Affiliation: University Hospital
- [Drug treatment of chronic inflammatory bowel diseases: current status and prospects]F Seibold
Abteilung für Gastroenterologie, Inselspital, Universitat, Bern
Schweiz Med Wochenschr 130:222-32. 2000..Infliximab, an anti-TNF-alpha antibody, is a potent therapy for fistulising Crohn's disease or steroid-refractory disease. Other approved and experimental treatments are discussed...
- ASCA: genetic marker, predictor of disease, or marker of a response to an environmental antigen?F Seibold
Department of Gastroenterology, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland
Gut 54:1212-3. 2005
- [Does conservative therapy of chronic inflammatory bowel diseases still play a role?]F Seibold
Inselspital, Abteilung für Gastroenterologie, Bern
Swiss Surg 9:127-30. 2003..In Crohn's patients with fistula surgical treatment or a therapy with antibiotics, immunosuppressants or infliximab is recommended...
- Ameliorative effect of IDS 30, a stinging nettle leaf extract, on chronic colitisAstrid Konrad
Division of Gastroenterology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010 Berne, Switzerland
Int J Colorectal Dis 20:9-17. 2005..The stinging nettle leaf extract, IDS 30, is an adjuvant remedy in rheumatic diseases dependent on a cytokine suppressive effect. We investigated the effect of IDS 30 on disease activity of murine colitis in different models...
- Association of deficiency for mannan-binding lectin with anti-mannan antibodies in Crohn's disease: a family studyFrank Seibold
Division of Gastroenterology, Inselspital, University of Bern, Bern, Switzerland
Inflamm Bowel Dis 13:1077-82. 2007..MBL concentration depends on genetic polymorphisms. The aim of this study was to evaluate whether low MBL is related to ASCA production in healthy family members of CD patients...
- [Laboratory diagnosis in inflammatory bowel disease]F Seibold
Departement für Magen Darm, Leber und Lungenkrankheiten, Abteilung Gastroenterologie, Inselspital, Bern
Ther Umsch 60:133-6. 2003..The detection of specific antibodies such as pANCA, PAB and ASCA is helpful for the differential diagnosis Crohn's disease--ulcerative colitis...
- [New knowledge on the pathogenesis of chronic inflammatory bowel diseases: what have we learned from colitis animal models?]F Seibold
Abteilung für Gastroenterologie, Inselspital Bern
Schweiz Med Wochenschr 130:749-55. 2000..Thus, the intestinal bacterial flora plays a crucial role. The loss of immune tolerance towards these bacterial antigens is an important current concept in the pathogenesis of inflammatory bowel disease...
- Food-induced immune responses as origin of bowel disease?Frank Seibold
Klinik fur Gastroenterologie, Inselspital, Universitat Bern, Bern, Switzerland
Digestion 71:251-60. 2005..This may have some significance in the perpetuation of intestinal inflammatory processes in patients with Crohn's disease...
- Esophageal strictures in adult eosinophilic esophagitis: dilation is an effective and safe alternative after failure of topical corticosteroidsA M Schoepfer
Department of Gastroenterology, University of Bern Inselspital, Switzerland
Endoscopy 40:161-4. 2008..Bougienage led to prompt symptom relief. Apart from transient postprocedural odynophagia, no severe complications occurred. During the follow-up (mean 6 months; range 2 - 11 months), all patients enjoyed sustained treatment response...
- Low Mannan-binding lectin serum levels are associated with complicated Crohn's disease and reactivity to oligomannan (ASCA)Alain M Schoepfer
Department of Visceral Surgery and Medicine, Division of Gastroenterology, Inselspital, Bern University Hospital, Bern 3010, Switzerland
Am J Gastroenterol 104:2508-16. 2009..This study aims at evaluating whether MBL deficiency is associated with distinct Crohn's disease (CD) phenotypes...
- Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogensStefan Muller
Department of Clinical Research, University of Bern, CH 3010 Bern, Switzerland
Gut 59:1493-500. 2010..However, the role of MBL in intestinal inflammation is currently unclear. A study was undertaken to analyse local MBL expression in human intestine and the consequences of MBL deficiency in experimental colitis and yeast infection...
- Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's diseaseFrank Seibold
Division of Gastroenterology, Inselspital, University of Bern, Switzerland
Gastroenterology 127:1076-84. 2004..cerevisiae . MBL concentration depends on genetic polymorphisms. The aim of this study was to evaluate whether low MBL contributes to anti-S. cerevisiae antibody (ASCA) production...
- Partial overlap of anti-mycobacterial, and anti-Saccharomyces cerevisiae mannan antibodies in Crohn's diseaseStefan Muller
Department of Clinical Research, Division of Gastroenterology, University of Bern, Bern CH 3010, Switzerland
World J Gastroenterol 14:3650-61. 2008..To test whether humoral immune reaction against mycobacteria may play a role in anti-Saccharomyces cerevisiae antibodies (ASCA) generation in Crohn's disease (CD) and/or whether it correlates with clinical subtypes...
- Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's diseaseAstrid Konrad
Division of Gastroenterology, Inselspital, University of Bern, Freiburgstrasse, Switzerland
Inflamm Bowel Dis 10:97-105. 2004..CONCLUSIONS: A disturbed humoral and cellular response to the yeast antigen mannan is specifically seen in a subgroup of CD patients. This phenomenon may be due to a loss of tolerance toward yeast and is possibly genetically determined...
- Response of cutaneous Crohn's disease to infliximab and methotrexateA Konrad
Division of Gastroenterology, Inselspital, University Hospital of Berne, Freiburgstrasse, CH 3010 Bern, Switzerland
Dig Liver Dis 35:351-6. 2003..Only the introduction of methotrexate, together with repetitive administration of infliximab, allowed maintenance of the patient in remission...
- Amelioration of murine colitis by feeding a solution of lysed Escherichia coliA Konrad
Division of Gastroenterology, Inselspital, University of Berne, Berne, Switzerland
Scand J Gastroenterol 38:172-9. 2003..05) reduced in verum-treated mice. CONCLUSION: The use of E. coli lysate is effective in the amelioration of murine colitis. This effect may be due to a decreased Th1 reaction and to an induction of tolerance against bacterial antigens...
- Accuracy of four fecal assays in the diagnosis of colitisAlain M Schoepfer
Department of Gastroenterology, University Hospital Inselspital, Bern, Switzerland
Dis Colon Rectum 50:1697-706. 2007....
- Discriminating IBD from IBS: comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodiesAlain M Schoepfer
Department of Gastroenterology, Inselspital University of Bern, Switzerland
Inflamm Bowel Dis 14:32-9. 2008..We aimed to determine the accuracy of fecal markers, C-reactive protein (CRP), blood leukocytes, and antibody panels for discriminating IBD from IBS and to define a "best test."..
- Anti-Saccharomyces cerevisiae mannan antibodies (ASCA) of Crohn's patients crossreact with mannan from other yeast strains, and murine ASCA IgM can be experimentally induced with Candida albicansThomas Schaffer
Department of Clinical Research, Division of Gastroenterology, University Hospital Bern, University of Bern, Bern, Switzerland
Inflamm Bowel Dis 13:1339-46. 2007..The present study aimed to determine crossreactivities of ASCA with cell wall mannans from other yeasts, including the opportunistic pathogen C. albicans, and to define the requirements for (crossreactive) ASCA in experimental mice...
- Phenotypic associations of Crohn's disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss CohortAlain M Schoepfer
Department of Gastroenterology, Inselspital Bern University Hospital, Bern, Switzerland
Inflamm Bowel Dis 15:1358-67. 2009....
- Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patientsA M Schoepfer
Department of Gastroenterology, Inselspital, Bern University Hospital, Bern, Switzerland
Neurogastroenterol Motil 20:1110-8. 2008..This observation supports the concept that immune reactivity to luminal antigens has a putative role in the development of IBS, at least in a subset of patients...
- Evaluation of assays for perinuclear antineutrophilic cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in dogs with inflammatory bowel diseaseKarin Allenspach
Department of Veterinary Clinical Medicine, Faculty of Veterinary Medicine, University of Bern, 3012 Bern, Switzerland
Am J Vet Res 65:1279-83. 2004..The pANCA immunofluorescence assay had high specificity for canine IBD, and pANCAs appear to be accurate markers of intestinal inflammation...
- Differences in yeast intolerance between patients with Crohn's disease and ulcerative colitisBrigitt Brunner
Department of Gastroenterology, University of Bern, Inselspital, Bern, Switzerland
Dis Colon Rectum 50:83-8. 2007..We evaluated the impact of eating habits with special respect to food containing yeast on the course of inflammatory bowel disease...
- Complementary alternative medicine in patients with inflammatory bowel disease: use and attitudesC Quattropani
Inselspital Bern, Division of Gastroenterology, Bern, Switzerland
Scand J Gastroenterol 38:277-82. 2003..Frequently cited reasons for the use of complementary therapies were safety of CAM; dissatisfaction with conventional therapies, including their side effects; and that CAM can be used in addition to conventional therapy...
- Serological and DNA-based evaluation of Chlamydia pneumoniae infection in inflammatory bowel diseaseStefan Muller
Division of Gastroenterology of the Inselspital and Department of Clinical Research, University of Bern, Switzerland
Eur J Gastroenterol Hepatol 18:889-94. 2006..In this study we assessed the relationship between chlamydial infection and IBD, as evidenced by serological measurement and DNA analysis of mucosal biopsy specimens...
- Mitochondrial neurogastrointestinal encephalomyopathy in three siblings: clinical, genetic and neuroradiological featuresW M M Schüpbach
Department of Neurology, University Hospital Inselspital, 3010 Bern, Switzerland
J Neurol 254:146-53. 2007..Urinary thymidine is for the first time reported to be detectable in a heterozygous carrier. MRS findings indicate loss of neurons, axons, and glial cells in patients with MNGIE, but not in heterozygous carriers...
- Dysphagia in Crohn's disease: a diagnostic challengeC Knoblauch
Gl Unit, Inselspital, University of Berne, Switzerland
Dig Liver Dis 34:660-4. 2002..Even if achalasia is suspected in a Crohn's patient, it should be taken into consideration that the motility disorder could be the result of a transmural inflammation with or without fibrosis caused by Crohn's disease...
- Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBDStefan Muller
Department of Clinical Research, Division of Gastroenterology, University Hospital, University of Bern, Switzerland
Inflamm Bowel Dis 12:588-97. 2006..The present study aims to determine galectin-3 expression in the normal and inflamed intestinal mucosa and to define its role in T cell activity...
- Treatment-resistant lingual Crohn's disease disappears after infliximabBrigitte Brunner
Department of Gastroenterology, University Hospital of Bern, Switzerland
Scand J Gastroenterol 40:1255-9. 2005..Furthermore, we report on different therapeutic options and their effectiveness. Oral manifestations of CD, which are refractory to systemic steroids and mesalamine, show an excellent response to infliximab...
- TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseasesMirjam Schenk
Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland
J Clin Invest 117:3097-106. 2007..Therefore, TREM-1 may also represent an attractive target for the treatment of chronic inflammatory disorders...
- Perinuclear antineutrophilic cytoplasmic antibody and response to treatment in diarrheic dogs with food responsive disease or inflammatory bowel diseaseNicole Luckschander
Department of Clinical Veterinary Medicine, Faculty of Veterinary Medicine, University of Bern, Switzerland
J Vet Intern Med 20:221-7. 2006..03). A positive pANCA test before therapy may aid in the diagnosis of FRD...
- Comparison of interferon-gamma release assay versus tuberculin skin test for tuberculosis screening in inflammatory bowel diseaseAlain M Schoepfer
Department of Gastroenterology, Inselspital, University of Bern, Switzerland
Am J Gastroenterol 103:2799-806. 2008..The interferon-gamma release assay (IGRA) QuantiFERON-TB Gold In-Tube (QFT-G-IT) shows better specificity for diagnosing TB than the skin test. This study evaluates the two test methods among IBD patients...
- Anti-Saccharomyces cerevisiae antibody titers are stable over time in Crohn's patients and are not inducible in murine models of colitisStefan Muller
Division of Gastroenterology, Department of Clinical Research, University Hospital Bern
World J Gastroenterol 11:6988-94. 2005..To investigate ASCA production over time in CD and murine colitis in order to further our understanding of their etiology...
- Resistin is an inflammatory marker of inflammatory bowel disease in humansAstrid Konrad
Department of Internal Medicine II, University of Munich, Munich, Germany
Eur J Gastroenterol Hepatol 19:1070-4. 2007..We therefore hypothesized that (i) resistin levels may be elevated in patients with inflammatory bowel disease (IBD) and (ii) resistin levels may be associated with disease activity in IBD...
- Apolipoprotein A-IV is an independent predictor of disease activity in patients with inflammatory bowel diseaseUli C Broedl
Department of Internal Medicine II, University of Munich, Germany
Inflamm Bowel Dis 13:391-7. 2007..We therefore hypothesized that apoA-IV may be associated with disease activity in patients with inflammatory bowel disease (IBD)...
- Screening for tuberculosis infection before the initiation of an anti-TNF-alpha therapyChristoph Beglinger
, , Basel, Switzerland
Swiss Med Wkly 137:620-2. 2007
- [Status of alternative medicine in Crohn disease and ulcerative colitis patents: a questionnaire survey]Brigitte Ausfeld-Hafter
Universitat Bern, Schweiz
Forsch Komplementarmed Klass Naturheilkd 12:134-8. 2005..Pharmaceuticals used in convention-al medicine have been proven to be effective but can have strong side-effects. Thus, it is no surprise that affected patients are very interested in complementary and alternative medicine (CAM)...
- Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cellsFengyu Shu
Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, 378 Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
Dev Immunol 9:73-84. 2002..These results suggest that the activation of the alpha4 integrins is parallel to that of T cells...