Martin E Schwab

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Electromyographic activity associated with spontaneous functional recovery after spinal cord injury in rats
    Sibille Kaegi
    Brain Research Institute, University of Zurich and Department of Biology ETH Zurich, 8057 Zurich, Switzerland
    Eur J Neurosci 16:249-58. 2002
  2. pmc Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion
    Marie Laure Beaud
    Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    BMC Neurosci 9:5. 2008
  3. ncbi Increasing plasticity and functional recovery of the lesioned spinal cord
    Martin E Schwab
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, Winterthurerstr 190, 8057 Zurich, Switzerland
    Prog Brain Res 137:351-9. 2002
  4. ncbi Nogo and axon regeneration
    Martin E Schwab
    Brain Research Institute University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Curr Opin Neurobiol 14:118-24. 2004
  5. doi Rewiring of hindlimb corticospinal neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Nat Neurosci 13:97-104. 2010
  6. ncbi Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury
    Marjo Simonen
    Brain Research Institute, University of Zurich, CH 8057, Zurich, Switzerland
    Neuron 38:201-11. 2003
  7. pmc Nogo-a regulates neural precursor migration in the embryonic mouse cortex
    Carole Mathis
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    Cereb Cortex 20:2380-90. 2010
  8. doi Neutralization of the membrane protein Nogo-A enhances growth and reactive sprouting in established organotypic hippocampal slice cultures
    Luis M Craveiro
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    Eur J Neurosci 28:1808-24. 2008
  9. ncbi Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 23:5393-406. 2003
  10. doi Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury
    Irin C Maier
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, 8057 Zurich, Switzerland
    J Neurosci 28:9386-403. 2008

Detail Information

Publications97

  1. ncbi Electromyographic activity associated with spontaneous functional recovery after spinal cord injury in rats
    Sibille Kaegi
    Brain Research Institute, University of Zurich and Department of Biology ETH Zurich, 8057 Zurich, Switzerland
    Eur J Neurosci 16:249-58. 2002
    ..Activity overlap between flexor and extensor muscles might be directly caused by altered descending input or by maladaptation of central pattern generating networks and/or sensory feedback...
  2. pmc Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion
    Marie Laure Beaud
    Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    BMC Neurosci 9:5. 2008
    ..The question therefore arises as to whether anti-Nogo-A treatment prevents the soma shrinkage observed in the contralesional M1?..
  3. ncbi Increasing plasticity and functional recovery of the lesioned spinal cord
    Martin E Schwab
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, Winterthurerstr 190, 8057 Zurich, Switzerland
    Prog Brain Res 137:351-9. 2002
    ..Enhanced growth is paralleled by various degrees of functional recovery...
  4. ncbi Nogo and axon regeneration
    Martin E Schwab
    Brain Research Institute University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Curr Opin Neurobiol 14:118-24. 2004
    ....
  5. doi Rewiring of hindlimb corticospinal neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Nat Neurosci 13:97-104. 2010
    ..Therefore, axotomized hindlimb corticospinal neurons can be incorporated into the sensorimotor circuits of the unaffected forelimb...
  6. ncbi Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury
    Marjo Simonen
    Brain Research Institute, University of Zurich, CH 8057, Zurich, Switzerland
    Neuron 38:201-11. 2003
    ..CST fibers caudal to the lesion-regenerating and/or sprouting from spared intact fibers-were also found to be more frequent in Nogo-A-deficient animals...
  7. pmc Nogo-a regulates neural precursor migration in the embryonic mouse cortex
    Carole Mathis
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    Cereb Cortex 20:2380-90. 2010
    ..These findings suggest that Nogo-A and its receptor complex play a role in the interplay of adhesive and repulsive cell interactions in radial migration during cortical development...
  8. doi Neutralization of the membrane protein Nogo-A enhances growth and reactive sprouting in established organotypic hippocampal slice cultures
    Luis M Craveiro
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    Eur J Neurosci 28:1808-24. 2008
    ..Nogo-A may therefore act as a tonic growth suppressor/stabilizer in the adult intact hippocampus...
  9. ncbi Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 23:5393-406. 2003
    ..This suggests that Nogo-A could have a second membrane topology. The two proposed topological variants may have different intracellular as well as extracellular functions...
  10. doi Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury
    Irin C Maier
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, 8057 Zurich, Switzerland
    J Neurosci 28:9386-403. 2008
    ....
  11. ncbi Nogo-A, -B, and -C are found on the cell surface and interact together in many different cell types
    Dana A Dodd
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, CH 8057 Zurich, Switzerland
    J Biol Chem 280:12494-502. 2005
    ..Nogo-A, -B, and -C share a 180-amino acid C-terminal domain with two highly conserved hydrophobic stretches that could form a channel or transporter in the ER and/or on the cell surface...
  12. ncbi Synaptic destabilization by neuronal Nogo-A
    Elisabeth M Aloy
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology ETH, Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Brain Cell Biol 35:137-56. 2006
    ..Our data suggest that neuronal Nogo-A might play a role in the maintenance of inhibitory synapses by modulating the expression of synaptic anchoring molecules...
  13. ncbi The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
    Florence M Bareyre
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 7:269-77. 2004
    ..Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans...
  14. doi Infusion of anti-Nogo-A antibodies in adult rats increases growth and synapse related proteins in the absence of behavioral alterations
    Luis M Craveiro
    Brain Research Institute, University of Zurich, Zurich, Switzerland Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
    Exp Neurol 250:52-68. 2013
    ..The data indicate that anti-Nogo-A therapy appears safe in the adult CNS over 4weeks of continuous administration. ..
  15. ncbi Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A
    Oliver Weinmann
    Brain Research Institute, University of Zurich and Department Biology, ETH Zurich, Winterthurerstr 190 8057 Zurich, Switzerland
    Mol Cell Neurosci 32:161-73. 2006
    ..These results demonstrate that antibodies against a CNS cell surface protein reach their antigen through the CSF and can induce its downregulation...
  16. pmc Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis
    Martin Kerschensteiner
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    J Exp Med 200:1027-38. 2004
    ..This framework will help to understand the endogenous repair capacity of the CNS and to develop therapeutic strategies to support it...
  17. doi Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system
    Marija M Petrinovic
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 137:2539-50. 2010
    ..Thus, Nogo-A is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching...
  18. doi Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury
    Irin C Maier
    Brain Research Institute, Winterthurerstrasse 190, Zurich, Switzerland
    Brain 132:1426-40. 2009
    ....
  19. ncbi Reorganization of descending motor tracts in the rat spinal cord
    Olivier Raineteau
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Eur J Neurosci 16:1761-71. 2002
    ....
  20. doi Sprouting of brainstem-spinal tracts in response to unilateral motor cortex stroke in mice
    Lukas C Bachmann
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland, and Department Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland
    J Neurosci 34:3378-89. 2014
    ....
  21. ncbi Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration
    Leda Dimou
    Brain Research Institute, University of Zurich, Department Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 26:5591-603. 2006
    ....
  22. doi Constitutive genetic deletion of the growth regulator Nogo-A induces schizophrenia-related endophenotypes
    Roman Willi
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    J Neurosci 30:556-67. 2010
    ..This study provides the first experimental demonstration that Nogo-A bears neuropsychiatric relevance, and alterations in its expression may be one etiological factor in schizophrenia and related disorders...
  23. ncbi Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy
    Nicolas T Lindau
    Brain Research Institute, University of Zurich and Department of Health Science and Technology Swiss Federal Institute of Technology Zurich, Switzerland
    Brain 137:739-56. 2014
    ....
  24. doi Nogo-A antibodies and training reduce muscle spasms in spinal cord-injured rats
    Roman R Gonzenbach
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Ann Neurol 68:48-57. 2010
    ....
  25. doi Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation
    Vincent Pernet
    Department of Biology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 28:7435-44. 2008
    ..Together, our results demonstrate that Nogo-A and MAG are differently involved in oligodendrocyte maturation in vivo, and suggest that Nogo-A may influence also remyelination in pathological conditions such as multiple sclerosis...
  26. ncbi Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats
    Thomas Liebscher
    University and ETH Zurich, Brain Research Institute, Zurich, Switzerland
    Ann Neurol 58:706-19. 2005
    ....
  27. ncbi Behavioral testing strategies in a localized animal model of multiple sclerosis
    Bigna S Buddeberg
    Brain Research Institute, University of Zurich and Department Biology Swiss Federal Institute of Technology, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Neuroimmunol 153:158-70. 2004
    ..Such refined behavioral testing in EAE will be crucial for the analysis of new therapeutic approaches for MS that seek to improve or prevent neurological impairment...
  28. doi Tail spasms in rat spinal cord injury: changes in interneuronal connectivity
    Sandra Kapitza
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Exp Neurol 236:179-89. 2012
    ....
  29. ncbi Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents
    Björn Zörner
    Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
    Nat Methods 7:701-8. 2010
    ..Our testing and analysis method enables comprehensive assessment of locomotor function in rodents and has broad application in various fields of life science research...
  30. pmc Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling
    Armela Joset
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    J Cell Biol 188:271-85. 2010
    ..Thus, Pincher-dependent macroendocytosis leads to the formation of Nogo-A signaling endosomes, which act both within growth cones and after retrograde transport in the cell body to negatively regulate the neuronal growth program...
  31. ncbi Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord
    Florence M Bareyre
    Brain Research Institute, Department of Biology, University of Zurich, ETH Zurich, 8057 Zurich, Switzerland
    J Neurosci 22:7097-110. 2002
    ..These gene expression changes may contribute to attraction, guidance, and stabilization of sprouting CST fibers...
  32. pmc Neuronal Nogo-A modulates growth cone motility via Rho-GTP/LIMK1/cofilin in the unlesioned adult nervous system
    Laura Montani
    Brain Research Institute and Functional Genomics Center, University of Zurich, Switzerland
    J Biol Chem 284:10793-807. 2009
    ..Our study suggests that in the unlesioned adult nervous system, neuronal Nogo-A can restrict neuronal growth through negative modulation of growth cone motility...
  33. pmc Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis
    Martin Kerschensteiner
    Brain Research Institute, University of Zurich, and the Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Pathol 164:1455-69. 2004
    ..We believe that this targeted EAE model will become a helpful new tool for the evaluation of therapeutic approaches for MS that attempt to protect axons or support their repair...
  34. doi Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats
    Angela Müllner
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur J Neurosci 27:326-33. 2008
    ..This appropriate restitution of the serotonergic innervation below the lesion site probably contributes to the impressive recovery of motor function...
  35. ncbi Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome
    Linard Filli
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Brain 134:2261-73. 2011
    ..Understanding these differences may help to develop future therapeutic strategies to improve upper and lower limb function in patients with incomplete cervical spinal cord injuries...
  36. doi Nogo-A represses anatomical and synaptic plasticity in the central nervous system
    Anissa Kempf
    Brain Research Institute, University of Zurich, Switzerland
    Physiology (Bethesda) 28:151-63. 2013
    ..This review summarizes current knowledge on how myelin and neuronal Nogo-A and its receptors exert physiological functions ranging from the regulation of growth suppression to synaptic plasticity in the developing and adult intact CNS...
  37. pmc Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum
    Marija M Petrinovic
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:1083-8. 2013
    ..Thus, Nogo-A appears as a negative regulator of PC input synapses, which orchestrates cerebellar connectivity through regulation of synapse morphology and the size of the PC dendritic tree...
  38. pmc Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord
    Lisa Schnell
    Brain Research Institute, University and ETH of Zurich, Zurich, Switzerland
    Eur J Neurosci 34:1256-67. 2011
    ..This novel combination treatment may help to improve function of the damaged spinal cord...
  39. ncbi Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system
    Anita D Buchli
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Ann Med 37:556-67. 2005
    ....
  40. ncbi Rapid induction of autoantibodies against Nogo-A and MOG in the absence of an encephalitogenic T cell response: implication for immunotherapeutic approaches in neurological diseases
    Doron Merkler
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8057 Zurich, Switzerland
    FASEB J 17:2275-7. 2003
    ..Our findings have critical implications for future strategies in the development of safe and efficient therapeutic vaccines for neurological diseases...
  41. doi Functional and anatomical reorganization of the sensory-motor cortex after incomplete spinal cord injury in adult rats
    Arko Ghosh
    Brain Research Institute and Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology Zurich, 8057 Zurich, Switzerland
    J Neurosci 29:12210-9. 2009
    ..Our results demonstrate profound reorganizations of the intact sensory-motor cortex after unilateral spinal cord injury. These changes may contribute to the behavioral adaptations, notably for the recovery of the ipsilesional hindlimb...
  42. ncbi Repair of the injured spinal cord. A joint approach of basic and clinical research
    Anita D Buchli
    Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
    Neurodegener Dis 4:51-6. 2007
    ....
  43. ncbi Deep brain stimulation of the midbrain locomotor region improves paretic hindlimb function after spinal cord injury in rats
    Lukas C Bachmann
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Sci Transl Med 5:208ra146. 2013
    ..We propose that therapeutic MLR DBS using the brain's own motor command circuits may offer a potential new approach to treat persistent gait disturbances in patients suffering from chronic incomplete spinal cord injury. ..
  44. doi Heterogeneous spine loss in layer 5 cortical neurons after spinal cord injury
    Arko Ghosh
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology, ETH, 8057 Zurich, Switzerland
    Cereb Cortex 22:1309-17. 2012
    ..The spine loss may reflect fast rearrangements of cortical circuits after axotomy, for example, by a disconnection of HL cortical neurons from synaptic inputs that no longer provide useful information...
  45. ncbi Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays
    Florence M Bareyre
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Trends Neurosci 26:555-63. 2003
    ..DNA microarrays have the potential to aid discovery of new targets for neuroprotective or restorative therapeutic approaches..
  46. pmc Synthetic microRNA-mediated downregulation of Nogo-A in transgenic rats reveals its role as regulator of synaptic plasticity and cognitive function
    Björn Tews
    Brain Research Institute, University of Zürich and Department of Health Sciences and Technology, Eidgenössiche Technische Hochschule, Switzerland, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:6583-8. 2013
    ..This fast and efficient microRNA-mediated knockdown provides a way to silence gene expression in vivo in transgenic rats and shows a role of Nogo-A in regulating higher cognitive brain functions...
  47. doi Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve
    Vincent Pernet
    Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neurobiol Dis 51:202-13. 2013
    ....
  48. doi The role of Nogo-A in axonal plasticity, regrowth and repair
    Vincent Pernet
    Brain Research Institute, University of Zürich ETH, Department of Health Sciences and Technology ETH Zürich, Winterthurerstrasse 190, Room 55J34a, 8057 Zurich, Switzerland
    Cell Tissue Res 349:97-104. 2012
    ..Function-blocking anti-Nogo-A antibodies are currently being tested in a clinical trial for improved outcome after spinal cord injury...
  49. doi Anti-Nogo-A and training: can one plus one equal three?
    Michelle L Starkey
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Exp Neurol 235:53-61. 2012
    ..We then discuss the efforts of rehabilitative training and the potential combination of the two therapies...
  50. ncbi Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord
    Armin Buss
    Department Biology, ETH Zurich and Brain Research Institute, University of Zurich, Zurich, Switzerland
    Glia 42:424-32. 2003
    ..In contrast, the bulk of myelin destruction is due to phagocytosis known to be slow, prolonged, and inefficient in the CNS. These results may also have implications for future intervention strategies aiming at enhancing CNS regeneration...
  51. doi Rehabilitative training following unilateral pyramidotomy in adult rats improves forelimb function in a non-task-specific way
    Michelle L Starkey
    Brain Research Institute, University of Zurich and ETH Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Exp Neurol 232:81-9. 2011
    ..Anatomically, only single pellet grasping training was associated with enhanced sprouting of the intact corticospinal tract across the cervical spinal cord midline to innervate the denervated side of the spinal cord...
  52. ncbi A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    FASEB J 17:1238-47. 2003
    ..These data emphasize on the one hand the universal role of reticulons in the eukaryotic system and on the other hand the acquisition of putative new functions through acquirement of novel amino-terminal exons...
  53. pmc Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury
    Caroline Pot
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology Zurich, CH 8057 Zurich, Switzerland
    J Cell Biol 159:29-35. 2002
    ..Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration...
  54. doi Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration
    Anissa Kempf
    Department of Health Sciences and Technology, Brain Research Institute, University of Zurich, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Eur J Neurosci 38:3567-79. 2013
    ..g. the EphrinA3/EphA4 ligand/receptor pair, and support their role in restricting neurite outgrowth in the absence of Nogo-A. ..
  55. doi Functions of Nogo proteins and their receptors in the nervous system
    Martin E Schwab
    University of Zurich and ETH, Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 11:799-811. 2010
    ..In addition, Nogo proteins interact with various intracellular components and may have roles in the regulation of endoplasmic reticulum (ER) structure, processing of amyloid precursor protein and cell survival...
  56. doi Anti-Nogo on the go: from animal models to a clinical trial
    Björn Zörner
    Brain Research Institute, University and ETH Zurich, Zurich, Switzerland
    Ann N Y Acad Sci 1198:E22-34. 2010
    ..A Phase I clinical trial applying anti-Nogo-A antibody to subjects with acute SCI has been successfully conducted and a multicentric, multinational Phase II trial is currently in preparation...
  57. ncbi Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4
    Thomas Oertle
    Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology, Switzerland
    J Mol Biol 325:299-323. 2003
    ..The 5'UTR of Nogo-C harbours a negative control element. These data may help to identify factors that can modulate Nogo transcription, thus offering an alternative approach for Nogo neutralisation...
  58. ncbi Nogo and its paRTNers
    Thomas Oertle
    Brain Research Institute, University of Zurich and Dept of Biology, ETH Zurich, Winterthurerstrasse 190, Switzerland
    Trends Cell Biol 13:187-94. 2003
    ..Here, we review the taxonomic distribution and tissue expression of RTNs, summarize recent discoveries about RTN localization and membrane topology, and discuss the possible functions of RTNs...
  59. pmc The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity
    Anissa Kempf
    Brain Research Institute, University of Zurich, and Dept of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, Switzerland
    PLoS Biol 12:e1001763. 2014
    ..Elucidating Nogo-A/S1PR2 signaling platforms will provide new insights into regulation of synaptic plasticity. ..
  60. ncbi Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions
    Andrea B Huber
    Brain Research Institute, University of Zurich, Zurich, 8057 Switzerland
    J Neurosci 22:3553-67. 2002
    ....
  61. ncbi Do cancer cells die because of Nogo-B?
    Thomas Oertle
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, Switzerland
    Oncogene 22:1390-9. 2003
    ..Our data do not support a function of Nogo-B as a physiological pro-apoptotic protein in certain types of cancer...
  62. ncbi Neutralization of nogo-a enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo
    Ajmal Zemmar
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland, Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland
    J Neurosci 34:8685-98. 2014
    ..Our results identify Nogo-A as an influential molecular modulator of synaptic plasticity and as a regulator for learning of skilled movements in the motor cortex. ..
  63. pmc Nogo-A is a negative regulator of CNS angiogenesis
    Thomas Wälchli
    Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:E1943-52. 2013
    ..These findings identify Nogo-A as an important negative regulator of developmental angiogenesis in the CNS. They may have important implications in CNS pathologies involving angiogenesis such as stroke, brain tumors, and retinopathies...
  64. doi Nogo and Nogo receptor: relevance to schizophrenia?
    Roman Willi
    Brain Research Institute, University of Zurich, Zurich, Switzerland
    Neurobiol Dis 54:150-7. 2013
    ....
  65. doi The rocky road to translation in spinal cord repair
    Linard Filli
    Brain Research Institute, University Zurich and Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
    Ann Neurol 72:491-501. 2012
    ..The time has come to translate the biologic-mechanistic knowledge from basic science into efficacious treatments able to improve the conditions of humans suffering from spinal cord injury...
  66. ncbi Repairing the injured spinal cord
    Martin E Schwab
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Science 295:1029-31. 2002
    ..Certain cell, molecular, and bioengineering strategies for repairing the injured spinal cord are showing encouraging results (either alone or in combination) in animal models, with limited recovery of mobility being reported in some cases...
  67. ncbi Red nucleus projections to distinct motor neuron pools in the rat spinal cord
    Martin Küchler
    Brain Research Institute, University and ETH Zurich, Zurich 8057, Switzerland
    J Comp Neurol 448:349-59. 2002
    ..These experiments support a specific, preferential role of the RST in distal forelimb muscle control...
  68. pmc Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity
    Irin C Maier
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 361:1611-34. 2006
    ....
  69. doi Distinct roles of Nogo-a and Nogo receptor 1 in the homeostatic regulation of adult neural stem cell function and neuroblast migration
    Chiara Rolando
    Department of Neuroscience, University of Turin, I 10126 Turin, Italy
    J Neurosci 32:17788-99. 2012
    ..Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS...
  70. ncbi Molecular analysis of Nogo expression in the hippocampus during development and following lesion and seizure
    Susan Meier
    Institute of Anatomy, Department of Cell Biology and Neurobiology, Humboldt University Hospital Charité, Oskar Hertwig House, Philippstr 12, Berlin, 10098 Germany
    FASEB J 17:1153-5. 2003
    ....
  71. ncbi Cell-autonomous mechanisms and myelin-associated factors contribute to the development of Purkinje axon intracortical plexus in the rat cerebellum
    Sara Gianola
    Department of Neuroscience, Rita Levi Montalcini Centre for Brain Repair, University of Turin, I 10125 Turin, Italy
    J Neurosci 23:4613-24. 2003
    ..Thus, the formation of Purkinje axon collaterals is, in part, controlled by intrinsic determinants, but their growth and distribution are regulated by environmental signals, among which are myelin-derived cues...
  72. ncbi Anti-Nogo-A antibody infusion 24 hours after experimental stroke improved behavioral outcome and corticospinal plasticity in normotensive and spontaneously hypertensive rats
    Christoph Wiessner
    Nervous Systeme Research, Novartis Parma AG, Basel, Switzerland
    J Cereb Blood Flow Metab 23:154-65. 2003
    ..The results suggest that specific anti-Nogo-A antibodies bear potential as a new rehabilitative treatment approach for ischemic stroke with a prolonged time-to-treatment window...
  73. ncbi Functional reorganization of the motor cortex in adult rats after cortical lesion and treatment with monoclonal antibody IN-1
    April J Emerick
    Research and Neurology Service, Edward Hines Veterans Affairs Hospital, Hines, Illinois 60141, USA
    J Neurosci 23:4826-30. 2003
    ..These results show that, after adult cortical lesion, treatment with mAb IN-1 induces a functional reorganization of the intact, opposite motor cortex...
  74. pmc Nogo-A inhibition induces recovery from neglect in rats
    Miranda M Brenneman
    Department of Psychology, Northern Illinois University, DeKalb, IL, USA
    Behav Brain Res 187:262-72. 2008
    ..Severing the corpus callosum to destroy inputs from the contralesional hemisphere resulted in reinstatement of severe neglect, pointing to a possible role of interhemispheric mechanisms in behavioral recovery from neglect...
  75. ncbi Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders
    Markus Reindl
    Department of Neurology, University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria
    J Neuroimmunol 145:139-47. 2003
    ..We finally demonstrate that human anti-Nogo-A antibodies recognize native Nogo-A in brain extracts, oligodendrocytes and cells expressing human Nogo-A...
  76. ncbi Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat
    Catherine M Papadopoulos
    Neurology and Research Services, Hines Veterans Affairs Hospital, Hines, IL 60153, USA
    Ann Neurol 51:433-41. 2002
    ..These results support the efficacy of Nogo-A blockade as a treatment for ischemic stroke and implicate plasticity from the unlesioned hemisphere as a mechanism for recovery...
  77. ncbi Identification of two NOGO/RTN4 genes and analysis of Nogo-A expression in Xenopus laevis
    Michael Klinger
    Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    Mol Cell Neurosci 25:205-16. 2004
    ..Nogo-A in Xenopus myelin might therefore contribute to the failure of spinal cord regeneration in frogs-a feature that may have evolved during the transition from fish to land vertebrates...
  78. ncbi Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions
    Ana Mingorance
    Development and Regeneration of the CNS, Barcelona Science Park IRBB, University of Barcelona, E 08028 Barcelona, Spain
    Mol Cell Neurosci 26:34-49. 2004
    ..In conclusion, our results show that Nogo and its receptor might play key roles during development of hippocampal connections and that they are implicated in neuronal plasticity in the adult...
  79. ncbi Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord
    Karim Fouad
    University of Alberta, Faculty of Rehabilitation Medicine, Edmonton, Canada T6G 2G4
    J Neurosci 25:1169-78. 2005
    ..Our study tests how proven experimental treatments interact in a well-established animal model, thus providing needed direction for the development of future combinatory treatment regimens...
  80. doi Improving outcome after stroke: overcoming the translational roadblock
    Matthias Endres
    Department of Neurology, Center for Stroke Research, Charite, Berlin, Germany
    Cerebrovasc Dis 25:268-78. 2008
    ..These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies...
  81. pmc Nogo-A expression after focal ischemic stroke in the adult rat
    Joseph L Cheatwood
    Research Service 151, Edward Hines Jr VA Hospital, 5000 S 5th Ave, Hines, IL 60141, USA
    Stroke 39:2091-8. 2008
    ..In this study, we describe the regional distribution of cortical neurons expressing Nogo-A in normal rats and following middle cerebral artery occlusion (MCAO)...
  82. doi DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis
    Carole Bourquin
    Department of Neuroimmunology, Max Planck Institute for Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Eur J Pharmacol 588:99-105. 2008
    ..In summary, DNA vaccination is a simple and efficient method for generating an antibody response to Nogo-A. No pathogenicity was observed even during a full-blown inflammatory response of the central nervous system...
  83. ncbi Dendritic plasticity in the adult rat following middle cerebral artery occlusion and Nogo-a neutralization
    Catherine M Papadopoulos
    Research, Hines VA Hospital, Hines, IL 60141, USA
    Cereb Cortex 16:529-36. 2006
    ..Interestingly, administration of mAb IN-1 without lesion resulted in transient dendritic outgrowth with no change in spine density. These results suggest a novel role for Nogo-A in limiting dendritic plasticity after stroke...
  84. pmc Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    J Neurosurg 107:844-53. 2007
    ..To elucidate a potential molecular response to Nogo-A inhibition, we evaluated the effects of 7B12 on hippocampal GAP-43 expression...
  85. ncbi Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke
    Shih Yen Tsai
    Neurology and Research Service, Hines VA Hospital, Roosevelt Road and Fifth Avenue, Hines, IL 60141, USA
    Exp Brain Res 182:261-6. 2007
    ..This is of great importance for the future application of anti-Nogo-A immunotherapy for ischemic stroke treatment...
  86. pmc Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?
    Gregoire Courtine
    Department of Physiological Science and Neurobiology, and Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Nat Med 13:561-6. 2007
  87. ncbi Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey
    Patrick Freund
    Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Comp Neurol 502:644-59. 2007
    ..These processes paralleled the observed improved functional recovery...
  88. pmc The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model
    Natasa Jokic
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, 11 rue Humann, F 67085 Strasbourg, France
    EMBO Rep 7:1162-7. 2006
    ..This suggests that the expression of Nogo-A occurring early in ALS skeletal muscle could cause repulsion and destabilization of the motor nerve terminals, and subsequent dying back of the axons and motor neurons...
  89. ncbi Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates
    Patrick Freund
    Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Nat Med 12:790-2. 2006
    ..Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody...
  90. ncbi Characterization of epidermal neural crest stem cell (EPI-NCSC) grafts in the lesioned spinal cord
    Maya Sieber-Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Mol Cell Neurosci 32:67-81. 2006
    ..Collectively, our data indicate that intraspinal EPI-NCSC demonstrate several desirable characteristics that may include local neural replacement and re-myelination...
  91. ncbi Identification of Nogo-66 receptor (NgR) and homologous genes in fish
    Michael Klinger
    Department of Biology, University of Konstanz, Konstanz, Germany
    Mol Biol Evol 21:76-85. 2004
    ..Expression of zebrafish NgR homologs was detected relatively early in development and prominently in the adult brain, suggesting functions in axon growth, guidance, or plasticity...
  92. ncbi Recovery and brain reorganization after stroke in adult and aged rats
    Tiffanie M Markus
    Neuroscience and Aging Institute, Loyola University Chicago, Maywood, IL, USA
    Ann Neurol 58:950-3. 2005
    ....
  93. ncbi Delayed treatment with monoclonal antibody IN-1 1 week after stroke results in recovery of function and corticorubral plasticity in adult rats
    Andrew B Seymour
    Neurology and Research Service, Hines VA Hospital, Roosevelt Road and Fifth Avenue, Hines, Illinois, USA
    J Cereb Blood Flow Metab 25:1366-75. 2005
    ....
  94. ncbi Analysis of the reticulon gene family demonstrates the absence of the neurite growth inhibitor Nogo-A in fish
    Heike Diekmann
    Department of Biology, University of Konstanz, Konstanz, Germany
    Mol Biol Evol 22:1635-48. 2005
    ..This result is in accordance with functional data showing that axon growth inhibitory molecules are less prominent in fish oligodendrocytes and CNS myelin compared to mammals...
  95. ncbi In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Martin Kerschensteiner
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:572-7. 2005
    ..These results suggest that time-lapse imaging of spinal cord injury may provide a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration...
  96. pmc Nogo receptor antagonizes p75NTR-dependent motor neuron death
    Luc Dupuis
    Institut National de la Sante et de la Recherche Medicale, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, F 67085 France
    Proc Natl Acad Sci U S A 105:740-5. 2008
    ..These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration...
  97. ncbi BMP2 and FGF2 cooperate to induce neural-crest-like fates from fetal and adult CNS stem cells
    Martin H M Sailer
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 118:5849-60. 2005
    ..This rapid and efficient induction of dorsal fates may allow identification of positional identity effectors that are co-regulated by FGF2 and BMP2...