Johann Sellner

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis
    Johann Sellner
    Department of Neurology, Im Neuenheimer Feld 400, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
    Neurosci Lett 374:197-202. 2005
  2. ncbi request reprint Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis
    Johann Sellner
    Department of Neurology, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
    Brain Res Mol Brain Res 137:267-71. 2005
  3. ncbi request reprint Experimental herpes simplex virus encephalitis: a long-term study of interleukin-6 expression in mouse brain tissue
    Florian Dvorak
    Department of Neurology, University of Heidelberg, INF 400, 69120, Germany
    Neurosci Lett 367:289-92. 2004
  4. ncbi request reprint Current treatment strategies for multiple sclerosis - efficacy versus neurological adverse effects
    Martin S Weber
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Curr Pharm Des 18:209-19. 2012
  5. ncbi request reprint In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging
    Johann Sellner
    Department of Neurology, Ruprecht Karls University Heidelberg, Germany
    J Neurovirol 10:255-9. 2004
  6. ncbi request reprint Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study
    Philipp R Rau
    University of Heidelberg, Department of Neurology, INF 400 Kopfklinik, D 69120 Heidelberg, Germany
    Life Sci 78:1175-80. 2006
  7. ncbi request reprint Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis
    Francisco J Martinez-Torres
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurosci Lett 368:274-8. 2004
  8. doi request reprint A case of maternal herpes simplex virus encephalitis during late pregnancy
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar at the Technical University of Munich, Munich, Germany
    Nat Clin Pract Neurol 5:51-6. 2009
  9. doi request reprint Favourable response to plasma exchange in tumefactive CNS demyelination with delayed B-cell response
    Christian L Seifert
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Mult Scler 18:1045-9. 2012
  10. doi request reprint Hyperacute detection of neurofilament heavy chain in serum following stroke: a transient sign
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurochem Res 36:2287-91. 2011

Detail Information

Publications22

  1. ncbi request reprint Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis
    Johann Sellner
    Department of Neurology, Im Neuenheimer Feld 400, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
    Neurosci Lett 374:197-202. 2005
    ..This pattern was substantially altered by anti-viral and anti-inflammatory treatment. Our findings indicate a pivotal role of these chemokines in the immunopathogenesis of HSVE...
  2. ncbi request reprint Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis
    Johann Sellner
    Department of Neurology, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
    Brain Res Mol Brain Res 137:267-71. 2005
    ..05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis...
  3. ncbi request reprint Experimental herpes simplex virus encephalitis: a long-term study of interleukin-6 expression in mouse brain tissue
    Florian Dvorak
    Department of Neurology, University of Heidelberg, INF 400, 69120, Germany
    Neurosci Lett 367:289-92. 2004
    ..IL-6 deficient mice presented early and severe clinical signs of HSVE as compared to the wild-type C57/bl6 mice...
  4. ncbi request reprint Current treatment strategies for multiple sclerosis - efficacy versus neurological adverse effects
    Martin S Weber
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Curr Pharm Des 18:209-19. 2012
    ..In this review, we aim to critically evaluate the risk/benefit ratio of therapeutic strategies in treatment of MS with a specific focus on infectious neurological side effects...
  5. ncbi request reprint In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging
    Johann Sellner
    Department of Neurology, Ruprecht Karls University Heidelberg, Germany
    J Neurovirol 10:255-9. 2004
    ..Our findings could further support the use of diffusion-weighted imaging for in vivo monitoring of acute flavivirus encephalitis and for the study of therapeutic approaches...
  6. ncbi request reprint Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study
    Philipp R Rau
    University of Heidelberg, Department of Neurology, INF 400 Kopfklinik, D 69120 Heidelberg, Germany
    Life Sci 78:1175-80. 2006
    ..According to our data ADCs remain nearly constant during the aging process of the brain with a small but statistically non-significant trend towards a decreased diffusion in older animals...
  7. ncbi request reprint Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis
    Francisco J Martinez-Torres
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurosci Lett 368:274-8. 2004
    ..Increased presence of MMP2 and MMP9 in chronic HSVE may contribute to ongoing damage. Inhibition of MMP2 and MMP9 might be a suitable target for therapeutic intervention...
  8. doi request reprint A case of maternal herpes simplex virus encephalitis during late pregnancy
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar at the Technical University of Munich, Munich, Germany
    Nat Clin Pract Neurol 5:51-6. 2009
    ..On admission, she had anterograde and retrograde amnesia, but no somatic neurological deficits were detected...
  9. doi request reprint Favourable response to plasma exchange in tumefactive CNS demyelination with delayed B-cell response
    Christian L Seifert
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Mult Scler 18:1045-9. 2012
    ..This delay in the development of a humoral immune response may reflect the step-wise B-cell colonization of the CNS and represent an attractive therapeutic window of opportunity...
  10. doi request reprint Hyperacute detection of neurofilament heavy chain in serum following stroke: a transient sign
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Neurochem Res 36:2287-91. 2011
    ..Further studies are required to evaluate whether NfH(SMI35) in hyperacute stroke reflects the extent of focal ischaemic injury seen on neuroimaging or is a consequence of more diffuse neuro-axonal damage...
  11. doi request reprint The increasing incidence and prevalence of female multiple sclerosis--a critical analysis of potential environmental factors
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Autoimmun Rev 10:495-502. 2011
    ..Vitamin D also appears to impact B cell activation and differentiation, another cell type that has been implicated in the inflammatory cascade underlying CNS autoimmune disease...
  12. ncbi request reprint Experimental herpes simplex virus encephalitis: a combination therapy of acyclovir and glucocorticoids reduces long-term magnetic resonance imaging abnormalities
    Uta K Meyding-Lamadé
    Department of Neurology, INF 400 Kopfklinik, Heidelberg, Germany
    J Neurovirol 9:118-25. 2003
    ..With respect to abnormal MRI findings, this study demonstrates a clear beneficial effect of an acyclovir and corticosteroid therapy without influencing brain viral load...
  13. pmc CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation
    Markus C Kowarik
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    J Neuroinflammation 9:93. 2012
    ....
  14. doi request reprint The value of the serum neurofilament protein heavy chain as a biomarker for peri-operative brain injury after carotid endarterectomy
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Neurochem Res 34:1969-74. 2009
    ....
  15. pmc Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease
    Martin S Weber
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 5:e16009. 2010
    ..Besides its therapeutic implication, this finding suggests that encounter of the immune system with microbial products may not only be part of CNS autoimmune disease pathogenesis but also of its regulation...
  16. doi request reprint The combination of interferon-beta and HMG-CoA reductase inhibition in multiple sclerosis: enthusiasm lost too soon?
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    CNS Neurosci Ther 16:362-73. 2010
    ..Moreover, we try to address the evident question whether usage of this combination routinely requires caution, since the number of IFN-β-treated MS patients receiving statins for lowering of cholesterol is expected to grow...
  17. doi request reprint Aquaporin 4 antibody positive central nervous system autoimmunity and multiple sclerosis are characterized by a distinct profile of antibodies to herpes viruses
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Neurochem Int 57:662-7. 2010
    ..Whether these findings reflect an epi-phenomenon of autoimmune disorders or indicate a disease-specific deregulated virus-host interaction needs to be examined in further studies...
  18. doi request reprint The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, D 81675 Munchen, Germany
    J Autoimmun 34:371-9. 2010
    ..However, current studies are not sufficient to define the place of parainfectious NMO syndromes within the spectrum of inflammatory disorders of the CNS...
  19. doi request reprint Effects of Toll-like receptor 2 agonist Pam(3)CysSK(4) on inflammation and brain damage in experimental pneumococcal meningitis
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, D 81675 Munchen, Germany
    J Neuroimmunol 206:28-31. 2009
    ..We conclude that TLR2 signaling triggered by Pam(3)CysSK(4) at a dosage capable to induce a neuroinflammatory response does not induce hippocampal apoptosis in the infant rat model of experimental pneumococcal meningitis...
  20. ncbi request reprint Herpes-simplex virus encephalitis is characterized by an early MMP-9 increase and collagen type IV degradation
    Johann Sellner
    Department of Neurology, University Hospital Bern, Inselspital, Freiburgstrasse, CH 3010 Bern, Switzerland
    Brain Res 1125:155-62. 2006
    ..The degradation of the neurovascular matrix in HSE facilitates the development of cerebrovascular complications and may represent a target for novel adjuvant treatment strategies...
  21. doi request reprint Atorvastatin does not alter interferon Beta-induced changes of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in patients with multiple sclerosis
    Johann Sellner
    Arch Neurol 65:672-4. 2008
  22. ncbi request reprint In bacterial meningitis cortical brain damage is associated with changes in parenchymal MMP-9/TIMP-1 ratio and increased collagen type IV degradation
    Johann Sellner
    Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, PO Box 61, CH 3010 Bern, Switzerland
    Neurobiol Dis 21:647-56. 2006
    ..These findings provide support to the concept that MMPs mediated disruption of the BBB contributes to the pathogenesis of bacterial meningitis and that protection of the vascular unit may have neuroprotective potential...