Affiliation: University of Geneva
- Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccinesNadine Schallert
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
Eur J Immunol 32:752-60. 2002....
- Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in miceC A Siegrist
W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
Eur J Immunol 28:4138-48. 1998..It suggests that effective vaccine responses may be obtained earlier in presence of maternal antibodies through the use of appropriate immunization strategies using conventional or novel vaccines for early priming...
- [Vaccinology update for 2008: what's new in Switzerland?]C A Siegrist
Centre de vaccinologie et d immunologie néonatale, CMU, 1211 Geneve
Rev Med Suisse 4:72-5. 2008..A source of information to be recommended without hesitation!..
- Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinantsClaire Anne Siegrist
Departments of Pathology and Pediatrics, Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Vaccine 21:3406-12. 2003..This allows the definition of the main determinants of the influence of MatAb on infant immunity...
- The challenges of vaccine responses in early life: selected examplesC A Siegrist
Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland
J Comp Pathol 137:S4-9. 2007..Novel vaccination strategies including early priming and subsequent boosting are most likely to counteract these effects and provide protection from exposure to infectious disease in early life...
- Mechanisms underlying adverse reactions to vaccinesC A Siegrist
Centre for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 Michel Servet, 1211 Geneva 4, Switzerland
J Comp Pathol 137:S46-50. 2007..Finally, many reported adverse events are simply chance instances of infection or disease onset around the time of vaccination and are not causally associated with administration of vaccine...
- [Vaccine adjuvants and macrophagic myofasciitis]C A Siegrist
Departement de Pathologie, centre de vaccinologie, Universite de Geneve, CMU, Suisse
Arch Pediatr 12:96-101. 2005..The existence of sampling bias inherent to the complexity of the clinical and pathological diagnoses remains the most likely hypothesis...
- Human papilloma virus immunization in adolescent and young adults: a cohort study to illustrate what events might be mistaken for adverse reactionsClaire Anne Siegrist
Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
Pediatr Infect Dis J 26:979-84. 2007..To anticipate events that might be mistakenly assumed to be caused by immunization, their prevalence was monitored before vaccine introduction...
- Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine responseClaire Anne Siegrist
Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Vaccine 23:615-22. 2004..This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity...
- [Why are boosters no longer necessary for protection against hepatitis B?]Claire Anne Siegrist
Centre de vaccinologie et d immunologie néonatale, Universite de Geneve, C M U, 1211 Geneve 4, Suisse
Rev Prat 54:509-11. 2004..This resulted into a change of initial recommendations, which now highlight that booster doses are unnecessary in immunocompetent persons after a complete course of vaccination...
- [Vaccinology update 2005: a new category of recommendations for optimal vaccine protection]C A Siegrist
Commission fédérale pour les vaccinations Centre de vaccinologie et d immunologie néonatale, Departement de pédiatrie Université de Genève CMU, 1211 Geneve 4
Rev Med Suisse 2:67-70. 2006..The challenge is now to inform parents about this new possibility of an optimal prevention, in addition to baseline immunizations...
- Influence of anesthesia on immune responses and its effect on vaccination in children: review of evidenceJ N Siebert
World Health Organization Collaborating Center for Neonatal Vaccinology, Departments of Pathology and Pediatrics, University of Geneva Medical School, Geneva, Switzerland
Paediatr Anaesth 17:410-20. 2007....
- How to improve communication on vaccine issues at the national level? INFOVAC-PED: an example from SwitzerlandC Siegrist
Department of Pediatrics and Pathology, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 4, Geneva, Switzerland
Vaccine 20:S98-S100. 2001..The rapid success of this novel initiative underlines the need to better support front line physicians...
- [First glance at the 2007 national immunization plan]C A Siegrist
Centre de vaccinologie et d immunologie néonatale, Départment de pédiatrie, Universite de Geneve
Rev Med Suisse 3:63-7. 2007..Recommendations about new vaccines, such as against cervical cancer, will be communicated in real time to all the physicians registered at InfoVac...
- [Vaccinology update 2004]C A Siegrist
Directrice du Département de pédiatrie, Centre de vaccinologie et d immunologie néonatale, Universite de Geneve, CMU, I, rue Michel Servet, 1211 Geneve 4
Rev Med Suisse 1:79-82. 2005..What did not change in 2004 ? The Internet address allowing physicians to send any question related to vaccination: www.infovac.ch..
- [The child with recurrent infections: which screening for immunoe deficiency?]C A Siegrist
Centre de vaccinologie et d immunologie néonatale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Suisse
Arch Pediatr 8:205-10. 2001..This article indicates for which pediatric patients an immunodeficiency screening should be considered, and how to analyze its results...
- Vaccination in the neonatal period and early infancyC A Siegrist
Department of Pediatrics, WHO Collaborating Centre for Neonatal Vaccinology, University of Geneva, CMU, Switzerland
Int Rev Immunol 19:195-219. 2000..The extent to which early life murine immunization models may be useful for preclinical evaluation of infant responses is outlined in this review...
- Neonatal and early life vaccinologyC A Siegrist
WHO Collaborating Centre for Neonatal Vaccinology, Departments of Pediatrics and Pathology, University of Geneva, 1 Michel Servet, 1211 4, Geneva, Switzerland
Vaccine 19:3331-46. 2001..Thus, neonatal priming and early boosting with vaccine formulations optimised for sufficient early life immunogenicity and maximal safety profiles, could allow better control of the huge infectious disease burden in early life...
- CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal miceMaria Pihlgren
Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
Vaccine 21:2492-9. 2003..In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool...
- A brief view of known landmarks reorientates path integration in hamstersA S Etienne
Laboratory of Ethology, University of Geneva, 54 route des Acacias, 1227 Geneva, Switzerland
Naturwissenschaften 87:494-8. 2000..Taking episodic positional fixes may greatly enhance the functional value of path integration...
- Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responsesMaria Pihlgren
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
Vaccine 23:329-35. 2004..Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation...
- Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigensMaria Pihlgren
Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
J Immunol 170:2824-32. 2003..Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life...
- Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survivalMaria Pihlgren
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Geneva, Switzerland
J Immunol 176:165-72. 2006..Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells...
- Can successful vaccines teach us how to induce efficient protective immune responses?Paul Henri Lambert
Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
Nat Med 11:S54-62. 2005....
- Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infectionMatthias Regner
WHO Collaborating Center for Vaccinology, Department of Pathology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Microbes Infect 6:666-75. 2004..Thus, the identification of hRSV antigen delivery systems with an age-appropriate adjuvanticity/reactogenicity balance may be feasible even in the vulnerable early-life period...
- CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particlesXavier Martinez
W.H.O. Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
Virology 305:428-35. 2003....
- Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussisCaroline Roduit
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology and Pediatrics, University of Geneva, Geneva, Switzerland
Infect Immun 70:3521-8. 2002..pertussis challenge. Thus, neonatal priming with antipertussis vaccines should be considered to reduce the window of vulnerability to pertussis at the time of its greatest severity...
- Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheresMatthias Regner
World Health Organization Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
J Immunol 173:2669-74. 2004....
- Autoimmune diseases after adolescent or adult immunization: what should we expect?Claire-Anne Siegrist
Center for Vaccinology and Neonatal Immunology, Department of Pediatrics, University of Geneva, Geneva, Switzerland
CMAJ 177:1352-4. 2007
- How do physicians immunize their own children? Differences among pediatricians and nonpediatriciansKlara M Posfay-Barbe
Centre for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland
Pediatrics 116:e623-33. 2005....
- Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cellsArun T Kamath
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
Eur J Immunol 38:1247-56. 2008..Thus, potent protective IFN-gamma-producing responses may be elicited by the exquisite activation of a minute number of in vivo targeted DC...
- Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cellsElodie Belnoue
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Centre Medical Universitaire, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
J Virol 81:7338-50. 2007..Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection...
- Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infantsAline Flatz-Jequier
Department of Pediatrics, Children s Hospital, University Hospitals of Geneva and Medical Faculty of the University of Geneva, Geneva, Switzerland
J Pediatr 153:429-31. 2008..A cardiorespiratory event associated with the first vaccination was the sole risk factor for recurrence identified...
- Vaccine-induced immunity in children after orthotopic liver transplantation: a 12-yr review of the Swiss national reference centerAlessandro Diana
Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
Pediatr Transplant 11:31-7. 2007....
- Effect of month of vaccine administration on antibody responses in The Gambia and PakistanSophie E Moore
MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 11:1529-41. 2006..To explore the relationship between calendar month of administration and antibody (Ab) response to vaccination in subjects from The Gambia and Pakistan, two countries with distinct patterns of seasonality...
- TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablastsClaudia Bossen
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Blood 111:1004-12. 2008..TACI supported survival of activated B cells and plasmablasts in vitro, providing a rational basis to explain the immunoglobulin deficiency reported in TACI-deficient persons...
- Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infantsMarkus Knuf
Paediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany
J Pediatr 152:655-60, 660.e1. 2008..Because young infants are at highest risk of pertussis complications, this study assessed whether neonatal acellular pertussis (aP) vaccination could provide earlier immunity...
- The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster responseGeraldine Blanchard Rohner
Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
J Immunol 180:2165-73. 2008..These findings suggest that these two parameters are good markers of B cell responses to priming and can be used as predictors of long term humoral immunity induced by glycoconjugate vaccines received in early infancy...
- Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high-quality antibodyYeh Chen Lee
University Department of Paediatrics, University of Oxford, Oxford, UK
Clin Infect Dis 46:186-92. 2008....
- Early appearance of bactericidal antibodies after polysaccharide challenge of toddlers primed with a group C meningococcal conjugate vaccine: what is its role in the maintenance of protection?Theodore F Tsai
Wyeth Research, 500 Arcola Rd, Collegeville, Pennsylvania 19426, USA
Clin Vaccine Immunol 13:854-61. 2006..The majority of toddlers previously immunized with MCC and challenged 1 year later with PS antigen mounted protective levels of bactericidal antibody within 2 to 4 days...
- Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infantsArnaud Marchant
Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
J Infect Dis 193:1598-605. 2006..CONCLUSIONS: Genetic determinants control the early phase of the vaccine antibody response in Gambian infants, whereas environmental determinants predominantly influence antibody persistence and avidity maturation...
- [Vaccine adjuvants and macrophagic myofasciitis]Claire-Anne Siegrist
Bull Acad Natl Med 187:1511-8; discussion 1519-21. 2003..The existence of sampling bias inherent to the complexity of the clinical and pathological diagnoses remains the most likely hypothesis...
- The immunomodulating properties of human respiratory syncytial virus and immunostimulating complexes containing Quillaja saponin components QH-A, QH-C and ISCOPREP703Ke Fei Hu
Section of Virology, Department of Veterinary Microbiology, College of Veterinary Medicine, Swedish University of Agricultural Sciences, Biomedical Center, Box 585, S 751 23 Uppsala, Sweden
FEMS Immunol Med Microbiol 43:269-76. 2005..The prospect to formulate an RSV ISCOM formulation with an optimal Th1/Th2 balance is in reach particularly in view of the versatile properties of the ISCOM concept...
- Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothersMartha Sedegah
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
J Immunol 171:3148-53. 2003..yoelii parasites or immunized with the vaccine were protected and had excellent T cell responses. These data support assessment of this immunization strategy in neonates/young infants in areas in which malaria exacts its greatest toll...
- Vaccine safety controversies and the future of vaccination programsGuido François
Viral Hepatitis Prevention Board, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, Department of Epidemiology and Social Medicine, University of Antwerpen, Antwerp, Belgium
Pediatr Infect Dis J 24:953-61. 2005....
- Influence of Mycobacterium bovis bacillus Calmette-GuÃ©rin on antibody and cytokine responses to human neonatal vaccinationMartin O C Ota
Medical Research Council Laboratories, Banjul, The Gambia
J Immunol 168:919-25. 2002..These results demonstrate that BCG influences the immune response to unrelated Ags in early life, likely through its influence on the maturation of dendritic cells...
- Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeysDouglas S Walsh
Department of Immunology and Medicine, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 70:499-509. 2004..RTS,S+TRAP/AS02A was safe and well tolerated. Vigorous antibody production and modest, selective cell-mediated immune responses suggest that RTS,S+TRAP/AS02A may be immunogenic in human infants...
- Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium)Marie Van der Wielen
Department of Epidemiology and Social Medicine, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
Vaccine 21:2412-7. 2003..These data confirm waning of vaccine-induced antibody levels and suggest pertussis resurgence during adolescence and young adulthood. These results support a pertussis booster vaccination policy for adolescents and adults...
- Enhanced pulmonary immunopathology following neonatal priming with formalin-inactivated respiratory syncytial virus but not with the BBG2NA vaccine candidateHélène Plotnicky
Centre d Immunologie Pierre Fabre, 5, Av Napoléon III, 74 164, St Julien en Genevois, France
Vaccine 21:2651-60. 2003..Importantly, our data emphasize that the induction of Th2-like responses by RSV subunit vaccines do not necessarily imply lung immunopathology...
- Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniaeCaroline L Trotter
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
Vaccine 26:4434-45. 2008..The aim of this paper is to review the state of the current evidence on conjugate vaccines and to identify important areas for further study, in order to inform the debate regarding the best use of these vaccines...
- Blame vaccine interference, not neonatal immunization, for suboptimal responses after neonatal diphtheria, tetanus, and acellular pertussis immunizationClaire-Anne Siegrist
J Pediatr 153:305-7. 2008
- Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6)F(1)-bcl-2 transgenic miceRegina Marquina
Laboratory of Immunology, Department of Molecular Biology, Unit Associated with Centro de Investigaciones Biologicas/Consejo Superior de Investigaciones Cientificas, University of Cantabria, Santander, Spain
J Immunol 172:7177-85. 2004....
- [Immunization guidelines in patients with chronic liver diseases]Florian Bihl
Service de gastroentérologie et hepatologie, HUG, 1211 Geneve 14
Rev Med Suisse 3:1948, 1950-1. 2007..As soon as a chronic liver disease is diagnosed patients should be immunized with the common vaccines (flu and pneumoccocci). Due to reduced seroconversion rates, antibody levels should be tested after a booster vaccination...
- The advantage of mucosal immunization for polysaccharide-specific memory responses in early lifeStefania P Bjarnarson
Department of Immunology, Landspitali-University Hospital, Reykjavik, Iceland
Eur J Immunol 35:1037-45. 2005..c. or i.n. priming with Pnc1-TT and LT-K63. These results demonstrate the advantage of the mucosal route for elicitation of PS-specific memory responses in early life...
- [Vaccinology, a new science at odds with beliefs]Claire-Anne Siegrist
Rev Med Suisse 1:3-6. 2005
- Workshop on vaccine pressure and Neisseria meningitidis, Annecy, France, 9-11 March 2005Jean Michel Alonso
Institut Pasteur, Paris, France
Vaccine 25:4125-9. 2007..The workshop concluded that there is no current evidence to suggest that serogroup C conjugate vaccine pressure has resulted in meningococcal serogroup switching or replacement...
- [Immunization and immuno-modulation for prevention of respiratory tract infections]Jesica Mazza-Stalder
Service de Pneumologie, HUG, 1211 Geneve 14
Rev Med Suisse 1:2645-6, 2649-51. 2005..In patients with diffuse bronchiectasis, the immunomodulatory effect of macrolides, and the use of inhaled corticosteroids should be confirmed by larger clinical investigations...
- Enhanced chickenpox exanthema in vaccine injection siteVéronique Hentgen
Service de Pediatrie, Centre Hospitalier de Versailles, France
Scand J Infect Dis 38:920-1. 2006..Specific local inflammatory modifications may explain the increased number of varicella skin lesions on the site of a previous vaccine-induced inflammation...
- A global perspective on vaccine safety and public health: the Global Advisory Committee on Vaccine SafetyPeter I Folb
Medical Research Council, PO Box 19070, Tygerberg 7505, Cape Town, South Africa
Am J Public Health 94:1926-31. 2004....