi request reprint Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants
    Arnaud Marchant
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    J Infect Dis 193:1598-605. 2006
    ..We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses...
  42. ncbi request reprint Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type
    Anne Cécile Rimaniol
    SPI Bio, c o Service de Neurovirologie, 92265 Fontenay aux Roses Cedex, France
    Vaccine 22:3127-35. 2004
    ....
  43. ncbi request reprint [Vaccine adjuvants and macrophagic myofasciitis]
    Claire Anne Siegrist
    Centre de vaccinologie et d immunologie néonatale, Université de Genève CMU, 1 rue Michel Servet 1211 Genève 4
    Bull Acad Natl Med 187:1511-8; discussion 1519-21. 2003
    ..The existence of sampling bias inherent to the complexity of the clinical and pathological diagnoses remains the most likely hypothesis...
  44. ncbi request reprint The immunomodulating properties of human respiratory syncytial virus and immunostimulating complexes containing Quillaja saponin components QH-A, QH-C and ISCOPREP703
    Ke Fei Hu
    Section of Virology, Department of Veterinary Microbiology, College of Veterinary Medicine, Swedish University of Agricultural Sciences, Biomedical Center, Box 585, S 751 23 Uppsala, Sweden
    FEMS Immunol Med Microbiol 43:269-76. 2005
    ..The prospect to formulate an RSV ISCOM formulation with an optimal Th1/Th2 balance is in reach particularly in view of the versatile properties of the ISCOM concept...
  45. ncbi request reprint Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 171:3148-53. 2003
    ..yoelii parasites or immunized with the vaccine were protected and had excellent T cell responses. These data support assessment of this immunization strategy in neonates/young infants in areas in which malaria exacts its greatest toll...
  46. pmc Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-Labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice
    Havard Jakobsen
    Department of Immunology, Landspitali University Hospital, Reykjavik, Iceland
    Infect Immun 70:1443-52. 2002
    ..This suggests that mucosal immunization with pneumococcal conjugate vaccines and LT-K63 may be able to circumvent some of the limitations of neonatal antibody responses, which are required for protective immunity in early life...
  47. ncbi request reprint Vaccine safety controversies and the future of vaccination programs
    Guido François
    Viral Hepatitis Prevention Board, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, Department of Epidemiology and Social Medicine, University of Antwerpen, Antwerp, Belgium
    Pediatr Infect Dis J 24:953-61. 2005
    ....
  48. ncbi request reprint Influence of Mycobacterium bovis bacillus Calmette-Guérin on antibody and cytokine responses to human neonatal vaccination
    Martin O C Ota
    Medical Research Council Laboratories, Banjul, The Gambia
    J Immunol 168:919-25. 2002
    ..These results demonstrate that BCG influences the immune response to unrelated Ags in early life, likely through its influence on the maturation of dendritic cells...
  49. ncbi request reprint Early life T cell responses to pneumococcal conjugates increase with age and determine the polysaccharide-specific antibody response and protective efficacy
    Havard Jakobsen
    Department of Immunology, Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland
    Eur J Immunol 36:287-95. 2006
    ..Whereas a weak and Th2-biased response was observed in neonatal mice, infant mice showed a mixed Th1-Th2 response as observed in adults...
  50. ncbi request reprint Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeys
    Douglas S Walsh
    Department of Immunology and Medicine, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 70:499-509. 2004
    ..RTS,S+TRAP/AS02A was safe and well tolerated. Vigorous antibody production and modest, selective cell-mediated immune responses suggest that RTS,S+TRAP/AS02A may be immunogenic in human infants...
  51. ncbi request reprint Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium)
    Marie Van der Wielen
    Department of Epidemiology and Social Medicine, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Vaccine 21:2412-7. 2003
    ..These data confirm waning of vaccine-induced antibody levels and suggest pertussis resurgence during adolescence and young adulthood. These results support a pertussis booster vaccination policy for adolescents and adults...
  52. ncbi request reprint Enhanced pulmonary immunopathology following neonatal priming with formalin-inactivated respiratory syncytial virus but not with the BBG2NA vaccine candidate
    Hélène Plotnicky
    Centre d Immunologie Pierre Fabre, 5, Av Napoléon III, 74 164, St Julien en Genevois, France
    Vaccine 21:2651-60. 2003
    ..Importantly, our data emphasize that the induction of Th2-like responses by RSV subunit vaccines do not necessarily imply lung immunopathology...
  53. doi request reprint Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae
    Caroline L Trotter
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
    Vaccine 26:4434-45. 2008
    ..The aim of this paper is to review the state of the current evidence on conjugate vaccines and to identify important areas for further study, in order to inform the debate regarding the best use of these vaccines...
  54. doi request reprint Blame vaccine interference, not neonatal immunization, for suboptimal responses after neonatal diphtheria, tetanus, and acellular pertussis immunization
    Claire Anne Siegrist
    J Pediatr 153:305-7. 2008
  55. ncbi request reprint Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6)F(1)-bcl-2 transgenic mice
    Regina Marquina
    Laboratory of Immunology, Department of Molecular Biology, Unit Associated with Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas, University of Cantabria, Santander, Spain
    J Immunol 172:7177-85. 2004
    ....
  56. ncbi request reprint [Immunization guidelines in patients with chronic liver diseases]
    Florian Bihl
    Service de gastroentérologie et hepatologie, HUG, 1211 Geneve 14
    Rev Med Suisse 3:1948, 1950-1. 2007
    ..As soon as a chronic liver disease is diagnosed patients should be immunized with the common vaccines (flu and pneumoccocci). Due to reduced seroconversion rates, antibody levels should be tested after a booster vaccination...
  57. ncbi request reprint The advantage of mucosal immunization for polysaccharide-specific memory responses in early life
    Stefania P Bjarnarson
    Department of Immunology, Landspitali University Hospital, Reykjavik, Iceland
    Eur J Immunol 35:1037-45. 2005
    ..c. or i.n. priming with Pnc1-TT and LT-K63. These results demonstrate the advantage of the mucosal route for elicitation of PS-specific memory responses in early life...
  58. ncbi request reprint [Vaccinology, a new science at odds with beliefs]
    Claire Anne Siegrist
    Rev Med Suisse 1:3-6. 2005
  59. ncbi request reprint Workshop on vaccine pressure and Neisseria meningitidis, Annecy, France, 9-11 March 2005
    Jean Michel Alonso
    Institut Pasteur, Paris, France
    Vaccine 25:4125-9. 2007
    ..The workshop concluded that there is no current evidence to suggest that serogroup C conjugate vaccine pressure has resulted in meningococcal serogroup switching or replacement...
  60. ncbi request reprint [Immunization and immuno-modulation for prevention of respiratory tract infections]
    Jesica Mazza-Stalder
    Service de Pneumologie, HUG, 1211 Geneve 14
    Rev Med Suisse 1:2645-6, 2649-51. 2005
    ..In patients with diffuse bronchiectasis, the immunomodulatory effect of macrolides, and the use of inhaled corticosteroids should be confirmed by larger clinical investigations...
  61. ncbi request reprint Enhanced chickenpox exanthema in vaccine injection site
    Véronique Hentgen
    Service de Pediatrie, Centre Hospitalier de Versailles, France
    Scand J Infect Dis 38:920-1. 2006
    ..Specific local inflammatory modifications may explain the increased number of varicella skin lesions on the site of a previous vaccine-induced inflammation...
  62. pmc A global perspective on vaccine safety and public health: the Global Advisory Committee on Vaccine Safety
    Peter I Folb
    Medical Research Council, PO Box 19070, Tygerberg 7505, Cape Town, South Africa
    Am J Public Health 94:1926-31. 2004
    ....
  63. ncbi request reprint Atorvastatin treatment and vaccination efficacy
    René R S Packard
    Division of Cardiology, Department of Medicine, Geneva University Hospital, 24 Micheli du Crest, 1211 Geneva, Switzerland
    J Clin Pharmacol 47:1022-7. 2007