B Schwaller

Summary

Affiliation: University of Fribourg
Country: Switzerland

Publications

  1. doi request reprint The continuing disappearance of "pure" Ca2+ buffers
    B Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, 1700, Fribourg, Switzerland
    Cell Mol Life Sci 66:275-300. 2009
  2. doi request reprint The use of transgenic mouse models to reveal the functions of Ca2+ buffer proteins in excitable cells
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Biochim Biophys Acta 1820:1294-303. 2012
  3. doi request reprint The regulation of a cell's Ca(2+) signaling toolkit: the Ca (2+) homeostasome
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700, Fribourg, Switzerland
    Adv Exp Med Biol 740:1-25. 2012
  4. pmc Cytosolic Ca2+ buffers
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
    Cold Spring Harb Perspect Biol 2:a004051. 2010
  5. ncbi request reprint Identification of calretinin and the alternatively spliced form calretinin-22k in primary pleural mesotheliomas and in their metastases
    Beat Schwaller
    Division of Histology, Department of Medicine, University of Fribourg, 14, chemin du Musee, CH 1700 Fribourg, Switzerland
    Anticancer Res 24:4003-9. 2004
  6. ncbi request reprint Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures
    B Schwaller
    Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
    Mol Cell Neurosci 25:650-63. 2004
  7. ncbi request reprint 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice
    Beat Schwaller
    Institute of Histology and General Embryology, University of Fribourg, Fribourg, Switzerland
    Cerebellum 1:241-58. 2002
  8. ncbi request reprint A polyclonal goat antiserum against the calcium-binding protein calretinin is a versatile tool for various immunochemical techniques
    B Schwaller
    Institute of Histology and General Embryology, University of Fribourg, Perolles, Switzerland
    J Neurosci Methods 92:137-44. 1999
  9. ncbi request reprint Deficiency in parvalbumin, but not in calbindin D-28k upregulates mitochondrial volume and decreases smooth endoplasmic reticulum surface selectively in a peripheral, subplasmalemmal region in the soma of Purkinje cells
    G Chen
    University of Fribourg, Division of Histology, Department of Medicine, University of Fribourg, 14, chemin du Musee, CH 1705 Fribourg, Switzerland
    Neuroscience 142:97-105. 2006
  10. ncbi request reprint Calretinin and calretinin-22k increase resistance toward sodium butyrate-induced differentiation in CaCo-2 colon adenocarcinoma cells
    D Marilley
    Institute of Histology and General Embryology, , CH-1705, Fribourg, Switzerland
    Exp Cell Res 268:93-103. 2001

Collaborators

Detail Information

Publications36

  1. doi request reprint The continuing disappearance of "pure" Ca2+ buffers
    B Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, 1700, Fribourg, Switzerland
    Cell Mol Life Sci 66:275-300. 2009
    ....
  2. doi request reprint The use of transgenic mouse models to reveal the functions of Ca2+ buffer proteins in excitable cells
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Biochim Biophys Acta 1820:1294-303. 2012
    ..Their physiological role in excitable cells has been investigated in vivo by analyzing the phenotype of mice either lacking one of the Ca2+ buffers or mice with ectopic expression...
  3. doi request reprint The regulation of a cell's Ca(2+) signaling toolkit: the Ca (2+) homeostasome
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700, Fribourg, Switzerland
    Adv Exp Med Biol 740:1-25. 2012
    ..Mechanistic details on the functioning of the Ca(2+) homeostasome are presented...
  4. pmc Cytosolic Ca2+ buffers
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
    Cold Spring Harb Perspect Biol 2:a004051. 2010
    ..All of these molecules are not only functionally coupled, but their expression is likely to be regulated in a Ca(2+)-dependent manner to maintain normal Ca(2+) signaling, even in the absence or malfunctioning of one of the components...
  5. ncbi request reprint Identification of calretinin and the alternatively spliced form calretinin-22k in primary pleural mesotheliomas and in their metastases
    Beat Schwaller
    Division of Histology, Department of Medicine, University of Fribourg, 14, chemin du Musee, CH 1700 Fribourg, Switzerland
    Anticancer Res 24:4003-9. 2004
    ..However, in studies published so far, the exact molecular identity of the immunoreactive protein(s) detected in mesothelioma sections has not yet been determined...
  6. ncbi request reprint Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures
    B Schwaller
    Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
    Mol Cell Neurosci 25:650-63. 2004
    ..Through an increase in inhibition, the absence of PV facilitates synchronous activity in the cortex and facilitates hypersynchrony through the depolarizing action of GABA in the hippocampus...
  7. ncbi request reprint 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice
    Beat Schwaller
    Institute of Histology and General Embryology, University of Fribourg, Fribourg, Switzerland
    Cerebellum 1:241-58. 2002
    ..Surprisingly, a major role of any of these three calcium-binding proteins as an endogenous neuroprotectant is not generally supported...
  8. ncbi request reprint A polyclonal goat antiserum against the calcium-binding protein calretinin is a versatile tool for various immunochemical techniques
    B Schwaller
    Institute of Histology and General Embryology, University of Fribourg, Perolles, Switzerland
    J Neurosci Methods 92:137-44. 1999
    ..Immunostaining of these samples is comparable to that with the well-characterized calretinin-specific polyclonal rabbit antiserum 7696...
  9. ncbi request reprint Deficiency in parvalbumin, but not in calbindin D-28k upregulates mitochondrial volume and decreases smooth endoplasmic reticulum surface selectively in a peripheral, subplasmalemmal region in the soma of Purkinje cells
    G Chen
    University of Fribourg, Division of Histology, Department of Medicine, University of Fribourg, 14, chemin du Musee, CH 1705 Fribourg, Switzerland
    Neuroscience 142:97-105. 2006
    ..Rather the cell attempts to restore spatiotemporal aspects of Ca(2+) signals prevailing in the undisturbed (wildtype) situation by subtly fine tuning existing components involved in the regulation of Ca(2+) fluxes...
  10. ncbi request reprint Calretinin and calretinin-22k increase resistance toward sodium butyrate-induced differentiation in CaCo-2 colon adenocarcinoma cells
    D Marilley
    Institute of Histology and General Embryology, , CH-1705, Fribourg, Switzerland
    Exp Cell Res 268:93-103. 2001
    ..This implicates that expression of CR and/or CR-22k in colon tumor cells may contribute to tumorigenesis by blocking differentiation-promoting signals...
  11. ncbi request reprint Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cells
    B Fellay
    Institute of Histology and General Embryology, University of Fribourg, CH-1705, Fribourg, Switzerland
    Brain Res 909:145-58. 2001
    ..Our results indicate that in the P19-cell model, CR and CB can help to delay the onset of cell death after excitotoxic stimulation...
  12. ncbi request reprint Alterations in Purkinje cell spines of calbindin D-28 k and parvalbumin knock-out mice
    M Vecellio
    Institute of Histology and General Embryology, University of Fribourg, CH 1705 Fribourg, Switzerland
    Eur J Neurosci 12:945-54. 2000
    ..The increase in various spine parameters, particularly volume, may counteract the lack of the calcium buffers, such as to adjust Ca2+-transients at the transitional zone between spines and dendrites...
  13. ncbi request reprint Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice
    B Schwaller
    Institute of Histology and General Embryology and Program in Neuroscience, University of Fribourg, CH 1705 Fribourg, Switzerland
    Am J Physiol 276:C395-403. 1999
    ..Acceleration of the contraction-relaxation cycle of fast-twitch muscle fibers by PV may confer an advantage in the performance of rapid, phasic movements...
  14. ncbi request reprint Monoclonal antibodies recognizing epitopes of calretinins: dependence on Ca2+-binding status and differences in antigen accessibility in colon cancer cells
    L Zimmermann
    Institute of Histology and General Embryology, University of Fribourg, Switzerland
    Cell Calcium 31:13-25. 2002
    ..These antibodies are valuable tools to further investigate the distribution and eventually the specific function of these two proteins in the nervous tissue and under pathological conditions, e.g. in colon tumours and mesotheliomas...
  15. ncbi request reprint Calretinin and calbindin D-28k, but not parvalbumin protect against glutamate-induced delayed excitotoxicity in transfected N18-RE 105 neuroblastoma-retina hybrid cells
    C D'Orlando
    Institute of Histology and General Embryology, University of Fribourg, CH 1705 Fribourg, Switzerland
    Brain Res 945:181-90. 2002
    ..The results indicate that the 'fast' Ca(2+)-buffers calretinin and calbindin D-28k, but not the 'slow' buffer parvalbumin can protect N18-RE 105 cells from this type of Ca(2+)-dependent L-glutamate-induced delayed cytotoxicity...
  16. ncbi request reprint Association between the calcium-binding protein calretinin and cytoskeletal components in the human colon adenocarcinoma cell line WiDr
    D Marilley
    Institute of Histology and General Embryology, Fribourg, CH 1705, Switzerland
    Exp Cell Res 259:12-22. 2000
    ..These data suggest that CR may contribute to the transformation of enterocytes by interfering with the differentiation process, i.e., acting at both levels: cell shape dynamics and mitosis...
  17. ncbi request reprint Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin D-28k or both
    Maria A Farré-Castany
    Unit of Anatomy, Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
    Behav Brain Res 178:250-61. 2007
    ..In summary, the lack of these calcium-binding proteins yields characteristic, yet distinct phenotypes with respect to locomotor activity and coordination...
  18. pmc SV40-induced expression of calretinin protects mesothelial cells from asbestos cytotoxicity and may be a key factor contributing to mesothelioma pathogenesis
    Thomas Henzi
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
    Am J Pathol 174:2324-36. 2009
    ..Up-regulation of calretinin, resulting from either asbestos exposure or SV40 oncoproteins, may be a common denominator that leads to increased resistance to asbestos cytotoxicity and thereby contributes to mesothelioma carcinogenesis...
  19. ncbi request reprint Alternative splicing of calretinin mRNA leads to different forms of calretinin
    B Schwaller
    Institute of Histology and General Embryology, University of Fribourg, Switzerland
    Eur J Biochem 230:424-30. 1995
    ..The fact that alternative splicing of calretinin was found in five different cell lines suggests that alternatively spliced calretinins fulfill a physiological function...
  20. ncbi request reprint Parvalbumin deficiency in fast-twitch muscles leads to increased 'slow-twitch type' mitochondria, but does not affect the expression of fiber specific proteins
    Peter Racay
    Department of Medicine, Division of Histology and General Embryology, University of Fribourg, Switzerland
    FEBS J 273:96-108. 2006
    ..We propose that 'slow-twitch type' mitochondria in PV-/- fast muscles are aimed to functionally replace the slow-onset buffer PV based on similar kinetic properties of Ca2+ removal...
  21. doi request reprint A bipartite butyrate-responsive element in the human calretinin (CALB2) promoter acts as a repressor in colon carcinoma cells but not in mesothelioma cells
    Katrin Häner
    Unit of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    J Cell Biochem 109:519-31. 2010
    ..Calretinin expression in colon cancer cells is negatively regulated by butyrate via a bipartite BRE flanking the TATA box and this may be linked to butyrate's chemopreventive activity...
  22. doi request reprint Lack of calbindin-D28k alters response of the murine circadian clock to light
    Frédéric Stadler
    Department of Medicine, Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
    Chronobiol Int 27:68-82. 2010
    ..Period length and circadian rhythmicity were comparable between Calb1(-/-) and wild-type animals. Our findings indicate an involvement of CB in the signaling pathway that modulates the behavioral and molecular response to light...
  23. ncbi request reprint Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancer
    Silvia Vonlanthen
    Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
    Anticancer Res 27:4279-88. 2007
    ....
  24. ncbi request reprint Parvalbumin-deficiency facilitates repetitive IPSCs and gamma oscillations in the hippocampus
    Martin Vreugdenhil
    Department of Neurophysiology, Division of Neuroscience, Medical School, University of Birmingham, B15 2TT, Birmingham, United Kingdom
    J Neurophysiol 89:1414-22. 2003
    ....
  25. ncbi request reprint Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction
    Ana Maria Gomez
    Department of Physiology, University of Bern, Bern, Switzerland
    Circ Res 91:323-30. 2002
    ..8%) observed in PMI cells. We conclude that the increase in NCX density may be a mechanism to maintain the required Ca2+ extrusion from a larger cell to allow adequate relaxation...
  26. doi request reprint Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse
    Iancu Bucurenciu
    Physiological Institute I, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Neuron 57:536-45. 2008
    ..Thus, tight coupling contributes to fast feedforward and feedback inhibition in the hippocampal network...
  27. pmc Renal expression of parvalbumin is critical for NaCl handling and response to diuretics
    Hendrica Belge
    Department of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 104:14849-54. 2007
    ..They also provide insights into the Ca(2+)-sparing action of thiazides and the pathophysiology of distal tubulopathies...
  28. ncbi request reprint Parvalbumin is a mobile presynaptic Ca2+ buffer in the calyx of held that accelerates the decay of Ca2+ and short-term facilitation
    Martin Muller
    Laboratory of Synaptic Mechanisms, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    J Neurosci 27:2261-71. 2007
    ..Thus, in young calyces of Held, a mobile Ca2+ buffer with slow binding kinetics, primarily represented by parvalbumin, accelerates the decay of spatially averaged [Ca2+]i and paired-pulse facilitation...
  29. ncbi request reprint Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatum
    Walter Maetzler
    Section of Neuroanatomy, Institute of Anatomy, University of Basel, Switzerland
    Exp Neurol 186:78-88. 2004
    ....
  30. pmc Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k
    Hartmut Schmidt
    Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
    J Physiol 551:13-32. 2003
    ..Our results suggest that the distinct kinetics of PV and CB underlie the biphasic kinetics of synaptically evoked Ca2+ transients in dendritic shafts of PCs...
  31. ncbi request reprint Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling
    Thibault Collin
    Laboratory of Cerebral Physiology, Centre National de la Recherche Scientifique, University Paris 5, 75006 Paris, France
    J Neurosci 25:96-107. 2005
    ..Overall, PV arises as a major contributor to presynaptic Ca(i) signals and synaptic integration in the cerebellar cortex...
  32. pmc Resolving the fast kinetics of cooperative binding: Ca2+ buffering by calretinin
    Guido C Faas
    Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Biol 5:e311. 2007
    ....
  33. pmc Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons
    Hartmut Schmidt
    Carl Ludwig Institut für Physiologie, Abteilung Neurophysiologie, Medizinische Fakultat, Universitat Leipzig, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 102:5850-5. 2005
    ..Our results suggest that CB acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound IMPase in central neurons...
  34. pmc Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching
    Hartmut Schmidt
    Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
    Biophys J 84:2599-608. 2003
    ..Our experimental approach represents a versatile tool for quantifying the mobility of proteins in neuronal dendrites...
  35. ncbi request reprint Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones
    Hartmut Schmidt
    Carl Ludwig Institut für Physiologie, Abteilung Neurophysiologie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    J Neurochem 100:727-35. 2007
    ..Our findings support the notion that PV functions as a pure Ca(2+) buffer and will aid simulations of neuronal Ca(2+) signalling...
  36. pmc Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins
    Sheila L Dargan
    Department of Neurobiology and Behaviour, University of California Irvine, CA 92697 4550, USA
    J Physiol 556:447-61. 2004
    ..The ability of Ca(2+) buffers and CaBPs with differing kinetics to fine-tune both global and local intracellular Ca(2+) signals is likely to have significant physiological implications...