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Genomes and Genes | B SchwallerSummaryAffiliation: University of Fribourg Country: Switzerland Publications
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Publications
The continuing disappearance of "pure" Ca2+ buffersB Schwaller
Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, 1700, Fribourg, Switzerland
Cell Mol Life Sci 66:275-300. 2009....- The use of transgenic mouse models to reveal the functions of Ca2+ buffer proteins in excitable cellsBeat Schwaller
Unit of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland
Biochim Biophys Acta 1820:1294-303. 2012..Their physiological role in excitable cells has been investigated in vivo by analyzing the phenotype of mice either lacking one of the Ca2+ buffers or mice with ectopic expression... - The regulation of a cell's Ca(2+) signaling toolkit: the Ca (2+) homeostasomeBeat Schwaller
Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700, Fribourg, Switzerland
Adv Exp Med Biol 740:1-25. 2012..Mechanistic details on the functioning of the Ca(2+) homeostasome are presented... 
Cytosolic Ca2+ buffersBeat Schwaller
Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
Cold Spring Harb Perspect Biol 2:a004051. 2010..All of these molecules are not only functionally coupled, but their expression is likely to be regulated in a Ca(2+)-dependent manner to maintain normal Ca(2+) signaling, even in the absence or malfunctioning of one of the components...
Identification of calretinin and the alternatively spliced form calretinin-22k in primary pleural mesotheliomas and in their metastasesBeat Schwaller
Division of Histology, Department of Medicine, University of Fribourg, 14, chemin du Musee, CH 1700 Fribourg, Switzerland
Anticancer Res 24:4003-9. 2004..However, in studies published so far, the exact molecular identity of the immunoreactive protein(s) detected in mesothelioma sections has not yet been determined...- Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizuresB Schwaller
Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
Mol Cell Neurosci 25:650-63. 2004..Through an increase in inhibition, the absence of PV facilitates synchronous activity in the cortex and facilitates hypersynchrony through the depolarizing action of GABA in the hippocampus... - 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout miceBeat Schwaller
Institute of Histology and General Embryology, University of Fribourg, Fribourg, Switzerland
Cerebellum 1:241-58. 2002..Surprisingly, a major role of any of these three calcium-binding proteins as an endogenous neuroprotectant is not generally supported... - A polyclonal goat antiserum against the calcium-binding protein calretinin is a versatile tool for various immunochemical techniquesB Schwaller
Institute of Histology and General Embryology, University of Fribourg, Perolles, Switzerland
J Neurosci Methods 92:137-44. 1999..Immunostaining of these samples is comparable to that with the well-characterized calretinin-specific polyclonal rabbit antiserum 7696... - Deficiency in parvalbumin, but not in calbindin D-28k upregulates mitochondrial volume and decreases smooth endoplasmic reticulum surface selectively in a peripheral, subplasmalemmal region in the soma of Purkinje cellsG Chen
University of Fribourg, Division of Histology, Department of Medicine, University of Fribourg, 14, chemin du Musee, CH 1705 Fribourg, Switzerland
Neuroscience 142:97-105. 2006..Rather the cell attempts to restore spatiotemporal aspects of Ca(2+) signals prevailing in the undisturbed (wildtype) situation by subtly fine tuning existing components involved in the regulation of Ca(2+) fluxes... - Calretinin and calretinin-22k increase resistance toward sodium butyrate-induced differentiation in CaCo-2 colon adenocarcinoma cellsD Marilley
Institute of Histology and General Embryology, , CH-1705, Fribourg, Switzerland
Exp Cell Res 268:93-103. 2001..This implicates that expression of CR and/or CR-22k in colon tumor cells may contribute to tumorigenesis by blocking differentiation-promoting signals... - Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cellsB Fellay
Institute of Histology and General Embryology, University of Fribourg, CH-1705, Fribourg, Switzerland
Brain Res 909:145-58. 2001..Our results indicate that in the P19-cell model, CR and CB can help to delay the onset of cell death after excitotoxic stimulation... - Alterations in Purkinje cell spines of calbindin D-28 k and parvalbumin knock-out miceM Vecellio
Institute of Histology and General Embryology, University of Fribourg, CH 1705 Fribourg, Switzerland
Eur J Neurosci 12:945-54. 2000..The increase in various spine parameters, particularly volume, may counteract the lack of the calcium buffers, such as to adjust Ca2+-transients at the transitional zone between spines and dendrites... - Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout miceB Schwaller
Institute of Histology and General Embryology and Program in Neuroscience, University of Fribourg, CH 1705 Fribourg, Switzerland
Am J Physiol 276:C395-403. 1999..Acceleration of the contraction-relaxation cycle of fast-twitch muscle fibers by PV may confer an advantage in the performance of rapid, phasic movements... - Monoclonal antibodies recognizing epitopes of calretinins: dependence on Ca2+-binding status and differences in antigen accessibility in colon cancer cellsL Zimmermann
Institute of Histology and General Embryology, University of Fribourg, Switzerland
Cell Calcium 31:13-25. 2002..These antibodies are valuable tools to further investigate the distribution and eventually the specific function of these two proteins in the nervous tissue and under pathological conditions, e.g. in colon tumours and mesotheliomas... - Calretinin and calbindin D-28k, but not parvalbumin protect against glutamate-induced delayed excitotoxicity in transfected N18-RE 105 neuroblastoma-retina hybrid cellsC D'Orlando
Institute of Histology and General Embryology, University of Fribourg, CH 1705 Fribourg, Switzerland
Brain Res 945:181-90. 2002..The results indicate that the 'fast' Ca(2+)-buffers calretinin and calbindin D-28k, but not the 'slow' buffer parvalbumin can protect N18-RE 105 cells from this type of Ca(2+)-dependent L-glutamate-induced delayed cytotoxicity... - Association between the calcium-binding protein calretinin and cytoskeletal components in the human colon adenocarcinoma cell line WiDrD Marilley
Institute of Histology and General Embryology, Fribourg, CH 1705, Switzerland
Exp Cell Res 259:12-22. 2000..These data suggest that CR may contribute to the transformation of enterocytes by interfering with the differentiation process, i.e., acting at both levels: cell shape dynamics and mitosis... - Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin D-28k or bothMaria A Farré-Castany
Unit of Anatomy, Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
Behav Brain Res 178:250-61. 2007..In summary, the lack of these calcium-binding proteins yields characteristic, yet distinct phenotypes with respect to locomotor activity and coordination... - SV40-induced expression of calretinin protects mesothelial cells from asbestos cytotoxicity and may be a key factor contributing to mesothelioma pathogenesisThomas Henzi
Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
Am J Pathol 174:2324-36. 2009..Up-regulation of calretinin, resulting from either asbestos exposure or SV40 oncoproteins, may be a common denominator that leads to increased resistance to asbestos cytotoxicity and thereby contributes to mesothelioma carcinogenesis... - Alternative splicing of calretinin mRNA leads to different forms of calretininB Schwaller
Institute of Histology and General Embryology, University of Fribourg, Switzerland
Eur J Biochem 230:424-30. 1995..The fact that alternative splicing of calretinin was found in five different cell lines suggests that alternatively spliced calretinins fulfill a physiological function... - Parvalbumin deficiency in fast-twitch muscles leads to increased 'slow-twitch type' mitochondria, but does not affect the expression of fiber specific proteinsPeter Racay
Department of Medicine, Division of Histology and General Embryology, University of Fribourg, Switzerland
FEBS J 273:96-108. 2006..We propose that 'slow-twitch type' mitochondria in PV-/- fast muscles are aimed to functionally replace the slow-onset buffer PV based on similar kinetic properties of Ca2+ removal... - A bipartite butyrate-responsive element in the human calretinin (CALB2) promoter acts as a repressor in colon carcinoma cells but not in mesothelioma cellsKatrin Häner
Unit of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland
J Cell Biochem 109:519-31. 2010..Calretinin expression in colon cancer cells is negatively regulated by butyrate via a bipartite BRE flanking the TATA box and this may be linked to butyrate's chemopreventive activity... - Lack of calbindin-D28k alters response of the murine circadian clock to lightFrédéric Stadler
Department of Medicine, Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Chronobiol Int 27:68-82. 2010..Period length and circadian rhythmicity were comparable between Calb1(-/-) and wild-type animals. Our findings indicate an involvement of CB in the signaling pathway that modulates the behavioral and molecular response to light... - Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancerSilvia Vonlanthen
Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
Anticancer Res 27:4279-88. 2007.... - Parvalbumin-deficiency facilitates repetitive IPSCs and gamma oscillations in the hippocampusMartin Vreugdenhil
Department of Neurophysiology, Division of Neuroscience, Medical School, University of Birmingham, B15 2TT, Birmingham, United Kingdom
J Neurophysiol 89:1414-22. 2003.... - Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarctionAna Maria Gomez
Department of Physiology, University of Bern, Bern, Switzerland
Circ Res 91:323-30. 2002..8%) observed in PMI cells. We conclude that the increase in NCX density may be a mechanism to maintain the required Ca2+ extrusion from a larger cell to allow adequate relaxation... - Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapseIancu Bucurenciu
Physiological Institute I, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
Neuron 57:536-45. 2008..Thus, tight coupling contributes to fast feedforward and feedback inhibition in the hippocampal network... - Renal expression of parvalbumin is critical for NaCl handling and response to diureticsHendrica Belge
Department of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
Proc Natl Acad Sci U S A 104:14849-54. 2007..They also provide insights into the Ca(2+)-sparing action of thiazides and the pathophysiology of distal tubulopathies... - Parvalbumin is a mobile presynaptic Ca2+ buffer in the calyx of held that accelerates the decay of Ca2+ and short-term facilitationMartin Muller
Laboratory of Synaptic Mechanisms, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
J Neurosci 27:2261-71. 2007..Thus, in young calyces of Held, a mobile Ca2+ buffer with slow binding kinetics, primarily represented by parvalbumin, accelerates the decay of spatially averaged [Ca2+]i and paired-pulse facilitation... - Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatumWalter Maetzler
Section of Neuroanatomy, Institute of Anatomy, University of Basel, Switzerland
Exp Neurol 186:78-88. 2004.... - Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28kHartmut Schmidt
Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
J Physiol 551:13-32. 2003..Our results suggest that the distinct kinetics of PV and CB underlie the biphasic kinetics of synaptically evoked Ca2+ transients in dendritic shafts of PCs... - Developmental changes in parvalbumin regulate presynaptic Ca2+ signalingThibault Collin
Laboratory of Cerebral Physiology, Centre National de la Recherche Scientifique, University Paris 5, 75006 Paris, France
J Neurosci 25:96-107. 2005..Overall, PV arises as a major contributor to presynaptic Ca(i) signals and synaptic integration in the cerebellar cortex... - Resolving the fast kinetics of cooperative binding: Ca2+ buffering by calretininGuido C Faas
Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS Biol 5:e311. 2007.... - Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neuronsHartmut Schmidt
Carl Ludwig Institut für Physiologie, Abteilung Neurophysiologie, Medizinische Fakultat, Universitat Leipzig, 04103 Leipzig, Germany
Proc Natl Acad Sci U S A 102:5850-5. 2005..Our results suggest that CB acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound IMPase in central neurons... - Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleachingHartmut Schmidt
Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
Biophys J 84:2599-608. 2003..Our experimental approach represents a versatile tool for quantifying the mobility of proteins in neuronal dendrites... - Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neuronesHartmut Schmidt
Carl Ludwig Institut für Physiologie, Abteilung Neurophysiologie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
J Neurochem 100:727-35. 2007..Our findings support the notion that PV functions as a pure Ca(2+) buffer and will aid simulations of neuronal Ca(2+) signalling... - Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteinsSheila L Dargan
Department of Neurobiology and Behaviour, University of California Irvine, CA 92697-4550, USA
J Physiol 556:447-61. 2004..The ability of Ca(2+) buffers and CaBPs with differing kinetics to fine-tune both global and local intracellular Ca(2+) signals is likely to have significant physiological implications...