Research Topics
| G SentiSummaryAffiliation: University Hospital Country: Switzerland Publications
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Detail Information
Publications
A cutaneous allergen neutralisation test that correlates with the duration of venom immunotherapyGabriela Senti
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Int Arch Allergy Immunol 141:377-83. 2006..CONCLUSION: The in vivo neutralisation test may become a promising tool in allergy diagnostics as well as in monitoring the success of SIT in patients undergoing allergen SIT...- Evaluation of visual analog scales for the assessment of symptom severity in allergic rhinoconjunctivitisGabriela Senti
Unit for Experimental Immunotherapy, Department of Dermatology, University of Zurich, Zurich, Switzerland
Ann Allergy Asthma Immunol 98:134-8. 2007..However, NPTs are time-consuming and stressful for patients; therefore, recording of symptoms during natural allergen exposure on visual analog scales (VASs) is increasingly being used in clinical trials... 
Intralymphatic immunotherapyGabriela Senti
Clinical Trials Center, Center for Clinical Research, University and University Hospital of Zurich, Switzerland
Curr Opin Allergy Clin Immunol 9:537-43. 2009..Recently, immunotherapy by direct administration of the allergen into lymph nodes [intralymphatic immunotherapy (ILIT)] has proven a promising alternative and this method is the focus of the present review...- Intralymphatic immunotherapy: from the rationale to human applicationsGabriela Senti
Clinical Trials Center, Center for Clinical Research, University and University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
Curr Top Microbiol Immunol 352:71-84. 2011.... - Epicutaneous/transcutaneous allergen-specific immunotherapy: rationale and clinical trialsGabriela Senti
Clinical Trials Center, Center for Clinical Research, University Hospital Zurich, Zurich, Switzerland
Curr Opin Allergy Clin Immunol 10:582-6. 2010..The epidermis, a nonvascularized multilayer epithelium that contains high numbers of potent antigen-presenting Langerhans cells, could therefore be an interesting administration route... - Antimicrobial silk clothing in the treatment of atopic dermatitis proves comparable to topical corticosteroid treatmentG Senti
Unit for Experimental Immunotherapy, Department of Dermatology, University of Zurich, Zurich, Switzerland
Dermatology 213:228-33. 2006..Atopic dermatitis (AD) is aggravated by mechanical irritation and bacterial colonization... - Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trialG Senti
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Clin Exp Allergy 39:562-70. 2009..Therefore, the phase I/IIa study presented represents the first test of A-type CpGs in humans... - Toll-like receptor ligands as adjuvants in allergen-specific immunotherapyP Johansen
Unit for Experimental Immunotherapy, University Hospital of Zurich, Zurich, Switzerland
Clin Exp Allergy 35:1591-8. 2005..The major disadvantage of SIT is its low efficiency, requiring treatment over years... - Medication with antihistamines impairs allergen-specific immunotherapy in miceP Johansen
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Clin Exp Allergy 38:512-9. 2008..Histamine released from activated mast cells and basophils is an important mediator in allergy. Therefore, antihistamines are efficiently and widely used to suppress allergic symptoms... - The contact sensitizer diphenylcyclopropenone has adjuvant properties in mice and potential application in epicutaneous immunotherapyS von Moos
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
Allergy 67:638-46. 2012..Such barrier function of the stratum corneum also hampers the use of common adjuvants used to enhance the efficacy of vaccination... - Targeting the MHC class II pathway of antigen presentation enhances immunogenicity and safety of allergen immunotherapyJ M Martínez-Gómez
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Allergy 64:172-8. 2009..The aim of this study was to test whether modified recombinant allergens can improve therapeutic efficacy in SIT while reducing allergic side-effects... - Double-blind, placebo-controlled study with sublingual immunotherapy in children with seasonal allergic rhinitis to grass pollenB Wuthrich
Allergy Unit, Department of Dermatology, University Hospital, Zurich, Switzerland
J Investig Allergol Clin Immunol 13:145-8. 2003..The purpose of this study was to assess the efficacy and tolerance of SLIT in children who are sensitized to grass pollen... - Coated textiles in the treatment of atopic dermatitisS Haug
Allergy Unit, Department of Dermatology, , Switzerland
Curr Probl Dermatol 33:144-51. 2006..Silk can be coated with antimicrobials (Dermasilk). The combination of the smoothness of silk with an antimicrobial finish appears to make an ideal textile for patients suffering from AD... - Direct intralymphatic injection of peptide vaccines enhances immunogenicityP Johansen
Department of Dermatology, University of Zurich, Zurich, Switzerland
Eur J Immunol 35:568-74. 2005..These results should have immediate implications for clinical immunotherapy of infectious disease and cancer... - Analysis of the relationship between pollinosis and date of birth in SwitzerlandN Graf
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Int Arch Allergy Immunol 143:269-75. 2007..The objective of this study was to examine the relationship between the month of birth and the development of birch and grass pollen allergy in the Swiss population... - Heat denaturation, a simple method to improve the immunotherapeutic potential of allergensPål Johansen
Unit for Experimental Immunotherapy, University Hospital of Zurich, Zurich, Switzerland
Eur J Immunol 35:3591-8. 2005..This enables Th1 skewing of the immune response with strong production of IgG2a in mice. Therefore, heat-denaturation represents probably the simplest way to enhance the efficiency of SIT while reducing its side effects... - Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adultsThomas M Kundig
University of Zurich, Department of Dermatology, University Hospital Zurich, Switzerland
J Allergy Clin Immunol 117:1470-6. 2006..In this study we covalently coupled a synthetic 16-amino-acid sequence of the allergen Der p 1 to a virus-like particle derived from the bacteriophage Qbeta (Qbeta-Der p 1)... - [Allergen specific immunotherapy: new approaches]F Tay
Clinical Trials Center, Zentrum für Klinische Forschung, Universitätsspital und Universität Zürich, Zurich
Praxis (Bern 1994) 99:1279-84. 2010..e. administration of allergens using a skin patch, are under investigation in clinical trials at the Zurich University Hospital... - Epicutaneous allergen administration: is this the future of allergen-specific immunotherapy?G Senti
Clinical Trials Center, University Hospital of Zurich, Zurich, Switzerland
Allergy 66:798-809. 2011..The present review will discuss the immunological rational, history and actual clinical experience with epicutaneous allergen-specific immunotherapy... - Efficacy and safety of allergen-specific immunotherapy in rhinitis, rhinoconjunctivitis, and bee/wasp venom allergiesG Senti
Department of Dermatology, University Hospital of Zurich, Switzerland
Int Rev Immunol 24:519-31. 2005..This review describes and discusses these new developments in the context of the many recent advances in our understanding of the mechanisms by which immunotherapy appears to act... - Intralymphatic injections as a new administration route for allergen-specific immunotherapyJulia M Martínez-Gómez
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Zurich CH 8091, Switzerland
Int Arch Allergy Immunol 150:59-65. 2009..To improve the safety and attractiveness of SIT for patients, alternative routes of allergen administration are being explored, such as sub-lingual or oral administration... - Epicutaneous allergen administration as a novel method of allergen-specific immunotherapyGabriela Senti
Unit for Experimental Immunotherapy, University Hospital of Zurich, Zurich, Switzerland
J Allergy Clin Immunol 124:997-1002. 2009..Transcutaneous immunotherapy may improve patient compliance and safety... 
Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trialGabriela Senti
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 105:17908-12. 2008..001), and was less painful than venous puncture (P = 0.018). In conclusion, intralymphatic allergen administration enhanced safety and efficacy of immunotherapy and reduced treatment time from 3 years to 8 weeks...- Nickel sensitisation in mice: a critical appraisalPål Johansen
Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
J Dermatol Sci 58:186-92. 2010.... - Antigen kinetics determines immune reactivityPål Johansen
Unit Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 105:5189-94. 2008..In conclusion, stimulation kinetics per se was shown to be a separate parameter of immunogenicity. These findings warrant a revision of current immunization models and have implications for vaccine development and immunotherapy... - Immunotherapeutic targeting of allergic diseaseGabriela Senti
Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Switzerland
Inflamm Allergy Drug Targets 5:243-52. 2006..This review describes and discusses these new developments in the context of the many recent advances in our understanding of the mechanisms by which immunotherapy appears to act... - Atopic eczema: genetics or environment?Brunello Wuthrich
Spital Zollikerberg, Allergologie, klinische Immunologie und Dermatologie, Trichtenhauserstrasse 20, 8125 Zollikerberg, Switzerland
Ann Agric Environ Med 14:195-201. 2007..From the therapeutic point of view, besides emollients and local corticosteroids, topic immunomodulatory drugs (tacrolimus and pimecrolimus) have substantially improved the treatment of AE...